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Total 290035 results found since Jan 2013.
Oxycodone alleviates mifepristone ‐stimulated human endometrial stromal cell injury by activating the Keap1/Nrf2/HO‐1 signaling pathway
ConclusionIn summary, we confirmed that oxycodone alleviates mifepristone-induced hEndoSC injury by activating the Keap1/Nrf2/HO-1 signaling pathway.
Source: Immunity, Inflammation and Disease - September 20, 2023 Category: Allergy & Immunology Authors: Aibing Zhu,
Fei Yao,
Mingkun Shen Tags: ORIGINAL ARTICLE Source Type: research
Current perspective on biological properties of plasmacytoid dendritic cells and dysfunction in gut
pDCs are a subset of dendritic cells, and transcription factors play a crucial role in the process. pDCs contribute to intestinal immune responses by generating interferon (IFN) and presenting antigens. pDCs guard the intestinal mucosa and protect against the invasion of microbiota and pathogens in the gut, playing a pivotal role in gut infection and colon cancer. AbstractPlasmacytoid dendritic cells (pDCs), a subtype of DC, possess unique developmental, morphological, and functional traits that have sparked much debate over the years whether they should be categorized as DCs. The digestive system has the greatest mucosal ...
Source: Immunity, Inflammation and Disease - September 20, 2023 Category: Allergy & Immunology Authors: Xueran Guo,
Chengwei He,
Shuzi Xin,
Han Gao,
Boya Wang,
Xiaohui Liu,
Sitian Zhang,
Fengrong Gong,
Xinyi Yu,
Luming Pan,
Fangling Sun,
Jingdong Xu Tags: REVIEW ARTICLE Source Type: research
Orally ‐Delivered, Cytokine‐Engineered Extracellular Vesicles for Targeted Treatment of Inflammatory Bowel Disease
A nested delivery system for oral delivery of the anti-inflammatory cytokine IL-10 for the treatment of inflammatory bowel disease is developed. The new method for orally taking protein has high patient compliance, compared with intravenous or intramuscular administration routes. This proof-of-concept for IBD treatment also affords a versatile methodology for other oral pr otein-based therapeutics delivery. AbstractThe use of orally-administered therapeutic proteins for treatment of inflammatory bowel disease (IBD) has been limited due to the harsh gastrointestinal environment and low bioavailability that affects deliver...
Source: Small - September 20, 2023 Category: Nanotechnology Authors: Jingang Liu,
He Ren,
Chen Zhang,
Jiexin Li,
Qian Qiu,
Nan Zhang,
Ning Jiang,
Jonathan F. Lovell,
Yumiao Zhang Tags: Research Article Source Type: research
Spontaneous dissection of digestive arteries: Outcomes of medical, surgical, and endovascular treatment in 169 patients
Isolated spontaneous dissection of the gastrointestinal arteries is a rare condition. Its course is still not well known, and the optimal treatment is not established. The aim of this study was to study the evolution and management of this pathology.
Source: Annals of Vascular Surgery - September 20, 2023 Category: Surgery Authors: Pierre Fontaine, Nicla Settembre, Rabie Ali Belkorissat, Charles Sadoul, Damien Mandr, Sergue ï Malikov Source Type: research
First French structure dedicated to intestinal vascular emergencies (SURVI): 7-year prospective Results
Acute mesenteric ischemia (AMI) is a vital, medico-surgical, vascular, and gastrointestinal emergency. The progression to intestinal infarction and its vital complications is unpredictable with a high mortality rate. Since 2009, we developed within a hospital group a standardized, multimodal and multidisciplinary therapeutic approach, targe ting intestinal viability that allowed for a radical change in prognosis with a> 70% survival rate. This motivated the opening of a first Structure of Intestinal Vascular Emergencies (SURVI) in January 2016.
Source: Annals of Vascular Surgery - September 20, 2023 Category: Surgery Authors: Iannis Ben Abdallah, Alexandre Nuzzo, Lorenzo Garzelli, Jean Senemaud, Arnaud Roussel, Pierre Cerceau, Catherine Chardigny, Lara Ribeiro Parenti, Brice Lortat-Jacob, Emmanuel Weiss, Val érie Vilgrain, Maxime Ronot, Yves Castier, Olivier Corcos Source Type: research
Neonatal erythema multiforme associated with a rotavirus infection: A case report
CONCLUSION: The possibility of rotavirus, a major cause of pediatric gastrointestinal infections, being a trigger for neonatal EM should be considered.PMID:37727716 | PMC:PMC10506005 | DOI:10.12998/wjcc.v11.i24.5749
Source: Herpes - September 20, 2023 Category: Infectious Diseases Authors: Jung Jae Kim Joon Kee Lee Source Type: research
Prognosis-related novel immunostaining pattern for programmed cell death ligand 1 and prognostic value of tumour-infiltrating lymphocytes in triple-negative breast cancer
This study aims to determine the prognostic significance of programmed cell death ligand 1 (PD-L1) expression and tumour-infiltrating lymphocytes (TILs) in triple- negative breast cancer (TNBC). PD-L1 expression and TIL percentage were determined in TNBCs that did not receive neoadjuvant therapy. The relationship between PD-L1 expression and the percentage of TILs with survival was investigated. The presence of intratumoural PD-L1-positive tumour-infiltrating immune cells (TIICs) in tumours with ≥ 1% PD-L1 expression was identified as a new PD-L1 evaluation parameter. The presence of intratumoural PD-L1-positive TIICs as...
Source: Polish Journal of Pathology - September 20, 2023 Category: Pathology Authors: P ınar Savaş G ürdeniz Serin P ınar Gürsoy Osman Zekio ğlu Necmettin Özdemir Source Type: research
ASO Visual Abstract: Association of Race/Ethnicity, Persistent Poverty, and Opioid Access Among Patients with Gastrointestinal Cancer Near the End of Life
Ann Surg Oncol. 2023 Sep 20. doi: 10.1245/s10434-023-14314-5. Online ahead of print.NO ABSTRACTPMID:37728821 | DOI:10.1245/s10434-023-14314-5
Source: Ann Oncol - September 20, 2023 Category: Cancer & Oncology Authors: Muhammad Musaab Munir Selamawit Woldesenbet Yutaka Endo Aslam Ejaz Jordan M Cloyd Samilia Obeng-Gyasi Mary Dillhoff Brittany Waterman Jillian Gustin Timothy M Pawlik Source Type: research
Clinical and dosimetric outcomes of image-guided, dose-painted radiotherapy in muscle invasive bladder cancer
CONCLUSION: Partial boost RT in MIBC is associated with good local disease control and high rates of cystectomy free survival. We observed a pattern of predominantly LR in the tumor bed, supporting the use of a dose-painted approach/de-escalation strategy to the uninvolved bladder. Prospective trials are required to compare oncological and toxicity outcomes between dose-painted and homogeneous bladder RT techniques.PMID:37730609 | DOI:10.1186/s13014-023-02338-w
Source: Cancer Control - September 20, 2023 Category: Cancer & Oncology Authors: Inmaculada Navarro-Domenech Shinthujah Arulanantham Zhihui Amy Liu Michael Tjong Vickie Kong Victor Malkov Tony Tadic Neil Fleshner Girish Kulkarni Alexandre R Zlotta Charles Catton Alejandro Berlin Srikala Sridhar Di Maria Jiang Peter Chung Srinivas Rama Source Type: research
Endoluminal treatment for Zenker's diverticulum - a population-based observational study
CONCLUSION: Both rigid endoscopic stapled oesophago-diverticulostomy and laser diverticulostomy are safe treatments for Zenker's diverticulum, however with a substantial risk of recurrence.PMID:37728323 | DOI:10.1080/00365521.2023.2260036
Source: Scandinavian Journal of Gastroenterology - September 20, 2023 Category: Gastroenterology Authors: Eirik Østensen Søfteland Anne Kristin Aaseb østøl Gjermund Johnsen Erling Audun Bringeland Source Type: research
Cognitive function in patients with irritable bowel syndrome: impairment is common and only weakly correlated with depression/anxiety and severity of gastrointestinal symptoms
CONCLUSION: Cognitive and emotional function were more severely affected in patients with IBS than in HCs. The weak correlation between the two functional areas suggests that both should be assessed as part of a clinical examination of patients with IBS.PMID:37727887 | DOI:10.1080/00365521.2023.2256916
Source: Scandinavian Journal of Gastroenterology - September 20, 2023 Category: Gastroenterology Authors: Julie Billing Birgitte Berentsen Arvid Lundervold Eline M R Hillestad G ülen A Lied Trygve Hausken Astri J Lundervold Source Type: research
Synchronous rectal adenocarcinoma and intestinal mantle cell lymphoma: A case report
CONCLUSION: Synchronous rectal adenocarcinoma and intestinal MCL presenting as multiple lymphomatous polyposis are extremely rare. MCL is often discovered fortuitously when rectal cancer is diagnosed. The coexistence of these tumors poses treatment challenges.PMID:37727717 | PMC:PMC10506007 | DOI:10.12998/wjcc.v11.i24.5772
Source: Clinical Colorectal Cancer - September 20, 2023 Category: Cancer & Oncology Authors: Kim-Van Vu Nguyen-Van Trong Nguyen-Thi Khuyen Do Huyen Nga Hoang Anh Nguyen Tien Trung Pham Trung Thong Nguyen Minh Duc Source Type: research
Neonatal erythema multiforme associated with a rotavirus infection: A case report
CONCLUSION: The possibility of rotavirus, a major cause of pediatric gastrointestinal infections, being a trigger for neonatal EM should be considered.PMID:37727716 | PMC:PMC10506005 | DOI:10.12998/wjcc.v11.i24.5749
Source: Herpes - September 20, 2023 Category: Infectious Diseases Authors: Jung Jae Kim Joon Kee Lee Source Type: research
Diagnosis and treatment of eosinophilic gastrointestinal disorders
Arerugi. 2023;72(8):1015-1020. doi: 10.15036/arerugi.72.1015.NO ABSTRACTPMID:37730343 | DOI:10.15036/arerugi.72.1015
Source: Allergology International - September 20, 2023 Category: Allergy & Immunology Authors: Yoshiyuki Yamada Source Type: research
Investigation of conditioned medium properties obtained from human umbilical cord mesenchymal stem/stromal cells preconditioned with dimethyloxalylglycine in a correlation with ultrastructural changes
Microsc Res Tech. 2023 Sep 20. doi: 10.1002/jemt.24420. Online ahead of print.ABSTRACTMesenchymal stem/stromal cells (MSCs) hold significant therapeutic value due to their regeneration abilities, migration capacity, and immunosuppressive and immunomodulatory properties. These cells secrete soluble and insoluble factors, and this complex secretome contributes to their therapeutic effect. Furthermore, stimulation of cells by various external stimuli lead to secretome modifications that can increase the therapeutic efficacy. So, this study examined the effect of dimethyloxalylglycine (DMOG), a hypoxia-mimetic agent, on secret...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Hanife Nurdan Olcar Basak Isildar Serbay Ozkan Merve Ercin Selda Gezginci-Oktayoglu Meral Koyuturk Source Type: research
