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Effects of in utero exposure to fluoxetine on the gastrointestinal tract of rat offspring
Am J Physiol Gastrointest Liver Physiol. 2023 Sep 19. doi: 10.1152/ajpgi.00223.2022. Online ahead of print.ABSTRACTPerinatal exposure to selective serotonin reuptake inhibitors (SSRIs) has been shown to disrupt the development of serotonergic signaling pathways. Serotonin (5-hydroxytryptamine; 5-HT) signaling is critical for gastrointestinal homeostasis; changes in 5-HT expression and regulation have been associated with gastrointestinal diseases of motility and inflammation. We tested the hypothesis that perinatal exposure to the SSRI, fluoxetine, can influence the development of the gastrointestinal tract in exposed offs...
Source: Am J Physiol Gastroi... - September 19, 2023 Category: Gastroenterology Authors: Katherine L Prowse Harriett Law Sergio Raez-Villanueva Filip Markovic Megan Wang Rajka Borojevic Sean P Parsons Alexander D Vincent Alison C Holloway Elyanne M Ratcliffe Source Type: research

Formulation and Development of Flurbiprofen Colon-Specific Eudragit Coated Matrix Tablets: Use of a Novel Crude Banana Peel Powder as a Time-Dependent Polymer
In conclusion, utilizing CBP as a natural, time-dependent polymer in conjunction with Eudragit® S 100 to develop the flurbiprofen tablets seems like a promising approach for delivering drugs specifically to the colon.PMID:37726501 | DOI:10.1208/s12249-023-02646-0
Source: AAPS PharmSciTech - September 19, 2023 Category: Drugs & Pharmacology Authors: Sateesh Kumar Vemula Bhaskar Daravath Sridhar Babu Gummadi Michael Repka Source Type: research

An analysis of quality of life and functional outcomes as reported in randomized trials for red cell transfusions
DISCUSSION: There is no evidence that a liberal transfusion strategy improves QoL and functional outcomes. However, the substantial limitations of many included studies indicate the need for further well-designed and adequately powered trials.PMID:37723866 | DOI:10.1111/trf.17540
Source: Transfusion - September 19, 2023 Category: Hematology Authors: Monica B Pagano Jane A Dennis Osaumwense M Idemudia Simon J Stanworth Jeffrey L Carson Source Type: research

Comprehensive Analysis of Iron Deficiency Anemia and Its Related Disorders in Premenopausal Women Based on a Propensity Score Matching Case Control Study Using National Health Insurance Service Database in Korea
CONCLUSION: In this study, we found that the gynecologic disease is the main cause of IDA in premenopausal women. Gynecological evaluations should be performed more actively in the clinic to prevent and control IDA and IRDs.PMID:37724497 | PMC:PMC10506900 | DOI:10.3346/jkms.2023.38.e299
Source: Journal of Korean Medical Science - September 19, 2023 Category: Biomedical Science Authors: Hyun Jung Lee Haeyong Pak Jae Joon Han Myung Hee Chang Source Type: research

Screening of Potential Probiotic Lactobacillaceae and Their Improvement of Type 2 Diabetes Mellitus by Promoting PI3K/AKT Signaling Pathway in db/db Mice
Pol J Microbiol. 2023 Sep 20;72(3):285-297. doi: 10.33073/pjm-2023-028. eCollection 2023 Sep 1.ABSTRACTThe study aimed to isolate Lactobacillaceae strains with in vitro hypoglycemic activity and probiotic properties and to determine their antidiabetic abilities in vivo. Lactiplantibacillus plantarum 22, L. plantarum 25, Limosilactobacillus fermentum 11, and L. fermentum 305 with high in vitro hypoglycemic activity were screened from 23 strains of Lactobacillaceae isolated from human feces and identified by 16S rDNA sequencing. The fasting blood glucose (FBG) of the mice was recorded weekly. After 12 weeks, liver, kidney, a...
Source: Polish Journal of Microbiology - September 19, 2023 Category: Microbiology Authors: Yueyang Li Tong Tong Peifan Li Yian Peng Michael Zhang Jia Liu Yongxin She Zuming Li Yongli Li Source Type: research

The Role of Mesenchymal Stem/Stromal Cells Secretome in Macrophage Polarization: Perspectives on Treating Inflammatory Diseases
Curr Stem Cell Res Ther. 2023 Sep 4. doi: 10.2174/1574888X18666230811093101. Online ahead of print.ABSTRACTMesenchymal stem/stromal cells (MSCs) have exhibited potential for treating multiple inflammation- related diseases (IRDs) due to their easy acquisition, unique immunomodulatory and tissue repair properties, and immune-privileged characteristics. It is worth mentioning that MSCs release a wide array of soluble bioactive components in the secretome that modulate host innate and adaptive immune responses and promote the resolution of inflammation. As the first line of defense, macrophages exist throughout the entire inf...
Source: Current Stem Cell Research and Therapy - September 19, 2023 Category: Stem Cells Authors: Dongdong Ti Jun Yi Huihua Chen Haojie Hao Chunmeng Shi Source Type: research

Estrogen sulfotransferase SULT1E1 expression levels and regulated factors in malignant tumours
Protein Pept Lett. 2023 Sep 15. doi: 10.2174/0929866530666230915103418. Online ahead of print.ABSTRACTEstrogen plays a key role in the development and progression of many malignant tumours, and the regulation of estrogen levels involves several metabolic pathways. Among these pathways, estrogen sulfotransferase (SULT1E1) is the enzyme with the most affinity for estrogen and is primarily responsible for catalysing the metabolic reaction of estrogen sulphation. Relevant studies have shown significant differences in the expression of SULT1E1 in different malignant tumours, suggesting that SULT1E1 plays a dual role in malignan...
Source: Protein and Peptide Letters - September 19, 2023 Category: Biochemistry Authors: Rui Wang Xia Li Yangyang Li Mengjie Zhao Lida Mi Weiwei Chen Jianxiang Song Source Type: research

Effects of in utero exposure to fluoxetine on the gastrointestinal tract of rat offspring
Am J Physiol Gastrointest Liver Physiol. 2023 Sep 19. doi: 10.1152/ajpgi.00223.2022. Online ahead of print.ABSTRACTPerinatal exposure to selective serotonin reuptake inhibitors (SSRIs) has been shown to disrupt the development of serotonergic signaling pathways. Serotonin (5-hydroxytryptamine; 5-HT) signaling is critical for gastrointestinal homeostasis; changes in 5-HT expression and regulation have been associated with gastrointestinal diseases of motility and inflammation. We tested the hypothesis that perinatal exposure to the SSRI, fluoxetine, can influence the development of the gastrointestinal tract in exposed offs...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - September 19, 2023 Category: Physiology Authors: Katherine L Prowse Harriett Law Sergio Raez-Villanueva Filip Markovic Megan Wang Rajka Borojevic Sean P Parsons Alexander D Vincent Alison C Holloway Elyanne M Ratcliffe Source Type: research

Novel Co-Crystal of 3-Methylcinnamic Acid with Berberine(1:1): Synthesis, Characterization, and Intestinal Absorption Property
CONCLUSIONS: The absolute molecular structure of the co-crystal was further confirmed by single crystal X-ray diffraction. The hydrogen bonds drove the formation of X-like one-dimensional unit. Compared to the BBR-HCl, BBR-3MCA cocrystal displayed superior dissolution and solubility performance, improve physical-chemical properties and significantly improve intestinal absorption.PMID:37725481 | DOI:10.1080/03639045.2023.2259460
Source: Drug Development and Industrial Pharmacy - September 19, 2023 Category: Drugs & Pharmacology Authors: Yong He Shiyun Chen Mengmeng Li Yonghao Gao Huiyi Feng Qasim Umar Dengke Yin Yisi Feng Source Type: research

Comprehensive Analysis of Iron Deficiency Anemia and Its Related Disorders in Premenopausal Women Based on a Propensity Score Matching Case Control Study Using National Health Insurance Service Database in Korea
CONCLUSION: In this study, we found that the gynecologic disease is the main cause of IDA in premenopausal women. Gynecological evaluations should be performed more actively in the clinic to prevent and control IDA and IRDs.PMID:37724497 | PMC:PMC10506900 | DOI:10.3346/jkms.2023.38.e299
Source: J Korean Med Sci - September 19, 2023 Category: General Medicine Authors: Hyun Jung Lee Haeyong Pak Jae Joon Han Myung Hee Chang Source Type: research

Respiratory and intestinal trichobezoar in a female: An unusual case report and literature review
We present an unusual case of a 25-year-old woman who experienced dyspnea, productive cough, and leukocytosis and was found to have a trichobezoar in her respiratory tract, accompanied by the presence of hair in her digestive tract. AbstractTrichobezoars are hairballs in the gastrointestinal tract that usually develop due to the consumption of hair after pulling it. However, some rare case reports suggest that trichobezoar can also occur in the respiratory system. In this context, we present an unusual case of a 25-year-old woman who experienced dyspnea, productive cough, and leukocytosis. The patient was found to have a t...
Source: Respirology Case Reports - September 19, 2023 Category: Respiratory Medicine Authors: Siavash Abedi, Masoud Aliyali, Amir ‐Hassan Bordbari, Mostafa Soleymani, Zakaria Zakariaei, Mahdi Fakhar Tags: CASE REPORT Source Type: research

A pediatric case series of catastrophic gastrointestinal complications of posttransplant lymphoproliferative disease with increasing incidence, high association with coronavirus disease 2019, higher mortality, and a plea for early endoscopy to prevent late fatal outcome
ConclusionSince 80% of our patients had exposure to coronavirus, a potential relationship might be suggested between the two. Furthermore, as we witnessed in one case, urgent endoscopic investigation in immunocompromised patients presenting with gastrointestinal symptoms can improve the clinical outcomes and therefore should be considered for early diagnosis of posttransplant lymphoproliferative disorder.
Source: Journal of Medical Case Reports - September 19, 2023 Category: General Medicine Source Type: research

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