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Dramatic response to local radiotherapy in a refractory metastatic mediastinal yolk sac tumor patient harboring a germline < em > BRCA2 < /em > frameshift mutation: a case report
Cancer Biol Ther. 2022 Dec 31;23(1):393-400. doi: 10.1080/15384047.2022.2072635.ABSTRACTMediastinal yolk sac tumors (YSTs) are highly aggressive germ cell tumors with an extremely poor prognosis. Radiotherapy plays an important role in the treatment of mediastinal YSTs. To maximize benefit from radiotherapy in patients with mediastinal YSTs, exploring functionally relevant biomarkers is essential. Previous studies have demonstrated that mutations in DNA-damage repair (DDR) genes, including BRCA1/2, potentially enhance sensitivity to radiotherapy in solid tumors. However, DDR-gene mutations, as possible predictive biomarker...
Source: Cancer Biology and Therapy - May 16, 2022 Category: Cancer & Oncology Authors: Xi Cheng Haiming Yu Jinying Li Xiaona Han Erhong Meng Houqing Zhou Dongliang Wang Beifang Niu Xiaotao Zhang Source Type: research

An Unusual Enteric Yolk Sac Tumor: First Report of an Ovarian Germ Cell Tumor Associated With a Germline Pathogenic Variant in DICER1
We report an unusual enteric variant of ovarian YST in a 28-yr-old woman associated with a germline PV c.901C>T (p.Gln301Ter) in exon 7 of DICER1, accompanied by a somatic (YST-only) hotspot mutation: c.5437G>A, p.E1813K. To our knowledge, this is the first report of an ovarian germ cell tumor associated with a germline DICER1 PV. We review other reported cases of ovarian germ cell tumor with DICER1 PVs and discuss the differential diagnosis of this unusual variant of YST which was originally diagnosed as a mucinous adenocarcinoma.
Source: International Journal of Gynecological Pathology - June 29, 2022 Category: Pathology Tags: Pathology of the Upper Tract: Case Reports Source Type: research

Clinicopathological features, prognosis, and fertility outcomes in Chinese Han women treated for ovarian yolk sac tumor: A retrospective case series study from two tertiary-care academic medical centers
Conclusions: The diagnosis of YST of childbearing age is very rare. Because the failure of primary treatment is related to the residual disease after salvage surgery, the fertility and survival results of patients undergoing fertility-preserving surgery are promising.
Source: Medicine - July 22, 2022 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Vaginal yolk sac tumors in infants and children: A case report and literature review
Oncol Lett. 2023 Feb 8;25(3):120. doi: 10.3892/ol.2023.13706. eCollection 2023 Mar.ABSTRACTA vaginal yolk sac tumor (YST) is a rare malignant germ cell tumor for infants and children, and it has been >50 years since the first case was reported. The treatment strategy has changed markedly in the past 50 years, from radical surgical treatment to conservative surgery combined with chemotherapy, and then to combined chemotherapy alone. The present study reports the case of a primary vaginal YST in a 13-month-old girl that was successfully treated by tumor resection combined with chemotherapy. The clinical symptoms, imaging ...
Source: Oncology Letters - March 13, 2023 Category: Cancer & Oncology Authors: Zhongli Ma Canyu Li Source Type: research