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Total 290035 results found since Jan 2013.
Analysing potent biomarkers along phytochemicals for breast cancer therapy: an in silico approach
CONCLUSION: The target-ligand complex of green tea active compound Epigallocatechin gallate with NOTCH (1-4) had the potential to become potent anti-breast cancer therapeutic candidates following further research involving wet-lab experiments.PMID:37726449 | DOI:10.1007/s10549-023-07107-7
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Nivruthi Shekar Paton Vuong Parwinder Kaur Source Type: research
EuHD1 protects against inflammatory injury driven by NLRP3 inflammasome
Int Immunopharmacol. 2023 Feb;115:109712. doi: 10.1016/j.intimp.2023.109712. Epub 2023 Jan 20.ABSTRACTNon-steroidal anti-inflammatory drugs (NSAIDs) possessing anti-inflammatory, analgesic and antipyretic activities, are widely used in the treatment of osteoarthritis, rheumatism and rheumatoid arthritis. However, its long-term or large use will cause serious gastrointestinal injury or cardiovascular adverse reactions, which limits its clinical application. We have synthesized a new class of NSAIDs, EuHD1, which can release hydrogen sulfide and have better gastrointestinal safety. However, the anti-inflammatory molecular me...
Source: International Immunopharmacology - September 19, 2023 Category: Allergy & Immunology Authors: Huanhuan Qiu Wei Wang Kejun Hu Wangwang Liu Shumin Pan Qi Lv Guanglin Xu Qingfeng Yu Source Type: research
Vegetarian diets and the risk of gastrointestinal cancers: a meta-analysis of observational studies
CONCLUSION: Adhering to vegetarian diets reduces the risk of gastrointestinal tumorigenesis. More data from well-conducted cohort and other studies are needed.PMID:37724454 | DOI:10.1097/MEG.0000000000002643
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Tongtong Bai Juanjuan Peng Xinqi Zhu Chengyu Wu Source Type: research
Interactive effects of CDKN2B-AS1 gene polymorphism and habitual risk factors on oral cancer
J Cell Mol Med. 2023 Sep 19. doi: 10.1111/jcmm.17966. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC) is a common malignant disease associated with a high mortality rate and heterogeneous disease aetiology. Cyclin dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1), is a long noncoding RNA that has been shown to act as a scaffold, sponge, or signal hub to promote carcinogenesis. Here, we attempted to assess the effect of CDKN2B-AS1 single-nucleotide polymorphisms (SNPs) on the susceptibility to OSCC. Five CDKN2B-AS1 SNPs, including rs564398, rs1333048, rs1537373, rs2151280 and rs8181047, were analy...
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Jung-Chun Yeh Yi-Tzu Chen Ying-Erh Chou Shih-Chi Su Lun-Ching Chang Yen-Lin Chen Chiao-Wen Lin Shun-Fa Yang Source Type: research
An analysis of quality of life and functional outcomes as reported in randomized trials for red cell transfusions
DISCUSSION: There is no evidence that a liberal transfusion strategy improves QoL and functional outcomes. However, the substantial limitations of many included studies indicate the need for further well-designed and adequately powered trials.PMID:37723866 | DOI:10.1111/trf.17540
Source: Transfusion - September 19, 2023 Category: Hematology Authors: Monica B Pagano Jane A Dennis Osaumwense M Idemudia Simon J Stanworth Jeffrey L Carson Source Type: research
Comprehensive Analysis of Iron Deficiency Anemia and Its Related Disorders in Premenopausal Women Based on a Propensity Score Matching Case Control Study Using National Health Insurance Service Database in Korea
CONCLUSION: In this study, we found that the gynecologic disease is the main cause of IDA in premenopausal women. Gynecological evaluations should be performed more actively in the clinic to prevent and control IDA and IRDs.PMID:37724497 | DOI:10.3346/jkms.2023.38.e299
Source: Journal of Korean Medical Science - September 19, 2023 Category: Biomedical Science Authors: Hyun Jung Lee Haeyong Pak Jae Joon Han Myung Hee Chang Source Type: research
The Role of Mesenchymal Stem/Stromal Cells Secretome in Macrophage Polarization: Perspectives on Treating Inflammatory Diseases
Curr Stem Cell Res Ther. 2023 Sep 4. doi: 10.2174/1574888X18666230811093101. Online ahead of print.ABSTRACTMesenchymal stem/stromal cells (MSCs) have exhibited potential for treating multiple inflammation- related diseases (IRDs) due to their easy acquisition, unique immunomodulatory and tissue repair properties, and immune-privileged characteristics. It is worth mentioning that MSCs release a wide array of soluble bioactive components in the secretome that modulate host innate and adaptive immune responses and promote the resolution of inflammation. As the first line of defense, macrophages exist throughout the entire inf...
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Dongdong Ti Jun Yi Huihua Chen Haojie Hao Chunmeng Shi Source Type: research
Heparin-collagen I bilayers stimulate FAK/ERK ½ signaling via α2β1 integrin to support the growth and anti-inflammatory potency of mesenchymal stromal cells
J Biomed Mater Res A. 2023 Sep 18. doi: 10.1002/jbm.a.37614. Online ahead of print.ABSTRACTUnderstanding mesenchymal stromal cells (MSCs) growth mechanisms in response to surface chemistries is essential to optimize culture methods for high-quality and robust cell yields in cell manufacturing applications. Heparin (HEP) and collagen 1 (COL) substrates have been reported to enhance cell adhesion, growth, viability, and secretory potential in MSCs. However, the biomolecular mechanisms underlying the benefits of combined HEP/COL substrates are unknown. This work used HEP/COL bilayered surfaces to investigate the role of integ...
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Said J Cifuentes Maribella Domenech Source Type: research
Farnesyltransferase (FTase) Inhibitors Increase Inhibition of KIT Mutants by Imatinib
CONCLUSIONS: Our results suggested the potential benefit of farnesyltransferase inhibitors either alone or combined with imatinib in the treatment of gastrointestinal stromal tumors carrying KIT mutations.PMID:37724142 | PMC:PMC10505455 | DOI:10.52547/rbmb.12.1.74
Source: Mol Biol Cell - September 19, 2023 Category: Molecular Biology Authors: Zhaoyang Fan Liangying Zhang Shaoting Zhang Anbu Liu Shujing Li Xu Cao Jinhai Tian Sien Zhao Jianmin Sun Source Type: research
An effective disease diagnostic model related to pyroptosis in ischemic cardiomyopathy
J Cell Mol Med. 2023 Sep 19. doi: 10.1111/jcmm.17957. Online ahead of print.ABSTRACTPyroptosis is involved in ischemic cardiomyopathy (ICM). The study aimed to investigate the pyroptosis-related genes and clarify their diagnostic value in ICM. The bioinformatics method identified the differential pyroptosis genes between the normal control and ICM samples from online datasets. Then, protein-protein interaction (PPI) and function analysis were carried out to explore the function of these genes. Following, subtype analysis was performed using ConsensusClusterPlus, functions, immune score, stromal score, immune cell proportio...
Source: Molecular Medicine - September 19, 2023 Category: Molecular Biology Authors: Zhankui Jin Fuqiang Liu Guoan Zhang Jingtao Zhang Xiangrong Zhao Xueping Huo Xiaoyan Huang Cuixiang Xu Source Type: research
Interactive effects of CDKN2B-AS1 gene polymorphism and habitual risk factors on oral cancer
J Cell Mol Med. 2023 Sep 19. doi: 10.1111/jcmm.17966. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC) is a common malignant disease associated with a high mortality rate and heterogeneous disease aetiology. Cyclin dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1), is a long noncoding RNA that has been shown to act as a scaffold, sponge, or signal hub to promote carcinogenesis. Here, we attempted to assess the effect of CDKN2B-AS1 single-nucleotide polymorphisms (SNPs) on the susceptibility to OSCC. Five CDKN2B-AS1 SNPs, including rs564398, rs1333048, rs1537373, rs2151280 and rs8181047, were analy...
Source: Molecular Medicine - September 19, 2023 Category: Molecular Biology Authors: Jung-Chun Yeh Yi-Tzu Chen Ying-Erh Chou Shih-Chi Su Lun-Ching Chang Yen-Lin Chen Chiao-Wen Lin Shun-Fa Yang Source Type: research
Construction of a novel cancer-associated fibroblast-related signature to predict clinical outcome and immune response in colon adenocarcinoma
Aging (Albany NY). 2023 Sep 16;15. doi: 10.18632/aging.205032. Online ahead of print.ABSTRACTThe interaction between the tumour and the surrounding microenvironment determines the malignant biological behaviour of the tumour. Cancer-associated fibroblasts (CAFs) coordinate crosstalk between cancer cells in the tumour immune microenvironment (TIME) and are extensively involved in tumour malignant behaviours, such as immune evasion, invasion and drug resistance. Here, we performed differential and prognostic analyses of genes associated with CAFs and constructed CAF-related signatures (CAFRs) to predict clinical outcomes in ...
Source: Aging - September 19, 2023 Category: Biomedical Science Authors: Lei Zheng Jiale Zhang Yingquan Ye Zhangpeng Shi Yi Huang Mengmeng Zhang Zhongxuan Gui Ping Li Huanlong Qin Weijie Sun Mei Zhang Source Type: research
The Role of Mesenchymal Stem/Stromal Cells Secretome in Macrophage Polarization: Perspectives on Treating Inflammatory Diseases
Curr Stem Cell Res Ther. 2023 Sep 4. doi: 10.2174/1574888X18666230811093101. Online ahead of print.ABSTRACTMesenchymal stem/stromal cells (MSCs) have exhibited potential for treating multiple inflammation- related diseases (IRDs) due to their easy acquisition, unique immunomodulatory and tissue repair properties, and immune-privileged characteristics. It is worth mentioning that MSCs release a wide array of soluble bioactive components in the secretome that modulate host innate and adaptive immune responses and promote the resolution of inflammation. As the first line of defense, macrophages exist throughout the entire inf...
Source: Current Stem Cell Research and Therapy - September 19, 2023 Category: Stem Cells Authors: Dongdong Ti Jun Yi Huihua Chen Haojie Hao Chunmeng Shi Source Type: research
Effects of < em > in utero < /em > exposure to fluoxetine on the gastrointestinal tract of rat offspring
Am J Physiol Gastrointest Liver Physiol. 2023 Sep 19. doi: 10.1152/ajpgi.00223.2022. Online ahead of print.ABSTRACTPerinatal exposure to selective serotonin reuptake inhibitors (SSRIs) has been shown to disrupt the development of serotonergic signaling pathways. Serotonin (5-hydroxytryptamine; 5-HT) signaling is critical for gastrointestinal homeostasis; changes in 5-HT expression and regulation have been associated with gastrointestinal diseases of motility and inflammation. We tested the hypothesis that perinatal exposure to the SSRI, fluoxetine, can influence the development of the gastrointestinal tract in exposed offs...
Source: Am J Physiol Gastroi... - September 19, 2023 Category: Gastroenterology Authors: Katherine L Prowse Harriett Law Sergio Raez-Villanueva Filip Markovic Megan Wang Rajka Borojevic Sean P Parsons Alexander D Vincent Alison C Holloway Elyanne M Ratcliffe Source Type: research
Formulation and Development of Flurbiprofen Colon-Specific Eudragit Coated Matrix Tablets: Use of a Novel Crude Banana Peel Powder as a Time-Dependent Polymer
In conclusion, utilizing CBP as a natural, time-dependent polymer in conjunction with Eudragit® S 100 to develop the flurbiprofen tablets seems like a promising approach for delivering drugs specifically to the colon.PMID:37726501 | DOI:10.1208/s12249-023-02646-0
Source: AAPS PharmSciTech - September 19, 2023 Category: Drugs & Pharmacology Authors: Sateesh Kumar Vemula Bhaskar Daravath Sridhar Babu Gummadi Michael Repka Source Type: research
