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Total 290035 results found since Jan 2013.
Silencing of keratin 15 impairs viability and mobility while facilitating the doxorubicin chemosensitivity by inactivating the β‑catenin pathway in liver cancer
In conclusion, KRT15 knockdown suppressed viability and mobility but facilitated Dox chemosensitivity via inactivating the β-catenin pathway in liver cancer, suggesting its potential as a target for liver cancer treatment.PMID:37720670 | PMC:PMC10502946 | DOI:10.3892/ol.2023.14034
Source: Oncology Letters - September 18, 2023 Category: Cancer & Oncology Authors: Junying Wang Guangyu Zhu Source Type: research
Dietary fat and lipid metabolism in the tumor microenvironment
Biochim Biophys Acta Rev Cancer. 2023 Sep 16:188984. doi: 10.1016/j.bbcan.2023.188984. Online ahead of print.ABSTRACTMetabolic reprogramming has been considered a core hallmark of cancer, in which excessive accumulation of lipids promote cancer initiation, progression and metastasis. Lipid metabolism is often considered as the digestion and absorption process of dietary fat, and the ways in which cancer cells utilize lipids are often influenced by the complex interactions within the tumor microenvironment. Among multiple cancer risk factors, obesity has a positive association with multiple cancer types, while diets like ca...
Source: Biochimica et Biophysica Acta - September 18, 2023 Category: Biochemistry Authors: Swagata Goswami Qiming Zhang Cigdem Elif Celik Ethan M Reich Ömer H Yilmaz Source Type: research
Intestinal ‑type mucinous carcinoma of the endometrium showing a polypoidal exophytic form: A case report
Oncol Lett. 2023 Aug 28;26(4):444. doi: 10.3892/ol.2023.14031. eCollection 2023 Oct.ABSTRACTAlthough endometrial cancer is a common malignancy in women, rare histological subtypes can pose diagnostic challenges. Primary endometrial intestinal-type mucinous carcinoma is a newly recognized subtype of endometrial cancer that differs from Müllerian-type endometrial mucinous carcinoma. The present case report documents a rare case of intestinal-type mucinous carcinoma of the endometrium showing a polypoidal exophytic form. The patient, an 80-year-old female, was incidentally diagnosed with a uterine tumor during a follow-up fo...
Source: Oncology Letters - September 18, 2023 Category: Cancer & Oncology Authors: Chiharu Nakano Takeshi Fukuda Sayaka Tanaka Takuya Noda Eijiro Uchikura Yuichiro Awazu Reiko Tasaka Kenji Imai Makoto Yamauchi Tomoyuki Ichimura Tomoyo Yasui Toshiyuki Sumi Source Type: research
Efficacy of a gluten-free diet in reducing the widespread pain index and symptom severity scale in patients affected by fibromyalgia
CONCLUSIONS: A GFD improved FM symptoms evaluated with WPI and SS. This was confirmed for the first time, also with a rechallenge of the GFD that followed a non-restricted gluten-containing diet.PMID:37721353 | DOI:10.4081/reumatismo.2023.1530
Source: Reumatismo - September 18, 2023 Category: Rheumatology Authors: V Bruzzese C Marrese P Scolieri J Pepe Source Type: research
Testicular tumours in children: a single-centre experience
CONCLUSION: Primary testicular tumours follow a bimodal age distribution pattern. Majority of patients can be cured with platinum-based chemotherapy despite having advanced disease at presentation.PMID:37721303 | DOI:10.4103/singaporemedj.SMJ-2021-380
Source: Singapore Medical Journal - September 18, 2023 Category: General Medicine Authors: Sajid Ali Tariq Latif Muhammad Ali Sheikh Shazia Perveen Muhammad Bilal Albash Sarwar Source Type: research
Mortality Risk Scoring System in Patients after Bleeding from Cancers in the Upper Gastrointestinal Tract
CONCLUSIONS: : Our new scoring system provides a better prediction of 30-day mortality than existing scoring systems in patients with UGI cancer bleeding. This new scoring system can be used to predict and prepare these patients who are known to have high mortality.PMID:37722853 | DOI:10.5009/gnl230069
Source: Gut and Liver - September 18, 2023 Category: Gastroenterology Authors: Hyun Min Kim Donghoon Kang Jun Young Park Yu Kyung Cho Myung-Gyu Choi Jae Myung Park Source Type: research
Nanostructured steady-state nanocarriers for nutrients preservation and delivery
Adv Food Nutr Res. 2023;106:31-93. doi: 10.1016/bs.afnr.2023.02.001. Epub 2023 Mar 21.ABSTRACTFood bioactives possess specific physiological benefits of preventing certain diet-related chronic diseases or maintain human health. However, the limitations of the bioactives are their poor stability, lower water solubility and unacceptable bioaccessibility. Structure damage or degradation is often found for the bioactives under certain environmental conditions like high temperature, strong light, extreme pH or high oxygen concentration during food processing, packaging, storage and absorption. Nanostructured steady-state nanoca...
Source: Advances in Food and Nutrition Research - September 18, 2023 Category: Nutrition Authors: Mingqian Tan Xuedi Zhang Shan Sun Guoxin Cui Source Type: research
ATP promotes resident CD34 < sup > + < /sup > cell migration mainly through P2Y2-Stim1-ERK/p38 pathway
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00048.2023. Online ahead of print.ABSTRACTExtracellular adenosine triphosphate (ATP) is one of the most abundant biochemical constitutes within the stem cell microenvironment and is postulated to play critical roles in cell migration. However, it is unclear whether ATP regulates the cell migration of CD34+ vascular wall-resident stem/progenitor cells (VW-SCs) and participates in angiogenesis. Therefore, the biological mechanisms of cell migration mediated by ATP was determined by in vivo subcutaneous matrigel plug assay, ex vivo aortic ring assay, in vitro transw...
Source: Am J Physiol Cell Ph... - September 18, 2023 Category: Cytology Authors: Ying Ma Chuting Han Cheng Xie Qingya Dang Liju Yang Yuan Li Min Zhang Jun Cheng Yan Yang Qingbo Xu Pengyun Li Source Type: research
Carboxymethyl konjac glucomannan-chitosan complex nanogels stabilized emulsions incorporated into alginate as microcapsule matrix for intestinal-targeted delivery of probiotics: In vivo and in vitro studies
In this study, we developed a novel delivery system using carboxymethyl konjac glucomannan-chitosan (CMKGM-CS) nanogels stabilized single and double emulsion incorporated into alginate hydrogel as microcapsule matrix for intestinal-targeted delivery of probiotics. Through in vitro experiments, it was demonstrated that alginate hydrogel provided favorable biocompatible growth conditions for the proliferation of Lactobacillus reuteri (LR). The alginate hydrogel containing single (ASE) or double emulsions (ACG) enhanced the resistance of LR to various adverse environments. Simulated gastrointestinal digestion experiments reve...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Xiaoqing Ding Danlei Li Yibin Xu Yuanyuan Wang Shuang Liang Lingyu Xie Weiqiang Yu Xiuan Zhan Aikun Fu Source Type: research
ATP promotes resident CD34 < sup > + < /sup > cell migration mainly through P2Y2-Stim1-ERK/p38 pathway
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00048.2023. Online ahead of print.ABSTRACTExtracellular adenosine triphosphate (ATP) is one of the most abundant biochemical constitutes within the stem cell microenvironment and is postulated to play critical roles in cell migration. However, it is unclear whether ATP regulates the cell migration of CD34+ vascular wall-resident stem/progenitor cells (VW-SCs) and participates in angiogenesis. Therefore, the biological mechanisms of cell migration mediated by ATP was determined by in vivo subcutaneous matrigel plug assay, ex vivo aortic ring assay, in vitro transw...
Source: American Journal of Physiology. Cell Physiology - September 18, 2023 Category: Cytology Authors: Ying Ma Chuting Han Cheng Xie Qingya Dang Liju Yang Yuan Li Min Zhang Jun Cheng Yan Yang Qingbo Xu Pengyun Li Source Type: research
Blood-based protein biomarkers and red blood cell aggregation in pancreatic cancer
CONCLUSION: This study indicated that there are significant differences in blood-based biomarkers for differentiating between PDAC and inflammatory tumours of the pancreas. We also confirmed that PDAC is associated with the excessive aggregation of RBCs.PMID:37718785 | DOI:10.3233/CH-231814
Source: Clinical Hemorheology and Microcirculation - September 18, 2023 Category: Hematology Authors: Maciej Wiewiora Janusz Jopek El żbieta Świętochowska Gregorczyn S ławomir Jerzy Piecuch Mateusz G ąska Jerzy Piecuch Source Type: research
Adverse event profile of CGRP monoclonal antibodies: findings from the FDA adverse event reporting database
CONCLUSION: We identified numerous shared underlying signals (overlapping signals) for CGRP-mAbs as suspected drugs in multiple systems and organs. The unlabeled common signals may indicate potential safety issues. In addition, the underlying safety signals varied among the four CGRP-mAbs, particularly in the cardiovascular system, and further studies are needed to confirm these associations and the potential clinical implications.PMID:37720989 | DOI:10.1080/14740338.2023.2250720
Source: Expert Opinion on Drug Safety - September 18, 2023 Category: Drugs & Pharmacology Authors: Qi Wang Jingfang Liu Hao Sun YongFei Dong WeiLiang Tan Zaixiang Tang YiGuo Jiang Source Type: research
A novel array of real-time RT-PCR assays for the rapid pathotyping of type I avian paramyxovirus (APMV-1)
J Virol Methods. 2023 Sep 16:114813. doi: 10.1016/j.jviromet.2023.114813. Online ahead of print.ABSTRACTNewcastle disease (ND) caused by virulent avian paramyxovirus type I (APMV-1) is a WOAH and EU listed disease affecting poultry worldwide. ND exhibits different clinical manifestations that may either be neurological, respiratory and/or gastrointestinal, accompanied by high mortality. In contrast, mild or subclinical forms are generally caused by lentogenic APMV-1 and are not subject to notification. The rapid discrimination of virulent and avirulent viruses is paramount to limit the spread of virulent APMV-1. The approp...
Source: Journal of Virological Methods - September 18, 2023 Category: Virology Authors: Andrea Fortin Andrea Laconi Isabella Monne Siamak Zohari Kristofer Andersson Christian Grund Mattia Cecchinato Marika Crimaudo Viviana Valastro Valeria D'Amico Alessio Bortolami Michele Gastaldelli Maria Varotto Newcastle Disease Collaborating Diagnostic Source Type: research
Does ghrelin regulate intestinal motility in rabbits? An in vitro study using isolated duodenal strips
In conclusion, ghrelin does not affect muscle contractility or motilin-induced contraction in the rabbit duodenum, which is due to the lack of ghrelin receptors. The present in vitro results suggest that ghrelin might not be a regulator of intestinal motility in rabbits.PMID:37722460 | DOI:10.1016/j.ygcen.2023.114384
Source: General and Comparative Endocrinology - September 18, 2023 Category: Endocrinology Authors: Shuangyi Zhang Hiroyuki Kaiya Takio Kitazawa Source Type: research
Prevalence and clinical correlations of SF3B1 variants in lactotroph tumours
CONCLUSIONS: SF3B1 variants are uncommon in lactotroph tumours but may be frequent in metastatic lactotroph tumours. When present, they associate with aggressive tumour behaviour and worse clinical outcome.PMID:37721395 | DOI:10.1093/ejendo/lvad114
Source: European Journal of Endocrinology - September 18, 2023 Category: Endocrinology Authors: Julia Simon Luis Gustavo Perez-Rivas Yining Zhao Fanny Chasseloup Helene Lasolle Christine Cortet Francoise Descotes Chiara Villa Bertrand Baussart Pia Burman Dominique Maiter Vivian von Selzam Roman Rotermund J örg Flitsch Jun Thorsteinsdottir Emmanuel Source Type: research
