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Total 26176 results found since Jan 2013.
Inhibition of heat shock protein 47 suppressed collagen production in Tenon's capsule fibroblasts
CONCLUSIONS: HSP47 siRNA inhibits the production of COLI in rat Tenon's fibroblasts, and may be the potential therapeutic method in bleb scarring after glaucoma filtration surgery.PMID:37724035 | DOI:10.5603/fhc.96514
Source: Folia Histochemica et Cytobiologica - September 19, 2023 Category: Cytology Authors: Weiwei Wang Haiyan lI Source Type: research
Deep Learning Estimation of 10-2 Visual Field Map Based on Macular Optical Coherence Tomography Angiography Measurements
Glaucoma is a progressive disease associated with characteristic structural changes to the eye and loss of visual function.1 Early diagnosis and monitoring of disease progression are crucial to prevent significant loss of vision and blindness.1,2
Source: American Journal of Ophthalmology - September 19, 2023 Category: Opthalmology Authors: Golnoush Mahmoudinezhad, Sasan Moghimi, Jiacheng Cheng, Liyang Ru, Dongchen Yang, Kushagra Agrawal, Rajeev Dixit, Siavash Beheshtaein, Kelvin H. Du, Kareem Latif, Gopikasree Gunasegaran, Eleonora Micheletti, Takashi Nishida, Alireza Kamalipour, Evan Walke Source Type: research
Causal association between common rheumatic diseases and glaucoma: a Mendelian randomization study
ConclusionsAS is related to an increased risk of POAG and PACG. We stress the importance of glaucoma screening for AS patients.
Source: Frontiers in Immunology - September 19, 2023 Category: Allergy & Immunology Source Type: research
Unleashing the potential of CRISPR multiplexing: Harnessing Cas12 and Cas13 for precise gene modulation in eye diseases
Vision Res. 2023 Sep 16;213:108317. doi: 10.1016/j.visres.2023.108317. Online ahead of print.ABSTRACTGene therapy is a flourishing field with the potential to revolutionize the treatment of genetic diseases. The emergence of CRISPR-Cas9 has significantly advanced targeted and efficient genome editing. Although CRISPR-Cas9 has demonstrated promising potential applications in various genetic disorders, it faces limitations in simultaneously targeting multiple genes. Novel CRISPR systems, such as Cas12 and Cas13, have been developed to overcome these challenges, enabling multiplexing and providing unique advantages. Cas13, in...
Source: Vision Research - September 18, 2023 Category: Opthalmology Authors: Fabio Bigini Soo Hyeon Lee Young Joo Sun Yang Sun Vinit B Mahajan Source Type: research
Systemic immuno-inflammatory index in patients with pseudoexfoliation syndrome and pseudoexfoliative glaucoma
CONCLUSIONS: In PEXS patients, both SII and NLR were significantly higher, albeit in a small group of patients, and SII may be a helpful and supportive parameter for NLR in risk estimation in these patients. There was a statistically significant difference only in NLR in patients with PEXG when compared with the control group. However, these results need to be supported by future longitudinal and larger studies to identify any possible link between hematological inflammatory markers and pseudoexfoliation.PMID:37720205 | PMC:PMC10504835 | DOI:10.1177/25158414231197072
Source: Adv Data - September 18, 2023 Category: Epidemiology Authors: Nejla Tukenmez Dikmen Yasemin Un Source Type: research
Fitness to drive with glaucoma - Rohrschneider K, Tost F.
Glaucoma is one of the eye diseases that are particularly relevant to driving in old age. The ophthalmologist often has to take on the task of traffic medical consultation or medical appraisal. It is essential to distinguish between fitness to drive and dr...
Source: SafetyLit - September 16, 2023 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Development of mucoadhesive Timolol loaded chitosan-nanocomposite to treat glaucoma
Int J Biol Macromol. 2023 Sep 14:126917. doi: 10.1016/j.ijbiomac.2023.126917. Online ahead of print.ABSTRACTTimolol Maleate is an aqueous soluble β-blocker antiglaucoma drug used to suppress intraocular pressure. Several commercially available ocular formulations are not effective in delivering to the target site due to their water-soluble property and low mucoadhesiveness. Hence, there is a requirement for a highly mucoadhesive drug-loaded nanocomposite to suppress intraocular pressure with enhanced bioavailability. Herein, we have prepared a mucoadhesive Timolol-loaded graphene quantum dot-chitosan-nanocomposite to trea...
Source: International Journal of Biological Macromolecules - September 16, 2023 Category: Biochemistry Authors: B N Kumara R Shambhu Yoon-Bo Shim Jayabalan Nirmal K Sudhakara Prasad Source Type: research
Genes, Vol. 14, Pages 1809: Factors Associated with Large Cup-to-Disc Ratio and Blindness in the Primary Open-Angle African American Glaucoma Genetics (POAAGG) Study
Conclusions: These findings underscore the importance of close monitoring of intraocular pressure and visual function in African ancestry POAG patients, particularly those with LCDR, to preserve visual function.
Source: Genes - September 16, 2023 Category: Genetics & Stem Cells Authors: Anusha Mamidipaka Isabel Di Rosa Roy Lee Yan Zhu Yineng Chen Rebecca Salowe Victoria Addis Prithvi Sankar Ebenezer Daniel Gui-Shuang Ying Joan M. O ’Brien Tags: Article Source Type: research
The continuous treatment of anterior segment open globe injury: an eye injury vitrectomy study
CONCLUSIONS: Initiating CST before fibrosis or scar formation might improve the prognosis of open AS injury, which was preferable to natural wound healing after wound repair.PMID:37711825 | PMC:PMC10498217 | DOI:10.21037/qims-23-645
Source: Hand Surgery - September 15, 2023 Category: Surgery Authors: Xijuan Wang Kang Feng Shikun He Xin Xie Zhizhong Ma Source Type: research
