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Total 58416 results found since Jan 2013.
Roles of Immune and Oxidative Stress-Related Factors in the Diagnosis of Coronary Artery Disease: A Retrospective Study
CONCLUSIONS: Bioinformatics analysis technology was used to identify 10 hub DEIOGs that might play a crucial role in CAD progression, and five special hub genes (Fos, Il6, Jun, Mapk3, and Mmp9) could be regarded as potential biomarkers for CAD diagnosis. However, further studies are required to verify the functions of these hub genes.PMID:37691276 | DOI:10.59958/hsf.5799
Source: The Heart Surgery Forum - September 11, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Yue Shu Yin Zheng Yilong Guo Dan Zhu Shian Huang Source Type: research
Molecular complexity of mammary glands development: a review of lactogenic differentiation in epithelial cells
Artif Cells Nanomed Biotechnol. 2023 Dec;51(1):491-508. doi: 10.1080/21691401.2023.2252872.ABSTRACTThe mammary gland is a dynamic organ with various physiological processes like cellular proliferation, differentiation, and apoptosis during the pregnancy-lactation-involution cycle. It is essential to understand the molecular changes during the lactogenic differentiation of mammary epithelial cells (MECs, the milk-synthesizing cells). The MECs are organized as luminal milk-secreting cells and basal myoepithelial cells (responsible for milk ejection by contraction) that form the alveoli. The branching morphogenesis and lactog...
Source: Artificial Cells, Nanomedicine and Biotechnology - September 11, 2023 Category: Biotechnology Authors: Manoj Kumar Jena Farheen Badrealam Khan Syed Azmal Ali Abdullah Abdullah Amarish Kumar Sharma Vikas Yadav Sudhakar Kancharla Prachetha Kolli Gowtham Mandadapu Anjan Kumar Sahoo Prasana Kumar Rath Jalal Taneera Sudarshan Kumar Ashok Kumar Mohanty Khang Wen Source Type: research
Linc00239 Promotes Colorectal Cancer Development via MicroRNA-182-5p/Metadherin Axis
Biochem Genet. 2023 Sep 11. doi: 10.1007/s10528-023-10510-w. Online ahead of print.ABSTRACTLong non-coding RNAs (lncRNAs) are associated with colorectal cancer (CRC); however, CRC-related linc00239 functions have not been fully elucidated. Prognostic analysis of patients with CRC with linc00239 overexpression was performed using data from The Cancer Genome Atlas database. Cell Counting Kit-8 and Transwell were used to determine linc00239 functions for CRC cells. The lncRNA-miRNA-mRNA interaction network was used to screen target miRNAs and mRNAs regulated by linc00239. Quantitative real-time polymerase chain reaction and w...
Source: Biochemical Genetics - September 11, 2023 Category: Genetics & Stem Cells Authors: Jianian Guo Tingting Xie Shi Zhang Source Type: research
miRNA-423 rs6505162 and miRNA-6811 rs2292879 SNP Associated with Lung Cancer in Hainan, China
CONCLUSION: The findings of our study indicate a potential decrease in LC risk among smokers with the miRNA-423 rs6505162 variants, while an increase in risk is associated with miRNA-6811 rs2292879 polymorphisms in the population of Southern Chinese. However, further well-designed research is necessary to fully understand the precise impact of these two SNPs on the development of LC.PMID:37694278 | DOI:10.1042/BSR20231152
Source: Bioscience Reports - September 11, 2023 Category: Biomedical Science Authors: Jing Zhou Chong Meng Yixuan Li Yihui Fu Wenfang Long Hairong Huang Yunru Liu Pengfei Lyu Sha Xiao Source Type: research
Roles of Immune and Oxidative Stress-Related Factors in the Diagnosis of Coronary Artery Disease: A Retrospective Study
CONCLUSIONS: Bioinformatics analysis technology was used to identify 10 hub DEIOGs that might play a crucial role in CAD progression, and five special hub genes (Fos, Il6, Jun, Mapk3, and Mmp9) could be regarded as potential biomarkers for CAD diagnosis. However, further studies are required to verify the functions of these hub genes.PMID:37691276 | DOI:10.59958/hsf.5799
Source: Atherosclerosis - September 11, 2023 Category: Cardiology Authors: Yue Shu Yin Zheng Yilong Guo Dan Zhu Shian Huang Source Type: research
Linc00239 Promotes Colorectal Cancer Development via MicroRNA-182-5p/Metadherin Axis
Biochem Genet. 2023 Sep 11. doi: 10.1007/s10528-023-10510-w. Online ahead of print.ABSTRACTLong non-coding RNAs (lncRNAs) are associated with colorectal cancer (CRC); however, CRC-related linc00239 functions have not been fully elucidated. Prognostic analysis of patients with CRC with linc00239 overexpression was performed using data from The Cancer Genome Atlas database. Cell Counting Kit-8 and Transwell were used to determine linc00239 functions for CRC cells. The lncRNA-miRNA-mRNA interaction network was used to screen target miRNAs and mRNAs regulated by linc00239. Quantitative real-time polymerase chain reaction and w...
Source: Biochemical Genetics - September 11, 2023 Category: Genetics & Stem Cells Authors: Jianian Guo Tingting Xie Shi Zhang Source Type: research
CD14 and CSF1R as developmental molecular targets for the induction of osteoarthritis
CONCLUSION: CD14 and CSF1R are highly expressed in osteoarthritis and may be therapeutic targets for osteoarthritis.PMID:37693684 | PMC:PMC10492034
Source: International Journal of Clinical and Experimental Pathology - September 11, 2023 Category: Pathology Authors: Meiliang Zheng Zheng Li Yingfa Feng Xiaoyu Zhang Source Type: research
Expression and function of CCN2-derived circRNAs in chondrocytes
J Cell Commun Signal. 2023 Sep 11. doi: 10.1007/s12079-023-00782-7. Online ahead of print.ABSTRACTCellular communication network factor 2 (CCN2) molecules promote endochondral ossification and articular cartilage regeneration, and circular RNAs (circRNAs), which arise from various genes and regulate gene expression by adsorbing miRNAs, are known to be synthesized from CCN2 in human vascular endothelial cells and other types of cells. However, in chondrocytes, not only the function but also the presence of CCN2-derived circRNA remains completely unknown. In the present study, we investigated the expression and function of C...
Source: Journal of Cell Communication and Signaling - September 11, 2023 Category: Molecular Biology Authors: Soma Kato Kazumi Kawata Takashi Nishida Tomomi Mizukawa Masaharu Takigawa Seiji Iida Satoshi Kubota Source Type: research
Bioinformatics, RNA sequencing, and targeted bisulfite sequencing analyses identify the role of PROM2 as a diagnostic and prognostic biomarker
CONCLUSION: Via this study, we effectively revealed PROM2 overexpression as a potential diagnostic and prognostic biomarker of survival in BRCA, LUAD, and UCEC.PMID:37692961 | PMC:PMC10492044
Source: American Journal of Translational Research - September 11, 2023 Category: Research Authors: Arsalan Ahmed Uqaili Gulzar Usman Urooj Bhatti Hilal Nasir Rabeea Zia Muhammad Aitzaz Akram Fahim Ali Jawad Afshan Farid Mohamed Ragab AbdelGawwad Saeedah Musaed Almutairi Mohamed S Elshikh Sajid Hussain Rabab Ahmed Rasheed Source Type: research
Potential of miR-181a-5p and miR-630 as clinical biomarkers in NSCLC
CONCLUSIONS: Our findings indicate the miR-181a-5p and miR-630 expression levels have the potential to prognose and predict and therefore improve the treatment individualization and the outcome of NSCLC patients. Circulating miR-181a-5p has the potential clinical value as a non-invasive biomarker for NSCLC.PMID:37697308 | DOI:10.1186/s12885-023-11365-5
Source: Cancer Control - September 11, 2023 Category: Cancer & Oncology Authors: Julija Simiene Daiva Dabkeviciene Diana Stanciute Rimvile Prokarenkaite Valerija Jablonskiene Renatas Askinis Kamile Normantaite Saulius Cicenas Kestutis Suziedelis Source Type: research
Expression and function of CCN2-derived circRNAs in chondrocytes
J Cell Commun Signal. 2023 Sep 11. doi: 10.1007/s12079-023-00782-7. Online ahead of print.ABSTRACTCellular communication network factor 2 (CCN2) molecules promote endochondral ossification and articular cartilage regeneration, and circular RNAs (circRNAs), which arise from various genes and regulate gene expression by adsorbing miRNAs, are known to be synthesized from CCN2 in human vascular endothelial cells and other types of cells. However, in chondrocytes, not only the function but also the presence of CCN2-derived circRNA remains completely unknown. In the present study, we investigated the expression and function of C...
Source: Journal of Cell Communication and Signaling - September 11, 2023 Category: Molecular Biology Authors: Soma Kato Kazumi Kawata Takashi Nishida Tomomi Mizukawa Masaharu Takigawa Seiji Iida Satoshi Kubota Source Type: research
CD14 and CSF1R as developmental molecular targets for the induction of osteoarthritis
CONCLUSION: CD14 and CSF1R are highly expressed in osteoarthritis and may be therapeutic targets for osteoarthritis.PMID:37693684 | PMC:PMC10492034
Source: International Journal of Clinical and Experimental Pathology - September 11, 2023 Category: Pathology Authors: Meiliang Zheng Zheng Li Yingfa Feng Xiaoyu Zhang Source Type: research
miRNA-423 rs6505162 and miRNA-6811 rs2292879 SNP Associated with Lung Cancer in Hainan, China
CONCLUSION: The findings of our study indicate a potential decrease in LC risk among smokers with the miRNA-423 rs6505162 variants, while an increase in risk is associated with miRNA-6811 rs2292879 polymorphisms in the population of Southern Chinese. However, further well-designed research is necessary to fully understand the precise impact of these two SNPs on the development of LC.PMID:37694278 | DOI:10.1042/BSR20231152
Source: Bioscience Reports - September 11, 2023 Category: Biomedical Science Authors: Jing Zhou Chong Meng Yixuan Li Yihui Fu Wenfang Long Hairong Huang Yunru Liu Pengfei Lyu Sha Xiao Source Type: research
Bioinformatics, RNA sequencing, and targeted bisulfite sequencing analyses identify the role of PROM2 as a diagnostic and prognostic biomarker
CONCLUSION: Via this study, we effectively revealed PROM2 overexpression as a potential diagnostic and prognostic biomarker of survival in BRCA, LUAD, and UCEC.PMID:37692961 | PMC:PMC10492044
Source: American Journal of Translational Research - September 11, 2023 Category: Research Authors: Arsalan Ahmed Uqaili Gulzar Usman Urooj Bhatti Hilal Nasir Rabeea Zia Muhammad Aitzaz Akram Fahim Ali Jawad Afshan Farid Mohamed Ragab AbdelGawwad Saeedah Musaed Almutairi Mohamed S Elshikh Sajid Hussain Rabab Ahmed Rasheed Source Type: research
