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Total 1161397 results found since Jan 2013.

Pediatric germ cell tumours.
Abstract Germ cell tumours include a group of highly heterogeneous tumours regarding to their clinical and histological appearance. Altogether, they represent 3% of cancers diagnosed in children and adolescent younger than 15 years. A bimodal age distribution is observed with a small peak during infancy and a larger peak after puberty. Non-seminomateous germ cell tumours are largely predominant as compared to seminomateous tumours, rarely seen before puberty. During infancy, sacrococcygeal locations predominate with either teratomas in neonates or yolk sac tumours in infants above three months. In adolescents, mix...
Source: Bulletin du Cancer - April 1, 2013 Category: Cancer & Oncology Authors: Faure-Conter C, Rocourt N, Sudour-Bonnange H, Vérité C, Martelli H, Patte C, Frappaz D, Orbach D Tags: Bull Cancer Source Type: research

Detection of a metastatic lesion and tiny yolk sac tumors in two teenage patients by FDG-PET: report of two cases
Abstract We herein report the efficacy of FDG-PET for detecting yolk sac tumors in two teenage patients. One patient had a rare bone metastasis and the other had tiny recurrent lesions at the mediastinum. Both lesions were difficult to detect by conventional diagnostic modalities. In contrast, FDG-PET was very effective for detecting these lesions. Furthermore, the SUVmax of the lesion reflected the tumor activity, which was also suggested by the fluctuating values of serum alpha-fetoprotein (AFP), an established marker of yolk sac tumors. FDG-PET may be a useful procedure to detect tiny and metastatic, pediatric yolk sac tumors.
Source: Surgery Today - September 25, 2014 Category: Surgery Source Type: research

Abstract 77: bcl-xL protein overexpression enhances tumor progression of human melanoma cells in zebrafish xenograft model: Involvement of CXCL8 chemokine
The anti-apoptotic protein bcl-xL, whose expression is associated with melanoma progression, enhances metastatic potential in different tumor hystotypes and promotes tumor angiogenesis through enhancing pro-inflammatory chemokine interleukin 8 (CXCL8) expression. Using the derivative clones of human melanoma M14 cell line stably overexpressing bcl-xL protein, we evaluated the impact of bcl-xL/CXCL8 axis in promoting melanoma angiogenesis and aggressiveness in vivo using zebrafish as experimental model. Implantation of M14 trasfectants overexpressing bcl-xL protein into the yolk sac of 2 days post-fertilization (dpf) zebraf...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Gabellini, C., Gomez, E., Oliveira, S. d., Bufalo, D. D., Mulero, V. Tags: Tumor Biology Source Type: research

Radiological-pathological correlation of yolk sac tumor in 20 patients.
CONCLUSION: YST usually appears as a large solid-cystic mass with intratumoral hemorrhage, capsular tear, marked heterogeneous enhancement, and enlarged intratumoral vessels on CT images. Intratumoral calcification and fatty tissue, although rare, may indicate a mixed YST containing teratoma component. PMID: 25492969 [PubMed - as supplied by publisher]
Source: Acta Radiologica - December 9, 2014 Category: Radiology Authors: Li Y, Zheng Y, Lin J, Xu G, Cai A, Chen R, Wu M Tags: Acta Radiol Source Type: research

Advanced testicular cancer associated with life-threatening tumour lysis syndrome and choriocarcinoma syndrome.
Abstract Tumour lysis syndrome (TLS) and choriocarcinoma syndrome (CS) are severe complications of chemotherapy for testicular cancer. They are rare, but can be life-threatening. A 37-year-old man complaining of persisting cough was referred to our hospital. A computed tomography (CT) scan revealed huge tumours that occupied the peritoneal cavity, with multiple lung, liver, and para-aortic metastases. Although there was no abnormal finding in the testes, serum testicular tumor markers showed marked elevation. A CT-guided biopsy for the peritoneal tumours revealed extragonadal germ cell tumour (GCT), including yolk...
Source: Canadian Urological Association Journal - January 1, 2015 Category: Urology & Nephrology Authors: Kobatake K, Kato M, Mita K Tags: Can Urol Assoc J Source Type: research

Yolk Sac Tumor of the Testis in Infants and Children: A Clinicopathologic Analysis of 33 Cases
We report 33 pure yolk sac tumors of the testis from boys 5 to 71 months of age (mean 20.7 mo) diagnosed from 1918 to 2014. All except 1 underwent orchiectomy, with lymph node dissections (all negative) performed in 18; 21 also received chemotherapy and 12 radiotherapy. The tumors were 1.6 to 7.0 cm (mean 3.7 cm) and were nonencapsulated, with a gray to yellow, often mucoid, cut surface. The commonest pattern was reticular-microcystic, but macrocystic, papillary, endodermal sinus (Schiller-Duval bodies), labyrinthine, myxomatous, glandular, and solid patterns were also observed. Follow-up was available for 32 patients (mea...
Source: The American Journal of Surgical Pathology - July 15, 2015 Category: Pathology Tags: Original Articles Source Type: research

Successful treatment of mixed yolk sac tumor and mature teratoma in the spinal cord: case report.
Abstract Primary spinal germ cell tumors are rare, and spinal nongerminomatous germ cell tumors represent an even rarer subset for which no standard therapy has been established. The authors report the case of a 24-year-old woman with multifocal primary spinal germ cell tumors scattered from T-12 to L-5 that consisted of yolk sac tumor and mature teratoma. After diagnostic partial resection, the patient was treated with 30 Gy of craniospinal irradiation and 30 Gy of local spinal irradiation, followed by 8 courses of chemotherapy based on ifosfamide, cisplatin, and etoposide (ICE). Salvage surgery was also performe...
Source: Journal of Neurosurgery.Spine - December 1, 2016 Category: Neurosurgery Authors: Mukasa A, Yanagisawa S, Saito K, Tanaka S, Takai K, Shibahara J, Ikegami M, Nakao Y, Takeshita K, Matsutani M, Saito N Tags: J Neurosurg Spine Source Type: research

Ovarian Yolk Sac Tumors; Does Age Matter?
Conclusions Ovarian yolk sac tumors have an excellent outcome across all age-groups. Age has no apparent impact on the probability of event or death, allowing pediatric and gynecologic oncologists to enroll patients onto joint pediatric and adult trials.
Source: International Journal of Gynecological Cancer - December 22, 2017 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Primary extragonadal yolk sac tumor originating from adrenal gland.
We present an extragonadal yolk sac tumor that presented as an adrenal carcinoma and required left adrenalectomy, nephrectomy, and significant IVC thrombectomy. This case, to our knowledge, is the first documented case of extragonadal yolk sac tumor originating from the adrenal gland. PMID: 31860425 [PubMed - in process]
Source: Canadian Journal of Urology - December 22, 2019 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

High-grade serous carcinoma of fallopian tube with yolk sac tumor differentiation in a postmenopausal patient.
Abstract Yolk sac tumors (YSTs) are the second most common germ cell malignancy of the ovaries, generally presenting in children and young women. However, they rarely occur in the fallopian tubes of postmenopausal patients. The current rare case is composed of yolk sac tumor differentiation within high-grade serous carcinoma (HGSC) arising in the fallopian tube of a 68-year-old woman. Serum α-fetoprotein was much higher than normal level. This case exhibited some areas of glandular architecture with positivity for SALL4, AFP, and Glypican-3 and negative staining for PAX8, supporting a germ cell tumor differentiat...
Source: International Journal of Clinical and Experimental Pathology - July 16, 2020 Category: Pathology Authors: Xing F, Jiang L, Wang T, Li W, Yang P, Qu G, Bao L Tags: Int J Clin Exp Pathol Source Type: research

Cancers, Vol. 13, Pages 220: Molecular Characterization of Ovarian Yolk Sac Tumor (OYST)
Marie Morfouace Isabelle Ray-Coquard Most patients with malignant ovarian germ cell tumors (MOGTCs) have a very good prognosis and chemotherapy provides curative treatment; however, patients with yolk sac tumors (OYSTs) have a significantly worse prognosis. OYSTs are rare tumors and promising results are expected with the use of specific therapeutic strategies after the failure of platinum-based first-line and salvage regimens. We initiated a project in collaboration with EORTC SPECTA, to explore the molecular characteristics of OYSTs. The pilot project used retrospective samples from ten OYST relapsed and disease-...
Source: Cancers - January 9, 2021 Category: Cancer & Oncology Authors: Khalil Hodroj Aleksandra Stevovic Valery Attignon Domenico Ferraioli Pierre Meeus Sabrina Croce Nicolas Chopin Lea Rossi Anne Floquet Christine Rousset-Jablonski Olivier Tredan Fr édéric Guyon Isabelle Treilleux Corinne Rannou Marie Morfouace Isabelle R Tags: Article Source Type: research

Somatically Derived Yolk Sac Tumor of the Ovary in a Young Woman
Ovarian carcinoma with a somatically derived yolk sac tumor component is a phenomenon known to mostly occur in postmenopausal women. Herein, we report an ovarian endometriosis-associated somatic yolk sac tumor arising in the background of a low-grade endometrioid adenocarcinoma in a young woman. A 27-yr-old woman presented with abdominal pain, subsequently recognized to be caused by a right ovarian mass undergoing torsion. Following operative management, microscopic examination of the salpingo-oophorectomy specimen showed endometriosis and a predominantly cystic ovarian neoplasm with 2 distinct phenotypic areas: (1) a yolk...
Source: International Journal of Gynecological Pathology - April 16, 2021 Category: Pathology Tags: PATHOLOGY OF THE UPPER TRACT: Case Reports Source Type: research

Sinonasal SMARCB1 (INI1) Deficient Carcinoma with Yolk Sac Tumor Differentiation: A Case Report and Treatment Options
AbstractSMARCB1 (INI1) deficient carcinoma (SDC) is a newly-described, aggressive, high-grade malignancy of the adult population. Rarely, these tumors demonstrate yolk sac differentiation. Treatment protocols are not defined due to the rarity of this entity. A 55 year-old-male presented with a tumor originating in the maxillary sinus. He was treated with neoadjuvant therapy followed by radical surgery and adjuvant treatment. We review the literature and discuss the course of disease and treatments of sinonasal SDC with yolk sac tumor differentiation. To our knowledge, this is the sixth reported case of sinonasal SDC with y...
Source: Head and Neck Pathology - August 21, 2021 Category: Pathology Source Type: research

SMARCB1 (INI1)-Deficient Sinonasal Carcinoma with Yolk Sac differentiation Showing Co-loss of SMARCA4 Immunostaining – A Case Report and Literature Review
We report the first case of SMARCB1-deficient sinonasal carcinoma that demonstrated co-loss of SMARCA4 immunostain, and reduced SMARCA2 and ARID1A staining, with the entire tumor showing histological and immunohistochemical evidence of yolk sac differentiation. The clinical, histological, immunohistochemical and molecular features were discussed and compared against SMARCB1-deficient sinonasal carcinomas with yolk sac differentiation and SMARCA4-deficeint sinonasal carcinomas reported in the literature. With a highly aggressive clinical course leading to mortality two months after presentation, the behavior of this tumor a...
Source: Head and Neck Pathology - March 7, 2022 Category: Pathology Source Type: research