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Total 1161397 results found since Jan 2013.

The pioneer and differentiation factor FOXA2 is a key driver of yolk-sac tumour formation and a new biomarker for paediatric and adult yolk-sac tumours.
Abstract Yolk-sac tumours (YSTs), a germ cell tumour subtype, occur in newborns and infants as well as in young adults of age 14-44 years. In clinics, adult patients with YSTs face a poor prognosis, as these tumours are often therapy-resistant and count for many germ cell tumour related deaths. So far, the molecular and (epi)genetic mechanisms that control development of YST are far from being understood. We deciphered the molecular and (epi)genetic mechanisms regulating YST formation by meta-analysing high-throughput data of gene and microRNA expression, DNA methylation and mutational burden. We validated our fi...
Source: J Cell Mol Med - January 14, 2021 Category: Molecular Biology Authors: Wruck W, Bremmer F, Kotthoff M, Fichtner A, Skowron MA, Schönberger S, Calaminus G, Vokuhl C, Pfister D, Heidenreich A, Albers P, Adjaye J, Nettersheim D Tags: J Cell Mol Med Source Type: research

CK19 is a sensitive marker for yolk sac tumours of the testis
Conclusion: CK19 proved to be a sensitive marker to identify yolk sac tumours of the testis and to distinguish them from other germ cell tumours, especially seminomas and embryonic carcinomas.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/4075546891400979.
Source: Diagnostic Pathology - March 24, 2015 Category: Pathology Authors: Felix BremmerPhilipp StröbelHubertus JarryJasmin StreckerNadine GaisaArne StraußStefan SchweyerHeinz-Joachim RadzunCarl-Ludwig Behnes Source Type: research

Yolk sac tumour involving floor of mouth: case report
We present a case of a yolk sac tumour that involved the floor of the mouth in a 14-month-old Chinese girl. The diagnosis was confirmed by histological examination that showed characteristic Schiller–Duval bodies, and immunohistochemical examination that showed α-fetoprotein being expressed within the cytoplasm of the neoplastic cells. The patient died 4 months postoperatively. To our knowledge, this is the first case of a yolk sac tumour of the floor of mouth that has been reported in an English journal.
Source: The British Journal of Oral and Maxillofacial Surgery - May 7, 2012 Category: ENT & OMF Authors: Q. Zhang, Y. Huang, C.Y. Bao, L.J. Li Tags: Short communications Source Type: research

Primary yolk sac tumour of the prostate mimicking small round blue cell tumour.
We report a rare case of primary yolk sac tumour of the prostate with extensive local and liver metastasis, the latter of which exhibited sheets of small blue cells expressing CD99 and focal sall4 on biopsy. Positivity for CD99 and gata3 in the initial biopsy raised the differential diagnosis of Ewing sarcoma and poorly differentiated carcinoma. The primary tumour demonstrated an admixture of solid and glandular growth patterns and occasional Schiller-Duval bodies. A panel of immunohistochemical stains showing positivity for AE1/3, sall4, cdx2, and focal alpha-fetoprotein, and negativity for oct-4, facilitated the diagnosi...
Source: Current Oncology - November 13, 2019 Category: Cancer & Oncology Tags: Curr Oncol Source Type: research

Primary extragonadal vaginal yolk sac tumour: A case report.
We described a case of extragonadal vaginal YST in a one year and seven months old girl who presented with vaginal discharge and bleeding, and discuss its differential diagnosis and potential pitfalls in immunohistochemistry. She was found to have a suprapubic mass on examination. The serum alpha fetoprotein was 11919.4 ng/mL. Computed tomography of the pelvis revealed a large 6.4 cm heterogenous pelvic mass. Colposcopic examination of the pelvis showed a fungating vaginal mass that was subsequently confirmed as a yolk sac tumour. Immunohistochemically, the malignant cells were positive toward CKAE1/AE3, AFP and glypican-3...
Source: Malaysian Journal of Pathology - August 30, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

Yolk sac tumours of the orbit and sinonasal tract
CONCLUSION: Sino-orbital yolk sac tumours are rare and have variable presentations, dependent on the extent of local invasion. Early diagnosis and treatment with multimodal therapy are paramount in having improved overall survival.PMID:35938374 | DOI:10.1080/01676830.2022.2106375
Source: Orbit - August 8, 2022 Category: Opthalmology Authors: Mason Jenner Burns Linda Zheng Luciano Dalla-Pozza Nicole S Graf Joanna Walton Krishna Tumuluri Source Type: research

Yolk Sac Tumours of the Female Genital Tract in Older Adults Commonly Derive from Somatic Epithelial Neoplasms: Somatically Derived Yolk Sac Tumours
ConclusionsPathologists should be aware of the association between YST and an epithelial neoplasm, the former probably arising from the latter through a process of neometaplasia/ retrodifferentiation. Those rare gynaecological pure glandular YSTs in adults may arise secondary to total overgrowth of an epithelial neoplasm. Pathologists need a high index of suspicion to diagnose the YST component since the morphology is characteristically of a glandular variant with marked morphological overlap with adenocarcinomas. There is also often significant immunophenotypic overlap with epithelial neoplasms since the YST component may...
Source: Histopathology - June 23, 2016 Category: Pathology Authors: Tamara McNamee, Stephen Damato, W Glenn McCluggage Tags: Original Article Source Type: research

Yolk sac tumours of the female genital tract in older adults derive commonly from somatic epithelial neoplasms: somatically derived yolk sac tumours
ConclusionsPathologists should be aware of the association between YST and an epithelial neoplasm, the former probably arising from the latter through a process of neometaplasia/retrodifferentiation. Those rare gynaecological pure glandular YSTs in adults may arise secondary to total overgrowth of an epithelial neoplasm. Pathologists need a high index of suspicion to diagnose the YST component, as the morphology is characteristically of a glandular variant with marked morphological overlap with adenocarcinomas. There is also often significant immunophenotypical overlap with epithelial neoplasms, as the YST component may be...
Source: Histopathology - August 4, 2016 Category: Pathology Authors: Tamara McNamee, Stephen Damato, W Glenn McCluggage Tags: Original Article Source Type: research

ZBTB16 is a sensitive and specific marker in detection of metastatic and extragonadal yolk sac tumour
ConclusionsZBTB16 is a sensitive and specific marker for YST and is diagnostically superior to AFP and glypican‐3 in metastatic and extragonadal settings.
Source: Histopathology - July 19, 2017 Category: Pathology Authors: Guang ‐Qian Xiao, David S Priemer, Christina Wei, Manju Aron, Qi Yang, Muhammad T Idrees Tags: Original Article Source Type: research

Yolk sac tumour of the ovary in pregnancy treated with surgery and chemotherapy: a case report
CONCLUSION: Yolk sac tumour of the ovary in pregnancy with concomitant chemotherapy is uncommon. Adverse outcomes, including restricted fetal growth, are possible and their identification may help guide timing of delivery.PMID:34000443 | DOI:10.1016/j.jogc.2021.04.013
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - May 17, 2021 Category: OBGYN Authors: Alida J Pokoradi Anita Agrawal Source Type: research

Administration of standard-dose BEP regimen (bleomycin+etoposide+cisplatin) is essential for treatment of ovarian yolk sac tumour
The aim of this study was to investigate prognostic factors, including postoperative chemotherapy regimen, for the treatment of ovarian yolk sac tumour (YST), and resulting fertility outcome.
Source: European Journal of Cancer - January 2, 2015 Category: Cancer & Oncology Authors: Toyomi Satoh, Yoichi Aoki, Takahiro Kasamatsu, Kazunori Ochiai, Masashi Takano, Yoh Watanabe, Fumitaka Kikkawa, Nobuhiro Takeshima, Masayuki Hatae, Harushige Yokota, Toshiaki Saito, Nobuo Yaegashi, Hiroaki Kobayashi, Tsukasa Baba, Shoji Kodama, Tsuyoshi S Source Type: research

A rare case of ovarian yolk sac tumour arising from mucinous adenocarcinoma in a 67-year-old woman.
Authors: Soylemez T, Aydin A, Gunduz N, Ozen F, Kir G PMID: 31339396 [PubMed - as supplied by publisher]
Source: Journal of Obstetrics and Gynaecology - July 26, 2019 Category: OBGYN Tags: J Obstet Gynaecol Source Type: research