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Total 290035 results found since Jan 2013.
Silencing of keratin 15 impairs viability and mobility while facilitating the doxorubicin chemosensitivity by inactivating the β‑catenin pathway in liver cancer
In conclusion, KRT15 knockdown suppressed viability and mobility but facilitated Dox chemosensitivity via inactivating the β-catenin pathway in liver cancer, suggesting its potential as a target for liver cancer treatment.PMID:37720670 | PMC:PMC10502946 | DOI:10.3892/ol.2023.14034
Source: Oncology Letters - September 18, 2023 Category: Cancer & Oncology Authors: Junying Wang Guangyu Zhu Source Type: research
Intestinal ‑type mucinous carcinoma of the endometrium showing a polypoidal exophytic form: A case report
Oncol Lett. 2023 Aug 28;26(4):444. doi: 10.3892/ol.2023.14031. eCollection 2023 Oct.ABSTRACTAlthough endometrial cancer is a common malignancy in women, rare histological subtypes can pose diagnostic challenges. Primary endometrial intestinal-type mucinous carcinoma is a newly recognized subtype of endometrial cancer that differs from Müllerian-type endometrial mucinous carcinoma. The present case report documents a rare case of intestinal-type mucinous carcinoma of the endometrium showing a polypoidal exophytic form. The patient, an 80-year-old female, was incidentally diagnosed with a uterine tumor during a follow-up fo...
Source: Oncology Letters - September 18, 2023 Category: Cancer & Oncology Authors: Chiharu Nakano Takeshi Fukuda Sayaka Tanaka Takuya Noda Eijiro Uchikura Yuichiro Awazu Reiko Tasaka Kenji Imai Makoto Yamauchi Tomoyuki Ichimura Tomoyo Yasui Toshiyuki Sumi Source Type: research
Does ghrelin regulate intestinal motility in rabbits? An in vitro study using isolated duodenal strips
In conclusion, ghrelin does not affect muscle contractility or motilin-induced contraction in the rabbit duodenum, which is due to the lack of ghrelin receptors. The present in vitro results suggest that ghrelin might not be a regulator of intestinal motility in rabbits.PMID:37722460 | DOI:10.1016/j.ygcen.2023.114384
Source: General and Comparative Endocrinology - September 18, 2023 Category: Endocrinology Authors: Shuangyi Zhang Hiroyuki Kaiya Takio Kitazawa Source Type: research
Prevalence and clinical correlations of SF3B1 variants in lactotroph tumours
CONCLUSIONS: SF3B1 variants are uncommon in lactotroph tumours but may be frequent in metastatic lactotroph tumours. When present, they associate with aggressive tumour behaviour and worse clinical outcome.PMID:37721395 | DOI:10.1093/ejendo/lvad114
Source: European Journal of Endocrinology - September 18, 2023 Category: Endocrinology Authors: Julia Simon Luis Gustavo Perez-Rivas Yining Zhao Fanny Chasseloup Helene Lasolle Christine Cortet Francoise Descotes Chiara Villa Bertrand Baussart Pia Burman Dominique Maiter Vivian von Selzam Roman Rotermund J örg Flitsch Jun Thorsteinsdottir Emmanuel Source Type: research
Blood-based protein biomarkers and red blood cell aggregation in pancreatic cancer
CONCLUSION: This study indicated that there are significant differences in blood-based biomarkers for differentiating between PDAC and inflammatory tumours of the pancreas. We also confirmed that PDAC is associated with the excessive aggregation of RBCs.PMID:37718785 | DOI:10.3233/CH-231814
Source: Clinical Hemorheology and Microcirculation - September 18, 2023 Category: Hematology Authors: Maciej Wiewiora Janusz Jopek El żbieta Świętochowska Gregorczyn S ławomir Jerzy Piecuch Mateusz G ąska Jerzy Piecuch Source Type: research
ATP promotes resident CD34 < sup > + < /sup > cell migration mainly through P2Y2-Stim1-ERK/p38 pathway
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00048.2023. Online ahead of print.ABSTRACTExtracellular adenosine triphosphate (ATP) is one of the most abundant biochemical constitutes within the stem cell microenvironment and is postulated to play critical roles in cell migration. However, it is unclear whether ATP regulates the cell migration of CD34+ vascular wall-resident stem/progenitor cells (VW-SCs) and participates in angiogenesis. Therefore, the biological mechanisms of cell migration mediated by ATP was determined by in vivo subcutaneous matrigel plug assay, ex vivo aortic ring assay, in vitro transw...
Source: Am J Physiol Cell Ph... - September 18, 2023 Category: Cytology Authors: Ying Ma Chuting Han Cheng Xie Qingya Dang Liju Yang Yuan Li Min Zhang Jun Cheng Yan Yang Qingbo Xu Pengyun Li Source Type: research
Mortality Risk Scoring System in Patients after Bleeding from Cancers in the Upper Gastrointestinal Tract
CONCLUSIONS: : Our new scoring system provides a better prediction of 30-day mortality than existing scoring systems in patients with UGI cancer bleeding. This new scoring system can be used to predict and prepare these patients who are known to have high mortality.PMID:37722853 | DOI:10.5009/gnl230069
Source: Gut and Liver - September 18, 2023 Category: Gastroenterology Authors: Hyun Min Kim Donghoon Kang Jun Young Park Yu Kyung Cho Myung-Gyu Choi Jae Myung Park Source Type: research
Adverse event profile of CGRP monoclonal antibodies: findings from the FDA adverse event reporting database
CONCLUSION: We identified numerous shared underlying signals (overlapping signals) for CGRP-mAbs as suspected drugs in multiple systems and organs. The unlabeled common signals may indicate potential safety issues. In addition, the underlying safety signals varied among the four CGRP-mAbs, particularly in the cardiovascular system, and further studies are needed to confirm these associations and the potential clinical implications.PMID:37720989 | DOI:10.1080/14740338.2023.2250720
Source: Expert Opinion on Drug Safety - September 18, 2023 Category: Drugs & Pharmacology Authors: Qi Wang Jingfang Liu Hao Sun YongFei Dong WeiLiang Tan Zaixiang Tang YiGuo Jiang Source Type: research
Molecular mechanism underlying epithelial ‐mesenchymal transformation and cisplatin resistance in esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) frequently develops resistance to cisplatin chemotherapy, a challenge linked to the epithelial-mesenchymal transformation (EMT) process. Our review elucidates the molecular crosstalk between EMT and cisplatin resistance in ESCC, spotlighting signaling pathways such as FOXO1, PI3K/Akt, and Wnt. Our insights offer a foundation for innovative therapeutic interventions, potentially revolutionizing ESCC treatment. AbstractEsophageal cancer (EC) occupies the seventh spot of the most prevalent malignancy cancer ailments worldwide and the sixth leading cause of cancer-related death. Esopha...
Source: Thoracic Cancer - September 18, 2023 Category: Cancer & Oncology Authors: Kewei Song,
Chenhui Ma,
Baohong Gu,
Bofang Wang,
Huanhuan Ma,
Xiaobo Deng,
Hao Chen Tags: REVIEW Source Type: research
Utility of Wnt family member 9b (Wnt9b) immunohistochemistry in the cytologic diagnosis of metastatic breast carcinoma
In this study, we examined the utility of Wnt9b in diagnosing metastatic breast carcinoma in cytology samples. Cell blocks from fine needle aspirations (FNA) and fluid specimens of 96 metastatic breast carcinomas and 123 primary and metastatic non-breast neoplasms from various organ systems were evaluated by Wnt9b and GATA3 immunohistochem istry (IHC). Wnt9b and GATA3 were positive in 81.3% and 92.7% of metastatic breast carcinomas, respectively. Conversely, 93.5% and 90.0% of non-breast, non-urothelial carcinomas were negative for Wnt9b and GATA3, respectively. Wnt9b expression was positive in rare gastrointe...
Source: Virchows Archiv - September 18, 2023 Category: Pathology Source Type: research
Predicting potential microbe-disease associations with graph attention autoencoder, positive-unlabeled learning, and deep neural network
ConclusionThe proposed GPUDMDA demonstrated the powerful MDA prediction ability. We anticipate that GPUDMDA helps screen the therapeutic clues for microbe-related diseases.
Source: Frontiers in Microbiology - September 18, 2023 Category: Microbiology Source Type: research
A phase I/II study of the safety and efficacy of 177LuLu-satoreotide tetraxetan in advanced somatostatin receptor-positive neuroendocrine tumours
Conclusion[177Lu]Lu-satoreotide tetraxetan, administered at a median cumulative activity of 13.0 GBq over three cycles, has an acceptable safety profile with a promising clinical response in patients with progressive, SSTR-positive NETs. A 5-year long-term follow-up study is ongoing.Trial registrationClinicalTrials.gov, NCT02592707. Registered October 30, 2015.
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 18, 2023 Category: Nuclear Medicine Source Type: research
Efficacy and safety of immunotherapy combined with single-agent chemotherapy as second- or later-line therapy for metastatic non-small cell lung cancer
ConclusionsImmunotherapy plus single-agent chemotherapy as a second- or later-line treatment is safe, effective, and tolerable for metastatic NSCLC. EV markers can be used as predictive markers of efficacy in patients with metastatic NSCLC treated with immunotherapy plus chemotherapy to help monitor treatment efficacy and guide treatment decisions.
Source: Frontiers in Immunology - September 18, 2023 Category: Allergy & Immunology Source Type: research
Monkeypox 2022 vs. COVID-19: a Review on a National Health Emergency with Emphasis on Cutaneous Manifestations
AbstractPurpose of ReviewMonkeypox virus (Mpox), a rare viral zoonotic disease, has recently resurfaced as a public health emergency of international concern in the context of the COVID-19 pandemic, spreading globally in both endemic and non-endemic countries. Thus, in this comprehensive narrative review, we attempted to provide an overview of the background, virology, epidemiology, clinical, diagnosis, treatment, and prevention of Mpox, with a focus on its cutaneous manifestations and a comparison with COVID-19 heterogeneous skin manifestations.Recent FindingsIn the current outbreak, however, several unusual clinical and ...
Source: Current Infectious Disease Reports - September 18, 2023 Category: Infectious Diseases Source Type: research
