This page shows you your search results in order of relevance. This is page number 9.

Order by Relevance | Date

Total 1161397 results found since Jan 2013.

Surveillance After Initial Surgery for Pediatric and Adolescent Girls With Stage I Ovarian Germ Cell Tumors: Report From the Children's Oncology Group Pediatric Oncology
Conclusion Fifty percent of patients with stage I pediatric MOGCT can be spared chemotherapy; treatment for those who experience recurrence preserves OS. Further study is needed to identify the factors that predict recurrence and whether this strategy can be extended successfully to older adolescents and young adults.
Source: Journal of Clinical Oncology - February 7, 2014 Category: Cancer & Oncology Authors: Billmire, Cullen, Rescorla, Davis, Schlatter, Olson, Malogolowkin, Pashankar, Villaluna, Krailo, Egler, Rodriguez-Galindo, Frazier Tags: Chemotherapy, Germ Cell Tumors Pediatric Oncology Source Type: research

Yolk Sac Tumor in Postmenopausal Patients: Pure or Associated With Adenocarcinoma, a Rare Phenomenon
We report two cases, both in older patients. One of the YSTs was associated with high-grade serous and endometrioid carcinoma, while the other case showed pure YST. The YST component showed positivity for SALL4, AFP and Glypican-3 and negative staining for PAX8 supporting a germ cell tumor differentiation; SALL4 and PAX8 markers have not been previously analyzed in this setting. Both tumors recurred within 7 months despite systemic chemotherapy.
Source: International Journal of Gynecological Pathology - September 1, 2014 Category: Pathology Tags: Pathology of the Upper Genital Tract: Case Report Source Type: research

Expression pattern of clinically relevant markers in paediatric germ cell- and sex-cord stromal tumours is similar to adult testicular tumours
Abstract Paediatric germ cell tumours (GCTs) are rare and account for less than 3 % of childhood cancers. Like adult GCTs, they probably originate from primordial germ cells, but the pattern of histopathological types is different, and they occur predominantly in extragonadal sites along the body midline. Because they are rare, histology of paediatric GCTs is poorly documented, and it remains unclear to what extent they differ from adult GCTs. We have analysed 35 paediatric germ cell tumours and 5 gonadal sex-cord stromal tumours from prepubertal patients aged 0–15 years, to gain further knowledge, elaborate ...
Source: Virchows Archiv - October 30, 2014 Category: Pathology Source Type: research

NUT protein immunoreactivity in ovarian germ cell tumours
SummaryThe aim of this study was to investigate NUT (nuclear protein in the testis) expression in ovarian germ cell tumours (GCTs). Immunostaining for NUT protein was performed in 10 mature cystic teratomas and in 49 malignant ovarian GCTs including 15 pure dysgerminomas, six dysgerminomas associated with gonadoblastoma, nine yolk sac tumours, 12 immature teratomas, and seven mixed malignant tumours. Only nuclear staining was considered a positive finding although cytoplasmic staining was noted when present. Thirty-seven (76%) malignant GCTs were NUT positive but staining was usually of weak to moderate intensity and obser...
Source: Pathology - January 8, 2015 Category: Pathology Tags: Anatomical Pathology Source Type: research

Extragonadal yolk sac tumor of the head and neck region: A report of two cases
We report two male children, aged 1 year 7 months and 3 years 5 months, with YST involving the head and neck region.
Source: Journal of Cancer Research and Therapeutics - February 15, 2016 Category: Cancer & Oncology Authors: Maitrayee RoyShipra AgarwalAashish GuptaSameer BakhshiAshu Seith Bhalla Source Type: research

Racial disparities in presentation and survival of ovarian yolk sac cancer patients: a study of 423 women
Ovarian germ cell cancers comprise 3-5% of all ovarian malignancies. Patients with yolk sac tumors have a worse prognosis compared to those with dysgerminomas or immature teratomas.1,2 Due to the rarity of yolk sac tumors, few studies have evaluated their distinct demographic and clinicopathologic features. Previous studies have demonstrated that Asians and blacks have an increased incidence of germ cell cancers.3,4 We propose to determine the factors associated with the presentation and survival rates of ovarian yolk sac cancer patients.
Source: American Journal of Obstetrics and Gynecology - May 4, 2016 Category: OBGYN Authors: John K. Chan, Austin B. Gardner, Cheng-I Liao, Joshua Chan, Andrew Guan, Mark Alshak, Daniel S. Kapp Tags: Letter to the Editor Source Type: research

Patterns and trends in the incidence of paediatric and adult germ cell tumours in Australia, 1982–2011
Conclusion Broad similarities in the shape of age-specific incidence curves, particularly for gonadal, central nervous system, and mediastinal tumours provide epidemiological support for commonalities in aetiology among clinically disparate GCT subtypes. Differences in peak ages reflect underlying subtype-specific biological differences. Declining incidence trends for some adult gonadal tumours accords with the global transition in GCT incidence, and supports the possibility of a reduction in prevalence of shared aetiological exposures.
Source: Cancer Epidemiology - May 25, 2016 Category: Cancer & Oncology Source Type: research

Primary Endometrial Yolk Sac Tumor With Endodermal-Intestinal Differentiation Masquerading as Metastatic Colorectal Adenocarcinoma
We report an unusual case of a primary endometrial YST showing florid endodermal-intestinal differentiation in a 63-yr-old woman with a history of colorectal adenocarcinoma. Histologically, the tumor exhibited a glandular and papillary architecture and showed widespread immunoreactivity for CDX2 and focal staining for CK20 and CEA, mimicking metastatic colorectal carcinoma on biopsy. The presence of subnuclear cytoplasmic clearing and positive staining for germ cell markers, however, pointed toward a diagnosis of primary endometrial YST, and this was supported by the radiologic and the subsequent pathologic finding of a pr...
Source: International Journal of Gynecological Pathology - June 7, 2016 Category: Pathology Tags: Pathology of the Corpus: Case Reports Source Type: research

Yolk Sac Tumors in Postmenopausal Patients Arising in Endometrioid Adenocarcinoma
Abstract: A nulliparous, obese, diabetic 68-year-old woman with a history of pelvic endometriosis presented with an International Federation of Gynecology and Obstetrics stage III 17-cm ovarian mass. Histology showed endometriotic cysts with an intracystic growth of well-differentiated endometrioid adenocarcinoma with squamous morular change. This coexisted with a second papillary epithelial pattern corresponding to a glandular yolk sac tumor (YST) that merged with the endometrioid adenocarcinoma. Immunohistochemistry discriminated between endometrioid adenocarcinoma and glandular YST phenotypes. The expression of traditio...
Source: Pathology Case Reviews - July 1, 2016 Category: Pathology Tags: Case Reviews Source Type: research

Patterns and trends in the incidence of paediatric and adult germ cell tumours in Australia, 1982 –2011
Conclusion Broad similarities in the shape of age-specific incidence curves, particularly for gonadal, central nervous system, and mediastinal tumours provide epidemiological support for commonalities in aetiology among clinically disparate GCT subtypes. Differences in peak ages reflect underlying subtype-specific biological differences. Declining incidence trends for some adult gonadal tumours accords with the global transition in GCT incidence, and supports the possibility of a reduction in prevalence of shared aetiological exposures.
Source: Cancer Epidemiology - June 17, 2016 Category: Cancer & Oncology Source Type: research

Racial disparities in presentation and survival of  ovarian yolk sac cancer patients: a study of 423 women
Ovarian germ cell cancers comprise 3-5% of all ovarian malignancies. Patients with yolk sac tumors have a worse prognosis compared to those with dysgerminomas or immature teratomas.1,2 Due to the rarity of yolk sac tumors, few studies have evaluated their distinct demographic and clinicopathologic features. Previous studies have demonstrated that Asians and blacks have an increased incidence of germ cell cancers.3,4 We propose to determine the factors associated with the presentation and survival rates of ovarian yolk sac cancer patients.
Source: American Journal of Obstetrics and Gynecology - May 4, 2016 Category: OBGYN Authors: John K. Chan, Austin B. Gardner, Cheng-I Liao, Joshua Chan, Andrew Guan, Mark Alshak, Daniel S. Kapp Tags: Letter to the Editor Source Type: research

Yolk Sac Tumor in Extragonadal Pelvic Sites: Still a Diagnostic Challenge
We present the clinicopathologic features of 15 cases of extragonadal yolk sac tumor (EGYST) detected in female patients and reviewed at our institution from 1988 to 2016. We recorded: patient age, clinical presentation, tumor location, FIGO stage (where applicable), histologic patterns including presence/absence of Schiller-Duval bodies, other germ cell or somatic components, immunoperoxidase results, treatment, and outcome. Patients’ ages ranged from 17 to 87 (median, 62) years and presentation included: abnormal uterine bleeding, 12; hematuria, 1; labial mass, 1; abdominal pain, 1. Primary sites were as follows: uteru...
Source: The American Journal of Surgical Pathology - December 15, 2016 Category: Pathology Tags: Original Articles Source Type: research

A Case of Urachal Yolk Sac Tumor With Spontaneous Rupture in a Child
Tumors arising from urachus in children are exceedingly rare and sporadically reported in literature. Being a midline structure, the urachus may harbor neoplastic germ cell elements and can occasionally present as a case of acute abdomen. A 20-month-old toddler presented with spontaneous rupture of an urachal yolk sac tumor causing hemoperitoneum. He underwent resection, received platinum-based chemotherapy and presently remains well on follow-up. Despite its rarity, urachal germ cell tumors must be considered in a child with acute abdomen and tumor markers must be measured preemptively in such cases.
Source: Journal of Pediatric Hematology Oncology - February 21, 2017 Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research

Primary intrarenal yolk sac tumor
Narasimhan Ragavan, P Dholakia Kunal, S AnnapurneshwariIndian Journal of Urology 2017 33(2):167-168 Extragonadal germ cell tumors (EGGCTs) usually are not coexistent with a gonadal tumor, hence in a way, are primary and are rare. The origin of primary EGGCT is still a matter of debate. Herewith, we report a patient with primary intrarenal yolk sac tumor in a 43-year-old man. The purpose of this report is to add a rare tumor to the differential diagnosis of renal neoplasms.
Source: Indian Journal of Urology - March 30, 2017 Category: Urology & Nephrology Authors: Narasimhan Ragavan P Dholakia Kunal S Annapurneshwari Source Type: research