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Total 478012 results found since Jan 2013.
Impact of tidal volume strategy at birth on initiating lung injury in preterm lambs
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 20. doi: 10.1152/ajplung.00159.2023. Online ahead of print.ABSTRACTTidal ventilation is essential in supporting the transition to air-breathing at birth, but excessive tidal volume (VT) is an important factor in preterm lung injury. Few studies have assessed the impact of specific VT levels on injury development. Here we used a lamb model of preterm birth to investigate the role of different levels of VT during positive pressure ventilation (PPV) in promoting aeration and initiating early lung injury pathways. VT was delivered as; (i) 7ml/kg throughout (VTstatic), (ii) begun at ...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - September 20, 2023 Category: Cytology Authors: Prue M Pereira-Fantini Kelly R Kenna Monique Fatmous Arun Sett Ellen Douglas Sophia Dahm Magdy Sourial Haoyun Fang David W Greening David G Tingay Source Type: research
Mechanisms of action of incretin receptor based dual- and tri-agonists in pancreatic islets
Am J Physiol Endocrinol Metab. 2023 Sep 20. doi: 10.1152/ajpendo.00236.2023. Online ahead of print.ABSTRACTSimultaneous activation of the incretin G protein coupled receptors via unimolecular dual-receptor agonists (UDRA) has emerged as a new therapeutic approach for type 2 diabetes. Recent studies also advocate triple agonism with molecules also capable of binding the glucagon receptor. In this scoping review we discuss the cellular mechanisms of action (MOA) underlying the actions of these novel and therapeutically important classes of peptide receptor agonists. Clinical efficacy studies of several UDRAs have demonstrate...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 20, 2023 Category: Physiology Authors: Franco Folli Giovanna Finzi Roberto Manfrini Alessandra Galli Francesca Casiraghi Lucia Centofanti Cesare Berra Paolo Fiorina Alberto Davalli Stefano La Rosa Carla Perego Paul B Higgins Source Type: research
A Case of Pyoderma Gangrenosum after Partial Small Bowel Resection
This report presents the case of a 55-year-old man who underwent partial small bowel resection for incomplete intestinal obstruction and developed postoperative infection-like manifestations, including redness and swelling of the incision, severe pain, and yellow-green turbid fluid from the drainage tube. After completing a skin biopsy that suggested massive neutrophil infiltration, multiple secretion cultures for Pseudomonas aeruginosa (+), and systemic screening without other comorbidities, a diagnosis of postoperative PG and P aeruginosa infection was determined.Early detection of this complication is essential for pati...
Source: Pain Physician - September 20, 2023 Category: Anesthesiology Authors: Jianing Wang Shiyao Jiang Xin Shi Wenlin Li Qianchun Yu Ting Pan Yuzhu Mu Lingling Chen Source Type: research
AnnexinA6: a potential therapeutic target gene for extracellular matrix mineralization
Front Cell Dev Biol. 2023 Sep 4;11:1201200. doi: 10.3389/fcell.2023.1201200. eCollection 2023.ABSTRACTThe mineralization of the extracellular matrix (ECM) is an essential and crucial process for physiological bone formation and pathological calcification. The abnormal function of ECM mineralization contributes to the worldwide risk of developing mineralization-related diseases; for instance, vascular calcification is attributed to the hyperfunction of ECM mineralization, while osteoporosis is due to hypofunction. AnnexinA6 (AnxA6), a Ca2+-dependent phospholipid-binding protein, has been extensively reported as an essential...
Source: Atherosclerosis - September 20, 2023 Category: Cardiology Authors: Jie Yang Tong Pei Guanyue Su Peiyan Duan Xiaoheng Liu Source Type: research
Real-time characterization of chemical threat agent aerosols for improvement of inhalation studies
CONCLUSIONS: In summary, the present work demonstrates the utility of the ELPI technology, in combination with off-line analysis, for characterizing aerosols with various size, shape, charge, and composition. This makes the aerosol generation and analysis suite described a promising tool for quantitative inhalation exposure studies.PMID:37729079 | DOI:10.1080/08958378.2023.2254323
Source: Inhalation Toxicology - September 20, 2023 Category: Respiratory Medicine Authors: Mirjam de Bruin-Hoeg ée Duurt P W Alkema Ruud W Busker Marloes J A Joosen Arjan L van Wuijckhuijse Source Type: research
Role of the tripartite motif-containing (TRIM) family of proteins in insulin resistance and related disorders
Diabetes Obes Metab. 2023 Sep 19. doi: 10.1111/dom.15294. Online ahead of print.ABSTRACTEmerging evidence suggests that the ubiquitin-mediated degradation of insulin-signalling-related proteins may be involved in the development of insulin resistance and its related disorders. Tripartite motif-containing (TRIM) proteins, a superfamily belonging to the E3 ubiquitin ligases, are capable of controlling protein levels and function by ubiquitination, which is essential for the modulation of insulin sensitivity. Recent research has indicated that some of these TRIMs act as key regulatory factors of metabolic disorders such as ty...
Source: Atherosclerosis - September 20, 2023 Category: Cardiology Authors: Jianrong Chen Xianjie Feng Xu Zhou Yong Li Source Type: research
Impact of Surgical Management for Relapse After Conversion Hepatectomy for Initially Unresectable Colorectal Liver Metastasis: A Retrospective Cohort Study
CONCLUSION: For IU-CRLM patients with liver relapse following conversion hepatectomy, the RLDT is essential for cure and prolonged survival. To avoid missing the opportunity for RLDT, intensive disease surveillance should be proposed.PMID:37730473 | DOI:10.1016/j.clcc.2023.08.007
Source: Clinical Colorectal Cancer - September 20, 2023 Category: Cancer & Oncology Authors: Yijiao Chen Dexiang Zhu Miao Chen Yuqiu Xu Qinghai Ye Xiaoying Wang Pingping Xu Qingyang Feng Meiling Ji Ye Wei Jia Fan Jianmin Xu Source Type: research
ZNF746 promotes M2 macrophage polarisation and favours tumour progression in breast cancer via the Jagged1/Notch pathway
In conclusion, this study uncovers the role of ZNF746 in promoting M2 macrophage polarisation and suggests that ZNF746 may be a promising therapeutic target for limiting BC progression.PMID:37730102 | DOI:10.1016/j.cellsig.2023.110892
Source: Cellular Signalling - September 20, 2023 Category: Cytology Authors: Lu Liu Wen-Yue Zhao Xin-Yu Zheng Source Type: research
Comparative Studies of Essential Oil Composition and Biological Activities of Callistemon citrinus from western Himalaya
Chem Biodivers. 2023 Sep 20:e202301129. doi: 10.1002/cbdv.202301129. Online ahead of print.ABSTRACTThis work described a comprehensive study to estimate chemical constituents of essential oils (EOs) extracted from different parts of the Callistemon citrinus viz: fruits, leaves and aerial part. The EOs were characterized using physicochemical parameters, and GC-FID/MS. It was observed that among different parts, aerial part has the highest oil yield (0.90%) followed by leaves and fruits. Further, seventeen compounds were characterized, and represented total amount (97.2-99.5%) with domination of monoterpenes (12.5-34.6%) an...
Source: Chemistry and Biodiversity - September 20, 2023 Category: Biochemistry Authors: Sachin Vashisath Smita Kapoor Vandana Kumari Shabana Butt Dinesh Kumar Source Type: research
A Novel pyroptosis-related signature for predicting prognosis and evaluating tumor immune microenvironment in ovarian cancer
J Ovarian Res. 2023 Sep 20;16(1):196. doi: 10.1186/s13048-023-01275-2.ABSTRACTOvarian cancer (OV) is the most fatal gynecological malignant tumor worldwide, with high recurrence rates and great heterogeneity. Pyroptosis is a newly-acknowledged inflammatory form of cell death with an essential role in cancer progression, though studies focusing on prognostic patterns of pyroptosis in OV are still lacking. Our research filtered 106 potential pyroptosis-related genes (PRGs) among the 6406 differentially expressed genes (DEGs) between the 376 TCGA-OV samples and 180 normal controls. Through the LASSO-Cox analysis, the 6-gene p...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Jiani Yang Chao Wang Yue Zhang Shanshan Cheng Yanna Xu Yu Wang Source Type: research
Time-course transcriptome analysis of a double challenge bleomycin-induced lung fibrosis rat model uncovers ECM homoeostasis-related translationally relevant genes
CONCLUSIONS: The model of lung fibrosis presented in this study lends itself as a valuable tool for preclinical efficacy evaluation of new potential drug candidates. The main finding was the identification of a group of persistently dysregulated genes, mostly related to ECM homoeostasis, which are shared with human IPF.PMID:37730279 | DOI:10.1136/bmjresp-2022-001476
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Martina Bonatti Vanessa Pitozzi Paola Caruso Silvia Pontis Maria Gloria Pittelli Caterina Frati Chiara Mangiaracina Costanza Anna Maria Lagrasta Federico Quaini Simona Cantarella Simone Ottonello Gino Villetti Maurizio Civelli Barbara Montanini Marcello T Source Type: research
Cisplatin-induced DNA crosslinks trigger neurotoxicity in C. elegans
Biochim Biophys Acta Mol Cell Res. 2023 Sep 18:119591. doi: 10.1016/j.bbamcr.2023.119591. Online ahead of print.ABSTRACTThe anticancer drug cisplatin (CisPt) injures post-mitotic neuronal cells, leading to neuropathy. Furthermore, CisPt triggers cell death in replicating cells. Here, we aim to unravel the relevance of different types of CisPt-induced DNA lesions for evoking neurotoxicity. To this end, we comparatively analyzed wild-type and loss of function mutants of C. elegans lacking key players of specific DNA repair pathways. Deficiency in ercc-1, which is essential for nucleotide excision repair (NER) and interstrand...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Fabian Wynen Johannes Krautstrunk Lisa Marie M üller Viktoria Graf Vanessa Brinkmann Gerhard Fritz Source Type: research
Optimizing Mental Health for Women: Recognizing and Treating Mood Disorders Throughout the Lifespan
J Clin Psychiatry. 2023 Sep 18;84(5):vtsmdd2136ahc. doi: 10.4088/JCP.vtsmdd2136ahc.ABSTRACTMood disorders can come and go during the reproductive stages of a woman's life and beyond and can include premenstrual-related mood disorders, depression and other psychiatric disorders during pregnancy, postpartum mood disorders, and depression during menopause, as well as comorbid psychiatric conditions. Women may have regular contact with health care providers at these various stages in their lives, providing an opportunity for treatment intervention. However, clinicians struggle to effectively identify and manage these disorders...
Source: Journal of Clinical Psychiatry - September 20, 2023 Category: Psychiatry Authors: Kathryn M Abel Marlene P Freeman Source Type: research
Mechanisms of action of incretin receptor based dual- and tri-agonists in pancreatic islets
Am J Physiol Endocrinol Metab. 2023 Sep 20. doi: 10.1152/ajpendo.00236.2023. Online ahead of print.ABSTRACTSimultaneous activation of the incretin G protein coupled receptors via unimolecular dual-receptor agonists (UDRA) has emerged as a new therapeutic approach for type 2 diabetes. Recent studies also advocate triple agonism with molecules also capable of binding the glucagon receptor. In this scoping review we discuss the cellular mechanisms of action (MOA) underlying the actions of these novel and therapeutically important classes of peptide receptor agonists. Clinical efficacy studies of several UDRAs have demonstrate...
Source: Am J Physiol Endocri... - September 20, 2023 Category: Endocrinology Authors: Franco Folli Giovanna Finzi Roberto Manfrini Alessandra Galli Francesca Casiraghi Lucia Centofanti Cesare Berra Paolo Fiorina Alberto Davalli Stefano La Rosa Carla Perego Paul B Higgins Source Type: research
Multidimensional Analysis of a Cell-Free DNA Whole Methylome Sequencing Assay for Early Detection of Gastric Cancer: Protocol for an Observational Case-Control Study
CONCLUSIONS: This is the first registered case-control study designed to investigate a stacked ensemble model integrating several cfDNA features generated from a bisulfite-free whole methylome sequencing assay. These features include methylation patterns, fragmentation profiles, and chromosomal copy number changes, with the aim of identifying the GC population. This study will determine whether multidimensional analysis of cfDNA will prove to be an effective strategy for distinguishing patients with GC from nonmalignant individuals within the Chinese population. We anticipate the THEMIS model will complement the standard-o...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Yongjun Han Jiangpeng Wei Weidong Wang Ruiqi Gao Ning Shen Xiaofeng Song Yang Ni Yulong Li Li-Di Xu Weizhi Chen Xiaohua Li Source Type: research
