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Bacillus subtilis Bacteremia from Gastrointestinal Perforation after Natto Ingestion, Japan
We report a case of Bacillus subtilis variant natto bacteremia from a gastrointestinal perforation in a patient who ingested natto. Genotypic methods showed the bacteria in a blood sample and the ingested natto were the same strains. Older or immunocompromised patients could be at risk for bacteremia from ingesting natto.PMID:37735785 | DOI:10.3201/eid2910.230084
Source: Emerging Infectious Diseases - September 22, 2023 Category: Infectious Diseases Authors: Takehiro Hashimoto Takaaki Yahiro Sakirul Khan Kazunori Kimitsuki Kazufumi Hiramatsu Akira Nishizono Source Type: research
Specialized Programs of Research Excellence (SPOREs) in Human Cancers for Years 2024, 2025, and 2026 (P50 Clinical Trial Required)
Funding Opportunity PAR-23-284 from the NIH Guide for Grants and Contracts. Through this funding opportunity announcement (FOA), the National Cancer Institute (NCI) invites applications for P50 Research Center Grants for Specialized Programs of Research Excellence (SPORE). The program will fund P50 SPORE grants to support state-of-the-art investigator-initiated translational research that will contribute to improved prevention, early detection, diagnosis, and treatment of an organ-specific cancer or a highly related group of cancers. For the purpose of this FOA, a group of highly related cancers are those that are derived...
Source: NIH Funding Opportunities (Notices, PA, RFA) - September 22, 2023 Category: Research Source Type: funding
GSE240886 Human fatty liver RT-PCR array on primary human hepatocytes grown with 3t3-J2 stromal cells in a micropatterned co-culture
Contributors : Karissa E Cottier ; Devika Bhalerao ; Jeannemarie Gaffney ; Candice Lewis ; Scott A HeywardSeries Type : Expression profiling by RT-PCROrganism : Homo sapiensNon-alcoholic fatty liver disease (NAFLD) is a highly prevalent, progressive disorder and growing public health concern. To address this issue considerable research has been undertaken in pursuit of new NAFLD therapeutics. Development of effective, high-throughput in vitro models is an important aspect of drug discovery. Here, a micropatterned hepatocyte co-culture (MPCC) was used to model liver steatosis. The MPCC model (HEPATOPAC) involves hepatocytes...
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by RT-PCR Homo sapiens Source Type: research
GSE240232 Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer
Contributor : Jincheng HanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusActivating KRAS mutations (KRAS*) in pancreatic ductal adenocarcinoma (PDAC) drive anabolic metabolism and support tumor maintenance. KRAS* inhibitors show initial anti-tumor activity followed by recurrence due to cancer cell intrinsic and immune mediated paracrine mechanisms. Here, we explored the potential role of cancer associated fibroblasts (CAFs) in enabling KRAS* bypass and identified CAF-derived NRG1 activation of cancer cell ERBB2/ERBB3 receptor tyrosine kinases as a mechanism by which KRAS* independent...
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE228062 Prostate tissue explant, epithelial cell, stromal cell, and extracellular vesicle microRNA characterization by NGS
Contributors : Larisa Nonn ; Morgan Zenner ; Trevor LeonardoSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensIntracellular and extracellular vesicle-contained microRNAs were profiled by next-generation sequencing from prostate cancer patient cells, tissues and serum.
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
Type III interferon exerts thymic stromal lymphopoietin in mediating adaptive antiviral immune response
In conclusion, our review highlights the unique role of the IFN-III/TSLP axis in mediating host adaptive immunity, which is mechanically different from IFN-I. Therefore, the IFN-III/TSLP axis may provide novel insights for clinical immunotherapy.
Source: Frontiers in Immunology - September 22, 2023 Category: Allergy & Immunology Source Type: research
New insight into the role of fibroblasts in the epithelial immune microenvironment in the single-cell era
The skin is exposed to environmental challenges and contains heterogeneous cell populations such as epithelial cells, stromal cells, and skin-resident immune cells. As the most abundant type of stromal cells, fibroblasts have been historically considered silent observers in the immune responses of the cutaneous epithelial immune microenvironment (EIME), with little research conducted on their heterogeneity and immune-related functions. Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) have overcome the limitations of bulk RNA sequencing and help recognize the functional and spatial heterogeneity of fi...
Source: Frontiers in Immunology - September 22, 2023 Category: Allergy & Immunology Source Type: research
Imaging findings of granular cell tumours of the head and neck
To review the imaging characteristics of granular cell tumours in the head and neck and assess their associations with pathological findings.
Source: Clinical Radiology - September 22, 2023 Category: Radiology Authors: H.H. Moon, K. Jin, Y.J. Choi, K.-J. Cho, Y.S. Lee, J.H. Lee Source Type: research
Potential involvement of the bone marrow in experimental Graves ’ disease and thyroid eye disease
ConclusionCollectively, these data indicate that the bone marrow is activated in experimental Graves’ disease and TED, which is prevented by linsitinib. Linsitinib-mediated immune-inhibition is mediated, at least in part, by arginase-1 up-regulation, consumption of arginine and thereby immune inhibition.
Source: Frontiers in Endocrinology - September 22, 2023 Category: Endocrinology Source Type: research
Updates in pathobiological aspects of anaplastic large cell lymphoma
Anaplastic large cell lymphomas (ALCL) encompass several distinct subtypes of mature T-cell neoplasms that are unified by the expression of CD30 and anaplastic cytomorphology. Identification of the cytogenetic abnormality t(2;5)(p23;q35) led to the subclassification of ALCLs into ALK+ ALCL and ALK- ALCL. According to the most recent World Health Organization (WHO) Classification of Haematolymphoid Tumours as well as the International Consensus Classification (ICC) of Mature Lymphoid Neoplasms, ALCLs encompass ALK+ ALCL, ALK- ALCL, and breast implant-associated ALCL (BI-ALCL). Approximately 80% of systemic ALCLs harbor rear...
Source: Frontiers in Oncology - September 22, 2023 Category: Cancer & Oncology Source Type: research
Viruses, Vol. 15, Pages 1976: Extracellular Vesicles as a Translational Approach for the Treatment of COVID-19 Disease: An Updated Overview
a Di Domenico
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global pandemic in the years 2020–2022. With a high prevalence, an easy route of transmission, and a long incubation time, SARS-CoV-2 spread quickly and affected public health and socioeconomic conditions. Several points need to be elucidated about its mechanisms of infection, in particular, its capability to evade the immune system and escape from neutralizing antibodies. Extracellular vesicles (EVs) are phospholipid bilayer-delimited particles that are involved in cell-to-cell communication; they contain biological infor...
Source: Viruses - September 22, 2023 Category: Virology Authors: Enrica Serretiello Andrea Ballini Annafrancesca Smimmo Marina Acunzo Mariarosaria Raimo Stefania Cantore Marina Di Domenico Tags: Review Source Type: research
Development and Current State of Digital Therapeutics for Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a common, debilitating disorder characterized by abdominal pain and disordered bowel habits. Current pharmacological treatments often provide incomplete symptom relief and may be poorly tolerated. Furthermore, alleviation of gastrointestinal symptoms does not always translate into improved quality of life (QOL) for IBS patients.Current treatment guidelines recommend brain-gut behavior therapy (BGBT) in conjunction with other IBS therapies, and in randomized controlled trials, BGBT has been shown to improve symptoms, patient satisfaction, functioning, and QOL.
Source: Clinical Gastroenterology and Hepatology - September 22, 2023 Category: Gastroenterology Authors: Darren M. Brenner, Amy M. Ladewski, Sarah Wimberly Kinsinger Tags: Narrative Reviews Source Type: research
Durable response to combination immunotherapy using Nivolumab and Ipilimumab in metastatic succinate dehydrogenase (SDH)- deficient gastrointestinal stroma tumour
The introduction of targeted therapy using c-kit and multityrosine kinase inhibitors has led to dramatic improvement in the outcome of patients with advanced gastrointestinal stroma tumours (GIST) over the last two decades [1]. Approximately 10% of GISTs are succinate dehydrogenase (SDH)- deficient either due to a germline or somatic mutation in the SDHA/B/C/D genes, or due to SDHC promotor methylation. The SDH-deficient GIST subgroup is associated with particular demographic features (younger age, female gender, stomach being primary tumour site) [2,3].
Source: European Journal of Cancer - September 22, 2023 Category: Cancer & Oncology Authors: O. Klein, J. Palmer, A. Behren, J. Cebon, D. Kee Tags: Letter Source Type: research
Host microbiome in tuberculosis: disease, treatment, and immunity perspectives
Tuberculosis (TB), an airborne pulmonary disease caused by Mycobacterium tuberculosis (M. tb), poses an unprecedented health and economic burden to most of the developing countries. Treatment of TB requires prolonged use of a cocktail of antibiotics, which often manifest several side effects, including stomach upset, nausea, and loss of appetite spurring on treatment non-compliance and the emergence of antibiotic resistant M. tb. The anti-TB treatment regimen causes imbalances in the composition of autochthonous microbiota associated with the human body, which also contributes to major side effects. The microbiota residing...
Source: Frontiers in Microbiology - September 22, 2023 Category: Microbiology Source Type: research
Proteome level analysis of drug-resistant Prevotella melaninogenica for the identification of novel therapeutic candidates
In conclusion, our study reported novel drug and vaccine targets and designed a multi-epitope vaccine against the P. melaninogenica infection. Further experimental validation will help open new avenues in the treatment of this multi-drug-resistant pathogen.
Source: Frontiers in Microbiology - September 22, 2023 Category: Microbiology Source Type: research
