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Total 58416 results found since Jan 2013.
MicroRNAs Regulate Tumorigenesis by Downregulating SOCS3 Expression: An < em > In silico < /em > Approach
This study identifies the interactions of known (miR-203a-5p) and novel (miR-6756-5p, miR-6732-5p, miR-1203, miR-6887-5p) microRNAs with SOCS3 regions due to their maximum interactions. Identifying the interactions of these microRNAs with SOCS3 will significantly advance the understanding of oncomiRs (miRNAs that are associated with cancer development) in tumor development due to their influence on SOCS3 expression. These insights will assist in future studies to understand the significance of miRNA-SOCS3-associated tumor development and progression.PMID:37701630 | PMC:PMC10493049 | DOI:10.1177/11779322231193535
Source: Bioinformatics and Biology Insights - September 13, 2023 Category: Bioinformatics Authors: Sura Al-Asadi Hiba Mansour Ahmed Jwaid Ataimish Rusul Al-Kahachi Jamila Rampurawala Source Type: research
miR-638 suppresses cervical cancer progression by inhibiting NCAPG2 under the treatment of Tetrandrine
CONCLUSION: We highlighted that miR-638 suppresses cervical cancer progression by inhibiting NCAPG2 under tetrandrine treatment.PMID:37702425 | DOI:10.14670/HH-18-657
Source: Histology and Histopathology - September 13, 2023 Category: Cytology Authors: Min Wang Kai Liu Zhongming Zhou Huizhuan Geng Source Type: research
MicroRNAs Regulate Tumorigenesis by Downregulating SOCS3 Expression: An < em > In silico < /em > Approach
This study identifies the interactions of known (miR-203a-5p) and novel (miR-6756-5p, miR-6732-5p, miR-1203, miR-6887-5p) microRNAs with SOCS3 regions due to their maximum interactions. Identifying the interactions of these microRNAs with SOCS3 will significantly advance the understanding of oncomiRs (miRNAs that are associated with cancer development) in tumor development due to their influence on SOCS3 expression. These insights will assist in future studies to understand the significance of miRNA-SOCS3-associated tumor development and progression.PMID:37701630 | PMC:PMC10493049 | DOI:10.1177/11779322231193535
Source: Bioinformatics and Biology Insights - September 13, 2023 Category: Bioinformatics Authors: Sura Al-Asadi Hiba Mansour Ahmed Jwaid Ataimish Rusul Al-Kahachi Jamila Rampurawala Source Type: research
Peripheral Blood MicroRNAs as Biomarkers of Schizophrenia: Expectations from A Meta-Analysis That Combines Deep Learning Methods
CONCLUSIONS: A meta-analysis that combines computational and mathematical methods provides a reliable tool for identifying candidate biomarkers of schizophrenia.PMID:37703215 | DOI:10.1080/15622975.2023.2258975
Source: The World Journal of Biological Psychiatry - September 13, 2023 Category: Psychiatry Authors: Shiyuan Han Yongning Li Jun Gaoa Source Type: research
MicroRNA signature from extracellular vesicles of HCV/HIV co-infected individuals differs from HCV mono-infected
J Mol Med (Berl). 2023 Sep 14. doi: 10.1007/s00109-023-02367-8. Online ahead of print.ABSTRACTHepatitis C virus (HCV) coinfection with human immunodeficiency virus (HIV) has a detrimental impact on disease progression. Increasing evidence points to extracellular vesicles (EVs) as important players of the host-viral cross-talk. The microRNAs (miRNAs), as essential components of EVs cargo, are key regulators of normal cellular processes and also promote viral replication, viral pathogenesis, and disease progression. We aimed to characterize the plasma-derived EVs miRNA signature of chronic HCV infected and HIV coinfected pat...
Source: Molecular Medicine - September 13, 2023 Category: Molecular Biology Authors: Victoria Cairoli Daniel Valle-Millares Mar ía C Terrón-Orellano Daniel Luque Pablo Ryan Lourdes Dominguez Luz Mart ín-Carbonero Ignacio De Los Santos Elena De Matteo Beatriz Ameigeiras Ver ónica Briz Paola Casciato Mar ía Victoria Preciado Pamela Val Source Type: research
MicroRNAs Regulate Tumorigenesis by Downregulating SOCS3 Expression: An < em > In silico < /em > Approach
This study identifies the interactions of known (miR-203a-5p) and novel (miR-6756-5p, miR-6732-5p, miR-1203, miR-6887-5p) microRNAs with SOCS3 regions due to their maximum interactions. Identifying the interactions of these microRNAs with SOCS3 will significantly advance the understanding of oncomiRs (miRNAs that are associated with cancer development) in tumor development due to their influence on SOCS3 expression. These insights will assist in future studies to understand the significance of miRNA-SOCS3-associated tumor development and progression.PMID:37701630 | PMC:PMC10493049 | DOI:10.1177/11779322231193535
Source: Bioinformatics and Biology Insights - September 13, 2023 Category: Bioinformatics Authors: Sura Al-Asadi Hiba Mansour Ahmed Jwaid Ataimish Rusul Al-Kahachi Jamila Rampurawala Source Type: research
Peripheral Blood MicroRNAs as Biomarkers of Schizophrenia: Expectations from A Meta-Analysis That Combines Deep Learning Methods
CONCLUSIONS: A meta-analysis that combines computational and mathematical methods provides a reliable tool for identifying candidate biomarkers of schizophrenia.PMID:37703215 | DOI:10.1080/15622975.2023.2258975
Source: The World Journal of Biological Psychiatry - September 13, 2023 Category: Psychiatry Authors: Shiyuan Han Yongning Li Jun Gaoa Source Type: research
Nucleic Acid-to-Small Molecule Converter through Amplified Hairpin DNA Circuits
Angew Chem Int Ed Engl. 2023 Sep 13:e202306587. doi: 10.1002/anie.202306587. Online ahead of print.ABSTRACTMany microRNAs (miRNAs) are characteristically found in cancer cells, making miRNAs promising marker biomolecules for cancer diagnosis and therapeutics. However, it is challenging to use miRNA as a cancer signature because it is difficult to convert the nucleic acid sequence information into molecular functionality. To address this challenge, we realize nucleic acid-to-small molecule converters using hairpin DNA circuits. Harnessing a Staudinger reduction as a trigger for the conversion, we constructed hybridization c...
Source: Angewandte Chemie - September 13, 2023 Category: Chemistry Authors: Kunihiko Morihiro Yasuhiro Tomida Daisuke Fukui Manami Hasegawa Akimitsu Okamoto Source Type: research
Peripheral Blood MicroRNAs as Biomarkers of Schizophrenia: Expectations from A Meta-Analysis That Combines Deep Learning Methods
CONCLUSIONS: A meta-analysis that combines computational and mathematical methods provides a reliable tool for identifying candidate biomarkers of schizophrenia.PMID:37703215 | DOI:10.1080/15622975.2023.2258975
Source: The World Journal of Biological Psychiatry - September 13, 2023 Category: Psychiatry Authors: Shiyuan Han Yongning Li Jun Gaoa Source Type: research
MicroRNAs Regulate Tumorigenesis by Downregulating SOCS3 Expression: An < em > In silico < /em > Approach
This study identifies the interactions of known (miR-203a-5p) and novel (miR-6756-5p, miR-6732-5p, miR-1203, miR-6887-5p) microRNAs with SOCS3 regions due to their maximum interactions. Identifying the interactions of these microRNAs with SOCS3 will significantly advance the understanding of oncomiRs (miRNAs that are associated with cancer development) in tumor development due to their influence on SOCS3 expression. These insights will assist in future studies to understand the significance of miRNA-SOCS3-associated tumor development and progression.PMID:37701630 | PMC:PMC10493049 | DOI:10.1177/11779322231193535
Source: Bioinformatics and Biology Insights - September 13, 2023 Category: Bioinformatics Authors: Sura Al-Asadi Hiba Mansour Ahmed Jwaid Ataimish Rusul Al-Kahachi Jamila Rampurawala Source Type: research
Bioinformatics identification and integrative analysis of ferroptosis-related key lncRNAs in patients with osteoarthritis
CONCLUSION: Comprehensive bioinformatics analysis of the FRGs-related ceRNA network determined three molecular biomarkers of lncRNAs that might be affiliated with OA progression.PMID:37702097 | DOI:10.1042/BSR20230255
Source: Bioscience Reports - September 13, 2023 Category: Biomedical Science Authors: Tengyun Yang Guang Yang Guoliang Wang Di Jia Bohan Xiong Xiaojun Lu Yanlin Li Source Type: research
MicroRNAs Regulate Tumorigenesis by Downregulating SOCS3 Expression: An < em > In silico < /em > Approach
This study identifies the interactions of known (miR-203a-5p) and novel (miR-6756-5p, miR-6732-5p, miR-1203, miR-6887-5p) microRNAs with SOCS3 regions due to their maximum interactions. Identifying the interactions of these microRNAs with SOCS3 will significantly advance the understanding of oncomiRs (miRNAs that are associated with cancer development) in tumor development due to their influence on SOCS3 expression. These insights will assist in future studies to understand the significance of miRNA-SOCS3-associated tumor development and progression.PMID:37701630 | PMC:PMC10493049 | DOI:10.1177/11779322231193535
Source: Bioinformatics and Biology Insights - September 13, 2023 Category: Bioinformatics Authors: Sura Al-Asadi Hiba Mansour Ahmed Jwaid Ataimish Rusul Al-Kahachi Jamila Rampurawala Source Type: research
MicroRNA-223: a key regulator of liver tumour microenvironment
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related deaths worldwide with few effective drug treatments. Recent combination therapies inhibiting immune checkpoints and angiogenesis showed better overall and progression-free survival outcomes than the protein kinase inhibitor sorafenib in patients with unresectable HCC,1 suggesting targeting tumour microenvironment (TME) is a promising strategy for the treatment of HCC. However, how the TME is developed and regulated is still poorly known. Thus, understanding the pathogenesis of HCC TME would be essential in order to develop more effective HCC thera...
Source: Gut - September 13, 2023 Category: Gastroenterology Authors: Avila, M. A. Tags: Gut Commentary Source Type: research
