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Ovarian yolk sac tumor coexisting with epithelial ovarian cancer: An aggressive rare entity
Publication date: Available online 20 September 2017 Source:Gynecologic Oncology Reports Author(s): Patrícia Taranto, Filomena M. Carvalho, Sergio Roithmann, Fernando C. Maluf Yolk sac tumor (YST) is the second most common subtype of ovarian germ cell tumors. It usually occurs in the second and third decades of life and is rare in postmenopausal women. In postmenopausal women, YST is commonly an aggressive tumor and can present as a pure germ cell component or as a mixed component with other germ cell or epithelial components. The recognition of this histological subtype is important not only for differential diagnosis b...
Source: Gynecologic Oncology Reports - September 21, 2017 Category: OBGYN Source Type: research
Rare Tumor Clinic: The University of California San Diego Moores Cancer Center Experience with a Precision Therapy Approach.
CONCLUSION: Identifying genomic and protein markers in patients with rare/ultrarare tumors was feasible. When therapies were matched, >50% of patients attained SD ≥6 months, PR, or CR. Further precision medicine clinical investigations focusing on rare and ultrarare tumors are urgently needed.
IMPLICATIONS FOR PRACTICE: Although rare tumors are infrequent by definition, when all subtypes of rare cancers are combined, they account for approximately 25% of adult malignancies. However, patients with rare tumors may lack approved treatments and clinical trial access. We recently initiated a Rare Tumor Clinic that foc...
Source: The Oncologist - October 16, 2017 Category: Cancer & Oncology Authors: Kato S, Kurasaki K, Ikeda S, Kurzrock R Tags: Oncologist Source Type: research
Endolymphatic sac tumour in von Hippel-Lindau disease: management strategies.
Authors: Zanoletti E, Girasoli L, Borsetto D, Opocher G, Mazzoni A, Martini A
Abstract
Endolymphatic sac tumour (ELST) is infrequent, as emerges from small series reported in the literature. It is a slow-growing malignancy with local aggressiveness and a low risk of distant metastases. It is often misdiagnosed because of the late onset of symptoms and difficulty in obtaining a biopsy. Its frequency is higher in von Hippel-Lindau (VHL) disease (a genetic systemic syndrome involving multiple tumours), with a prevalence of around 25%. The diagnosis is based on radiology, with specific patterns on contrast-enhanced MRI...
Source: Acta Otorhinolaryngologica Italica - November 24, 2017 Category: ENT & OMF Tags: Acta Otorhinolaryngol Ital Source Type: research
Bilateral lung metastases unveils an asymptomatic sacrococcygeal yolk sac tumor.
We describe one such neoplasm in an 18-month-old male child who turned symptomatic with multiple bilateral lung metastases. The tumor produced the least deformity to his physique, to become detectable on routine inspection and clinical examination. Finally, a combined approach through clinical, radiological, pathological, and biochemical perspectives established the diagnosis.
PMID: 29323075 [PubMed - in process]
Source: Indian Journal of Pathology and Microbiology - October 1, 2017 Category: Pathology Authors: Mondal K, Mandal R Tags: Indian J Pathol Microbiol Source Type: research
Effect of dietary manipulation and vaccination of turkey breeder hens on immunoglobulin levels of yolk, yolk sac and neonate poults
Summary
Two hundred turkey breeder hens and 24 viable toms of 30–35 weeks age of small white variety were distributed into two treatment groups having four replicates of 25 hens and three toms in each treatment. First four replicates were offered a turkey breeder diet (Diet A) (Nutrient requirements of poultry, 1994, National Academic Press, Washington, DC) and the rest four replicates were maintained on a higher plane of nutrition (Diet B) for 8‐week duration. After 6 weeks of experimental feeding, two replicates from each treatment groups were vaccinated with ND (R2B) vaccine. Yolk sac of embryo from birds fed Diet...
Source: Journal of Animal Physiology and Animal Nutrition - January 20, 2018 Category: Zoology Authors: A. Bhattacharyya, S. Majumdar, S. K. Bhanja, A. B. Mandal, B. B. Dash Tags: ORIGINAL ARTICLE Source Type: research
Environmental calcium and variation in yolk sac size influence swimming performance in larval lake sturgeon (Acipenser fulvescens) RESEARCH ARTICLE
David Deslauriers, Jon C. Svendsen, Janet Genz, Alex J. Wall, Henrik Baktoft, Eva C. Enders, and W. Gary Anderson In many animal species, performance in the early life stages strongly affects recruitment to the adult population; however, factors that influence early life history stages are often the least understood. This is particularly relevant for lake sturgeon, Acipenser fulvescens, living in areas where environmental calcium concentrations are declining, partly due to anthropogenic activity. As calcium is important for muscle contraction and fatigue resistance, declining calcium levels could constrain swimming perform...
Source: Journal of Experimental Biology - February 13, 2018 Category: Biology Authors: Deslauriers, D., Svendsen, J. C., Genz, J., Wall, A. J., Baktoft, H., Enders, E. C., Anderson, W. G. Tags: RESEARCH ARTICLE Source Type: research
Rare Tumor Clinic: The University of California San Diego Moores Cancer Center Experience with a Precision Therapy Approach
Conclusion.Identifying genomic and protein markers in patients with rare/ultrarare tumors was feasible. When therapies were matched,>50% of patients attained SD ≥6 months, PR, or CR. Further precision medicine clinical investigations focusing on rare and ultrarare tumors are urgently needed.Implications for Practice.Although rare tumors are infrequent by definition, when all subtypes of rare cancers are combined, they account for approximately 25% of adult malignancies. However, patients with rare tumors may lack approved treatments and clinical trial access. This paper describes an institutional a Rare Tumor Clinic focu...
Source: The Oncologist - February 15, 2018 Category: Cancer & Oncology Authors: Shumei Kato, Kellie Kurasaki, Sadakatsu Ikeda, Razelle Kurzrock Tags: Precision Medicine, Cancer Diagnostics and Molecular Pathology Source Type: research
Environmental calcium and variation in yolk sac size influence swimming performance in larval lake sturgeon (Acipenser fulvescens) RESEARCH ARTICLE
David Deslauriers, Jon C. Svendsen, Janet Genz, Alex J. Wall, Henrik Baktoft, Eva C. Enders, and W. Gary Anderson
In many animal species, performance in the early life stages strongly affects recruitment to the adult population; however, factors that influence early life history stages are often the least understood. This is particularly relevant for lake sturgeon, Acipenser fulvescens, living in areas where environmental calcium concentrations are declining, partly due to anthropogenic activity. As calcium is important for muscle contraction and fatigue resistance, declining calcium levels could constrain swimming perfor...
Source: Journal of Experimental Biology - March 29, 2018 Category: Biology Authors: Deslauriers, D., Svendsen, J. C., Genz, J., Wall, A. J., Baktoft, H., Enders, E. C., Anderson, W. G. Tags: Comparative biomechanics of movement RESEARCH ARTICLE Source Type: research
Ovarian endometrioid carcinoma with yolk sac tumor component in a postmenopausal woman.
Authors: Kabukcuoglu S, Arik D
Abstract
Yolk sac tumor (YST) coexisting with a variety of histologic patterns have been described, but with an epithelial malignant component is extremely rare. It has been suggested that this rare tumor represents an adenocarcinoma with aberrant differentiation because it occurs in the same age range as epithelial ovarian carcinoma and shows an aggressive behavior and poor prognosis. Although chemotherapy is effective for pure YST, YST with endometrioid adenocarcinoma does not respond to chemotherapy. Here the authors report a postmenopousal women with ovarian endometrioid adenocarc...
Source: European Journal of Gynaecological Oncology - June 29, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research
Yolk sac tumor of stomach: Case report and review of literature
We report a 3-year-old boy who presented to us with recurrent episodes of melena and anemia of 2 months' duration. Upper gastrointestinal endoscopy revealed a deeply excavated ulcer on the lesser curvature, 4 cm from the gastroesophageal junction. Computed tomography (CT) abdomen revealed large heterogeneously enhancing soft-tissue mass lesion in the lesser sac with indistinct fat planes with the lesser curvature of the stomach with multiple peripherally enhancing lesions in both lobes of liver and omentum, suggestive of metastasis. Serum alpha-fetoprotein (AFP) was 21,000 ng/ml. Tru-cut biopsy from the mass was...
Source: Journal of Indian Association of Pediatric Surgeons - October 4, 2018 Category: Surgery Authors: Ankur Mandelia Nijagal Mutt Richa Lal Raghunandan Prasad Source Type: research
Is fertility sparing surgery a treatment option for young patients with yolk sac tumor?
We present a narrative review of the multispecialty fertility sparing surgical and medical approach of women with YST.
PMID: 30465413 [PubMed - in process]
Source: Minerva Ginecologica - November 23, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Virilization in a Girl Caused by an Ovarian Yolk Sac Tumor: A Case Report
We report a case of a 13-year-old girl with a YST manifesting as virilization.
Source: Journal of Pediatric and Adolescent Gynecology - January 7, 2019 Category: OBGYN Authors: Min Yang, Ying Xin Source Type: research
The Significance of Yolk Sac Number in Monoamniotic Twins
Conclusions: Two yolk sacs are present in up to a third of all MCMA twin pregnancies, dispelling the original concept that a single yolk sac is diagnostic of MCMA pregnancies. Yolk sac number should not be used to determine amnionicity. The presence of two yolk sacs on first trimester ultrasound is associated with an increased rate of male fetuses. The number of yolk sacs has no other significant impact on perinatal outcomes.Fetal Diagn Ther
Source: Fetal Diagnosis and Therapy - February 14, 2019 Category: Perinatology & Neonatology Source Type: research
Extragonadal yolk sac tumor following congenital buccal mature cystic teratoma
Nur Rahadiani, Ening Krisnuhoni, Marini Stephanie, Diah Rini HandjariJournal of Oral and Maxillofacial Pathology 2019 23(4):49-53
Yolk sac tumor (YST) and teratoma both categorized as germ cell tumor (GCT). YST shows preferential differentiation toward yolk sac structures, while teratoma consists of tissues that originate from at least two embryonic germinal layers. Extragonadal location of YST is rare, whereas extragonadal teratoma is majority presented in nasopharynx area. Mature teratoma tends to be benign although some malignant transformation can occur. Recurrence of teratoma was reported mostly in the case of immatu...
Source: Journal of Oral and Maxillofacial Pathology - February 22, 2019 Category: ENT & OMF Authors: Nur Rahadiani Ening Krisnuhoni Marini Stephanie Diah Rini Handjari Source Type: research
Virilization in a Girl Caused by an Ovarian Yolk Sac Tumor: A Case Report
We report a case of a 13-year-old girl with a YST manifesting as virilization.
Source: Journal of Pediatric and Adolescent Gynecology - January 6, 2019 Category: OBGYN Authors: Min Yang, Ying Xin Tags: Case Report Source Type: research
