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Total 290035 results found since Jan 2013.
An effective disease diagnostic model related to pyroptosis in ischemic cardiomyopathy
J Cell Mol Med. 2023 Sep 19. doi: 10.1111/jcmm.17957. Online ahead of print.ABSTRACTPyroptosis is involved in ischemic cardiomyopathy (ICM). The study aimed to investigate the pyroptosis-related genes and clarify their diagnostic value in ICM. The bioinformatics method identified the differential pyroptosis genes between the normal control and ICM samples from online datasets. Then, protein-protein interaction (PPI) and function analysis were carried out to explore the function of these genes. Following, subtype analysis was performed using ConsensusClusterPlus, functions, immune score, stromal score, immune cell proportio...
Source: Molecular Medicine - September 19, 2023 Category: Molecular Biology Authors: Zhankui Jin Fuqiang Liu Guoan Zhang Jingtao Zhang Xiangrong Zhao Xueping Huo Xiaoyan Huang Cuixiang Xu Source Type: research
Interactive effects of CDKN2B-AS1 gene polymorphism and habitual risk factors on oral cancer
J Cell Mol Med. 2023 Sep 19. doi: 10.1111/jcmm.17966. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC) is a common malignant disease associated with a high mortality rate and heterogeneous disease aetiology. Cyclin dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1), is a long noncoding RNA that has been shown to act as a scaffold, sponge, or signal hub to promote carcinogenesis. Here, we attempted to assess the effect of CDKN2B-AS1 single-nucleotide polymorphisms (SNPs) on the susceptibility to OSCC. Five CDKN2B-AS1 SNPs, including rs564398, rs1333048, rs1537373, rs2151280 and rs8181047, were analy...
Source: Molecular Medicine - September 19, 2023 Category: Molecular Biology Authors: Jung-Chun Yeh Yi-Tzu Chen Ying-Erh Chou Shih-Chi Su Lun-Ching Chang Yen-Lin Chen Chiao-Wen Lin Shun-Fa Yang Source Type: research
The Role of Mesenchymal Stem/Stromal Cells Secretome in Macrophage Polarization: Perspectives on Treating Inflammatory Diseases
Curr Stem Cell Res Ther. 2023 Sep 4. doi: 10.2174/1574888X18666230811093101. Online ahead of print.ABSTRACTMesenchymal stem/stromal cells (MSCs) have exhibited potential for treating multiple inflammation- related diseases (IRDs) due to their easy acquisition, unique immunomodulatory and tissue repair properties, and immune-privileged characteristics. It is worth mentioning that MSCs release a wide array of soluble bioactive components in the secretome that modulate host innate and adaptive immune responses and promote the resolution of inflammation. As the first line of defense, macrophages exist throughout the entire inf...
Source: Current Stem Cell Research and Therapy - September 19, 2023 Category: Stem Cells Authors: Dongdong Ti Jun Yi Huihua Chen Haojie Hao Chunmeng Shi Source Type: research
Comprehensive Analysis of Iron Deficiency Anemia and Its Related Disorders in Premenopausal Women Based on a Propensity Score Matching Case Control Study Using National Health Insurance Service Database in Korea
CONCLUSION: In this study, we found that the gynecologic disease is the main cause of IDA in premenopausal women. Gynecological evaluations should be performed more actively in the clinic to prevent and control IDA and IRDs.PMID:37724497 | DOI:10.3346/jkms.2023.38.e299
Source: J Korean Med Sci - September 19, 2023 Category: General Medicine Authors: Hyun Jung Lee Haeyong Pak Jae Joon Han Myung Hee Chang Source Type: research
Construction of a novel cancer-associated fibroblast-related signature to predict clinical outcome and immune response in colon adenocarcinoma
Aging (Albany NY). 2023 Sep 16;15. doi: 10.18632/aging.205032. Online ahead of print.ABSTRACTThe interaction between the tumour and the surrounding microenvironment determines the malignant biological behaviour of the tumour. Cancer-associated fibroblasts (CAFs) coordinate crosstalk between cancer cells in the tumour immune microenvironment (TIME) and are extensively involved in tumour malignant behaviours, such as immune evasion, invasion and drug resistance. Here, we performed differential and prognostic analyses of genes associated with CAFs and constructed CAF-related signatures (CAFRs) to predict clinical outcomes in ...
Source: Aging - September 19, 2023 Category: Biomedical Science Authors: Lei Zheng Jiale Zhang Yingquan Ye Zhangpeng Shi Yi Huang Mengmeng Zhang Zhongxuan Gui Ping Li Huanlong Qin Weijie Sun Mei Zhang Source Type: research
Comprehensive Analysis of Iron Deficiency Anemia and Its Related Disorders in Premenopausal Women Based on a Propensity Score Matching Case Control Study Using National Health Insurance Service Database in Korea
CONCLUSION: In this study, we found that the gynecologic disease is the main cause of IDA in premenopausal women. Gynecological evaluations should be performed more actively in the clinic to prevent and control IDA and IRDs.PMID:37724497 | PMC:PMC10506900 | DOI:10.3346/jkms.2023.38.e299
Source: Journal of Korean Medical Science - September 19, 2023 Category: Biomedical Science Authors: Hyun Jung Lee Haeyong Pak Jae Joon Han Myung Hee Chang Source Type: research
An effective disease diagnostic model related to pyroptosis in ischemic cardiomyopathy
J Cell Mol Med. 2023 Sep 19. doi: 10.1111/jcmm.17957. Online ahead of print.ABSTRACTPyroptosis is involved in ischemic cardiomyopathy (ICM). The study aimed to investigate the pyroptosis-related genes and clarify their diagnostic value in ICM. The bioinformatics method identified the differential pyroptosis genes between the normal control and ICM samples from online datasets. Then, protein-protein interaction (PPI) and function analysis were carried out to explore the function of these genes. Following, subtype analysis was performed using ConsensusClusterPlus, functions, immune score, stromal score, immune cell proportio...
Source: J Cell Mol Med - September 19, 2023 Category: Molecular Biology Authors: Zhankui Jin Fuqiang Liu Guoan Zhang Jingtao Zhang Xiangrong Zhao Xueping Huo Xiaoyan Huang Cuixiang Xu Source Type: research
Interactive effects of CDKN2B-AS1 gene polymorphism and habitual risk factors on oral cancer
J Cell Mol Med. 2023 Sep 19. doi: 10.1111/jcmm.17966. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC) is a common malignant disease associated with a high mortality rate and heterogeneous disease aetiology. Cyclin dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1), is a long noncoding RNA that has been shown to act as a scaffold, sponge, or signal hub to promote carcinogenesis. Here, we attempted to assess the effect of CDKN2B-AS1 single-nucleotide polymorphisms (SNPs) on the susceptibility to OSCC. Five CDKN2B-AS1 SNPs, including rs564398, rs1333048, rs1537373, rs2151280 and rs8181047, were analy...
Source: J Cell Mol Med - September 19, 2023 Category: Molecular Biology Authors: Jung-Chun Yeh Yi-Tzu Chen Ying-Erh Chou Shih-Chi Su Lun-Ching Chang Yen-Lin Chen Chiao-Wen Lin Shun-Fa Yang Source Type: research
EuHD1 protects against inflammatory injury driven by NLRP3 inflammasome
Int Immunopharmacol. 2023 Feb;115:109712. doi: 10.1016/j.intimp.2023.109712. Epub 2023 Jan 20.ABSTRACTNon-steroidal anti-inflammatory drugs (NSAIDs) possessing anti-inflammatory, analgesic and antipyretic activities, are widely used in the treatment of osteoarthritis, rheumatism and rheumatoid arthritis. However, its long-term or large use will cause serious gastrointestinal injury or cardiovascular adverse reactions, which limits its clinical application. We have synthesized a new class of NSAIDs, EuHD1, which can release hydrogen sulfide and have better gastrointestinal safety. However, the anti-inflammatory molecular me...
Source: International Immunopharmacology - September 19, 2023 Category: Allergy & Immunology Authors: Huanhuan Qiu Wei Wang Kejun Hu Wangwang Liu Shumin Pan Qi Lv Guanglin Xu Qingfeng Yu Source Type: research
Farnesyltransferase (FTase) Inhibitors Increase Inhibition of KIT Mutants by Imatinib
CONCLUSIONS: Our results suggested the potential benefit of farnesyltransferase inhibitors either alone or combined with imatinib in the treatment of gastrointestinal stromal tumors carrying KIT mutations.PMID:37724142 | PMC:PMC10505455 | DOI:10.52547/rbmb.12.1.74
Source: Mol Biol Cell - September 19, 2023 Category: Molecular Biology Authors: Zhaoyang Fan Liangying Zhang Shaoting Zhang Anbu Liu Shujing Li Xu Cao Jinhai Tian Sien Zhao Jianmin Sun Source Type: research
Effects of < em > in utero < /em > exposure to fluoxetine on the gastrointestinal tract of rat offspring
Am J Physiol Gastrointest Liver Physiol. 2023 Sep 19. doi: 10.1152/ajpgi.00223.2022. Online ahead of print.ABSTRACTPerinatal exposure to selective serotonin reuptake inhibitors (SSRIs) has been shown to disrupt the development of serotonergic signaling pathways. Serotonin (5-hydroxytryptamine; 5-HT) signaling is critical for gastrointestinal homeostasis; changes in 5-HT expression and regulation have been associated with gastrointestinal diseases of motility and inflammation. We tested the hypothesis that perinatal exposure to the SSRI, fluoxetine, can influence the development of the gastrointestinal tract in exposed offs...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - September 19, 2023 Category: Physiology Authors: Katherine L Prowse Harriett Law Sergio Raez-Villanueva Filip Markovic Megan Wang Rajka Borojevic Sean P Parsons Alexander D Vincent Alison C Holloway Elyanne M Ratcliffe Source Type: research
Screening of Potential Probiotic < em > Lactobacillaceae < /em > and Their Improvement of Type 2 Diabetes Mellitus by Promoting PI3K/AKT Signaling Pathway in db/db Mice
Pol J Microbiol. 2023 Sep 20;72(3):285-297. doi: 10.33073/pjm-2023-028. eCollection 2023 Sep 1.ABSTRACTThe study aimed to isolate Lactobacillaceae strains with in vitro hypoglycemic activity and probiotic properties and to determine their antidiabetic abilities in vivo. Lactiplantibacillus plantarum 22, L. plantarum 25, Limosilactobacillus fermentum 11, and L. fermentum 305 with high in vitro hypoglycemic activity were screened from 23 strains of Lactobacillaceae isolated from human feces and identified by 16S rDNA sequencing. The fasting blood glucose (FBG) of the mice was recorded weekly. After 12 weeks, liver, kidney, a...
Source: Polish Journal of Microbiology - September 19, 2023 Category: Microbiology Authors: Yueyang Li Tong Tong Peifan Li Yian Peng Michael Zhang Jia Liu Yongxin She Zuming Li Yongli Li Source Type: research
Heparin-collagen I bilayers stimulate FAK/ERK ½ signaling via α2β1 integrin to support the growth and anti-inflammatory potency of mesenchymal stromal cells
J Biomed Mater Res A. 2023 Sep 18. doi: 10.1002/jbm.a.37614. Online ahead of print.ABSTRACTUnderstanding mesenchymal stromal cells (MSCs) growth mechanisms in response to surface chemistries is essential to optimize culture methods for high-quality and robust cell yields in cell manufacturing applications. Heparin (HEP) and collagen 1 (COL) substrates have been reported to enhance cell adhesion, growth, viability, and secretory potential in MSCs. However, the biomolecular mechanisms underlying the benefits of combined HEP/COL substrates are unknown. This work used HEP/COL bilayered surfaces to investigate the role of integ...
Source: Biomed Res - September 19, 2023 Category: Research Authors: Said J Cifuentes Maribella Domenech Source Type: research
Estrogen sulfotransferase SULT1E1 expression levels and regulated factors in malignant tumours
Protein Pept Lett. 2023 Sep 15. doi: 10.2174/0929866530666230915103418. Online ahead of print.ABSTRACTEstrogen plays a key role in the development and progression of many malignant tumours, and the regulation of estrogen levels involves several metabolic pathways. Among these pathways, estrogen sulfotransferase (SULT1E1) is the enzyme with the most affinity for estrogen and is primarily responsible for catalysing the metabolic reaction of estrogen sulphation. Relevant studies have shown significant differences in the expression of SULT1E1 in different malignant tumours, suggesting that SULT1E1 plays a dual role in malignan...
Source: Protein and Peptide Letters - September 19, 2023 Category: Biochemistry Authors: Rui Wang Xia Li Yangyang Li Mengjie Zhao Lida Mi Weiwei Chen Jianxiang Song Source Type: research
Novel Co-Crystal of 3-Methylcinnamic Acid with Berberine(1:1): Synthesis, Characterization, and Intestinal Absorption Property
CONCLUSIONS: The absolute molecular structure of the co-crystal was further confirmed by single crystal X-ray diffraction. The hydrogen bonds drove the formation of X-like one-dimensional unit. Compared to the BBR-HCl, BBR-3MCA cocrystal displayed superior dissolution and solubility performance, improve physical-chemical properties and significantly improve intestinal absorption.PMID:37725481 | DOI:10.1080/03639045.2023.2259460
Source: Drug Development and Industrial Pharmacy - September 19, 2023 Category: Drugs & Pharmacology Authors: Yong He Shiyun Chen Mengmeng Li Yonghao Gao Huiyi Feng Qasim Umar Dengke Yin Yisi Feng Source Type: research
