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Total 1161397 results found since Jan 2013.

Unusual Presentation, Relapse, and Metastasis of a Pediatric Testicular Yolk Sac Tumor: Case Report
Testicular tumors are not uncommon in children and represent 1%-2% of all pediatric malignancies. Prepubertal testicular yolk sac tumor is the most common childhood testicular cancer, accounting for 70%-80% of all cases. The clinical presentation varies from one patient to another; most common presentation is painless scrotal mass. Herein, we present a case of pediatric patient with a testicular yolk sac tumor who had unusual presentation followed by a local relapse and metastasis and continued to have high markers while he was on chemotherapy, then underwent retroperitoneal lymph node dissection and local recurrence excision.
Source: Urology - October 23, 2020 Category: Urology & Nephrology Authors: Hend Alshamsi, Osama M. Sarhan, Ashraf Almatar, Batool Al Ali, Deena Boqari, Fouad Al Kawai Tags: Pediatric Case Report Source Type: research

CT-Based Radiomics to Differentiate Pelvic Rhabdomyosarcoma From Yolk Sac Tumors in Children
ConclusionsThe CT-based radiomics model can be used to effectively distinguish RMS and YST, and combined with clinical features, which can improve diagnostic accuracy and increase the confidence of radiologists in the diagnosis of pelvic solid tumors in children.
Source: Frontiers in Oncology - November 24, 2020 Category: Cancer & Oncology Source Type: research

Primary mediastinal yolk sac tumor: a case report and literature review.
This article reports a 42-year-old man with a primary mediastinal YST. The patient presented with chest tightness and shortness of breath. Using a contrast-enhanced computer tomography (CT) scan, the mediastinal space was found to be occupied by a mass shadow, about 10 cm × 8 cm with a clear boundary and low density. Serum alpha-fetoprotein (AFP) was elevated to 7169.66 ng/ml. The 5th day after hospitalization, a percutaneous biopsy of the mediastinal mass was performed. Malignant tumor cells were found by cytologic examination. According to the pathological morphology and immunohistochemical results, the tumor was diagno...
Source: International Journal of Clinical and Experimental Pathology - December 9, 2020 Category: Pathology Authors: Zhu F, Wang L, Zhai X Tags: Int J Clin Exp Pathol Source Type: research

Post-treatment Residual Clinicopathological Outcomes in Testicular Germ Cell Tumours
AbstractSurgical resection is a generally accepted treatment for residual masses after chemotherapy for metastatic testicular germ cell tumour (GCT). About half the patients have necrosis in post-chemotherapy residual masses, whereas rest have viable tumour and teratoma. The likelihood of leaving behind teratoma with its subsequent complications such as growing teratoma syndrome necessitates resection outweighing its surgical complications. Ours is a retrospective observational study and aims at assessing post-chemotherapy residual masses in testicular GCTs and to predict importance of teratomatous and non-seminomatous com...
Source: Indian Journal of Surgical Oncology - January 29, 2022 Category: Cancer & Oncology Source Type: research

Yolk Sac Tumor of the Ovary: A Report of 150 Cases and Review of the Literature
One hundred fifty yolk sac tumors (YSTs) of the ovary in patients from 1 to 61 (mean: 21.5) years of age are described; 75% of the patients were in the second and third decades and only 1 was above 50 years of age. The clinical manifestations were typically related to a fast-growing adnexal mass; endocrine manifestations (hirsutism) were present in only 2 cases. The tumors were all unilateral and 70% were ≥15 cm; an associated dermoid cyst was present in 20 cases. The tumors were solid and cystic in 57% of the cases, 25% were multicystic, and 18% uniformly solid. The solid tissue was typically tan to pink or yellow and...
Source: The American Journal of Surgical Pathology - February 17, 2022 Category: Pathology Tags: Original Articles Source Type: research

Detailed characterization of PD-1/PD-L1 and CTLA4 expression and tumor-infiltrating lymphocytes in yolk sac tumors
CONCLUSION: Generally a high frequency of CTLA4 expression was found, PD-1/PD-L1 expression, the immune-inflamed phenotype, and TLSs were low frequency in YSTs, however, YSTs in testes showed a higher density of TILs and higher expression of immune checkpoint molecules.PMID:37453913 | DOI:10.1016/j.humimm.2023.07.003
Source: Human Immunology - July 15, 2023 Category: Allergy & Immunology Authors: Danya Zhang Hanjie Xu Can Zhao Lingzhi Qin Rui Wei Ling Xi Fei Li Source Type: research

Testicular tumours in children: a single-centre experience
CONCLUSION: Primary testicular tumours follow a bimodal age distribution pattern. Majority of patients can be cured with platinum-based chemotherapy despite having advanced disease at presentation.PMID:37721303 | DOI:10.4103/singaporemedj.SMJ-2021-380
Source: Singapore Medical Journal - September 18, 2023 Category: General Medicine Authors: Sajid Ali Tariq Latif Muhammad Ali Sheikh Shazia Perveen Muhammad Bilal Albash Sarwar Source Type: research

Yolk Sac Tumors: An Aggressive Germ Cell Malignancy in Adolescents
Ovarian yolk sac tumors, previously called endodermal sinus tumors, account for less than 1% of ovarian malignancies, but 20% of germ cell malignancies. Due to the rarity of these tumors, there are few detailed descriptions of their presentation and clinical features. We report four cases of yolk sac tumors at our institution over a short five-month period. The purpose of this report is to alert and educate general practitioners regarding these malignancies as they present in adolescents.
Source: Journal of Pediatric and Adolescent Gynecology - April 1, 2013 Category: OBGYN Authors: Candice Fraser, Amy Vallerie Tags: Poster Abstracts Source Type: research

Primary intracranial yolk sac tumor in the posterior fossa: Case report of a child with Down syndrome
We report a case of intracranial YST originating from the posterior fossa dura mater. Although DS related intracranial GCTs tend to occur in atypical sites such as the basal ganglia, origination in the posterior fossa dura is extremely rare.
Source: Clinical Neurology and Neurosurgery - August 20, 2012 Category: Neurosurgery Authors: Shogo Endo, Hiroyuki Kobayashi, Shunsuke Terasaka, Akihiro Iguchi, Yuko Cho, Junjiro Ohshima, Kanako Kubota, Kiyohiro Houkin Tags: Case reports Source Type: research

Yolk Sac Tumor of the Ovary: A Retrospective Multicenter Study of 33 Japanese Women by Tohoku Gynecologic Cancer Unit (TGCU).
Abstract Yolk sac tumor (YST) of the ovary is a rare germ cell tumor comprising about 1% of all ovarian malignancies. YST usually occurs as a rapidly growing unilateral tumor in young women. With the introduction of cisplatin, YST has been changed from a fatal tumor to a curable tumor. The standard treatment of YST consists of fertility-preserving surgery and 3 or 4 courses of adjuvant combination chemotherapy with bleomycin, etoposide, and cisplatin (BEP). However, the long-term prognosis of BEP-treated YST patients has not been well studied. We therefore conducted a retrospective multicenter study to investigate...
Source: The Tohoku Journal of Experimental Medicine - August 10, 2013 Category: Research Authors: Kojimahara T, Nakahara K, Takano T, Yaegashi N, Nishiyama H, Fujimori K, Sato N, Terada Y, Tase T, Yokoyama Y, Mizunuma H, Shoji T, Sugiyama T, Kurachi H Tags: Tohoku J Exp Med Source Type: research