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Progress in quantum dot-based biosensors for microRNA assay: A review
Anal Chim Acta. 2023 Oct 16;1278:341615. doi: 10.1016/j.aca.2023.341615. Epub 2023 Jul 13.ABSTRACTMicroRNAs (miRNAs) are responsible for post-transcriptional gene regulation, and may function as valuable biomarkers for diseases diagnosis. Accurate and sensitive analysis of miRNAs is in great demand. Quantum dots (QDs) are semiconductor nanomaterials with superior optoelectronic features, such as high quantum yield and brightness, broad absorption and narrow emission, long fluorescence lifetime, and good photostability. Herein, we give a comprehensive review about QD-based biosensors for miRNA assay. Different QD-based bios...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: Wen-Jing Liu Li-Juan Wang Chun-Yang Zhang Source Type: research
Bioinspired superhydrophobic SERS substrates for machine learning assisted miRNA detection in complex biomatrix below femtomolar limit
Anal Chim Acta. 2023 Oct 16;1278:341708. doi: 10.1016/j.aca.2023.341708. Epub 2023 Aug 11.ABSTRACTSurface-enhanced Raman spectroscopy (SERS) is an analytical method with high potential in the field of medicine. The design of SERS substrates, based on specific morphology and/or chemical modification, allow the recognition of the presence of specific analytes with precision close to a single-molecule detection limit. However, the SERS analysis of real samples is significantly complicated by the presence of a large number of "minor" molecules that can shield the signal from the target analyte and make it impossible to determi...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: A Zabelina A Trelin A Skvortsova D Zabelin V Burtsev E Miliutina V Svorcik O Lyutakov Source Type: research
Progress in quantum dot-based biosensors for microRNA assay: A review
Anal Chim Acta. 2023 Oct 16;1278:341615. doi: 10.1016/j.aca.2023.341615. Epub 2023 Jul 13.ABSTRACTMicroRNAs (miRNAs) are responsible for post-transcriptional gene regulation, and may function as valuable biomarkers for diseases diagnosis. Accurate and sensitive analysis of miRNAs is in great demand. Quantum dots (QDs) are semiconductor nanomaterials with superior optoelectronic features, such as high quantum yield and brightness, broad absorption and narrow emission, long fluorescence lifetime, and good photostability. Herein, we give a comprehensive review about QD-based biosensors for miRNA assay. Different QD-based bios...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: Wen-Jing Liu Li-Juan Wang Chun-Yang Zhang Source Type: research
Comprehensive analysis of OsJAZ gene family deciphers rhizobacteria-mediated nutrient stress modulation in rice
Int J Biol Macromol. 2023 Sep 12:126832. doi: 10.1016/j.ijbiomac.2023.126832. Online ahead of print.ABSTRACTThe JASMONATE-ZIM DOMAIN (JAZ) repressors are crucial proteins in jasmonic acid signaling pathway that are critical for plant growth. Therefore, the present study aimed to identify and characterize OsJAZs in the rice genome, revealing their structural attributes, regulatory elements, miRNA interactions, and subcellular localization. 23 JAZ transcripts across the 6 chromosomes of rice genome were identified having conserved domains and different physiochemical characteristics. Phylogenetically classified into five cla...
Source: International Journal of Biological Macromolecules - September 14, 2023 Category: Biochemistry Authors: Nikita Bisht Anshu Anshu Poonam C Singh Puneet Singh Chauhan Source Type: research
Bioinspired superhydrophobic SERS substrates for machine learning assisted miRNA detection in complex biomatrix below femtomolar limit
Anal Chim Acta. 2023 Oct 16;1278:341708. doi: 10.1016/j.aca.2023.341708. Epub 2023 Aug 11.ABSTRACTSurface-enhanced Raman spectroscopy (SERS) is an analytical method with high potential in the field of medicine. The design of SERS substrates, based on specific morphology and/or chemical modification, allow the recognition of the presence of specific analytes with precision close to a single-molecule detection limit. However, the SERS analysis of real samples is significantly complicated by the presence of a large number of "minor" molecules that can shield the signal from the target analyte and make it impossible to determi...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: A Zabelina A Trelin A Skvortsova D Zabelin V Burtsev E Miliutina V Svorcik O Lyutakov Source Type: research
Integrative transcriptomic analysis unveils lncRNA-miRNA-mRNA interplay in tomato plants responding to Ralstonia solanacearum
Int J Biol Macromol. 2023 Sep 12:126891. doi: 10.1016/j.ijbiomac.2023.126891. Online ahead of print.ABSTRACTRalstonia solanacearum, a bacterial plant pathogen, poses a significant threat to tomato (Solanum lycopersicum) production through destructive wilt disease. While noncoding RNA has emerged as a crucial regulator in plant disease, its specific involvement in tomato bacterial wilt remains limited. Here, we conducted a comprehensive analysis of the transcriptional landscape, encompassing both mRNAs and noncoding RNAs, in a tomato resistant line ('ZRS_7') and a susceptible line ('HTY_9') upon R. solanacearum inoculation ...
Source: International Journal of Biological Macromolecules - September 14, 2023 Category: Biochemistry Authors: Xiuyang Si Hongyan Liu Xi Cheng Chengcui Xu Zhanghui Han Zhongren Dai Rongqing Wang Changtian Pan Gang Lu Source Type: research
Single-cell analysis of the miRNA activities in tuberculous meningitis (TBM) model mice injected with the BCG vaccine
CONCLUSION: In our study, an in-depth exploration of the mRNA expression and miRNA activity of macrophages, microglia, epididymal cells, neurons and vascular smooth muscle cells during TBM progression was conducted using scRNA-Seq, which provided novel insights into the immune cell engagement in TBM patients.PMID:37708706 | DOI:10.1016/j.intimp.2023.110871
Source: International Immunopharmacology - September 14, 2023 Category: Allergy & Immunology Authors: Xiaolin Zhang Lei Pan Peng Zhang Lei Wang Yidan Shen Ping Xu Yang Ren Wei Huang Ping Liu Qingguo Wu Feng Li Source Type: research
Circulating MicroRNAs in the Screening of Prenatal Down Syndrome
CONCLUSION: In light of these data, we believe that miRNAs may have an important role in the noninvasive prenatal diagnosis of fetal birth defects, especially Down syndrome.PMID:37709679
Source: Puerto Rico Health Sciences Journal - September 14, 2023 Category: International Medicine & Public Health Authors: Senay Balci Filiz Cayan Gurbet Dogru Ozdemir Mustafa Ertan Ay Didem Derici Yildirim Lulufer Tamer Source Type: research
Dumbbell hybridization chain reaction coupled with positively charged Au@luminol nanoparticles for enhanced electrochemiluminescent sensing of exosomal miRNA-21
Bioelectrochemistry. 2023 Sep 6;155:108556. doi: 10.1016/j.bioelechem.2023.108556. Online ahead of print.ABSTRACTMicroRNAs (miRNAs) are important cancer biomarkers in cancer cell-derived exosomes. Herein, positively charged Au@luminol nanoparticles ((+)Au@luminol NPs) with enhanced electrochemiluminescence (ECL) and extreme stability were firstly established for the sensitive detection of miRNA-21 in exosome. In the presence of miRNA-21, dumbbell hybridization chain reaction (DHCR) happened at gold nanoparticles and ZIF-67 metal-organic framework modified glass carbon electrode (AuNP/ZIF-MOF/GCE) with the help of dumbbell ...
Source: Bioelectrochemistry - September 14, 2023 Category: Biochemistry Authors: Yun Zhang Shiqiang Li Chenxu Peng Zhe Shi Xiangmin Miao Source Type: research
Progress in quantum dot-based biosensors for microRNA assay: A review
Anal Chim Acta. 2023 Oct 16;1278:341615. doi: 10.1016/j.aca.2023.341615. Epub 2023 Jul 13.ABSTRACTMicroRNAs (miRNAs) are responsible for post-transcriptional gene regulation, and may function as valuable biomarkers for diseases diagnosis. Accurate and sensitive analysis of miRNAs is in great demand. Quantum dots (QDs) are semiconductor nanomaterials with superior optoelectronic features, such as high quantum yield and brightness, broad absorption and narrow emission, long fluorescence lifetime, and good photostability. Herein, we give a comprehensive review about QD-based biosensors for miRNA assay. Different QD-based bios...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: Wen-Jing Liu Li-Juan Wang Chun-Yang Zhang Source Type: research
Circulating MicroRNAs in the Screening of Prenatal Down Syndrome
CONCLUSION: In light of these data, we believe that miRNAs may have an important role in the noninvasive prenatal diagnosis of fetal birth defects, especially Down syndrome.PMID:37709679
Source: Puerto Rico Health Sciences Journal - September 14, 2023 Category: International Medicine & Public Health Authors: Senay Balci Filiz Cayan Gurbet Dogru Ozdemir Mustafa Ertan Ay Didem Derici Yildirim Lulufer Tamer Source Type: research
Bioinspired superhydrophobic SERS substrates for machine learning assisted miRNA detection in complex biomatrix below femtomolar limit
Anal Chim Acta. 2023 Oct 16;1278:341708. doi: 10.1016/j.aca.2023.341708. Epub 2023 Aug 11.ABSTRACTSurface-enhanced Raman spectroscopy (SERS) is an analytical method with high potential in the field of medicine. The design of SERS substrates, based on specific morphology and/or chemical modification, allow the recognition of the presence of specific analytes with precision close to a single-molecule detection limit. However, the SERS analysis of real samples is significantly complicated by the presence of a large number of "minor" molecules that can shield the signal from the target analyte and make it impossible to determi...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: A Zabelina A Trelin A Skvortsova D Zabelin V Burtsev E Miliutina V Svorcik O Lyutakov Source Type: research
Dumbbell hybridization chain reaction coupled with positively charged Au@luminol nanoparticles for enhanced electrochemiluminescent sensing of exosomal miRNA-21
Bioelectrochemistry. 2023 Sep 6;155:108556. doi: 10.1016/j.bioelechem.2023.108556. Online ahead of print.ABSTRACTMicroRNAs (miRNAs) are important cancer biomarkers in cancer cell-derived exosomes. Herein, positively charged Au@luminol nanoparticles ((+)Au@luminol NPs) with enhanced electrochemiluminescence (ECL) and extreme stability were firstly established for the sensitive detection of miRNA-21 in exosome. In the presence of miRNA-21, dumbbell hybridization chain reaction (DHCR) happened at gold nanoparticles and ZIF-67 metal-organic framework modified glass carbon electrode (AuNP/ZIF-MOF/GCE) with the help of dumbbell ...
Source: Bioelectrochemistry - September 14, 2023 Category: Biochemistry Authors: Yun Zhang Shiqiang Li Chenxu Peng Zhe Shi Xiangmin Miao Source Type: research
Circulating MicroRNAs in the Screening of Prenatal Down Syndrome
CONCLUSION: In light of these data, we believe that miRNAs may have an important role in the noninvasive prenatal diagnosis of fetal birth defects, especially Down syndrome.PMID:37709679
Source: Puerto Rico Health Sciences Journal - September 14, 2023 Category: International Medicine & Public Health Authors: Senay Balci Filiz Cayan Gurbet Dogru Ozdemir Mustafa Ertan Ay Didem Derici Yildirim Lulufer Tamer Source Type: research
