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Primary yolk sac tumour of the liver: A diagnostic pitfall
A yolk sac tumour (YST) is a malignant germ cell tumour, which typically occurs in the gonads. The common sites of extragonadal YST are midline structures, including the mediastinum, retroperitoneum  and sacral region. Primary YST of the liver is extremely rare, and only four man adult cases have been reported to date [1–4]. The description of clinicopathological features and outcomes of this tumour is rare. It is challenging for pathologists to render a diagnosis of the YST on biopsy materi al [5].
Source: European Journal of Cancer - December 9, 2021 Category: Cancer & Oncology Authors: Junwei Zhang, Jie Shi, Xin Lu Tags: Letter to the Editor Source Type: research

GATA3 expression is present in primitive patterns of Yolk Sac Tumors but is not expressed by differentiated variants
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Source: Histopathology - July 14, 2015 Category: Pathology Authors: Maolly Schuldt, Alejandro Rubio, Ovidiu Preda, Francisco F Nogales Tags: Correspondence Source Type: research

Yolk Sac Tumour Arising in the Glans Penis an Achondroplasic Child: A Case Report with Summary of Prior Published Cases
CONCLUSION: Yolk sac tumor can occur in the penis during the prepubertal period. Penile yolk sac tumor associated with achondroplasia has not been previously reported, but this could be incidental.PMID:37534583 | DOI:10.1080/15513815.2023.2242941
Source: Fetal and Pediatric Pathology - August 3, 2023 Category: Pathology Authors: Sanjana Karan Raktim Mukherjee Pritam Singha Roy Md Mohin Wasim Firdous Uttara Chatterjee Source Type: research

Post-menopausal presentation of yolk sac germ cell tumour
We present an unusual case of a pure yolk sac germ cell tumour in a post-menopausal patient, which was initially diagnosed as colonic in aetiology, highlighting the need for clinicians to broaden their differential diagnoses in older patients presenting with a pelvic-abdominal mass.
Source: Gynecologic Oncology Reports - November 15, 2014 Category: OBGYN Source Type: research

Cases of Yolk sac tumor associated with gynecological malignant tumor
Yolk sac tumour (YST) is the second most common ovarian germ cell tumour and usually presents in children and young women. However, tumours rarely occur as malignant gynaecological tumours with YST components.
Source: BMC Women's Health - June 30, 2023 Category: OBGYN Authors: Shengchao Wang, Kelie Chen, Qin Chen, Shuai Huang and Weiguo Lu Tags: Case Report Source Type: research

Adult metastatic yolk sac tumor descending from an intra-abdominal testis: A case report and review of the literature.
Authors: Wang Z, Yan B, Wei YB, Yin Z, Zhou KQ, Yang JR Abstract Pure yolk sac tumors are extremely rare in adults; to the best of our knowledge, <20 cases have been reported. Multiple metastases originating from a pure yolk sac testicular tumor, descending from an intra-abdominal testis, are additionally extremely rare. In the present case, a man exhibiting a 30-year history of cryptorchidism and indirect inguinal hernia, was admitted to the Department of Urology (The Second Xiangya Hospital, Changsha, China) due to a mass that had descended from the abdominal cavity 7 months previously. Elevated levels of spec...
Source: Oncology Letters - January 21, 2016 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Buccal mucosa vaginoplasty through an anterior sagittal transrectal approach (astra) for management of yolk sac tumor in a 3-year old girl
Vaginal yolk sac tumours (vYST) are rare pediatric malignant tumours and the most common form of vaginal germ-cell tumours in children. They are almost exclusively found in females under 3 years of age. Treatment involves local excision either with or without chemotherapy. Herein, we describe a case of a 3 year old girl with vaginal Yolk sac tumor, who underwent buccal mucosa vaginoplasty through an anterior sagittal transrectal approach (ASTRA), as an effective oncological procedure, with preservation of reproductive function.
Source: Urology - December 22, 2022 Category: Urology & Nephrology Authors: Ziyad Alzahrani, Yaqoub Jafar, Catherine Anne Lovatt, Melissa McGrath, Leslie B, Luis H. Braga Tags: Pediatric Case Reports Source Type: research

Laparoscopic trachelectomy for cervix yolk sac tumor in 11 months old female: the youngest case
We describe the case of an 11-month-old girl who was referred to our centre for vaginal bleeding with evidence of a uterine mass on ultrasonography. Preoperative investigations confirmed YST of the uterine cervix without metastasis. After four cycles of systemic chemotherapy, the patient was treated with laparoscopic trachelectomy (fertility-sparing surgery) without perioperative complications.
Source: Journal of Pediatric and Adolescent Gynecology - June 19, 2021 Category: OBGYN Authors: Giovanni Torino, Agnese Roberti, Francesco Turr à, Vittoria Donofrio, Delfina Bifano, Massimo Abate, Giovanni Di Iorio Source Type: research

Pediatric Primary Yolk Sac Tumour of the Kidney: Recommendations for Pretreatment Diagnosis
Conclusion: Renal YST may be indistinguishable from Wilms tumor clinically and radiologically. For pre-biopsy chemotherapy management protocols, serum tumor markers such as AFP may be recommended to identify the occasional GCT, including YST. Pre-chemotherapy needle biopsies may lead to misdiagnosis, and may require confirmation by an experienced pathologist or central review.PMID:35188860 | DOI:10.1080/15513815.2022.2042631
Source: Fetal and Pediatric Pathology - February 21, 2022 Category: Pathology Authors: Shilpi Thakur Aanchal Kakkar Manisha Jana Prasenjit Das Sandeep P Agarwala Venkateswaran K Iyer Source Type: research

Advanced stage yolk sac ovarian tumour: clinical approach with cytoreductive surgery upfront.
Authors: Pimentel I, González Martin A, Bratos R, Marquez R, Toledo G, Chiva L Abstract The authors report the case of a 21-year-old woman that presented a Pseudo Meigs' syndrome, secondary to a pure endodermal sinus tumour (yolk sac tumour). Fine needle aspiration biopsy was compatible with high-grade carcinoma and the alpha fetoprotein (αFP) was at 13,185 U/ml. Cytoreductive surgery was performed, followed by bleomycin, etoposide, and cisplatin (BEP) chemotherapy. PMID: 29953803 [PubMed - in process]
Source: European Journal of Gynaecological Oncology - July 1, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research