This page shows you your search results in order of relevance. This is page number 18.

Order by Relevance | Date

Total 1161397 results found since Jan 2013.

Successful radiotherapy in postoperative recurrence of a primary mediastinal yolk sac tumor: A case report
Abstract A woman in her 60s was evaluated for anterior chest pain. Computed tomography (CT) revealed a 50 mm mass with irregular contrast enhancement in the anterior mediastinum. α‐fetoprotein (AFP) level was elevated to 1188 ng/mL. A germ cell tumor was diagnosed, mostly comprising of a yolk sac tumor (YST). Two courses of chemotherapy with cisplatin (CDDP) and etoposide (VP16) were administered and surgical tumor resection was then performed. The final diagnosis was YST. CDDP and VP16 were continued postoperatively; however, because the AFP level increased about six months after surgery, the chemotherapy regimen was...
Source: Thoracic Cancer - August 20, 2015 Category: Cancer & Oncology Authors: Masakuni Sakaguchi, Toshiya Maebayashi, Takuya Aizawa, Naoya Ishibashi, Shoko Fukushima, Tsutomu Saito Tags: Case Report Source Type: research

Extragonadal yolk sac tumor: A rare case of penile location.
PMID: 26387830 [PubMed - as supplied by publisher]
Source: Archives de Pediatrie - September 17, 2015 Category: Pediatrics Authors: Delforge X, Buisson P, Ricard J, Gourmel A, Mesureur S, Canarelli JP, Gouron R, Haraux E Tags: Arch Pediatr Source Type: research

Primary orbital yolk sac tumor: report of a case and review of literature
Abstract Germ cell tumor can affect extragonadal sites. Teratoma is a well-recognized extragonadal tumor in the orbit. Primary yolk sac tumor (YST) or endodermal sinus tumor of orbit is rare and only few cases have been reported in the literature. Its clinical presentation may mimic many common pediatric orbital conditions, and delay in diagnosis affects ocular morbidity and mortality. In the past orbital YST has been treated with multimodal therapy including surgery, systemic chemotherapy, and radiotherapy. Herein we describe a case of primary orbital YST and reviewed the literature for similar cases. The rev...
Source: International Ophthalmology - October 19, 2015 Category: Opthalmology Source Type: research

Prognostic value of programmed-death-1 receptor (PD-1) and its ligand 1 (PD-L1) in testicular germ cell tumors
Conclusions In this translational study, we showed, for the first time, the prognostic value of PD-L1 expression in TGCTs and our data imply that the PD-1/PD-L1 pathway could be a novel therapeutic target in TGCTs.
Source: Annals of Oncology - January 22, 2016 Category: Cancer & Oncology Authors: Cierna, Z., Mego, M., Miskovska, V., Machalekova, K., Chovanec, M., Svetlovska, D., Hainova, K., Rejlekova, K., Macak, D., Spanik, S., Ondrus, D., Kajo, K., Mardiak, J., Babal, P. Tags: urogenital tumors Source Type: research

Targeting peptidyl-prolyl isomerase pin1 to inhibit tumor cell aggressiveness.
CONCLUSIONS: Our results support that PIN1 may be a valuable target to hit in cancer cells characterized by increased aggressive potential, overexpression of erbB receptor family members, and defective p53. PMID: 26917410 [PubMed - as supplied by publisher]
Source: Tumori - February 29, 2016 Category: Cancer & Oncology Tags: Tumori Source Type: research

Giant seminoma case with very small yolk sac and embryo carcinoma components, detected by intensive histopathological examination
Publication date: September 2016 Source:Human Pathology: Case Reports, Volume 5 Author(s): Takeo Nakaya, Shuichiro Kobayashi, Satoshi Kitahara, Akira Tanaka, Hiroshi Kamma, Akio Komatsu We experienced the giant seminoma with 18×10×10cm sized and about 2.6kg weight of 25year old patient. We intensively examined the histological tissue type distributions in this giant seminoma. Most of the tumor consisted of seminoma components. In addition, the tumor included the very small fragments of yolk sac tumor and embryonal carcinoma component at the root part of the seminoma mass. This shows that intensive histological ex...
Source: Human Pathology: Case Reports - March 12, 2016 Category: Pathology Source Type: research

Epicardium is required for cardiac seeding by yolk sac macrophages, precursors of resident macrophages of the adult heart.
Abstract A subset of macrophages that reside in adult tissues originate from the fetal yolk sac, while others derive from circulating monocytes. These ontologically different macrophage subsets have distinct roles in tissue injury responses, with the embryonic population overall having beneficial activity in cardiac repair. Here we show that fetal yolk macrophages are recruited to a niche within and just below the epicardium, the mesothelial covering of the heart. The epicardium was required for establishment of yolk sac macrophages in this region of the fetal heart, and this function of epicardium depended on its...
Source: Developmental Biology - March 14, 2016 Category: Biology Authors: Stevens SM, von Gise A, VanDusen N, Bin Zhou, Pu WT Tags: Dev Biol Source Type: research

Placentation in mammals: definitive placenta, yolk sac and paraplacenta
An overview is given of variations in placentation with particular focus on yolk sac, paraplacenta and other structures important to histotrophic nutrition. The placenta proper varies in general shape, internal structure and the number of tissues in the interhemal barrier. Yolk sac membranes persist to term in insectivores, colugos, rodents and lagomorphs. In the latter two orders they are of known importance for maternal-fetal transfer of antibodies, vitamins, lipids and proteins. The detached yolk sac of bats is also active throughout gestation.
Source: Theriogenology - April 20, 2016 Category: Genetics & Stem Cells Authors: A.M. Carter, A.C. Enders Source Type: research

Placentation in mammals: Definitive placenta, yolk sac, and paraplacenta
An overview is given of variations in placentation with particular focus on yolk sac, paraplacenta, and other structures important to histotrophic nutrition. The placenta proper varies in general shape, internal structure, and the number of tissues in the interhemal barrier. Yolk sac membranes persist to term in insectivores, colugos, rodents, and lagomorphs. In the latter two orders, they are of known importance for maternal–fetal transfer of antibodies, vitamins, lipids, and proteins. The detached yolk sac of bats is also active throughout gestation.
Source: Theriogenology - April 20, 2016 Category: Genetics & Stem Cells Authors: A.M. Carter, A.C. Enders Tags: Review Source Type: research

ZBTB16: a novel sensitive and specific biomarker for yolk sac tumor
David E Burstein
Source: Modern Pathology - May 30, 2016 Category: Pathology Authors: Guang-Qian XiaoFaqian LiPamela D UngerHani KaterjiQi YangLoralee McMahonDavid E Burstein Source Type: research

Occult Mediastinal Yolk Sac Tumor Producing α-Fetoprotein Detected by 18F-FDG PET/CT
Abstract: Malignant mediastinal yolk sac tumor (YST), especially adult onset, is rare. Herein, we report a case of occult mediastinal YST with α-fetoprotein production revealed by 18F-FDG PET/CT in a young adult, in which the intense tracer uptake was demonstrated in the anterior mediastinum. This case indicates 18F-FDG PET/CT may be a useful tool for detecting the occult primaries of YST.
Source: Clinical Nuclear Medicine - June 8, 2016 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

High-level expression of divergent endodermal lineage markers in gonadal and extra-gonadal yolk sac tumors
edline
Source: Modern Pathology - September 26, 2016 Category: Pathology Authors: Hadi Shojaei Hong Hong Raymond W Redline Source Type: research

Identification of novel genetic markers for mouse yolk sac cells by using microarray analyses
The mouse embryonic yolk sac consists of a visceral yolk sac (VYS) and parietal yolk sac (PYS), and may function as a materno-fetal exchange system for nutrients and wastes, and physical protector for the embryo/fetus. The present study was undertaken to characterize gene expression of the VYS and PYS endodermal cells, and to identify their novel genetic markers from microarray data. Apoa4, Lrp2, Fxyd2, Slc34a3 and Entpd2 were predominantly expressed in VYS epithelial cells. Gkn2 and Pga5 were selected as markers for PYS cells.
Source: Placenta - November 23, 2016 Category: Reproduction Medicine Authors: Shinomi Yagi, Nobuyoshi Shiojiri Tags: Technical note Source Type: research

Suppression of Neu1 sialidase delays the absorption of yolk sac in medaka (Oryzias latipes) accompanied with the accumulation of α2-3 sialo-glycoproteins.
Abstract Sialidase catalyzes the removal of sialic acids from glycoconjugates. Recently, medaka sialidase Neu1 has been cloned and its enzymatic properties were investigated. Although enzymatic properties of this sialidase, such as optimal pH and substrate specificity, exhibits high similarity with human NEU1, Neu1 physiological functions in fish are still unclear. Here, to understand Neu1 significance in medaka embryogenesis, sialidase translation knockdown was carried out with one-cell stage fertilized egg using morpholino oligo injection. Neu1 exhibited desialylation of α2-3 sialic acid linkage in vitro and ly...
Source: Biochimie - January 18, 2017 Category: Biochemistry Authors: Ryuzono S, Takase R, Kamada Y, Ikenaga T, Chigwechokha PK, Komatsu M, Shiozaki K Tags: Biochimie Source Type: research

Tissue growth pressure drives early blood flow in the chicken yolk sac
Conclusions ‐ This study shows that tissue growth pressure can drive early blood flow, and suggests that the mechanical environment, beyond hemodynamics, can contribute to vascular morphogenesis. This article is protected by copyright. All rights reserved.
Source: Developmental Dynamics - May 5, 2017 Category: Molecular Biology Authors: Rapha ël Clément, Benjamin Mauroy, Annemiek J.M. Cornelissen Tags: Research Article Source Type: research