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Yolk sac tumor of the parotid gland in a child and its differentials
Riddhi Jaiswal, Swati AgnihotriJournal of Indian Association of Pediatric Surgeons 2022 27(5):617-619
Yolk sac tumors (YST) (or endodermal sinus tumors) are rare neoplasms of germ cell origin that have been reported in gonadal sites (testis and ovary). Extragonadal YST are uncommon and are extremely rare in the extracranial head-and-neck regions. Here, we present a rare case of a 1-year-old male with isolated YST of the right parotid gland initially diagnosed as malignant epithelial neoplasm with possibilities of mucoepidermoid carcinoma and epithelial–myoepithelial carcinoma.
Source: Journal of Indian Association of Pediatric Surgeons - September 9, 2022 Category: Surgery Authors: Riddhi Jaiswal Swati Agnihotri Source Type: research
Chick Yolk Sac Development Developmental Biology
During chicken yolk sac (YS) growth, mesodermal cells in the area vasculosa follow the migrating endodermal epithelial cell (EEC) layer in the area vitellina. Ultimately, these cells form the vascularized YS that functions in nutrient transfer to the embryo. How and when EECs, with their apical aspect directly contacting the oocytic yolk, acquire the ability to take up yolk macromolecules during the vitellina-to-vasculosa transition has not been investigated. In addressing these questions, we found that with progressive vascularization, the expression level in EECs of the nutrient receptor triad, LRP2-cubilin-amnionless, c...
Source: Journal of Biological Chemistry - January 11, 2013 Category: Chemistry Authors: Bauer, R., Plieschnig, J. A., Finkes, T., Riegler, B., Hermann, M., Schneider, W. J. Tags: Metabolism Source Type: research
Nasopharyngeal yolk sac tumors: A rare pediatric occurrence.
PMID: 23975485 [PubMed - in process]
Source: Ear, Nose and Throat Journal - August 1, 2013 Category: ENT & OMF Authors: Mantle B, Osborne RF Tags: Ear Nose Throat J Source Type: research
Development and morphology of the inverted yolk sac in the guinea pig (Cavia porcellus)
Abstract: Although the guinea pig is an important animal model for human placentation, aspects of fetal nutrition are not fully understood, especially in regard to the yolk sac that is regarded to be essential for early development of the embryo. We investigated differentiation by means of histology, histochemistry, immunohistochemistry, and transmission electron microscopy. Data suggest that the guinea pig's yolk sac was not sufficiently developed to facilitate substantial fetal nutrition in early pregnancy. On Day 12, it was a flat, inverted, but avascular structure. This was followed by differentiation to form the typic...
Source: Theriogenology - July 12, 2013 Category: Genetics & Stem Cells Authors: Bruno Gomes Vasconcelos, Phelipe Oliveira Favaron, Maria Angelica Miglino, Andrea Maria Mess Tags: Research articles Source Type: research
Extragonadal GCT: A rare case report of sacrococcygeal pure yolk sac tumor.
PMID: 24152532 [PubMed - in process]
Source: Indian Journal of Pathology and Microbiology - July 1, 2013 Category: Pathology Authors: Pawar NP, Mahajan SV, Chaudhari RA, Chavan SD Tags: Indian J Pathol Microbiol Source Type: research
All-trans Retinoic Acid Promotes Nerve Cell Differentiation of Yolk Sac-Derived Mesenchymal Stem Cells.
In this study, we observed the gene expression of pluripotent markers in yolk sac mesenchymal stem cells (YS-MSCs) and the capacity of YS-MSCs to differentiate into neural-like cells using quantitative RT-PCR, immunocytochemistry, and western blotting. YS-MSCs have a spindle shape and revealed the expression of the MSC-related proteins β-integrin, CD44, CD71, and CD73, but not CD34. YS-MSCs express pluripotent markers such as octamer-binding transcription factor 4 (Oct4) and Nanog at the protein and mRNA levels. QRT-PCR analyses revealed that YS-MSCs expressed nestin. Immunocytochemical and western blotting data showed th...
Source: Applied Biochemistry and Biotechnology - August 3, 2014 Category: Biochemistry Authors: Gao Y, Bai C, Wang K, Sun B, Guan W, Zheng D Tags: Appl Biochem Biotechnol Source Type: research
Imaging diagnosis—use of radiography and computed tomography in the diagnosis of a mineralized yolk sac in a brown kiwi (apteryx mantelli)
A 12‐day‐old Brown Kiwi (Apteryx mantelli) was presented with anorexia, torticollis, head‐tilt, and coelomic distension. Radiographs showed an ill‐defined, fat‐opaque, coelomic mass displacing viscera craniodorsally. Curvilinear mineral opacities were superimposed over the ventral aspect of the mass. Computed tomography demonstrated the presence of mineral within the periphery of a fat attenuating mass consistent with a retained yolk sac. A deutectomy (yolk sac excision) was performed. Histopathology of the excised tissue confirmed the diagnosis of a retained yolk sac with multifocal mineralization.
Source: Veterinary Radiology and Ultrasound - July 1, 2014 Category: Veterinary Research Authors: Paul Wightman, Eli B. Cohen, Stuart Hunter, Brett Gartrell Tags: Imaging Diagnosis Source Type: research
900p * prognostic significance of serum alphafoetoprotein early decline in ovarian yolk sac tumor
Conclusions: Serum AFP early decline help to identify poor prognosis ovarian YSTs pts. This may be relevant for the management of OYSTs since it has been shown in a phase III study (GETUG 13) in testicular poor prognosis germ cell tumor that early switch to a dose dense chemotherapy regimen for pts with slow tumor marker decline reduces the risk of progression or death.Disclosure: All authors have declared no conflicts of interest.
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Rouge, T. D. L. M., Pautier, P., Duvillard, P., Rey, A., Morice, P., Meder, C. H., Kerbrat, P., Culine, S., Fizazi, K., Lhomme, C. Tags: gynaecological cancers Source Type: research
Loss of PiT-1 results in abnormal endocytosis in the yolk sac visceral endoderm
Publication date: August 2014 Source:Mechanisms of Development, Volume 133 Author(s): Mary C. Wallingford , Cecilia M. Giachelli PiT-1 protein is a transmembrane sodium-dependent phosphate (Pi) transporter. PiT-1 knock out (KO) embryos die from largely unknown causes by embryonic day (E) 12.5. We tested the hypothesis that PiT-1 is required for endocytosis in the embryonic yolk sac (YS) visceral endoderm (VE). Here we present data supporting that PiT-1 KO results in a YS remodeling defect and decreased endocytosis in the YS VE. The remodeling defect is not due to an upstream cardiomyocyte requirement for PiT-1, as SM22α...
Source: Mechanisms of Development - October 12, 2014 Category: Biology Source Type: research
Changes in mouse liver and chicken embryo yolk sac membrane soluble proteins due to an organophosphorous insecticide (OPI) diazinon linked to several noncholinergic OPI effects in mice and chicken embryos
The objective of this study was to identify proteins in mouse livers and chicken embryo yolk sac membranes whose quantities were altered by an organophosphorous insecticide (OPI) treatment and which might be linked, based on their functionality, to the recognized noncholinergic effects of OPI. Mice and fertile chicken eggs were treated with an OPI representative diazinon. The quantitative changes in mouse liver and chicken embryo yolk sac membrane soluble proteins caused by diazinon were determined by two-dimensional electrophoresis. Proteins whose quantity was affected by diazinon were identified by the mass spectrometry....
Source: Pesticide Biochemistry and Physiology - November 13, 2014 Category: Biochemistry Source Type: research
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
Nature advance online publication 03 December 2014. doi:10.1038/nature13989
Authors: Elisa Gomez Perdiguero, Kay Klapproth, Christian Schulz, Katrin Busch, Emanuele Azzoni, Lucile Crozet, Hannah Garner, Celine Trouillet, Marella F. de Bruijn, Frederic Geissmann & Hans-Reimer Rodewald
Most haematopoietic cells renew from adult haematopoietic stem cells (HSCs), however, macrophages in adult tissues can self-maintain independently of HSCs. Progenitors with macrophage potential in vitro have been described in the yolk sac before emergence of HSCs, and fetal macrophages can develop independently of Myb, a transcription fac...
Source: Nature AOP - December 3, 2014 Category: Research Authors: Elisa Gomez PerdigueroKay KlapprothChristian SchulzKatrin BuschEmanuele AzzoniLucile CrozetHannah GarnerCeline TrouilletMarella F. de BruijnFrederic GeissmannHans-Reimer Rodewald Tags: Letter Source Type: research
Live confocal microscopy of the developing mouse embryonic yolk sac vasculature.
Abstract
Understanding of mouse embryonic development is an invaluable resource for our interpretation of human embryology. Traditional imaging approaches such as immunofluorescence and in situ hybridization are excellent methods for characterizing gene expression and morphology but lack the ability to reveal the dynamic morphogenesis. Furthermore, mammalian embryonic development occurs in utero, which bars our ability to visualize development in dynamics. With the use of live confocal microscopy, vital fluorescent reporters, and embryo culture methods, we can observe cell migration, proliferation, differentiation...
Source: Mol Biol Cell - December 5, 2014 Category: Molecular Biology Authors: Lopez AL, Garcia MD, Dickinson ME, Larina IV Tags: Methods Mol Biol Source Type: research
Characterization of putative haematopoietic cells from bovine yolk sac
This study is crucial for the understanding of the development of the haematopoietic system and the embryonic function of this organ. Copyright © 2015 John Wiley & Sons, Ltd.
Source: Journal of Tissue Engineering and Regenerative Medicine - February 25, 2015 Category: Molecular Biology Authors: Vanessa C. Oliveira, Celina A. F. Mançanares, Lilian J. Oliveira, Natalia J. N. Gonçalves, Maria A. Miglino, Felipe Perecin, Flávio V. Meirelles, Jorge Piedrahita, Carlos E. Ambrósio Tags: Research Article Source Type: research
Sinonasal yolk sac (Endodermal sinus) tumor in an adult female – A case report and review of the literature
We present a case of sinonasal YST admixed with transitional cell carcinoma in a 58‐year‐old female. Magnetic resonance imaging revealed a mass in the right ethmoid fissure infiltrating into the posterior and anterior ethmoid sinuses and nasopharynx. Positron emission tomography examination showed a maximum standardized uptake value of 6.8. Histological examination of the biopsy specimen revealed two distinct features, YST and transitional cell carcinoma, with evidence of mutual transition that indicated the composite nature of the tumor. Immunohistochemical analysis revealed positive immunoreactivity for Sal‐like p...
Source: APMIS - June 1, 2015 Category: Research Authors: Xianglin Mei, Yang Xia, Hironobu Sasano, Hongwen Gao Tags: Case Report Source Type: research
Pediatric Vaginal Yolk Sac Tumor: Reappraisal of Treatment Strategy in a Rare Tumor at a Unique Location
Review of the management of 6 young girls with vaginal yolk sac tumor over 25 years showed that the α-fetoprotein levels normalized in 5/6 within 4 cycles of primary cisplatin, bleomycin, etoposide (PEB)/carboplatin, etoposide, bleomycin (JEB)/cisplatin, vinblastine, bleomycin (PVB) chemotherapy. Radioimaging revealed residual tissue but viable tumor was found in only 1 of 2 biopsied. Resection/biopsy is necessary to avoid giving additional primary chemotherapy or to identify patients who need different treatment. If markers do not decay appropriately, PEB/JEB/PVB chemotherapy should not be continued. Taxol-containing sal...
Source: Journal of Pediatric Hematology Oncology - June 25, 2015 Category: Hematology Tags: Clinical and Laboratory Observations Source Type: research
