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Role of S100 and YKL40 on Intraventricular Cerebral Hemorrhages in the Preterm Infant and the Neuroprotective Role of miR-138-siRNAs-HIF-1a and miR-21-siRNAs-HVCN1 in Neonatal Mice with Nerve Injury
CONCLUSION: Our findings demonstrate that miR-138-siRNAs-HIF-1a and miR-21-siRNAs-HVCN1 injections prevent cerebral ischemia-induced brain damage in hypoxia mice by increasing HVCN1 and HIF-1a and decreasing S100b, which in turn lessens apoptosis and epilepsy in hypoxic mice.PMID:37724672 | DOI:10.2174/0929867331666230915103147
Source: Current Medicinal Chemistry - September 19, 2023 Category: Chemistry Authors: Roghayeh Ijabi Zachary A Kaminsky Parisa Roozehdar Janat Ijabi Hemen Moradi-Sardareh King Hwa Ling Najmeh Tehranian Source Type: research
Pre-operative Neo-adjuvant Chemotherapy Related miRNAs as Key Regulators and Therapeutic Targets in Colorectal Cancer
CONCLUSION: In patients with colorectal cancer, miRNA expression in the tumoral regions before and after neoadjuvant therapy has represented a variable pattern. It has been shown that miRNA studies can be used to predict the clinical course and response to treatment with differences in expression levels. It has been concluded that specific miRNAs may be candidate biomarkers for colorectal cancer.PMID:37723961 | DOI:10.2174/1874609816666230816152744
Source: Current Aging Science - September 19, 2023 Category: Geriatrics Authors: Orcun Yalav Ozge Sonmezler Kivilcim Eren Erdogan Ahmet Rencuzogullari Figen Doran Atil Bisgin Ibrahim Boga Source Type: research
Identification of Hub Genes and Typing of Tuberculosis Infections Based on Autophagy-Related Genes
Pol J Microbiol. 2023 Sep 20;72(3):223-238. doi: 10.33073/pjm-2023-022. eCollection 2023 Sep 1.ABSTRACTTuberculosis (TB) caused by Mycobacterium tuberculosis is one of the leading causes of morbidity and death in humans worldwide. Some autophagy genes associated with TB and some miRNAs regulating TB have been found, but the identification of autophagy-related genes in M. tuberculosis remains to be explored. Forty-seven autophagy-related genes differentially expressed in TB were identified in this study by analysis of TB-related datasets in the Gene Expression Omnibus (GEO) and autophagy-related genes in the Human Autophagy...
Source: Polish Journal of Microbiology - September 19, 2023 Category: Microbiology Authors: Yunfeng Sheng Haibo Hua Yan Yong Lihong Zhou Source Type: research
Sequencing and analysis of micro RNAs in camel milk exosomes
Acta Vet Hung. 2023 Sep 19. doi: 10.1556/004.2023.00869. Online ahead of print.ABSTRACTIn order to study the species and functions of micro (mi)RNAs in the exosomes of camel milk, non-coding small (s)RNAs were sequenced and identified by Illumina sequencing technology, and the miRNA fraction was analysed by bioinformatics. After quality control, the average length of sRNA of camel milk exosomes was 18-24 nucleotides. A total of 2,659 miRNAs were identified, including 2,458 known, and 201 new miRNAs. Among the known miRNAs, miR-148a and let-7i had the highest expression levels. The results of gene ontology enrichment analys...
Source: Acta Veterinaria Hungarica - September 19, 2023 Category: Veterinary Research Authors: Rinile Wu Caifeng Yue Yina Xie Yuerong Fu Xin Yu Zhuoyuan Li Bin Yang Source Type: research
Pre-operative Neo-adjuvant Chemotherapy Related miRNAs as Key Regulators and Therapeutic Targets in Colorectal Cancer
CONCLUSION: In patients with colorectal cancer, miRNA expression in the tumoral regions before and after neoadjuvant therapy has represented a variable pattern. It has been shown that miRNA studies can be used to predict the clinical course and response to treatment with differences in expression levels. It has been concluded that specific miRNAs may be candidate biomarkers for colorectal cancer.PMID:37723961 | DOI:10.2174/1874609816666230816152744
Source: Current Aging Science - September 19, 2023 Category: Geriatrics Authors: Orcun Yalav Ozge Sonmezler Kivilcim Eren Erdogan Ahmet Rencuzogullari Figen Doran Atil Bisgin Ibrahim Boga Source Type: research
Zona pellucida removal modifies the expression and release of specific microRNAs in domestic cat blastocysts
In conclusion, in vitro culture of domestic cat embryos without the zona pellucida modifies the expression of miR-21, miR-25, miR-29, miR-199 and miR-96 at the blastocyst stage and the release of miR-21, miR-25 and miR-98.PMID:37724015 | DOI:10.1017/S0967199423000436
Source: Zygote - September 19, 2023 Category: Reproduction Medicine Authors: Daniel Veraguas-D ávila Diego Caama ño Darling Sa éz-Ruiz Yazm ín Vásquez Fernando Saravia Fidel Ovidio Castro Lleretny Rodr íguez-Alvarez Source Type: research
Role of S100 and YKL40 on Intraventricular Cerebral Hemorrhages in the Preterm Infant and the Neuroprotective Role of miR-138-siRNAs-HIF-1a and miR-21-siRNAs-HVCN1 in Neonatal Mice with Nerve Injury
CONCLUSION: Our findings demonstrate that miR-138-siRNAs-HIF-1a and miR-21-siRNAs-HVCN1 injections prevent cerebral ischemia-induced brain damage in hypoxia mice by increasing HVCN1 and HIF-1a and decreasing S100b, which in turn lessens apoptosis and epilepsy in hypoxic mice.PMID:37724672 | DOI:10.2174/0929867331666230915103147
Source: Epilepsy Curr - September 19, 2023 Category: Neurology Authors: Roghayeh Ijabi Zachary A Kaminsky Parisa Roozehdar Janat Ijabi Hemen Moradi-Sardareh King Hwa Ling Najmeh Tehranian Source Type: research
MicroRNAs in equine Endometritis: A review of pathophysiology and molecular insights for diagnostic and therapeutic strategies
Int Immunopharmacol. 2023 Sep 17;124(Pt B):110949. doi: 10.1016/j.intimp.2023.110949. Online ahead of print.ABSTRACTEndometritis plays an important role in mare infertility. Certain infectious agents interfere with the innate immune system of endometrium, causing a systemic inflammatory response that lasts for a long time and circulates via the blood or cellular degeneration, leading to endometritis due to bacterial endotoxins. Different small, non-coding RNA molecules are involved in many biological functions. For instance, microRNAs (miRNAs) are involved in the post-transcriptional regulation of gene expression. These mi...
Source: International Immunopharmacology - September 19, 2023 Category: Allergy & Immunology Authors: Sana Asif Talha Umar Zaima Umar Huma Jamil Huili Feng Peipei Zhang Saqib Umer Source Type: research
Effect of miR-18a-5p, miR-19a-3p, and miR-20a-5p on < em > In Vitro < /em > Cardiomyocyte Differentiation of Human Endometrium Tissue-Derived Stem Cells Through Regulation of Smad4 Expression
CONCLUSION: Our results indicate that miR-18a-5p, miR-19a-3p, and miR-20a-5p are involved in the cardiac differentiation propensity of hEMSCs potentially by regulation of Smad levels. Although, more mechanistic experiments are required to confirm this idea.PMID:37724150 | PMC:PMC10505458 | DOI:10.52547/rbmb.12.1.136
Source: Mol Biol Cell - September 19, 2023 Category: Molecular Biology Authors: Behnaz Maleki Mahdi Noureddini Somayeh Saadat Javad Verdi Alireza Farrokhian Hossein Ghanbarian Ebrahim Cheraghi Behrang Alani Source Type: research
Identification of Hub Genes and Typing of Tuberculosis Infections Based on Autophagy-Related Genes
Pol J Microbiol. 2023 Sep 20;72(3):223-238. doi: 10.33073/pjm-2023-022. eCollection 2023 Sep 1.ABSTRACTTuberculosis (TB) caused by Mycobacterium tuberculosis is one of the leading causes of morbidity and death in humans worldwide. Some autophagy genes associated with TB and some miRNAs regulating TB have been found, but the identification of autophagy-related genes in M. tuberculosis remains to be explored. Forty-seven autophagy-related genes differentially expressed in TB were identified in this study by analysis of TB-related datasets in the Gene Expression Omnibus (GEO) and autophagy-related genes in the Human Autophagy...
Source: Polish Journal of Microbiology - September 19, 2023 Category: Microbiology Authors: Yunfeng Sheng Haibo Hua Yan Yong Lihong Zhou Source Type: research
Sequencing and analysis of micro RNAs in camel milk exosomes
Acta Vet Hung. 2023 Sep 19. doi: 10.1556/004.2023.00869. Online ahead of print.ABSTRACTIn order to study the species and functions of micro (mi)RNAs in the exosomes of camel milk, non-coding small (s)RNAs were sequenced and identified by Illumina sequencing technology, and the miRNA fraction was analysed by bioinformatics. After quality control, the average length of sRNA of camel milk exosomes was 18-24 nucleotides. A total of 2,659 miRNAs were identified, including 2,458 known, and 201 new miRNAs. Among the known miRNAs, miR-148a and let-7i had the highest expression levels. The results of gene ontology enrichment analys...
Source: Acta Veterinaria Hungarica - September 19, 2023 Category: Veterinary Research Authors: Rinile Wu Caifeng Yue Yina Xie Yuerong Fu Xin Yu Zhuoyuan Li Bin Yang Source Type: research
GSE220586 IL-17 mediated downregulation of miR-101 facilitates expression of EZH2 to promote epidermal hyperplasia in psoriasis
Contributors : Prabha Sampath ; Candida Vaz ; Gopinath SundaramSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiens ; synthetic constructEpidermal hyperplasia, a characteristic feature of psoriatic skin lesions, is epigenetically driven by Enhancer of Zeste homolog 2 (EZH2). EZH2 and EZH2-mediated trimethylation of histone H3 lysine 27 (H3K27me3) are both abnormally upregulated in psoriatic lesions. To identify microRNAs that could potentially target these epigenetic regulators we profiled miRNAs from psoriatic lesional skin in comparison with healthy skin. Analysis of the differentially expressed miRNAs ...
Source: GEO: Gene Expression Omnibus - September 19, 2023 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens synthetic construct Source Type: research
Clinical Significance of Apurinic/Apyrimidinic Endodeoxyribonuclease 1 and MicroRNA Axis in Hepatocellular Carcinoma
CONCLUSIONS: APE1 regulates specific miRNAs having prognostic value in HCC.PMID:37719963 | PMC:PMC10500290 | DOI:10.14218/JCTH.2022.00179
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Giovanna Mangiapane Devis Pascut Emiliano Dalla Giulia Antoniali Monica Degrassi Lory Saveria Croc è Veronica De Sanctis Silvano Piazza Giulia Canarutto Claudio Tiribelli Gianluca Tell Source Type: research
MiR-4270 acts as a tumor suppressor by directly targeting Bcl-xL in human osteosarcoma cells
Front Oncol. 2023 Aug 31;13:1220459. doi: 10.3389/fonc.2023.1220459. eCollection 2023.ABSTRACTChondrosarcomas and osteosarcomas are malignant bone tumors with a poor prognosis when unresectable or metastasized. Moreover, radiotherapy and chemotherapy could be ineffective. MiRNAs represent an alternative therapeutic approach. Based on high-throughput functional screening, we identified four miRNAs with a potential antiproliferative effect on SW1353 chondrosarcoma cells. Individual functional validations were then performed in SW1353 cells, as well as in three osteosarcoma cell lines. The antiproliferative and cytotoxic effe...
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Cl ément Veys Flavie Boulouard Abderrahim Benmoussa Manon Jammes Emilie Brotin Fran çoise Rédini Laurent Poulain Nicolas Gruchy Christophe Denoyelle Florence Legendre Philippe Galera Source Type: research
The Potential Dual Role of H2.0-like Homeobox in the Tumorgenesis and Development of Colorectal Cancer and Its Prognostic Value
CONCLUSION: HLX probably played a carcinostasis role in the early stages of CRC but exhibited a cancer-promoting effect in the advanced stages. Meanwhile, HLX could serve as a reliable prognostic indicator for CRC.PMID:37719132 | PMC:PMC10505080 | DOI:10.1155/2023/5521544
Source: Canadian Journal of Gastroenterology - September 18, 2023 Category: Gastroenterology Authors: Shuo Chen Lin Zhang Kai Wang Jizhen Huo Siqi Zhang Xipeng Zhang Source Type: research
