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Total 1161397 results found since Jan 2013.

Post-pubertal ovarian yolk sac tumor with unusual follicular growth pattern, simulating struma ovarii
AbstractYolk sac tumors (YST), formerly known as endodermal sinus tumors, are uncommon ovarian neoplasms. They are most common in the second and third decades of life and are rare in women older than 39  years of age. YST exhibit various histologic patterns. Microfollicular pattern resembling thyroid tissue has not been reported. We introduce here a case of yolk sac tumor in a 39 y/o female, presented with pelvic masses and high level of serum Alpha-fetoprotein (Alpha Fetoprotein) (>  1000 IU/ml). The patient underwent left salpingo-oophorectomy. On microscopic study, morphologic findings demonstrated a neoplasm com...
Source: International Cancer Conference Journal - June 15, 2022 Category: Cancer & Oncology Source Type: research

Imaging Findings and Clinical Analysis of Primary Intracranial Pure Yolk Sac Tumors in Children and Adolescents: A Retrospective Study from China PEDIATRICS
CONCLUSIONS: There are some relatively specific imaging findings of primary intracranial yolk sac tumors that could assist in their diagnosis. Surgery combined with radiation therapy and/or chemotherapy can achieve a better prognosis.
Source: American Journal of Neuroradiology - July 7, 2022 Category: Radiology Authors: Dai, W., Liu, H., Chen, Y., Chen, Z. Tags: PEDIATRICS Source Type: research

Cancer Stem Cell Markers — CD133 and CD44 — in Paediatric Solid Tumours: A Study of Immunophenotypic Expression and Correlation with Clinicopathological Parameters
This study was a cross-sectional observational study conducted in the department of pathology at a tertiary care centre. All the histologically diagnosed paediatric solid tumours for a period of one year and four months were retrieved from the archives. The cases were reviewed and included in the study after obtaining informed con sent. Immunohistochemistry using the monoclonal antibodies for CD133 and CD44 was performed in the representative tissue sections of all the cases. Immuno-scores were assessed, and the results were compared using Pearson’s chi-square test. The present study included 50 cases of paediatric solid...
Source: Indian Journal of Surgical Oncology - August 28, 2022 Category: Cancer & Oncology Source Type: research

Ovarian yolk sac tumor in a  premenarchal girl
We describe the case of an ovarian yolk sac tumor in a 12-year-old premenarchal girl suffering from Hashimoto’s thyroiditis and chronic spontaneous urticaria, which presented as a rapidly growing solid cystic formation in the hypogastrium with an extreme increase in alpha fetoprotein (52,778 mg/ml). After ultrasound and MRI imaging, fertility-sparing staging surgery was performed, and the diagnosis of an ovarian yolk sac tumor with positive malignant cells in ascites was confirmed. The specificity of this case is the tumor classification into stag e IC3 according to the FIGO and stage III according to the Children...
Source: Wiener Medizinische Wochenschrift - January 13, 2023 Category: General Medicine Source Type: research

Metastatic yolk sac tumor masquerading as multifocal hepatocellular carcinoma in a young adult: A case report
We present a case of a young adolescent who presented with bleeding per rectum abdominal pain and multiple liver lesions.
Source: Clinical Case Reports - February 3, 2023 Category: General Medicine Authors: Kamran Mushtaq, Muhammad Umair Khan, Deema Al  Soub, Sheija Mary Koshy, Maher Petkar, Khalid Mohsin Al Ejji Tags: CASE REPORT Source Type: research

Testicular germ cell tumour cells release microRNA-containing extracellular vesicles that induce phenotypic and genotypic changes in cells of the tumour microenvironment
Int J Cancer. 2023 Aug 26. doi: 10.1002/ijc.34697. Online ahead of print.ABSTRACTMalignant germ-cell-tumours (GCTs) are characterised by microRNA (miRNA/miR-) dysregulation, with universal over-expression of miR-371~373 and miR-302/367 clusters regardless of patient age, tumour site, or subtype (seminoma/yolk-sac-tumour/embryonal carcinoma). These miRNAs are released into the bloodstream, presumed within extracellular-vesicles (EVs) and represent promising biomarkers. Here, we comprehensively examined the role of EVs, and their miRNA cargo, on (fibroblast/endothelial/macrophage) cells representative of the testicular GCT (...
Source: Cancer Control - August 26, 2023 Category: Cancer & Oncology Authors: Luz Alonso-Crisostomo Jennifer Trendell Marta Ferraresso Shivani Bailey Dawn Ward Zachary G L Scurlock Stephanie C Wenlock Carlos A P Bastos Ravin Jugdaohsingh Nuno J Faria Anton J Enright Cinzia G Scarpini Nicholas Coleman Matthew J Murray Source Type: research

Sacrococcygeal yolk sac tumor developing after teratoma: A clinicopathological study of pediatric sacrococcygeal germ cell tumors and a proposal of the pathogenesis of sacrococcygeal yolk sac tumors
Conclusions: The characteristics of SGCT in Japanese children were similar with those reported in Europe or the United States. YST developed after SCT resection not only in patients with previously reported risk factors. We recommend that patients undergo serum AFP monitoring every 3months for≥3years after SCT resection.
Source: Journal of Pediatric Surgery - April 1, 2013 Category: Surgery Authors: Mariko Yoshida, Kentaro Matsuoka, Atsuko Nakazawa, Makiko Yoshida, Takeshi Inoue, Hiroshi Kishimoto, Masahiro Nakayama, Emi Takaba, Minoru Hamazaki, Shigeaki Yokoyama, Hiroshi Horie, Mio Tanaka, Kiyoshi Gomi, Youkatsu Ohama, Hisato Kigasawa, Yoshihiro Kit Tags: Original Articles Source Type: research

A diagnostic immunohistochemical panel for yolk sac (primitive endodermal) tumours based on an immunohistochemical comparison with the human yolk sac
ConclusionsCPs reproduce the immunophenotype of HYS and early endoderm with variable expression of both AFP and markers of early gut or hepatic differentiation. SGPs with intestinal differentiation often have incomplete immunophenotypes. A differential diagnosis panel including both markers of pluripotentiality (SALL4 and LIN28) and endoderm (AFP, GPC3 and villin) is proposed. It identifies overlapping multidifferentiation of primitive and somatic immunophenotypes, supporting the recently proposed term of primitive endodermal tumours.This article is protected by copyright. All rights reserved.
Source: Histopathology - January 20, 2014 Category: Pathology Authors: Francisco F. Nogales, Enoe Quiñonez, Laura López‐Marín, Isabel Dulcey, Ovidiu Preda Tags: Original Article Source Type: research

Role of neoadjuvant chemotherapy in the management of advanced ovarian yolk sac tumor.
CONCLUSIONS: NACT is the better treatment option for some patients with advanced stage OYST, especially for those with unresectable tumors and poor general condition. PMID: 24582864 [PubMed - as supplied by publisher]
Source: Gynecologic Oncology - February 28, 2014 Category: Cancer & Oncology Authors: Lu Y, Yang J, Cao D, Huang H, Wu M, You Y, Chen J, Lang J, Shen K Tags: Gynecol Oncol Source Type: research

“Somatic-type” Malignancies Arising From Testicular Germ Cell Tumors: A Clinicopathologic Study of 124 Cases With Emphasis on Glandular Tumors Supporting Frequent Yolk Sac Tumor Origin
Somatic-type malignancies (SMs) in patients with testicular germ cell tumors (GCT) are rare and mostly attributed to “transformation” of teratoma, although yolk sac tumor (YST) origin has also been proposed. We studied 124 cases of “SM” of testicular GCT origin from 106 patients to evaluate their morphology, immunohistochemical features (especially the utility of SALL4), and relationship to YST. Primitive neuroectodermal and nephroblastomatous tumors were excluded because of prior studies. Patients ranged in age from 15 to 68 years (mean, 33 y). The tumors ranged from 0.7 to 30 cm (mean, 7.6 cm) and involved the re...
Source: The American Journal of Surgical Pathology - October 1, 2014 Category: Pathology Tags: Original Articles Source Type: research

Comparative analysis of Napsin A, alpha-methylacyl-coenzyme A racemase (AMACR, P504S), and hepatocyte nuclear factor 1 beta as diagnostic markers of ovarian clear cell carcinoma: an immunohistochemical study of 279 ovarian tumours
SummaryNapsin A and α-methylacyl-coenzyme A racemase (AMACR, P504S) have recently been described as being frequently expressed in clear cell carcinomas (CCC) of the gynecological tract. The present study was conducted to assess the test performance of these newer markers relative to the more traditional marker, hepatocyte nuclear factor 1β (HNF1β), in a large and histotypically diverse dataset. A total of 279 ovarian tumours in tissue microarrays were immunohistochemically assessed for the expression of Napsin A, AMACR and HNF1β. HNF1β, Napsin A and AMACR were expressed in 92%, 82% and 63% of 65 CCC, 7%, 1% and 1% of ...
Source: Pathology - January 8, 2015 Category: Pathology Tags: Anatomical Pathology Source Type: research

Many Postchemotherapy Sarcomatous Tumors in Patients With Testicular Germ Cell Tumors Are Sarcomatoid Yolk Sac Tumors: A Study of 33 Cases
Sarcomatoid neoplasms in patients with testicular germ cell tumors (TGCTs) may show diverse lineages and are usually attributed to “transformation” of teratoma, although origin from yolk sac tumor (YST) has also been suggested. We evaluated 33 sarcomatoid tumors from 23 TGCT patients that lacked specific features of a defined sarcoma subtype for a number of features, including: atypia (mild, moderate, severe), cellularity, tumor necrosis, mitotic index, stromal vascularity, cell profile (spindle or epithelioid), and stromal quality (myxoid and/or fibrous). Immunohistochemical staining analyses directed against cytokera...
Source: The American Journal of Surgical Pathology - January 13, 2015 Category: Pathology Tags: Original Articles Source Type: research

Mediastinal Yolk Sac Tumor Producing Protein Induced by Vitamin K Absence or Antagonist-II.
Authors: Akutsu N, Adachi Y, Isosaka M, Mita H, Takagi H, Sasaki S, Yamamoto H, Arimura Y, Ishii Y, Masumori N, Endo T, Shinomura Y Abstract Extragonadal yolk sac tumors (YSTs) are rare. We herein report the case of a 66-year-old man with mediastinal, lung and liver tumors. The largest mass was located in the liver and contained a high concentration of protein induced by vitamin K absence or antagonist-II (PIVKA-II) and alpha-fetoprotein. Therefore, the lesion was difficult to distinguish from hepatocellular carcinoma. Finally, YST was diagnosed based on the results of a liver biopsy. Although chemotherapy was effe...
Source: Internal Medicine - June 16, 2015 Category: Internal Medicine Tags: Intern Med Source Type: research

Endometrioid like yolk sac tumor of the testis with small teratomatous foci: A case report and review of the literature.
Abstract I have reported a case of endometrioid like yolk sac tumor of the testis in a 20-year-old boy. Endometrioid like yolk sac tumor is a rare tumor. A few cases have been reported in ovary. In case of male, a case of pure glandular endometrioid like yolk sac tumor is reported in a 43 years male in right undescended testis and another case of abdominal metastasis showing endometrioid pattern from mixed testicular germ cell tumor comprising of teratoma and embryonal carcinoma. My patient was a 20-year-old male presented with painless enlargement of right testis. Grossly the tumor was glistening creamish white w...
Source: Indian Journal of Pathology and Microbiology - October 1, 2015 Category: Pathology Authors: Hazarika P Tags: Indian J Pathol Microbiol Source Type: research

Endoscopic surgery combining chemotherapy for vaginal yolk-sac tumor: a case report.
CONCLUSION: The use hysteroscopy equipment to exam vagina can diagnose early vaginal yolk-sac tumor and cytoreductive surgery which can preserve fertility can then be performed. Cytoreductive surgery may also be able to reduce the cycles of the chemotherapy to reduce the side effects and the risks of chemotherapy. PMID: 26189265 [PubMed - indexed for MEDLINE]
Source: European Journal of Gynaecological Oncology - November 28, 2015 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research