This page shows you your search results in order of date. This is page number 19.
Order by Relevance | Date
Total 26176 results found since Jan 2013.
Primary Open Angle Glaucoma
Klin Monbl Augenheilkd. 2023 Aug 16. doi: 10.1055/a-2129-1126. Online ahead of print.ABSTRACTPrimary open angle glaucoma is the most frequent type among the glaucomas. It is characterized by a progressive loss of retinal ganglion cells and a corresponding visual field loss. Risk factors include older age, ethnicity, family history of glaucoma and, most important, an elevated intraocular pressure (IOP). The IOP is the only modifiable risk factor for glaucoma progression. Therapeutic approaches aim to lowering the IOP and incorporate topical pressure lowering medication, laser treatment, and different surgical approaches. Su...
Source: Klinische Monatsblatter fur Augenheilkunde - August 16, 2023 Category: Opthalmology Authors: Philip Keye Jan L übke Source Type: research
Narrative Review of Topiramate: Clinical Uses and Pharmacological Considerations
AbstractDue to the diverse mechanisms of action of antiseizure drugs, there has been a rise in prescriptions of these drugs for non-epileptic pathologies. One drug that is now being used for a variety of conditions is topiramate. This is a narrative review that used PubMed, Google Scholar, MEDLINE, and ScienceDirect to review literature on the clinical and pharmacologic properties of topiramate. Topiramate is a commonly prescribed second-generation antiseizure drug. The drug works through multiple pathways to prevent seizures. In this regard, topiramate blocks sodium and calcium voltage-gated channels, inhibits glutamate r...
Source: Advances in Therapy - August 16, 2023 Category: Drugs & Pharmacology Source Type: research
African American patient-provider communication about glaucoma vision quality-of-life
Eye, Published online: 14 August 2023; doi:10.1038/s41433-023-02693-8African American patient-provider communication about glaucoma vision quality-of-life
Source: Eye - August 14, 2023 Category: Opthalmology Authors: Betsy Sleath Bethany Beznos Delesha M. Carpenter Donald L. Budenz Kelly W. Muir Maria S. Romero Charles Lee Gail Tudor Nacire Garcia Alan L. Robin Source Type: research
Computational study of the mechanical behavior of the astrocyte network and axonal compartments in the mouse optic nerve head
The objective of this study was to develop a computational modeling method to estimate the IOP-induced strains and stresses in the axonal compartments in the mouse astrocytic lamina (AL) of the ONH, and to investigate the effect of the structural features on the mechanical behavior. We developed experimentally informed finite element (FE) models of six mouse ALs to investigate the effect of structure on the strain responses of the astrocyte network and axonal compartments to pressure elevation. The specimen-specific geometries of the FE models were reconstructed from confocal fluorescent images of cryosections of the mouse...
Source: Biomechanics and Modeling in Mechanobiology - August 13, 2023 Category: Biomedical Science Authors: Yik Tung Tracy Ling Arina Korneva Harry A Quigley Thao D Nguyen Source Type: research
Risk of new ‐onset glaucoma in patients with systemic lupus erythematosus: A nationwide, population‐based cohort study: Correspondence
Source: International Journal of Rheumatic Diseases - August 11, 2023 Category: Rheumatology Authors: Yi ‐Ting Lee,
Renin Chang Tags: CORRESPONDENCE Source Type: research
Relationship of Choroidal Microvasculature Dropout and Beta-Zone Parapapillary Area with Visual Field Changes in Glaucoma
To evaluate the association between rates of choroidal microvasculature dropout (MvD) change, beta-zone parapapillary atrophy ( β-PPA) area change, and visual field (VF) changes in primary open-angle glaucoma (POAG) eyes.
Source: American Journal of Ophthalmology - August 11, 2023 Category: Opthalmology Authors: Kareem Latif, Takashi Nishida, Sasan Moghimi, Eleonora Micheletti, Kelvin Du, Robert N. Weinreb Tags: Original Articles Source Type: research
Influence of Goniotomy Size on Treatment Safety and Efficacy for Primary Open-Angle Glaucoma: A Multicenter Study
As the most common type of glaucoma, primary open-angle glaucoma (POAG) is a potentially blinding eye disease.1 It is essential to seek effective and safe treatments for this chronic condition.2 Currently, treatment of POAG is directed at lowering the intraocular pressure (IOP), which is the only proven and treatable risk factor for the disease. Surgical treatment is generally indicated when medications and appropriate laser therapy are insufficient to control the progression of the disease.
Source: American Journal of Ophthalmology - August 11, 2023 Category: Opthalmology Authors: Yu Zhang, Ping Yu, Yingzhe Zhang, Kazunobu Sugihara, Xiaomin Zhu, Yao Zhang, Xiao Yang, Xiaoyan Li, Yacong Liu, Hengli Zhang, Xiaowei Yan, Hengkai Zhang, Fengbin Lin, Yunhe Song, Xinbo Gao, Huiping Yuan, Guangxian Tang, Wenzong Zhou, Sujie Fan, Guangfu Da Tags: Original Articles Source Type: research
Associations between vision impairment and vision-related interventions on crash risk and driving cessation: systematic review and meta-analysis
Conclusion
Impaired vision identified through a variety of measures is associated with both increased MVC involvement and cessation. Cataract surgery can reduce MVC risk. Despite literature being highly heterogeneous, this review shows that detection of vision problems and appropriate treatment are critical to road safety.
PROSPERO registration number
CRD42020172153.
Source: BMJ Open - August 11, 2023 Category: General Medicine Authors: Nguyen, H., Di Tanna, G. L., Coxon, K., Brown, J., Ren, K., Ramke, J., Burton, M. J., Gordon, I., Zhang, J. H., Furtado, J., Mdala, S., Kitema, G. F., Keay, L. Tags: Open access, Ophthalmology Source Type: research
The correlation between primary open-angle glaucoma (POAG) and gut microbiota: a pilot study towards predictive, preventive, and personalized medicine
ConclusionThis bioinformatic study elucidates NFKB1, IL18, KITLG, TLR9, FKBP2, and HDAC4 as hub genes for POAG and GM regulation. Immune response modulated by macrophages plays an important role in POAG and may be potential targets for future predictive, preventive, and personalized diagnosis and treatment.
Source: EPMA Journal - August 11, 2023 Category: International Medicine & Public Health Source Type: research
Microbead-Induced Ocular Hypertension in a Rodent Model of Glaucoma
Methods Mol Biol. 2023;2708:71-76. doi: 10.1007/978-1-0716-3409-7_8.ABSTRACTGlaucoma is an irreversible blinding disease characterized by the loss of retinal ganglion cells. Development of therapeutics relies on suitable models and, given its complex nature, these are typically in vivo models. A widely used model, owing to its relative simplicity, is the microbead model. This model involves the injections of beads into the anterior chamber, which are suitably sized to block the aqueous outflow pathway, leading to an elevation in intraocular pressure and ultimately, retinal ganglion cell death. In this chapter, we describe ...
Source: Mol Biol Cell - August 9, 2023 Category: Molecular Biology Authors: Ben Mead Source Type: research
High-Throughput Binocular Pattern Electroretinograms in the Mouse
We describe a novel method for obtaining user-friendly, robust PERG simultaneously from each eye using asynchronous binocular stimulation and one-channel acquisition of signals recorded from a subcutaneous needle in the snout.PMID:37558969 | DOI:10.1007/978-1-0716-3409-7_16
Source: Molecular Medicine - August 9, 2023 Category: Molecular Biology Authors: Tsung-Han Chou Jonathon Toft-Nielsen Vittorio Porciatti Source Type: research
Laser-Induced Ocular Hypertension in a Mouse Model of Glaucoma
Methods Mol Biol. 2023;2708:49-56. doi: 10.1007/978-1-0716-3409-7_6.ABSTRACTGlaucoma is a neurodegenerative disease that leads to the loss of retinal ganglion cells (RGC) and thus to blindness. There are numerous experimental models used for the study of this pathology. Among the different models, episcleral vein photocoagulation is one of the most widely used. In this model there is a transient increase in intraocular pressure that returns to normal values about 7 days after induction of ocular hypertension (OHT). In addition, typical glaucoma changes, such as loss of RGC, thinning of the optic nerve fiber layer, and glia...
Source: Molecular Medicine - August 9, 2023 Category: Molecular Biology Authors: Jos é M Ramírez Elena Salobrar-Garc ía Rosa de Hoz Juan J Salazar Jos é A Matamoros Lidia S ánchez-Puebla In és López-Cuenca Jos é A Fernández-Albarral Ana I Ram írez Source Type: research
