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Total 478012 results found since Jan 2013.

Mutation Profile via Next-Generation Sequencing in Patients with Colorectal Adenocarcinoma and Its Clinicopathological Correlation
CONCLUSION: It is necessary to have a comprehensive database of genomic alterations of colorectal carcinomas to interpret mutations more accurately clinically. There are no studies on the frequency of mutations in colorectal carcinomas in the Turkish population; thus, follow-up and treatment protocols are organized following the European and American databases and guidelines. A comprehensive study of the colorectal carcinoma patients' mutation profile in the Turkish patient cohort by the next-generation sequencing method will help to provide significant therapeutic, prognostic, and predictive data and design more successfu...
Source: The Turkish Journal of Gastroenterology - September 22, 2023 Category: Gastroenterology Authors: Sibel Osman Nesibe Kahraman Çetin İbrahim Halil Erdoğdu İbrahim Meteoğlu Source Type: research

Pseudomonas aeruginosa High-Risk Sequence Type 463 Co-Producing KPC-2 and AFM-1 Carbapenemases, China, 2020-2022
We report the clonal spread and evolution of high-risk Pseudomonas aeruginosa sequence type 463 co-producing KPC-2 and AFM-1 carbapenemases isolated from hospital patients in China during 2020-2022. Those strains pose a substantial public health threat and surveillance and stricter infection-control measures are essential to prevent further infections.PMID:37735755 | DOI:10.3201/eid2910.230509
Source: Emerging Infectious Diseases - September 22, 2023 Category: Infectious Diseases Authors: Piaopiao Zhang Wenhao Wu Nanfei Wang Haiting Feng Jie Wang Fang Wang Yan Zhang Hongchao Chen Qing Yang Yan Jiang Tingting Qu Source Type: research

Identification and validation of a fatty acid metabolism gene signature for the promotion of metastasis in liver cancer
Oncol Lett. 2023 Sep 6;26(4):457. doi: 10.3892/ol.2023.14044. eCollection 2023 Oct.ABSTRACTMetastasis is a fatal status for liver cancer, and the identification of an effective prediction model and promising therapeutic target is essential. Given the known relationship between fatty acid (FA) metabolism and the liver, the present study aimed to investigate dysregulation of genes associated with FA metabolism in liver cancer. Bioinformatics analyses were performed on data from patients with hepatocellular carcinoma (HCC) obtained from The Cancer Genome Atlas database using R software packages. Online public tools such as th...
Source: Oncology Letters - September 22, 2023 Category: Cancer & Oncology Authors: Zhenshan Zhang Jun Sun Chao Jin Likun Zhang Leilei Wu Gendong Tian Source Type: research

Embracing Leadership: How Junior Medical Officers Shape the Future
Mil Med. 2023 Sep 20:usad374. doi: 10.1093/milmed/usad374. Online ahead of print.ABSTRACTTransitioning from medical residency to an operational role challenges junior medical officers as their leadership skills are put to the test. In the multifaceted role of Military Medical Corps Officers, patient care remains paramount, and effective leadership hinges on core values. From clinical competence and mentorship to modeling behavior and fostering adaptability, this article underscores the importance of leadership development for junior officers as they transition from the training centers into the operational environment. Eff...
Source: Military Medicine - September 22, 2023 Category: International Medicine & Public Health Authors: Jose Redondo Rachel Robbins Source Type: research

Teaching Clinical Reasoning in  the Preclinical Period
CONCLUSION: Our Introduction to Clinical Reasoning course offers students repeated exposure to well-selected cases to promote their development of clinical reasoning. The course is an example of how clinical reasoning can be taught across the preclinical curriculum without extensive faculty training in medical education or clinical reasoning theory. The course can be adapted into different instructional formats to cover a variety of topics to provide the early learner with sequential exposure and practice in diagnostic reasoning.PMID:37738179 | DOI:10.1093/milmed/usad370
Source: Military Medicine - September 22, 2023 Category: International Medicine & Public Health Authors: Renee Mallory Joseph M Maciuba Michael Roy Steven J Durning Source Type: research

Accuracy of Essential TNM to stage large colorectal (T3/T4) cancers in absence of nodal status information
Acta Oncol. 2023 Sep 22:1-3. doi: 10.1080/0284186X.2023.2257376. Online ahead of print.NO ABSTRACTPMID:37738263 | DOI:10.1080/0284186X.2023.2257376
Source: Acta Oncologica - September 22, 2023 Category: Cancer & Oncology Authors: Marion Pi ñeros James Brierley Enrique Barrios Patricia Cueva Carina Musetti Constanza Pardo Kevin Ward D Maxwell Parkin Source Type: research

The Lysosomal Calcium Channel TRPML1 Maintains Mitochondrial Fitness in NK Cells through Interorganelle Cross-Talk
In this study, we examined the role of TRPML1 (TRP cation channel, mucolipin subfamily, member 1) in regulating the homeostasis of secretory lysosomes and their cross-talk with mitochondria in human NK cells. We found that genetic deletion of TRPML1, which localizes to lysosomes in NK cells, led to mitochondrial fragmentation with evidence of collapsed mitochondrial cristae. Consequently, TRPML1-/- NK92 (NK92ML1-/-) displayed loss of mitochondrial membrane potential, increased reactive oxygen species stress, reduced ATP production, and compromised respiratory capacity. Using sensitive organelle-specific probes, we observed...
Source: Journal of Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Dennis Clement Edina K Szabo Silje Zandstra Krokeide Merete Thune Wiiger Marianna Vincenti Daniel Palacios Young-Tae Chang Christian Grimm Sandip Patel Harald Stenmark Andreas Brech Rakesh Kumar Majhi Karl-Johan Malmberg Source Type: research

Recommendations on data sharing in HIV drug resistance research
PLoS Med. 2023 Sep 22;20(9):e1004293. doi: 10.1371/journal.pmed.1004293. Online ahead of print.ABSTRACTAuthor summary • Human immunodeficiency virus (HIV) drug resistance has implications for antiretroviral treatment strategies and for containing the HIV pandemic because the development of HIV drug resistance leads to the requirement for antiretroviral drugs that may be less effective, less well-tolerated, and more expensive than those used in first-line regimens. • HIV drug resistance studies are designed to determine which HIV mutations are selected by antiretroviral drugs and, in turn, how these mutations affect ant...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Seth C Inzaule Mark J Siedner Susan J Little Santiago Avila-Rios Alisen Ayitewala Ronald J Bosch Vincent Calvez Francesca Ceccherini-Silberstein Charlotte Charpentier Diane Descamps Susan H Eshleman Joseph Fokam Lisa M Frenkel Ravindra K Gupta John P A Io Source Type: research

Epigenetic reprogramming of a distal developmental enhancer cluster drives SOX2 overexpression in breast and lung adenocarcinoma
Nucleic Acids Res. 2023 Sep 22:gkad734. doi: 10.1093/nar/gkad734. Online ahead of print.ABSTRACTEnhancer reprogramming has been proposed as a key source of transcriptional dysregulation during tumorigenesis, but the molecular mechanisms underlying this process remain unclear. Here, we identify an enhancer cluster required for normal development that is aberrantly activated in breast and lung adenocarcinoma. Deletion of the SRR124-134 cluster disrupts expression of the SOX2 oncogene, dysregulates genome-wide transcription and chromatin accessibility and reduces the ability of cancer cells to form colonies in vitro. Analysis...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Luis E Abatti Patricia Lado-Fern ández Linh Huynh Manuel Collado Michael M Hoffman Jennifer A Mitchell Source Type: research

Effect of lactic acid bacteria by different concentrations of copper based on non-target metabolomic analysis
In this study, a strain of lactic acid bacteria (LAB), namely, Lactiplantibacillus plantarum CICC 23121 (L23121), was selected as a prebiotic indicator strain to indirectly assess the effects of food-limited Cu (II) concentrations (issued by Tolerance limit of copper in foods in 1994) on the functions of intestinal microbes. We used non-target metabolomics, automatic growth curve detector, scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy (FTIR) to investigate the effects of Cu (II) on L23121. The study revealed shows that the 50% minimum inhibitory concentration (MIC50) of Cu (II) for most la...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Xinlei Li Shiyue Chen Lili Zhao Xiangpeng Zeng Yanyan Liu Chaochuang Li Qingxiang Yang Source Type: research

MAPK Signaling Pathway Plays Different Regulatory Roles in the Effects of Boric Acid on Proliferation, Apoptosis, and Immune Function of Splenic Lymphocytes in Rats
In this study, ERK1/2, JNK, and p38MAPK signaling pathways were blocked using specific blockers to investigate the impact of low-dose and high-dose boron on proliferation, apoptosis, and immune function of lymphocytes, and the expression of genes related to cell proliferation and apoptosis in rats. The addition of 0.4 mmol/L boron did not affect the ratio of CD4+/CD8+ T cells (P>0.05), IgG and IFN-γ contents (P>0.05), the proliferation rate of lymphocytes (P>0.05), and mRNA and protein expressions of PCNA (P>0.05) in the spleen after ERK1/2 signal pathway was selectively inhibited. Moreover, the addition of 40...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Shuqin Chen Haoran Fan Yaqiong Pei Kaihuan Zhang Feng Zhang Qianqian Hu Erhui Jin Shenghe Li Source Type: research

Elevated profiles of peripheral Th22, Th17, Th2 cells, and decreased percentage of Th1 cells in breast cancer patients
ConclusionTh22, Th17, Th1, and Th2 subsets may play an essential role in BC patients. Th22, Th17, Th1, and Th2 cells may have potential significance to be used as clinical markers in BC patients with different molecular classification. Th22 cells may have potential value in BC patients ’ outcomes prediction, providing clinical value.
Source: Thoracic Cancer - September 22, 2023 Category: Cancer & Oncology Authors: Zhiguo Peng, Xinyue Dong, Miao He, Yajing Zhao, Yujia Liu, Mo Li, Guosheng Li, Xiuwen Wang, Li Li, Yu Hu Tags: ORIGINAL ARTICLE Source Type: research

Directional Cell Migration Guided by a Strain Gradient
This work reports directional single cell migration guided by a strain gradient, termed tensotaxis. A programmable uniaxial cell stretch device is developed to establish a continuous strain gradient field without generating a stiffness gradient. Focal adhesion analysis and motor-clutch model demonstrate that tensotaxis is driven by strain-introduced traction force and integrin fibronectin pairs' catch-release dynamics. AbstractStrain gradients widely exist in development and physiological activities. The directional movement of cells is essential for proper cell localization, and directional cell migration in responses to ...
Source: Small - September 22, 2023 Category: Nanotechnology Authors: Feiyu Yang, Pengcheng Chen, Han Jiang, Tianfa Xie, Yue Shao, Deok ‐Ho Kim, Bo Li, Yubing Sun Tags: Research Article Source Type: research

GSE243125 Transcriptome analysis of differentially expressed genes by tryptophanyl-tRNA synthetase 1 in human peripheral blood mononuclear cells
Contributors : Yoon T Kim ; Sang M Lee ; Mirim JinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTryptophanyl tRNA synthetase 1 (WARS1) is classically known as an essential housekeeping enzyme that ligates tryptophan to its cognate tRNA for protein synthesis. Interestingly, in the presence of pathogenic infection, WARS1 is immediately released from monocytes into the extracellular space. Secreted WARS1 promotes the innate inflammatory response by activating toll-like receptor (TLR) 2 and TLR4/myeloid differentiation factor-2 (MD-2) signaling. The purpose of this study was to investig...
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE235546 Mutations in AK9 impair male fertility by altering sperm motility in mice and cattle.
Contributors : Elena O'Callaghan ; Paula Navarrete-L ópez ; Maria Maroto ; Miriama Stiavnicka ; Jose M Sanchez ; Eva Pericuesta ; Raúl Fernández-González ; Ciara O'Meara ; Bernard Eivers ; Margaret Kelleher ; Ross D Evans ; Xena M Mapel ; Audald Lloret-Villas ; Hubert Pausch ; Ana Sanchez-Rodriguez ; Eduardo R Roldan ; David A Kenny ; Se an Fair ; Alfonso Gutiérrez-Adán ; Patrick LonerganSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDespite passing routine laboratory tests for semen quality, bulls used in artificial insemination (AI) can exhibit a significant variation in fert...
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research