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Total 290035 results found since Jan 2013.
Efficacy of a gluten-free diet in reducing the widespread pain index and symptom severity scale in patients affected by fibromyalgia
CONCLUSIONS: A GFD improved FM symptoms evaluated with WPI and SS. This was confirmed for the first time, also with a rechallenge of the GFD that followed a non-restricted gluten-containing diet.PMID:37721353 | DOI:10.4081/reumatismo.2023.1530
Source: Reumatismo - September 18, 2023 Category: Rheumatology Authors: V Bruzzese C Marrese P Scolieri J Pepe Source Type: research
Prevalence of Enteric Infections in Patients on Immune Checkpoint Inhibitors and Impact on Management and Outcomes
CONCLUSIONS: GI infections in ICI-treated patients presenting with diarrhea are linked to more severe but self-limited clinical presentations and may be optimally treated with observation and supportive care alone. Routine and timely stool pathogen testing may help avert unnecessary empiric immunosuppression for suspected irEC, which has been linked to blunted antitumor responses and numerous adverse effects.PMID:37721546 | DOI:10.1093/oncolo/oyad226
Source: The Oncologist - September 18, 2023 Category: Cancer & Oncology Authors: Patrick T Magahis Deepika Satish Ngolela Esther Babady Mini Kamboj Michael A Postow Monika Laszkowska David M Faleck Source Type: research
ATP promotes resident CD34 < sup > + < /sup > cell migration mainly through P2Y2-Stim1-ERK/p38 pathway
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00048.2023. Online ahead of print.ABSTRACTExtracellular adenosine triphosphate (ATP) is one of the most abundant biochemical constitutes within the stem cell microenvironment and is postulated to play critical roles in cell migration. However, it is unclear whether ATP regulates the cell migration of CD34+ vascular wall-resident stem/progenitor cells (VW-SCs) and participates in angiogenesis. Therefore, the biological mechanisms of cell migration mediated by ATP was determined by in vivo subcutaneous matrigel plug assay, ex vivo aortic ring assay, in vitro transw...
Source: Am J Physiol Cell Ph... - September 18, 2023 Category: Cytology Authors: Ying Ma Chuting Han Cheng Xie Qingya Dang Liju Yang Yuan Li Min Zhang Jun Cheng Yan Yang Qingbo Xu Pengyun Li Source Type: research
Sinonasal phosphaturic mesenchymal tumour: radiation oncologist's perspective
We present the case of a woman in her 30s with a sinonasal phosphaturic mesenchymal tumour, treated with surgical excision followed by adjuvant intensity-modulated radiotherapy and subsequent adjuvant chemotherapy. The patient experienced minimal adverse effects during radiation. There was good local control and cosmetic outcomes with no radiation-related toxicity at a follow-up period of 32 months.PMID:37723097 | DOI:10.1136/bcr-2023-255896
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Sudharshan Gupta Simon Pradeep Pavamani Source Type: research
ATP promotes resident CD34 < sup > + < /sup > cell migration mainly through P2Y2-Stim1-ERK/p38 pathway
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00048.2023. Online ahead of print.ABSTRACTExtracellular adenosine triphosphate (ATP) is one of the most abundant biochemical constitutes within the stem cell microenvironment and is postulated to play critical roles in cell migration. However, it is unclear whether ATP regulates the cell migration of CD34+ vascular wall-resident stem/progenitor cells (VW-SCs) and participates in angiogenesis. Therefore, the biological mechanisms of cell migration mediated by ATP was determined by in vivo subcutaneous matrigel plug assay, ex vivo aortic ring assay, in vitro transw...
Source: American Journal of Physiology. Cell Physiology - September 18, 2023 Category: Cytology Authors: Ying Ma Chuting Han Cheng Xie Qingya Dang Liju Yang Yuan Li Min Zhang Jun Cheng Yan Yang Qingbo Xu Pengyun Li Source Type: research
Health-related quality of life is impaired in bleeding disorders of unknown cause: results from the Vienna Bleeding Biobank
CONCLUSION: The impairments in HrQoL in patients with BDUC emphasize the burden of BDUC on mental and physical well-being, encouraging early recognition and better counseling of patients with BDUC.PMID:37720482 | PMC:PMC10502434 | DOI:10.1016/j.rpth.2023.102176
Source: Thrombosis and Haemostasis - September 18, 2023 Category: Hematology Authors: Dino Mehic Stephan Schwarz Ihor Shulym Cihan Ay Ingrid Pabinger Johanna Gebhart Source Type: research
Physiological Activities of the King of Bitters (Andrographis paniculata): A Review
Cureus. 2023 Aug 15;15(8):e43515. doi: 10.7759/cureus.43515. eCollection 2023 Aug.ABSTRACTAndrographis paniculata is a versatile tropical plant that is considered to have many essential medicinal properties. Plants can combine an open scope of the natural active compound that carries out significant organic roles and are used as pharmaceuticals. Herbal plants have therapeutic and prophylactic properties, so scientists are concentrating on developing crude drugs to make people's lives easier. Medicinal plants are the primary sources of therapeutic remedies for various ailments. These potential medicinal effects are primaril...
Source: Herpes - September 18, 2023 Category: Infectious Diseases Authors: Sweza Bhaisare Swanand Pathak Vaishnavi V Ajankar Source Type: research
Does ghrelin regulate intestinal motility in rabbits? An in vitro study using isolated duodenal strips
In conclusion, ghrelin does not affect muscle contractility or motilin-induced contraction in the rabbit duodenum, which is due to the lack of ghrelin receptors. The present in vitro results suggest that ghrelin might not be a regulator of intestinal motility in rabbits.PMID:37722460 | DOI:10.1016/j.ygcen.2023.114384
Source: General and Comparative Endocrinology - September 18, 2023 Category: Endocrinology Authors: Shuangyi Zhang Hiroyuki Kaiya Takio Kitazawa Source Type: research
Testicular tumours in children: a single-centre experience
CONCLUSION: Primary testicular tumours follow a bimodal age distribution pattern. Majority of patients can be cured with platinum-based chemotherapy despite having advanced disease at presentation.PMID:37721303 | DOI:10.4103/singaporemedj.SMJ-2021-380
Source: Singapore Medical Journal - September 18, 2023 Category: General Medicine Authors: Sajid Ali Tariq Latif Muhammad Ali Sheikh Shazia Perveen Muhammad Bilal Albash Sarwar Source Type: research
Silencing of keratin 15 impairs viability and mobility while facilitating the doxorubicin chemosensitivity by inactivating the β‑catenin pathway in liver cancer
In conclusion, KRT15 knockdown suppressed viability and mobility but facilitated Dox chemosensitivity via inactivating the β-catenin pathway in liver cancer, suggesting its potential as a target for liver cancer treatment.PMID:37720670 | PMC:PMC10502946 | DOI:10.3892/ol.2023.14034
Source: Oncology Letters - September 18, 2023 Category: Cancer & Oncology Authors: Junying Wang Guangyu Zhu Source Type: research
Intestinal ‑type mucinous carcinoma of the endometrium showing a polypoidal exophytic form: A case report
Oncol Lett. 2023 Aug 28;26(4):444. doi: 10.3892/ol.2023.14031. eCollection 2023 Oct.ABSTRACTAlthough endometrial cancer is a common malignancy in women, rare histological subtypes can pose diagnostic challenges. Primary endometrial intestinal-type mucinous carcinoma is a newly recognized subtype of endometrial cancer that differs from Müllerian-type endometrial mucinous carcinoma. The present case report documents a rare case of intestinal-type mucinous carcinoma of the endometrium showing a polypoidal exophytic form. The patient, an 80-year-old female, was incidentally diagnosed with a uterine tumor during a follow-up fo...
Source: Oncology Letters - September 18, 2023 Category: Cancer & Oncology Authors: Chiharu Nakano Takeshi Fukuda Sayaka Tanaka Takuya Noda Eijiro Uchikura Yuichiro Awazu Reiko Tasaka Kenji Imai Makoto Yamauchi Tomoyuki Ichimura Tomoyo Yasui Toshiyuki Sumi Source Type: research
Prevalence and clinical correlations of SF3B1 variants in lactotroph tumours
CONCLUSIONS: SF3B1 variants are uncommon in lactotroph tumours but may be frequent in metastatic lactotroph tumours. When present, they associate with aggressive tumour behaviour and worse clinical outcome.PMID:37721395 | DOI:10.1093/ejendo/lvad114
Source: European Journal of Endocrinology - September 18, 2023 Category: Endocrinology Authors: Julia Simon Luis Gustavo Perez-Rivas Yining Zhao Fanny Chasseloup Helene Lasolle Christine Cortet Francoise Descotes Chiara Villa Bertrand Baussart Pia Burman Dominique Maiter Vivian von Selzam Roman Rotermund J örg Flitsch Jun Thorsteinsdottir Emmanuel Source Type: research
Blood-based protein biomarkers and red blood cell aggregation in pancreatic cancer
CONCLUSION: This study indicated that there are significant differences in blood-based biomarkers for differentiating between PDAC and inflammatory tumours of the pancreas. We also confirmed that PDAC is associated with the excessive aggregation of RBCs.PMID:37718785 | DOI:10.3233/CH-231814
Source: Clinical Hemorheology and Microcirculation - September 18, 2023 Category: Hematology Authors: Maciej Wiewiora Janusz Jopek El żbieta Świętochowska Gregorczyn S ławomir Jerzy Piecuch Mateusz G ąska Jerzy Piecuch Source Type: research
Nanostructured steady-state nanocarriers for nutrients preservation and delivery
Adv Food Nutr Res. 2023;106:31-93. doi: 10.1016/bs.afnr.2023.02.001. Epub 2023 Mar 21.ABSTRACTFood bioactives possess specific physiological benefits of preventing certain diet-related chronic diseases or maintain human health. However, the limitations of the bioactives are their poor stability, lower water solubility and unacceptable bioaccessibility. Structure damage or degradation is often found for the bioactives under certain environmental conditions like high temperature, strong light, extreme pH or high oxygen concentration during food processing, packaging, storage and absorption. Nanostructured steady-state nanoca...
Source: Advances in Food and Nutrition Research - September 18, 2023 Category: Nutrition Authors: Mingqian Tan Xuedi Zhang Shan Sun Guoxin Cui Source Type: research
Nutrition for critically ill children with congenital heart disease
Nutr Clin Pract. 2023 Oct;38 Suppl 2:S158-S173. doi: 10.1002/ncp.11046.ABSTRACTChildren with congenital heart disease often require admission to the cardiac intensive care unit at some point in their lives, either after elective surgical or catheter-based procedures or during times of acute critical illness. Meeting both the macronutrient and micronutrient needs of children in the cardiac intensive care unit requires complex decision-making when considering gastrointestinal perfusion, vasoactive support, and fluid balance goals. Although nutrition guidelines exist for critically ill children, these cannot always be extrapo...
Source: Nutrition in Clinical Practice - September 18, 2023 Category: Nutrition Authors: Jason S Kerstein Corie M Klepper Emily G Finnan Kimberly I Mills Source Type: research
