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Total 26176 results found since Jan 2013.

The emerging Janus face of SVEP1 in development and disease
Trends Mol Med. 2023 Sep 4:S1471-4914(23)00187-9. doi: 10.1016/j.molmed.2023.08.002. Online ahead of print.ABSTRACTSushi, von Willebrand factor type A, EGF, and pentraxin domain containing 1 (SVEP1) is a large extracellular matrix protein that is also detected in circulation. Recent plasma proteomic and genomic studies have revealed a large number of associations between SVEP1 and human traits, particularly chronic disease. These include associations with cardiac death and disease, diabetes, platelet traits, glaucoma, dementia, and aging; many of these are causal. Animal models demonstrate that SVEP1 is critical in vascula...
Source: Trends in Molecular Medicine - September 6, 2023 Category: Molecular Biology Authors: Jared S Elenbaas In-Hyuk Jung Ariella Coler-Reilly Paul C Lee Arturo Alisio Nathan O Stitziel Source Type: research

Secondary glaucoma: Toward interventions based on molecular underpinnings
This article is categorized under: Neurological Diseases> Molecular and Cellular Physiology
Source: Wiley Interdisciplinary Reviews: Systems Biology and Medicine - September 6, 2023 Category: Biomedical Science Authors: Anna Mueller, Isabel Lam, Krishna Kishor, Richard K. Lee, Sanjoy Bhattacharya Tags: Advanced Review Source Type: research

GSE241782 Regional Gene Expression in the Retina, Optic Nerve Head, and Optic Nerve of Mice with Optic Nerve Crush and Experimental Glaucoma
Contributors : Casey J Keuthan ; Julie A Schaub ; Meihan Wei ; Weixiang Fang ; Sarah Quillen ; Elizabeth Kimball ; Thomas V Johnson ; Hongkai Ji ; Donald J Zack ; Harry A QuigleySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusA major risk factor for glaucomatous optic neuropathy is the level of intraocular pressure (IOP), which can lead to retinal ganglion cell axon injury and cell death. The optic nerve has a rostral unmyelinated portion at the optic nerve head followed by a caudal myelinated region. The unmyelinated region is differentially susceptible to IOP-induced damage in roden...
Source: GEO: Gene Expression Omnibus - September 6, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Cost-utility analysis of commonly used anti-glaucoma interventions for mild-to-moderate primary open-angle glaucoma patients in rural and urban China
Conclusions The long-term cost-effectiveness of commonly used surgical procedures could be better than the short-term cost-effectiveness for mild-to-moderate POAG patients in China. Health economic studies, supported by more rigorous structured real-world data, are needed to assess their everyday cost-effectiveness.
Source: BMJ Open - September 6, 2023 Category: General Medicine Authors: Li, R., Zhang, K., Lu, Z., Mou, D., Wang, J., Li, H., Fan, S., Wang, N., Liu, H. Tags: Open access, Ophthalmology Source Type: research

Clinical efficacy of sclerotonyxis for acute angle-closure glaucoma with persistent high intraocular pressure
CONCLUSIONS: Sclerotonyxis can rapidly lower IOP, release the pupillary blockage, reconstruct the anterior chamber, and reduce systemic complications caused by long-term high-dose antiglaucoma drugs. Thus, it normalizes the IOP and provides a safe operating space for stage II surgery, effectively reducing complications in patients in a persistent high IOP state.PMID:37667925 | DOI:10.26355/eurrev_202308_33400
Source: European Review for Medical and Pharmacological Sciences - September 5, 2023 Category: Drugs & Pharmacology Authors: Y-Y Zhang B-B Xu Z-X Hu L-G Zhang Source Type: research