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Total 58416 results found since Jan 2013.
Altered microRNA expression in patients with sarcoidosis
Conclusion This is the first miRNA report of differentially expressed miRNAs in the serum of patients with sarcoidosis and matched healthy controls in South Africa. The results obtained suggest that miRNAs may play a role in sarcoidosis pathogenesis. Whether these molecules have diagnostic or prognostic implications, needs future studies recruiting larger patient cohorts.PMID:37712378 | DOI:10.36141/svdld.v40i3.13399
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - September 15, 2023 Category: Respiratory Medicine Authors: Rajen Morar Caroline Dickens Therese Dix-Peek Raquel Duarte Charles Feldman Source Type: research
Serum ‑derived exosomal hsa‑let‑7b‑5p as a biomarker for predicting the severity of coronary stenosis in patients with coronary heart disease and hyperglycemia
In conclusion, the present study demonstrated that serum‑derived exosomal hsa‑let‑7b‑5p is upregulated in patients with CHD and hyperglycemia, and may serve as a noninvasive biomarker for the severity of coronary stenosis.PMID:37711034 | DOI:10.3892/mmr.2023.13090
Source: Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Shufang Han Jie Fang Lili Yu Bin Li Yuhong Hu Ruimin Chen Changyong Li Chuanxu Zhao Jiaying Li Yinan Wang Yuqi Gao Hong Tan Qun Jin Source Type: research
MiR-301a-5p modulates parathyroid hormone secretion in secondary hyperparathyroidism possibly by regulating calcium-sensing receptor
CONCLUSION: MiR-301a-5p affects PTH secretion in SHPT possibly by regulating the expression of CaSR.PMID:37712273 | DOI:10.12122/j.issn.1673-4254.2023.08.13
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: L Liu L Qian P Li J Li S Huang W Yi S Liu W Wu Source Type: research
Melodic maestros: Unraveling the role of miRNAs in the diagnosis, progression, and drug resistance of malignant pleural mesothelioma
Pathol Res Pract. 2023 Sep 13;250:154817. doi: 10.1016/j.prp.2023.154817. Online ahead of print.ABSTRACTMalignant pleural mesothelioma (MPM) is a highly lethal form of pleural cancer characterized by a scarcity of effective therapeutic interventions, resulting in unfavorable prognoses for afflicted individuals. Besides, many patients experience substantial consequences from being diagnosed in advanced stages. The available diagnostic, prognostic, and therapeutic options for MPM are restricted in scope. MicroRNAs (miRNAs) are a subset of small, noncoding RNA molecules that exert significant regulatory influence over several...
Source: Pathology, Research and Practice - September 15, 2023 Category: Pathology Authors: Mai A Abd-Elmawla Sherif S Abdel Mageed Tohada M Al-Noshokaty Mohammed S Elballal Ahmed I Abulsoud Shereen Saeid Elshaer Ahmed A El-Husseiny Doaa Fathi Heba M Midan Nehal I Rizk Mahmoud A Elrebehy Ghadir A Sayed Manar Mohammed El Tabaa Aya Salman Osama A Source Type: research
Bta-miR-127 inhibits secretion, proliferation and promotes apoptosis by targeting ITAG6 in bovine Sertoli cell
In this study, bta-miR-127 overexpression in SC inhibited cell secretion, proliferation, cell viability, and S-phase cells number. However, inhibition of bta-miR-127 had the opposite effect. An over-expression of bta-miR-127 significantly promotes SC apoptosis, and bta-miR-127 inhibition can significantly inhibit this process. These results reveal that bta-miR-127 is an inhibitor of SC proliferation and secretion. A combination of transcriptome sequencing, bioinformatics analysis, and dual-luciferase reporter assay showed that ITAG6 was targeted by bta-miR-127. The small interfering RNA of ITGA6 (si-ITGA6) inhibits SC prol...
Source: International Journal of Biological Macromolecules - September 15, 2023 Category: Biochemistry Authors: Ge Yang Mei Li Qiwen Yang Xiangqin Zhai Jafari Halima Qiaoyan Hu Chuzhao Lei Ruihua Dang Source Type: research
The Dual Role of Non-coding RNAs in the Development of Periodontitis
Biomed Environ Sci. 2023 Aug 20;36(8):743-755. doi: 10.3967/bes2023.079.ABSTRACTThis review aims to sum up how Non-coding RNAs (ncRNAs) regulate the development of periodontitis and provides a new perspective for understanding the pathogenesis of periodontitis. We explored the ncRNA's dual role in the development of periodontitis by summarizing evidence from previous in vivo and in vitro studies as well as clinical samples. In our review, the downregulation of 18 miRNAs, 22 lncRNAs and 10 circRNAs demonstrates protective roles in periodontitis. In contrast, the expression of other 11 miRNAs, 7 lncRNAs and 6 circRNAs are up...
Source: Biomedical and Environmental Sciences : BES - September 15, 2023 Category: Biomedical Science Authors: Xi Xu Guang Ping Lang Zhong Lan Chen Jing Le Wang Ying Ying Han Source Type: research
The macrophage polarization by miRNAs and its potential role in the treatment of tumor and inflammation (Review)
Oncol Rep. 2023 Oct;50(4):190. doi: 10.3892/or.2023.8627. Epub 2023 Sep 15.ABSTRACTThe characteristics of monocyte/macrophage lineage are diversity and plasticity, mainly manifested by M1 and M2 subtypes in the body tissues, and playing different roles in the immunity. In the polarization process of macrophages, the classic molecular mechanism is related to sequential transcription factors. Whether in tumor or inflammatory local microenvironment, the pathological factors of the local microenvironment often affect the polarization of M1 and M2 macrophages, and participate in the occurrence and development of these pathologi...
Source: Oncology Reports - September 15, 2023 Category: Cancer & Oncology Authors: Chaozhe Wang Xidi Wang Danfeng Zhang Xiaolin Sun Yunhua Wu Jing Wang Qing Li Guosheng Jiang Source Type: research
Serum ‑derived exosomal hsa‑let‑7b‑5p as a biomarker for predicting the severity of coronary stenosis in patients with coronary heart disease and hyperglycemia
In conclusion, the present study demonstrated that serum‑derived exosomal hsa‑let‑7b‑5p is upregulated in patients with CHD and hyperglycemia, and may serve as a noninvasive biomarker for the severity of coronary stenosis.PMID:37711034 | DOI:10.3892/mmr.2023.13090
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Shufang Han Jie Fang Lili Yu Bin Li Yuhong Hu Ruimin Chen Changyong Li Chuanxu Zhao Jiaying Li Yinan Wang Yuqi Gao Hong Tan Qun Jin Source Type: research
Exosomes and their miRNA/protein profile in keratoconus-derived corneal stromal cells
Exp Eye Res. 2023 Sep 13:109642. doi: 10.1016/j.exer.2023.109642. Online ahead of print.ABSTRACTKeratoconus (KC) is a corneal thinning disorder and a leading cause of corneal transplantation worldwide. Exosomes are small, secreted extracellular vesicles (30-150 nm) that mediate cellular communication via their proteins, lipids, and nucleic acid content. We aimed to characterize the exosomes secreted by primary corneal fibroblasts from subjects with or without KC. Using human keratoconus stromal fibroblast cells (HKC, n = 4) and healthy stromal fibroblasts (HCF, n = 4), we collected and isolated exosomes using serial ultrac...
Source: Experimental Eye Research - September 15, 2023 Category: Opthalmology Authors: Rachel Hadvina Mariam Lotfy Khaled Theresa Akoto Wenbo Zhi Dimitrios Karamichos Yutao Liu Source Type: research
Cognitive-exercise dual-task intervention ameliorates cognitive decline in natural aging rats via inhibiting the promotion of LncRNA NEAT1/miR-124-3p on caveolin-1-PI3K/Akt/GSK3 β Pathway
This study aimed to investigate the effects of CEDI and the role of regulation of the lncRNA NEAT1/miR-124-3p on the caveolin-1-PI3K/Akt/GSK3β pathway in CEDI improving cognitive function. Forty 18-month-old natural aging rats were randomly assigned to four groups: exercise training group, cognitive training group, CEDI group, and aging control group, and underwent 12 weeks of intervention. A novel object recognition test was performed to determine the cognitive function, and the hippocampus was separated three days after the behavioral tests for further molecular detection. In an in vitro study, the mouse hippocampal neu...
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Tiancong Li Xue Tao Ruifeng Sun Conglin Han Xiaoling Li Ziman Zhu Wenshan Li Peiling Huang Weijun Gong Source Type: research
Melodic maestros: Unraveling the role of miRNAs in the diagnosis, progression, and drug resistance of malignant pleural mesothelioma
Pathol Res Pract. 2023 Sep 13;250:154817. doi: 10.1016/j.prp.2023.154817. Online ahead of print.ABSTRACTMalignant pleural mesothelioma (MPM) is a highly lethal form of pleural cancer characterized by a scarcity of effective therapeutic interventions, resulting in unfavorable prognoses for afflicted individuals. Besides, many patients experience substantial consequences from being diagnosed in advanced stages. The available diagnostic, prognostic, and therapeutic options for MPM are restricted in scope. MicroRNAs (miRNAs) are a subset of small, noncoding RNA molecules that exert significant regulatory influence over several...
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Mai A Abd-Elmawla Sherif S Abdel Mageed Tohada M Al-Noshokaty Mohammed S Elballal Ahmed I Abulsoud Shereen Saeid Elshaer Ahmed A El-Husseiny Doaa Fathi Heba M Midan Nehal I Rizk Mahmoud A Elrebehy Ghadir A Sayed Manar Mohammed El Tabaa Aya Salman Osama A Source Type: research
Molecular subtypes and prognostic models for predicting prognosis of lung adenocarcinoma based on miRNA-related genes
CONCLUSION: Such miRNA-associated target gene characterization could be useful for prognostic prediction and contribute to therapeutic decision-making in LUAD.PMID:37711127 | DOI:10.2174/0929867331666230914151943
Source: Current Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Yuxi Wei Wei Zhong Yalan Bi Xiaoyan Liu Qing Zhou Jia Liu Mengzhao Wang Hong Zhang Minjiang Chen Source Type: research
Extracellular Vesicles and Endocannabinoid Signaling in Patients with COVID-19
Conclusions: EVs carry immunologically functional endocannabinoids in COVID-19 along with miRNAs which may regulate the expression of mRNA transcripts involved in the regulation of endocannabinoid signaling and metabolism. This mechanism could fine-tune and adapt endocannabinoid effects in recipient cells in relationship to the present biological context.PMID:37713293 | DOI:10.1089/can.2023.0040
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Florian Brandes Annekathrin M Keiler Benedikt Kirchner Melanie Borrmann Jean-No ël Billaud Marlene Reithmair Matthias Klein Patrizia Campolongo Detlef Thieme Michael W Pfaffl Gustav Schelling Agnes S Meidert Source Type: research
Secretome Derived from Mesenchymal Stem/Stromal Cells: A Promising Strategy for Diabetes and its Complications
Curr Stem Cell Res Ther. 2023 Sep 13. doi: 10.2174/1574888X19666230913154544. Online ahead of print.ABSTRACTDiabetes is a complex metabolic disease with a high global prevalence. The health and quality of life of patients with diabetes are threatened by many complications, including diabetic foot ulcers, diabetic kidney diseases, diabetic retinopathy, and diabetic peripheral neuropathy. The application of mesenchymal stem/stromal cells (MSCs) in cell therapies has been recognized as a potential treatment for diabetes and its complications. MSCs were originally thought to exert biological effects exclusively by differentiat...
Source: Current Stem Cell Research and Therapy - September 15, 2023 Category: Stem Cells Authors: Ling Li Siyu Hua Lianghui You Tianying Zhong Source Type: research
