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Total 1161397 results found since Jan 2013.

The Yolk Sac Tumor: Reflections on a Remarkable Neoplasm and Two of the Many Intrigued By It--Gunnar Teilum and Aleksander Talerman--and the Bond It Formed Between Them
One of the most remarkable of human neoplasms, the yolk sac tumor, is reviewed, emphasizing its histologic diversity and differential diagnosis, occurrence at many sites, and the shared passion for this unique neoplasm of Dr Gunnar Teilum (who deserves almost all credit for delineation of the nature of the tumor and its features) and Dr Aleksander Talerman (who made his own contribution to our knowledge of it) and the friendship it helped forge between these 2 distinguished pathologists. In a unique series of articles, beginning in the early 1940s, Teilum delineated the distinctive features of the neoplasm and recognized t...
Source: International Journal of Surgical Pathology - December 3, 2014 Category: Pathology Authors: Young, R. H. Tags: Original Articles Source Type: research

Testicular yolk sac tumors in children: a review of 61 patients over 19 years
Conclusion: Testicular yolk sac tumor presents as a painless scrotal mass, increased serum AFP levels, and a solid mass on ultrasound. Chest radiography and abdominal ultrasound should be used to accurately stage the tumor. We advocate for inguinal orchiectomy for Stage I disease and postoperative chemotherapy to prevent recurrence in the ipsilateral or contralateral testis.
Source: World Journal of Surgical Oncology - December 29, 2014 Category: Cancer & Oncology Authors: Yi WeiShengde WuTao LinDawei HeXuliang LiJunhong LiuXing LiuYi HuaPeng LuGuanghui Wei Source Type: research

Ovarian Yolk Sac Tumor With High-Grade Serous Carcinoma in a 62-Year-Old Woman
We present a case of mixed ovarian yolk sac tumor and high-grade serous carcinoma in a postmenopausal woman, including a brief discussion of the immunohistochemical findings and differential diagnosis. Despite the rarity of mixed ovarian yolk sac tumor and surface epithelial tumors, it is important to recognize the biphasic nature of the tumor, which should prompt a thorough immunohistochemical evaluation. The therapeutic and prognostic implications of proper diagnosis cannot be overemphasized.
Source: International Journal of Surgical Pathology - May 9, 2016 Category: Pathology Authors: McCarthy, W. A., Masand, R. P. Tags: Case Reports Source Type: research

Yolk sac tumor in the abdominal wall of an 18-month-old girl: a case report
ConclusionsClinicians should be aware that a yolk sac tumor can present in an unusual extragonadal place, for example in this case it was subcutaneous. In some cases, conservative treatment can be carried out with careful monitoring of the patient and their alpha-fetoprotein.
Source: Journal of Medical Case Reports - February 19, 2017 Category: Journals (General) Source Type: research

Primary mediastinal yolk sac tumor treated with platinum ‐based chemotherapy and extended resection: Report of seven cases
ConclusionPrimary mediastinal yolk sac tumor is rare, and the prognosis is poor. A multimodality aggressive approach including adjuvant chemotherapy followed by surgical resection is the optimal treatment and may lead to long‐term survival.
Source: Thoracic Cancer - January 10, 2018 Category: Cancer & Oncology Authors: Bing Liu, Gang Lin, Jingwei Liu, Haibo Liu, Xueqian Shang, Jian Li Tags: BRIEF REPORT Source Type: research

PGC-1 α activator-induced fatty acid oxidation in tumor-infiltrating CTLs enhances effects of PD-1 blockade therapy in lung cancer.
CONCLUSIONS: Bezafibrate synergized the tumoricidal effect of PD-1 blockade in hyporesponsive lung cancer by expansion of effector CTLs within tumor microenvironment. The potential mechanism may relate to the capacity of bezafibrate in regulating FAO of tumor-infiltrating CTLs. PMID: 31451071 [PubMed - as supplied by publisher]
Source: Tumori - August 28, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

SMARCB1 (INI-1)-Deficient Adenocarcinoma of the Sinonasal Tract: A Potentially Under-Recognized form of Sinonasal Adenocarcinoma with Occasional Yolk Sac Tumor-Like Features
We present a dedicated series of 12 SMARCB1-deficient SNACs. All tumors had an oncocytoid/plasmacytoid cytomorphology with variable degrees of glandular differentiation consisting of tubules and cribriform structures with foci of intracellular or intraluminal mucin. Three of 12 tumors exhibited foci of yolk sac tumor-like histologic features. The tumors were uniformly high-grade, with nuclear pleomorphism, elevated mitotic rates and frequent necrosis. By immunohistochemistry, all tumors were entirely SMARCB1-deficient, and 10 of 12 were CK7-positive. Occasional expression of CDX2 (4 of 12), CK20 (3 of 12), and p40 (3 of 10...
Source: Head and Neck Pathology - May 18, 2020 Category: Pathology Source Type: research

Genes, Vol. 12, Pages 168: Expression of BARD1 β Isoform in Selected Pediatric Tumors
This study determines the expression level of BARD1 and its isoform beta (&beta;) in three different histogenetic groups of pediatric cancer &ndash; neuroblastic tumours, and for the first time in chosen germ cell tumours (GCT), and rhabdomyosarcoma (RMS), using the qPCR method. We found higher expression of beta isoform in tumour compared to healthy tissue with no such changes concerning BARD1 full-length. Additionally, differences in expression of BARD1 &beta; between histological types of neuroblastic tumours were observed, with higher levels in ganglioneuroblastoma and ganglioneuroma. Furthermor...
Source: Genes - January 26, 2021 Category: Genetics & Stem Cells Authors: Anna Jasiak Natalia Krawczy ńska Mariola Iliszko Katarzyna Czarnota Kamil Buczkowski Joanna Stefanowicz El żbieta Adamkiewicz-Drożyńska Grzegorz Cichosz Ewa I życka-Świeszewska Tags: Article Source Type: research

Vasculogenic Mesenchymal Tumor: A Clinicopathologic and Molecular Study of 55 Cases of a Distinctive Neoplasm Originating From Mediastinal Yolk Sac Tumor and an Occasional Precursor to Angiosarcoma
We report 55 postchemotherapy resections of primary nonseminomatous mediastinal germ cell tumors with prominent vasculogenic features showing the formation of rudimentary to well-developed neoplastic vessels within primitive mesenchyme. These cases represented 25% of a cohort of 221 such specimens. The patients were 19 to 49 years old (mean, 28 y) and 98% had serological evidence of yolk sac tumor. The vasculogenic lesions, felt to represent a neoplastic reiteration of embryonic vasculogenesis in the splanchnic mesoderm of the yolk sac, were further subdivided into teratoma with vasculogenic stroma (n=9), vasculogenic me...
Source: The American Journal of Surgical Pathology - March 19, 2021 Category: Pathology Tags: Original Articles Source Type: research

Renal Yolk Sac Tumor Clinically Misdiagnosed as Nephroblastoma: A Case Report
Conclusion: Imaging examination of renal yolk sac tumor can easily be misdiagnosed as Wilms tumor. SIOP treatment plan for Wilms tumor requires preoperative chemotherapy, which is different from the treatment regimen for yolk sac tumor. Preoperative alpha-fetoprotein could have been helpful in avoiding this clinical misdiagnosis.PMID:36645844 | DOI:10.1080/15513815.2023.2166800
Source: Fetal and Pediatric Pathology - January 16, 2023 Category: Pathology Authors: Meng Zhu Chengmao Xia Jie Yang Zhe Liu Xiaowen Zhao Yaling Li Bin Liu Yanli Yang Yali She Source Type: research

SALL4 and SF-1 Are Sensitive and Specific Markers for Distinguishing Granulosa Cell Tumors From Yolk Sac Tumors
In this study, the authors performed immunohistochemical stains for SALL4 and steroidogenic factor-1 (SF-1) on 27 cases of yolk sac tumors and 24 granulosa cell tumors. Nuclear stains for both antibodies were considered as positive and the intensity of staining was graded as negative, weak, moderate, and strong. All the yolk sac tumors were positive for SALL4 (100%) with moderate to strong grade staining and negative for SF-1 (100%). In contrast, all the granulosa cell tumors were positive for SF-1 (85% moderate to strong grade staining and 15% weak staining) and negative for SALL4 (100%). The difference was significant (P...
Source: International Journal of Surgical Pathology - March 20, 2013 Category: Pathology Authors: Bai, S., Wei, S., Ziober, A., Yao, Y., Bing, Z. Tags: Original Articles Source Type: research

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