Mirnas RSS Page 15

This page shows you your search results in order of date. This is page number 15.

Order by Relevance | Date

Total 58416 results found since Jan 2013.

Genes, Vol. 14, Pages 1796: The Role of MicroRNA in Graft-Versus-Host-Disease: A Review
o Massimo Martino Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a clinically challenging modality for the treatment of many hematologic diseases such as leukemia, lymphoma, and myeloma. Graft-versus-host disease (GVHD) is a common complication after allo-HSCT and remains a major cause of morbidity and mortality, limiting the success of a potentially curative transplant. Several microRNAs (miRNAs) have recently been shown to impact the biology of GVHD. They are molecular regulators involved in numerous processes during T-cell development, homeostasis, and activation, and contribute to the pathologi...
Source: Genes - September 13, 2023 Category: Genetics & Stem Cells Authors: Martina Pitea Filippo Antonio Canale Gaetana Porto Chiara Verduci Giovanna Utano Giorgia Policastro Caterina Alati Ludovica Santoro Lucrezia Imbalzano Massimo Martino Tags: Review Source Type: research

Genes, Vol. 14, Pages 1795: Towards In Silico Identification of Genes Contributing to Similarity of Patients & rsquo; Multi-Omics Profiles: A Case Study of Acute Myeloid Leukemia
Genes, Vol. 14, Pages 1795: Towards In Silico Identification of Genes Contributing to Similarity of Patients’ Multi-Omics Profiles: A Case Study of Acute Myeloid Leukemia Genes doi: 10.3390/genes14091795 Authors: Declan J. Batten Jonathan J. Crofts Nadia Chuzhanova We propose a computational framework for selecting biologically plausible genes identified by clustering of multi-omics data that reveal patients&rsquo; similarity, thus giving researchers a more comprehensive view on any given disease. We employ spectral clustering of a similarity network created by fusion of three similarity netwo...
Source: Genes - September 13, 2023 Category: Genetics & Stem Cells Authors: Declan J. Batten Jonathan J. Crofts Nadia Chuzhanova Tags: Article Source Type: research

Construction of a novel circRNA-miRNA-ferroptosis related mRNA network in ischemic stroke
Sci Rep. 2023 Sep 12;13(1):15077. doi: 10.1038/s41598-023-41028-1.ABSTRACTMolecule alterations are important to explore the pathological mechanism of ischemic stroke (IS). Ferroptosis, a newly recognized type of regulated cell death, is related to IS. Identification of the interactions between circular RNA (circRNA), microRNA (miRNA) and ferroptosis related mRNA may be useful to understand the molecular mechanism of IS. The circRNA, miRNA and mRNA transcriptome data in IS, downloaded from the Gene Expression Omnibus (GEO) database, was used for differential expression analysis. Ferroptosis related mRNAs were identified fro...
Source: Atherosclerosis - September 12, 2023 Category: Cardiology Authors: Huirong Xie Yijie Huang Yanli Zhan Source Type: research

Inhibitory role of bone marrow mesenchymal stem cells-derived exosome in non-small-cell lung cancer: microRNA-30b-5p, EZH2 and PI3K/AKT pathway
J Cell Mol Med. 2023 Sep 12. doi: 10.1111/jcmm.17933. Online ahead of print.ABSTRACTExosomal microRNA (miRNA) exerts potential roles in non-small-cell lung cancer (NSCLC). The current study elucidated the role of miR-30b-5p shuttled by bone marrow mesenchymal stem cells (BMSCs)-derived exosomes in treating NSCLC. Bioinformatics analysis was performed with NSCLC-related miRNA microarray GSE169587 and mRNA data GSE74706 obtained for collection of the differentially expressed miRNAs and mRNAs. The relationship between miR-30b-5p and EZH2 was predicted and confirmed. Exosomes were isolated from BMSCs and identified. BMSCs-deri...
Source: Molecular Medicine - September 12, 2023 Category: Molecular Biology Authors: Tong Wu Qi Tian Ruiji Liu Ke Xu Shanshan Shi Xiudi Zhang Liming Gao Xiaobo Yin Shufeng Xu Ping Wang Source Type: research

MicroRNAs and their regulators: Potential therapeutic targets in pulmonary arterial hypertension
Vascul Pharmacol. 2023 Sep 10;153:107216. doi: 10.1016/j.vph.2023.107216. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is a complex and progressive disease characterized by pulmonary arterial remodeling. Despite that current combination therapy has shown improvement in morbidity and mortality, a better deciphering of the underlying pathological mechanisms and novel therapeutic targets is urgently needed to combat PAH. MicroRNA, the critical element in post-transcription mechanisms, mediates cellular functions mainly by tuning downstream target gene expression. Meanwhile, upstream regulators can regul...
Source: Vascular Pharmacology - September 12, 2023 Category: Drugs & Pharmacology Authors: Yang-Zhi-Ge He Yi-Xuan Wang Jing-Si Ma Ruo-Nan Li Jia Wang Tian-Yu Lian Yu-Ping Zhou Hao-Pu Yang Kai Sun Zhi-Cheng Jing Source Type: research

microRNA silencing in a whole worm cestode model provides insight into miR-71 function
This study provides new knowledge on gene expression regulation in cestodes and suggests that miRNAs could be evaluated as new selective therapeutic targets for treating Neglected Tropical Diseases prioritised by the World Health Organization.PMID:37699506 | DOI:10.1016/j.ijpara.2023.08.002
Source: International Journal for Parasitology - September 12, 2023 Category: Parasitology Authors: Andr és Grecco Natalia Macchiaroli Mat ías Pérez Adriano Casulli Marcela Cucher Mara Cecilia Rosenzvit Source Type: research

Deciphering a shared transcriptomic regulation and the relative contribution of each regulator type through endometrial gene expression signatures
CONCLUSIONS: This study revealed novel hormonal and non-hormonal regulators and their relative contributions to endometrial progression and pathology, providing new leads for the potential causes of endometrial-factor infertility.PMID:37700285 | DOI:10.1186/s12958-023-01131-4
Source: Reproductive Biology - September 12, 2023 Category: Reproduction Medicine Authors: Antonio Parraga-Leo Patricia Sebastian-Leon Almudena Devesa-Peiro Diana Marti-Garcia Nuria Pellicer Jose Remohi Francisco Dominguez Patricia Diaz-Gimeno Source Type: research

MicroRNAs and their regulators: Potential therapeutic targets in pulmonary arterial hypertension
Vascul Pharmacol. 2023 Sep 10:107216. doi: 10.1016/j.vph.2023.107216. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is a complex and progressive disease characterized by pulmonary arterial remodeling. Despite that current combination therapy has shown improvement in morbidity and mortality, a better deciphering of the underlying pathological mechanisms and novel therapeutic targets is urgently needed to combat PAH. MicroRNA, the critical element in post-transcription mechanisms, mediates cellular functions mainly by tuning downstream target gene expression. Meanwhile, upstream regulators can regulate ...
Source: Vascular Pharmacology - September 12, 2023 Category: Drugs & Pharmacology Authors: Yang-Zhi-Ge He Yi-Xuan Wang Jing-Si Ma Ruo-Nan Li Jia Wang Tian-Yu Lian Yu-Ping Zhou Hao-Pu Yang Kai Sun Zhi-Cheng Jing Source Type: research

Inhibitory role of bone marrow mesenchymal stem cells-derived exosome in non-small-cell lung cancer: microRNA-30b-5p, EZH2 and PI3K/AKT pathway
J Cell Mol Med. 2023 Sep 12. doi: 10.1111/jcmm.17933. Online ahead of print.ABSTRACTExosomal microRNA (miRNA) exerts potential roles in non-small-cell lung cancer (NSCLC). The current study elucidated the role of miR-30b-5p shuttled by bone marrow mesenchymal stem cells (BMSCs)-derived exosomes in treating NSCLC. Bioinformatics analysis was performed with NSCLC-related miRNA microarray GSE169587 and mRNA data GSE74706 obtained for collection of the differentially expressed miRNAs and mRNAs. The relationship between miR-30b-5p and EZH2 was predicted and confirmed. Exosomes were isolated from BMSCs and identified. BMSCs-deri...
Source: J Cell Mol Med - September 12, 2023 Category: Molecular Biology Authors: Tong Wu Qi Tian Ruiji Liu Ke Xu Shanshan Shi Xiudi Zhang Liming Gao Xiaobo Yin Shufeng Xu Ping Wang Source Type: research

Pages: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20