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MicroRNA-143 as a potential tumor suppressor in cancer: An insight into molecular targets and signaling pathways
Pathol Res Pract. 2023 Sep 6;250:154792. doi: 10.1016/j.prp.2023.154792. Online ahead of print.ABSTRACTMicroRNAs (MiRNAs), which are highly conserved and small noncoding RNAs, negatively regulate gene expression and influence signaling pathways involved in essential biological activities, including cell proliferation, differentiation, apoptosis, and cell invasion. MiRNAs have received much attention in the past decade due to their significant roles in cancer development. In particular, microRNA-143 (miR-143) is recognized as a tumor suppressor and is downregulated in most cancers. However, it seems that miR-143 is upregula...
Source: Pathology, Research and Practice - September 9, 2023 Category: Pathology Authors: Vahid Asghariazar Mahtab Kadkhodayi Mehdi Sarailoo Amir Ghaffari Jolfayi Behzad Baradaran Source Type: research

GSE242360 Drosha-dependent microRNAs modulate FUS-mediated neurodegeneration in vivo
Contributors : Sukhleen Kour ; Tyler Fortuna ; Dhivyaa Rajasundaram ; Udai PandeySeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensMutations in Fused in Sarcoma (FUS) gene cause the familial and progressive form of amyotrophic lateral sclerosis (ALS). FUS is a nuclear RNA-binding protein involved in RNA processing and the biogenesis of a specific set of microRNAs. Here we report that Drosha and two previously uncharacterized Drosha-dependent miRNAs are strong modulators of FUS expression and prevent the cytoplasmic segregation of insoluble mutant FUS in vivo. We demonstrate that dep...
Source: GEO: Gene Expression Omnibus - September 9, 2023 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research

MicroRNAs as the critical regulators of Forkhead box protein family during gynecological and breast tumor progression and metastasis
AbstractGynecological and breast tumors are one of the main causes of cancer-related mortalities among women. Despite recent advances in diagnostic and therapeutic methods, tumor relapse is observed in a high percentage of these patients due to the treatment failure. Late diagnosis in advanced tumor stages is one of the main reasons for the treatment failure and recurrence in these tumors. Therefore, it is necessary to assess the molecular mechanisms involved in progression of these tumors to introduce the efficient early diagnostic markers. Fokhead Box (FOX) is a family of transcription factors with a key role in regulati...
Source: European Journal of Medical Research - September 9, 2023 Category: Research Source Type: research

Meta analysis of the diagnostic value of circulating miRNA in benign and malignant pulmonary nodules
A meta-analysis was conducted to assess the impact of miRNAs in circulation on diagnosing benign and malignant pulmonary nodules (BPNs and MPNs).
Source: World Journal of Surgical Oncology - September 9, 2023 Category: Cancer & Oncology Authors: Ziqiang Hong, Baiqiang Cui, Xiangdou Bai, Hongchao Li, Tao Cheng, Yannan Sheng, Yingjie Lu, Xusheng Wu, Dacheng Jin, Jing Zhao and Yunjiu Gou Tags: Research Source Type: research

The pathological and therapeutically role of mesenchymal stem cell (MSC)-derived exosome in degenerative diseases; Particular focus on LncRNA and microRNA
Pathol Res Pract. 2023 Aug 22;250:154778. doi: 10.1016/j.prp.2023.154778. Online ahead of print.ABSTRACTBy releasing exosomes, which create the ideal milieu for the resolution of inflammation, mesenchymal stem cells (MSCs) enhance tissue healing and have strong immunomodulatory capabilities. MSCs-derived exosome also can affect tumor progress by a myriad of mechanisms. Exosomes function as a cell-cell communication tool to affect cellular activity in recipient cells and include an array of efficient bioactive chemicals. Understanding the fundamental biology of inflammation ablation, tissue homeostasis, and the creation of ...
Source: Pathology, Research and Practice - September 8, 2023 Category: Pathology Authors: Aiman Mohammed Baqir Al-Dhalimy Haitham Mukhlif Salim A H Shather Israa Habeeb Naser Manar Mohammed Hizam Mohannd Kadhim Alshujery Source Type: research

The interplay between toxoplasmosis and host miRNAs: Mechanisms and consequences
Pathol Res Pract. 2023 Sep 6;250:154790. doi: 10.1016/j.prp.2023.154790. Online ahead of print.ABSTRACTToxoplasmosis is one of the highly prevalent zoonotic diseases worldwide caused by the parasite Toxoplasma gondii (T. gondii). The infection with T. gondii could pass unidentified in immunocompetent individuals; however, latent cysts remain dormant in their digestive tract, but they could be shed and excreted with feces infesting the environment. However, active toxoplasmosis can create serious consequences, particularly in newborns and infected persons with compromised immunity. These complications include ocular toxopla...
Source: Pathology, Research and Practice - September 8, 2023 Category: Pathology Authors: Ahmed S Doghish Mohamed A Ali Mahmoud A Elrebehy Hend H Mohamed Reda Mansour Aml Ghanem Ahmed Hassan Mohammed S Elballal Ola Elazazy Ahmed E Elesawy Sherif S Abdel Mageed Yara A Nassar Osama A Mohammed Ahmed I Abulsoud Source Type: research

miR-136-5p: A key player in human cancers with diagnostic, prognostic and therapeutic implications
Pathol Res Pract. 2023 Sep 3;250:154794. doi: 10.1016/j.prp.2023.154794. Online ahead of print.ABSTRACTMiRNAs have emerged as crucial modulators of the expression of their target genes, attracting significant attention due to their engagement in various cellular processes, like cancer onset and development. Amidst the extensive repertoire of miRNAs implicated in cancer, miR-136-5p has emerged as an emerging miRNA with diverse roles. Dysregulation of miR-136-5p has been proved in human cancers. Accumulating evidence suggests that miR-136-5p mainly functions as a tumor suppressor. These data proposed that miR-136-5p is engag...
Source: Pathology, Research and Practice - September 8, 2023 Category: Pathology Authors: Chou-Yi Hsu Omer Qutaiba B Allela Sheereehan Adull-Hussein Mahdi Ojas Prakashbhai Doshi Mohaned Adil Mohammed Shnain Ali Mohamed J Saadh Source Type: research

The pathological and therapeutically role of mesenchymal stem cell (MSC)-derived exosome in degenerative diseases; Particular focus on LncRNA and microRNA
Pathol Res Pract. 2023 Aug 22;250:154778. doi: 10.1016/j.prp.2023.154778. Online ahead of print.ABSTRACTBy releasing exosomes, which create the ideal milieu for the resolution of inflammation, mesenchymal stem cells (MSCs) enhance tissue healing and have strong immunomodulatory capabilities. MSCs-derived exosome also can affect tumor progress by a myriad of mechanisms. Exosomes function as a cell-cell communication tool to affect cellular activity in recipient cells and include an array of efficient bioactive chemicals. Understanding the fundamental biology of inflammation ablation, tissue homeostasis, and the creation of ...
Source: Cell Research - September 8, 2023 Category: Cytology Authors: Aiman Mohammed Baqir Al-Dhalimy Haitham Mukhlif Salim A H Shather Israa Habeeb Naser Manar Mohammed Hizam Mohannd Kadhim Alshujery Source Type: research

miR-136-5p: A key player in human cancers with diagnostic, prognostic and therapeutic implications
Pathol Res Pract. 2023 Sep 3;250:154794. doi: 10.1016/j.prp.2023.154794. Online ahead of print.ABSTRACTMiRNAs have emerged as crucial modulators of the expression of their target genes, attracting significant attention due to their engagement in various cellular processes, like cancer onset and development. Amidst the extensive repertoire of miRNAs implicated in cancer, miR-136-5p has emerged as an emerging miRNA with diverse roles. Dysregulation of miR-136-5p has been proved in human cancers. Accumulating evidence suggests that miR-136-5p mainly functions as a tumor suppressor. These data proposed that miR-136-5p is engag...
Source: Cell Research - September 8, 2023 Category: Cytology Authors: Chou-Yi Hsu Omer Qutaiba B Allela Sheereehan Adull-Hussein Mahdi Ojas Prakashbhai Doshi Mohaned Adil Mohammed Shnain Ali Mohamed J Saadh Source Type: research

A Novel Saliva and Serum miRNA Panel as a potential useful index for Oral Cancer and the Association of miR-21 with smoking history: a pilot study
Cancer Prev Res (Phila). 2023 Sep 8. doi: 10.1158/1940-6207.CAPR-23-0219. Online ahead of print.ABSTRACTTobacco use is implicated in the carcinogenesis of oral squamous cell carcinoma (OSCC), which is associated with poor survival if not diagnosed early. Identification of novel non-invasive, highly sensitive, and cost-effective diagnostic and risk assessment methods for OSCC would improve early detection. Here, we report a pilot study assessing salivary and serum miRNAs associated with OSCC and stratified by smoking status. Saliva and paired serum samples were collected from 23 OSCC patients and 21 healthy volunteers, with...
Source: Cell Research - September 8, 2023 Category: Cytology Authors: Dimitra P Vageli Panagiotis G Doukas Rema Shah Trinithas Boyi Christina Liu Benjamin L Judson Source Type: research

The pathological and therapeutically role of mesenchymal stem cell (MSC)-derived exosome in degenerative diseases; Particular focus on LncRNA and microRNA
Pathol Res Pract. 2023 Aug 22;250:154778. doi: 10.1016/j.prp.2023.154778. Online ahead of print.ABSTRACTBy releasing exosomes, which create the ideal milieu for the resolution of inflammation, mesenchymal stem cells (MSCs) enhance tissue healing and have strong immunomodulatory capabilities. MSCs-derived exosome also can affect tumor progress by a myriad of mechanisms. Exosomes function as a cell-cell communication tool to affect cellular activity in recipient cells and include an array of efficient bioactive chemicals. Understanding the fundamental biology of inflammation ablation, tissue homeostasis, and the creation of ...
Source: Pathology, Research and Practice - September 8, 2023 Category: Pathology Authors: Aiman Mohammed Baqir Al-Dhalimy Haitham Mukhlif Salim A H Shather Israa Habeeb Naser Manar Mohammed Hizam Mohannd Kadhim Alshujery Source Type: research

The interplay between toxoplasmosis and host miRNAs: Mechanisms and consequences
Pathol Res Pract. 2023 Sep 6;250:154790. doi: 10.1016/j.prp.2023.154790. Online ahead of print.ABSTRACTToxoplasmosis is one of the highly prevalent zoonotic diseases worldwide caused by the parasite Toxoplasma gondii (T. gondii). The infection with T. gondii could pass unidentified in immunocompetent individuals; however, latent cysts remain dormant in their digestive tract, but they could be shed and excreted with feces infesting the environment. However, active toxoplasmosis can create serious consequences, particularly in newborns and infected persons with compromised immunity. These complications include ocular toxopla...
Source: Pathology, Research and Practice - September 8, 2023 Category: Pathology Authors: Ahmed S Doghish Mohamed A Ali Mahmoud A Elrebehy Hend H Mohamed Reda Mansour Aml Ghanem Ahmed Hassan Mohammed S Elballal Ola Elazazy Ahmed E Elesawy Sherif S Abdel Mageed Yara A Nassar Osama A Mohammed Ahmed I Abulsoud Source Type: research

miR-136-5p: A key player in human cancers with diagnostic, prognostic and therapeutic implications
Pathol Res Pract. 2023 Sep 3;250:154794. doi: 10.1016/j.prp.2023.154794. Online ahead of print.ABSTRACTMiRNAs have emerged as crucial modulators of the expression of their target genes, attracting significant attention due to their engagement in various cellular processes, like cancer onset and development. Amidst the extensive repertoire of miRNAs implicated in cancer, miR-136-5p has emerged as an emerging miRNA with diverse roles. Dysregulation of miR-136-5p has been proved in human cancers. Accumulating evidence suggests that miR-136-5p mainly functions as a tumor suppressor. These data proposed that miR-136-5p is engag...
Source: Pathology, Research and Practice - September 8, 2023 Category: Pathology Authors: Chou-Yi Hsu Omer Qutaiba B Allela Sheereehan Adull-Hussein Mahdi Ojas Prakashbhai Doshi Mohaned Adil Mohammed Shnain Ali Mohamed J Saadh Source Type: research

MicroRNAs as novel biomarkers and potential therapeutic options for inflammatory cardiomyopathy
ConclusionsThe identification of specific miRNAs offers a novel diagnostic perspective for recognizing intramyocardial inflammation within virus-negative DCMi patients. Furthermore, these miRNAs hold promise as potential candidates for tailored therapeutic strategies in the context of virus-negative DCMi.
Source: ESC Heart Failure - September 8, 2023 Category: Cardiology Authors: Ganna Aleshcheva, Christian Baumeier, Dominik Harms, C. ‐Thomas Bock, Felicitas Escher, Heinz‐Peter Schultheiss Tags: Original Article Source Type: research

Cancers, Vol. 15, Pages 4449: MicroRNAs Can Influence Ovarian Cancer Progression by Dysregulating Integrin Activity
mihail Emmanuel N. Kontomanolis George Daskalakis Panos Antsaklis Ovarian cancer is a deadly disease that affects thousands of women worldwide. Integrins, transmembrane receptors that mediate cell adhesion and signaling, play important roles in ovarian cancer progression, metastasis, and drug resistance. Dysregulated expression of integrins is implicated in various cellular processes, such as cell migration, invasion, and proliferation. Emerging evidence suggests that microRNAs (miRNAs) can regulate integrin expression and function, thus affecting various physiological and pathological processes, including ovaria...
Source: Cancers - September 8, 2023 Category: Cancer & Oncology Authors: Zacharias Fasoulakis Michaela-Zoi Psarommati Angeliki Papapanagiotou Vasilios Pergialiotis Antonios Koutras Athanasios Douligeris Anastasia Mortaki Antonios Mihail Marianna Theodora Sofoklis Stavros Defkalion Karakalpakis Maria Papamihail Emmanuel N. Kont Tags: Review Source Type: research