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Total 478012 results found since Jan 2013.
Head Scarf Pin in the Airway and Challenges in Rigid Bronchoscopy: A Case Series
AbstractAccidental Foreign body aspiration, especially sharp metallic objects may lead to life threatening complications. A metallic object is identified readily on a Xray chest or CT chest and helps us in ascertaining its location. A straight pin with blunt head in the shape of pearl is used in wearing a head scarf also known as hijab to hold it in place. The head scarf pin (hijab pin) if accidentally aspirated into the airway may lead to grave complications. Hence timely intervention with suitable instrumentation is essential to prevent any lethal complications. We have reported four different cases of adolescent females...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - September 21, 2023 Category: ENT & OMF Source Type: research
A look at radiation detectors and their applications in medical imaging
AbstractThe effectiveness and precision of disease diagnosis and treatment have increased, thanks to developments in clinical imaging over the past few decades. Science is developing and progressing steadily in imaging modalities, and effective outcomes are starting to show up as a result of the shorter scanning periods needed as well as the higher-resolution images generated. The choice of one clinical device over another is influenced by technical disparities among the equipment, such as detection medium, shorter scan time, patient comfort, cost-effectiveness, accessibility, greater sensitivity and specificity, and spati...
Source: Japanese Journal of Radiology - September 21, 2023 Category: Radiology Source Type: research
IJERPH, Vol. 20, Pages 6794: Enhancing Food Literacy and Food Security through School Gardening in Rural and Regional Communities
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Kiran D. K. Ahuja
A qualitative case study approach with in-depth, semi-structured interviews of key school staff, and student feedback was used to assess a school kitchen and garden program in the regional area of North-West Tasmania, Australia. A detailed program description was produced to conduct a realist evaluation with a Context-Mechanism-Outcome configuration, followed by a program theory evaluation through the construction of a retrospective program logic model. Dedicated kitchen and garden spaces, knowledgeable teachers committed to the program, provision of sufficient materials and consumables, and suppo...
Source: International Journal of Environmental Research and Public Health - September 21, 2023 Category: Environmental Health Authors: Timothy P. Holloway Sisitha Jayasinghe Lisa Dalton Michelle L. Kilpatrick Roger Hughes Kira A. E. Patterson Robert Soward Kylie Burgess Nuala M. Byrne Andrew P. Hills Kiran D. K. Ahuja Tags: Article Source Type: research
Relationship of NLRP3 Inflammasome with Oral Health
AbstractPurpose of ReviewThe aim of this review is whether the NLRP3 inflammasome is associated with oral health and to understand whether the biology of the NLRP3 inflammasome is for the prevention of oral inflammatory and immunological disorders.Recent FindingsAccording to the studies, understanding the biology of the NLRP3 inflammasome is essential for the treatment and prevention of oral inflammatory and immunological disorders. It has been observed that the pathways of chronic inflammatory diseases are similar both in oral and systemic diseases. Recent investigations have demonstrated that inflammasomes play important...
Source: Current Oral Health Reports - September 21, 2023 Category: Dentistry Source Type: research
Genes, Vol. 14, Pages 1828: Aromatic L-Amino-Acid Decarboxylase Deficiency Screening by Analysis of 3-O-Methyldopa in Dried Blood Spots: Results of a Multicentric Study in Neurodevelopmental Disorders
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Daniele Frattini
Carlo Fusco
Aromatic L-amino acid decarboxylase deficiency (AADCd) is a rare recessive metabolic disorder caused by pathogenic homozygous or compound heterozygous variants in the dopa decarboxylase (DDC) gene. Adeno-associated viral vector-mediated gene transfer of the human DDC gene injected into the putamen is available. The typical presentation is characterized by early-onset hypotonia, severe developmental delay, movement disorders, and dysautonomia. Recently, mild and even atypical phenotypes have been reported, increasing the diagnostic challenge. The aim of this multicentric study is to id...
Source: Genes - September 21, 2023 Category: Genetics & Stem Cells Authors: Susanna Rizzi Carlotta Spagnoli Melissa Bellini Carlo Alberto Cesaroni Elisabetta Spezia Patrizia Bergonzini Elisa Caramaschi Luca Soliani Emanuela Claudia Turco Benedetta Piccolo Laura Demuth Duccio Maria Cordelli Giacomo Biasucci Daniele Frattini Carlo Tags: Article Source Type: research
Genes, Vol. 14, Pages 1827: Identification and Characterization of ABCG15 & mdash;A Gene Required for Exocarp Color Differentiation in Pear
Genes, Vol. 14, Pages 1827: Identification and Characterization of ABCG15—A Gene Required for Exocarp Color Differentiation in Pear
Genes doi: 10.3390/genes14091827
Authors:
Simeng Zhang
Jiayu Xu
Ying Zhang
Yufen Cao
Exocarp color is a commercially essential quality for pear which can be divided into two types: green and russet. The occurrence of russet color is associated with deficiencies and defects in the cuticular and epidermal layers, which affect the structure of the cell wall and the deposition of suberin. Until now, the genetic basics triggering this trait have not been well understood, and...
Source: Genes - September 21, 2023 Category: Genetics & Stem Cells Authors: Simeng Zhang Jiayu Xu Ying Zhang Yufen Cao Tags: Article Source Type: research
Cancers, Vol. 15, Pages 4672: An Observatory for the MET Oncogene: A Guide for Targeted Therapies
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The MET proto-oncogene encodes a pivotal tyrosine kinase receptor, binding the hepatocyte growth factor (HGF, also known as scatter factor, SF) and governing essential biological processes such as organogenesis, tissue repair, and angiogenesis. The pleiotropic physiological functions of MET explain its diverse role in cancer progression in a broad range of tumors; genetic/epigenetic alterations of MET drive tumor cell dissemination, metastasis, and acquired resistance to conventional and targeted therapies. Therefore, targeting MET emerged as a promising strategy, and many efforts were devoted to identifying the op...
Source: Cancers - September 21, 2023 Category: Cancer & Oncology Authors: Dogus M. Altintas Paolo M. Comoglio Tags: Review Source Type: research
Molecules, Vol. 28, Pages 6728: Myrcene: A Natural Compound Showing Anticancer Activity in HeLa Cells
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Chiara Zalambani
γ-terpinene, α-terpinene, p-cymene, and myrcene are monoterpenes found in many essential oils extracted from a variety of plants and spices. Myrcene also occurs naturally in plants such as hops, cannabis, lemongrass, and verbena and is used as a flavoring agent in food and beverage manufacturing. In this research, the biological efficacy of γ-terpinene, α-terpinene, p-cymene, and myrcene was studied in human cell lines (HeLa, SH-SY5Y, and HDFa). Cytotoxicity, cell proliferation, cell migration, and morphology assays were performed to obtain d...
Source: Molecules - September 21, 2023 Category: Chemistry Authors: Luca Pincigher Francesca Valenti Christian Bergamini Cecilia Prata Romana Fato Riccardo Amorati Zongxin Jin Giovanna Farruggia Diana Fiorentini Natalia Calonghi Chiara Zalambani Tags: Article Source Type: research
Solid pseudopapillary neoplasms of the pancreas in childhood and adolescence —an analysis of the German Registry for Rare Pediatric Tumors (STEP)
Conclusion: SPN of the pancreas in childhood are low-grade malignancies with usually favorable treatment outcomes. However, therapy can lead to relevant long-term sequelae. To prevent recurrence, complete surgical resection is recommended, sparing as much healthy pancreatic tissue as possible. Interdisciplinary collaboration between specialists is essential to optimize treatment. Molecular genetic analysis of these tumors could improve understanding of their genesis.What is Known:• Solid pseudopapillary neoplasms (SPNs) of the pancreas are very rare tumors in childhood.• Little is known about tumorigenesis, and there a...
Source: European Journal of Pediatrics - September 21, 2023 Category: Pediatrics Source Type: research
Herd health and reproductive management associated with lamb weight gain and mortality in sub-Saharan drylands —a case from Ethiopia
This study highlights that health interventions in ewes improve lamb survival and weight gain and that the care of lambs during the first month of life is crucial for overall herd productivity.
Source: Tropical Animal Health and Production - September 21, 2023 Category: Veterinary Research Source Type: research
Regulation of nucleo-cytosolic 26S proteasome translocation by aromatic amino acids via mTOR is essential for cell survival under stress
Livneh et al. show that cellular stress, such as amino acid starvation, leads to translocation of the proteasome from the nucleus to the cytosol, where it stimulates proteolysis. The migration is inhibited by Tyr, Trp, and Phe—newly identified mTOR agonists acting via Sestrin3—leading to cell death.
Source: Molecular Cell - September 21, 2023 Category: Cytology Authors: Ido Livneh, Victoria Cohen-Kaplan, Bertrand Fabre, Ifat Abramovitch, Chen Lulu, Nishanth Belugali Nataraj, Ikrame Lazar, Tamar Ziv, Yosef Yarden, Yaniv Zohar, Eyal Gottlieb, Aaron Ciechanover Tags: Article Source Type: research
Indias latest essential medicines list: gaps, strengths and opportunities in evidence-based decision-making
Essential medicines—defined by the WHO as ‘those that satisfy the priority health care needs of the population’—are meant to be always accessible within health systems, in sufficient quantities, in optimal dosage forms, of guaranteed quality and at affordable costs.1 The WHO Model Essential Medicines List (EML)1 serves as a reference for countries to design and update national EMLs to support medicine procurement, supply, manufacture, pricing and prescribing practices. In this commentary, we discuss the gaps, strengths and opportunities in evidence-based decision-making in India’s latest natio...
Source: Evidence-Based Medicine - September 21, 2023 Category: Internal Medicine Authors: Satheesh, G., Unnikrishnan, M. K., Jha, V., Salam, A. Tags: EBM opinion and debate Source Type: research
Health data ecosystem in Pakistan: a multisectoral qualitative assessment of needs and opportunities
Conclusions
Our study identified key areas of focus that can contribute to orient a national health data roadmap and ecosystem in Pakistan.
Source: BMJ Open - September 21, 2023 Category: General Medicine Authors: Mahmood, S., Noorali, A. A., Manji, A., Afzal, N., Abbas, S., Qamar, J. B., Siddiqi, S., Hoodbhoy, Z., Virani, S. S., Bhutta, Z. A., Samad, Z. Tags: Open access, Public health Source Type: research
Psychosocial patient perspectives following major lower-limb amputation due to vascular aetiology: a protocol for a systematic meta-aggregation study
Introduction
Persistent psychosocial problems in people with lower-limb amputation due to vascular aetiology indicate a great need for long-lasting holistic rehabilitation. An in-depth understanding of the psychosocial problems is essential for the guidance of health professionals in meeting and normalising patients’ experiences and emotions. Furthermore, identifying the psychological problems may help develop effective rehabilitation and counselling programmes. This meta-aggregation study aims to explore the psychosocial perspectives of individuals who have undergone a major lower-limb amputation due to vascular aet...
Source: BMJ Open - September 21, 2023 Category: General Medicine Authors: Laursen, S. H., Rasmussen, H. L., Seidelin, D., Pedersen, P. H., Chraemmer, T. M. Tags: Open access, Rehabilitation medicine Source Type: research
Therapeutic potential of vasculogenic mimicry in urological tumors
Angiogenesis is an essential process in the growth and metastasis of cancer cells, which can be hampered by an anti-angiogenesis mechanism, thereby delaying the progression of tumors. However, the benefit of this treatment modality could be restricted, as most patients tend to develop acquired resistance during treatment. Vasculogenic mimicry (VM) is regarded as a critical alternative mechanism of tumor angiogenesis, where studies have demonstrated that patients with tumors supplemented with VM generally have a shorter survival period and a poorer prognosis. Inhibiting VM may be an effective therapeutic strategy to prevent...
Source: Frontiers in Oncology - September 21, 2023 Category: Cancer & Oncology Source Type: research
