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Total 1132 results found since Jan 2013.
Hepcidin and its multiple partners: Complex regulation of iron metabolism in health and disease
Vitam Horm. 2023;123:249-284. doi: 10.1016/bs.vh.2023.03.001. Epub 2023 Mar 30.ABSTRACTThe peptide hormone hepcidin is central to the regulation of iron metabolism, influencing the movement of iron into the circulation and determining total body iron stores. Its effect on a cellular level involves binding ferroportin, the main iron export protein, preventing iron egress and leading to iron sequestration within ferroportin-expressing cells. Hepcidin expression is enhanced by iron loading and inflammation and suppressed by erythropoietic stimulation. Aberrantly increased hepcidin leads to systemic iron deficiency and/or iron...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Yelena Z Ginzburg Source Type: research
Naotaifang formula attenuates OGD/R-induced inflammation and ferroptosis by regulating microglial M1/M2 polarization through BMP6/SMADs signaling pathway
CONCLUSION: Microglial M1/M2 polarization plays a pivotal role in inflammation and ferroptosis during OGD/R. The BMP6/SMADs signaling pathway is a potential therapeutical target of inflammation and ferroptosis induced by the transformation of microglia. Moreover, NTF could alleviate inflammation and ferroptosis through the BMP6/SMADs signaling pathway in OGD/R-injured microglia.PMID:37713988 | DOI:10.1016/j.biopha.2023.115465
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 15, 2023 Category: Drugs & Pharmacology Authors: Jun Liao Mengzhen Wei Jianjun Wang Jinsong Zeng Danhong Liu Qiusi Du Jinwen Ge Zhigang Mei Source Type: research
Dyshomeostasis of Iron and Its Transporter Proteins in Cypermethrin-Induced Parkinson ’s Disease
AbstractThe etiology of Parkinson ’s disease (PD) is highly complex and is still indefinable. However, a number of studies have indicated the involvement of pesticides and transition metals. Copper, magnesium, iron, and zinc have emerged as important metal contributors. Exposure to pesticides causes an accumulation of transition m etals in the substantia nigra (SN) region of the brain. The cypermethrin model of PD is characterized by mitochondrial dysfunction, autophagy impairment, oxidative stress, etc. However, the effect of cypermethrin on metal homeostasis is not yet explored. The study was designed to delineate the ...
Source: Molecular Neurobiology - September 7, 2023 Category: Neurology Source Type: research
Iron Homeostasis in Mice: Does Liver Lobe Matter?
In this study, we compared iron-related parameters in distinct liver lobes of C57BL/6 wild-type mice across different ages. We found that the non-heme iron levels, as well as the mRNA and protein expression of iron storage protein Ferritin and the iron importer Transferrin Receptor 1, were similar between liver lobes. Additionally, the mRNA expression of Hepcidin, as well as its regulators, Bmp2 and Bmp6, and iron importers Zip8 and Zip14 were comparable. Minor differences were observed in Ferroportin mRNA levels of 24-weeks old mice; however, this did not correlate with altered iron content. The findings in wild-type mice...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - September 5, 2023 Category: Physiology Authors: Silvia Colucci Tiago Carvalho Oliveira Martina U Muckenthaler Oriana Marques Source Type: research
