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Total 58416 results found since Jan 2013.
Roles of Immune and Oxidative Stress-Related Factors in the Diagnosis of Coronary Artery Disease: A Retrospective Study
CONCLUSIONS: Bioinformatics analysis technology was used to identify 10 hub DEIOGs that might play a crucial role in CAD progression, and five special hub genes (Fos, Il6, Jun, Mapk3, and Mmp9) could be regarded as potential biomarkers for CAD diagnosis. However, further studies are required to verify the functions of these hub genes.PMID:37691276 | DOI:10.59958/hsf.5799
Source: The Heart Surgery Forum - September 11, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Yue Shu Yin Zheng Yilong Guo Dan Zhu Shian Huang Source Type: research
Bioinformatics, RNA sequencing, and targeted bisulfite sequencing analyses identify the role of PROM2 as a diagnostic and prognostic biomarker
CONCLUSION: Via this study, we effectively revealed PROM2 overexpression as a potential diagnostic and prognostic biomarker of survival in BRCA, LUAD, and UCEC.PMID:37692961 | PMC:PMC10492044
Source: American Journal of Translational Research - September 11, 2023 Category: Research Authors: Arsalan Ahmed Uqaili Gulzar Usman Urooj Bhatti Hilal Nasir Rabeea Zia Muhammad Aitzaz Akram Fahim Ali Jawad Afshan Farid Mohamed Ragab AbdelGawwad Saeedah Musaed Almutairi Mohamed S Elshikh Sajid Hussain Rabab Ahmed Rasheed Source Type: research
GSE242513 Real-Time qPCR Array of miRNAs in Leishmania-infected THP-1 macrophages
Contributors : J C Fernandes ; S M Muxel ; L M Floeter-WinterSeries Type : OtherOrganism : Homo sapiensLeishmania amazonensis is a protozoan that primarily infects macrophages and causes cutaneous leishmaniasis in humans. MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at posttranscriptional levels. Previous work demonstrated changes in miRNA profile of host cells favoring parasite survivel. Thus, here we demonstrate that human macrophages upregulate several miRNAs on the initial time points of infection, including the hsa-miR-372, hsa-miR-373, and hsa-miR-520d, which present the same seed. Furthe...
Source: GEO: Gene Expression Omnibus - September 11, 2023 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
LncRNA MALAT1 signaling pathway and clinical applications in overcome on cancers metastasis
AbstractIn spite of its high mortality rate and difficulty in finding a cure, scientific advancements have contributed to a reduction in cancer-related fatalities. Aberrant gene expression during carcinogenesis emphasizes the importance of targeting the signaling networks that control gene expression in cancer treatment. Long noncoding RNAs (lncRNAs), which are transcribed RNA molecules that play a role in gene expression regulation, are a recent innovative therapeutic approach for diagnosing and treating malignancies. MALAT1, a well-known lncRNA, functions in gene expression, RNA processing, and epigenetic control. High e...
Source: Clinical and Experimental Medicine - September 11, 2023 Category: Research Source Type: research
Unlocking the potential of microRNAs: machine learning identifies key biomarkers for myocardial infarction diagnosis
MicroRNAs (miRNAs) play a crucial role in regulating adaptive and maladaptive responses in cardiovascular diseases, making them attractive targets for potential biomarkers. However, their potential as novel bi...
Source: Cardiovascular Diabetology - September 11, 2023 Category: Cardiology Authors: Mehrdad Samadishadlou, Reza Rahbarghazi, Zeynab Piryaei, Mahdad Esmaeili, Çığır Biray Avcı, Farhad Bani and Kaveh Kavousi Tags: Research Source Type: research
MicroRNA-92b targets tumor suppressor gene FBXW7 in glioblastoma
This study investigated the expression of miR-92b in GBM tumors compared to normal brain tissue samples, revealing a significant upregulation. Inhibition of miR-92b using oligonucleotide microRNA inhibitors (OMIs) suppressed GBM cell growth, migration, and induced apoptosis, while ectopic expression of miR-92b yielded opposite effects. Systemic administration of liposomal-miR92b-OMIs in GBM xenograft mice resulted in reductions in tumor volume and weight. Subsequent experiments identified F-Box and WD Repeat Domain Containing 7 (FBXW7) as a direct target gene of miR-92b in GBM cells.DiscussionFBXW7 acts as a tumor suppress...
Source: Frontiers in Oncology - September 11, 2023 Category: Cancer & Oncology Source Type: research
Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Exosome-derived miR-372-5p promotes stemness and metastatic ability of CRC cells by inducing macrophage polarization
In this study, we used miRNA-seq technology to screen out the highly expressed miR-372-5p among the miRNAs differentially expressed in plasma exosomes of clinical CRC patients. It was found that miR-372-5p highly expressed in HCT116 exosomes could be phagocytosed by macrophages and promote their polarization into M2 macrophages by regulating the PTEN/AKT pathway. Meanwhile, co-culture of CRC cells with conditioned medium (CM) of macrophages enhanced the EMT, stemness and metastasis of CRC cells. Mechanistically, CRC cells exosome-derived miR-372-5p induced polarized M2 macrophages to secrete chemokine C-X-C-Motif Ligand 12...
Source: Cellular Signalling - September 10, 2023 Category: Cytology Authors: Xiuru Shi Ke Wei Yulun Wu Lingyu Mao Wenhao Pei Haitao Zhu Yinxiang Shi Shiwen Zhang Shuang Tao Jing Wang Siyan Pang Huilan Mao Wenrui Wang Qingling Yang Changjie Chen Source Type: research
Therapeutic potential of mesenchymal stem cell-derived exosomal miR-296-5p and miR-337-3p in age-related erectile dysfunction via regulating PTEN/PI3K/AKT pathway
Biomed Pharmacother. 2023 Sep 7;167:115449. doi: 10.1016/j.biopha.2023.115449. Online ahead of print.ABSTRACTMesenchymal stem cells (MSCs) are viewed as an increasingly promising treatment for age-related erectile dysfunction (AED). Owing to the limitations of injecting living cells, the injection of exosomes appears to be a more plausible option. However, whether MSC-derived exosomes (MSC-Exos) improve AED and their potential mechanism remains unknown. MSC-Exos were prepared and injected intracavernously into aged rats to determine their effects on AED. Masson's trichrome staining was used to ascertain the changes in the ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 9, 2023 Category: Drugs & Pharmacology Authors: Kefan Li Ruiyu Li Zongyong Zhao Chen Feng Shuai Liu Qiang Fu Source Type: research
MicroRNA-143 as a potential tumor suppressor in cancer: An insight into molecular targets and signaling pathways
Pathol Res Pract. 2023 Sep 6;250:154792. doi: 10.1016/j.prp.2023.154792. Online ahead of print.ABSTRACTMicroRNAs (MiRNAs), which are highly conserved and small noncoding RNAs, negatively regulate gene expression and influence signaling pathways involved in essential biological activities, including cell proliferation, differentiation, apoptosis, and cell invasion. MiRNAs have received much attention in the past decade due to their significant roles in cancer development. In particular, microRNA-143 (miR-143) is recognized as a tumor suppressor and is downregulated in most cancers. However, it seems that miR-143 is upregula...
Source: Pathology, Research and Practice - September 9, 2023 Category: Pathology Authors: Vahid Asghariazar Mahtab Kadkhodayi Mehdi Sarailoo Amir Ghaffari Jolfayi Behzad Baradaran Source Type: research
Proliferation-promoting roles of linear and circular PVT1 are independent of their ability to bind miRNAs in B-cell lymphoma
Int J Biol Macromol. 2023 Sep 7:126744. doi: 10.1016/j.ijbiomac.2023.126744. Online ahead of print.ABSTRACTPlasmacytoma Variant Translocation 1 (PVT1) is a long non-coding RNA located at 8q24.21 immediately downstream of MYC. Both the linear and circular PVT1 transcripts contribute to cancer pathogenesis by binding microRNAs. However, little is known about their roles in B-cell lymphoma. Here we studied their expression patterns, role in growth, and ability to bind miRNAs in B-cell lymphoma. Linear PVT1 transcripts were downregulated in B-cell cell lymphoma lines compared to germinal center B cells, while circPVT1 levels w...
Source: International Journal of Biological Macromolecules - September 9, 2023 Category: Biochemistry Authors: Xing Zhao Anke van den Berg Melanie Winkle Jasper Koerts Annika Seitz Debora de Jong Bea Rutgers Tineke van der Sluis Emke Bakker Joost Kluiver Source Type: research
A DNAzyme dual-feedback autocatalytic exponential amplification biocircuit for microRNA imaging in living cells
Biosens Bioelectron. 2023 Sep 7;241:115669. doi: 10.1016/j.bios.2023.115669. Online ahead of print.ABSTRACTAutocatalytic biocircuit are powerful tools for analysing intracellular biomarkers, but these tools are constrained by limitations in amplification capacity and intracellular delivery efficiency. In this work, we developed a DNAzyme-based dual-feedback autocatalytic exponential amplification biocircuit sustained by a honeycomb MnO2 nanosponge (EDA2@hMNS) for live-cell imaging of intracellular low-abundance microRNAs (miRNA). The EDA2 biocircuit comprises a blocked DNAzyme (b-DNAzyme), a Fuel strand and a Substrate str...
Source: Biosensors and Bioelectronics - September 9, 2023 Category: Biotechnology Authors: Xing Huang Zihao Li Yakun Shi Yanfei Zhang Taorong Shen Meng Chen Zhan Huang Yanli Tong Si-Yang Liu Jianhe Guo Xiaoyong Zou Zong Dai Source Type: research
