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Effect of the mGlu4 positive allosteric modulator ADX-88178 on parkinsonism, psychosis-like behaviours and dyskinesia in the MPTP-lesioned marmoset
ConclusionsWhereas these results provide additional evidence of the anti-parkinsonian and anti-dyskinetic effects of mGlu4 positive allosteric modulation as an adjunct to L-DOPA, they also suggest that ADX-88178 may exacerbate dopaminergic psychosis. Further studies are needed to evaluate this possible adverse effect of mGlu4 PAMs on PD psychosis.
Source: Psychopharmacology - September 21, 2023 Category: Psychiatry Source Type: research
Operations at WHO ’s logistics hub in Dubai reach an unprecedented scale and impact, says new ...
21 September 2023, Cairo, Egypt – WHO has released an innovative, interactive report that provides insights into the vast operations and global impact of WHO’s logistics hub in Dubai, United Arab Emirates. The new report reveals the logistics hub’s impressive ability to provide support on an unprecedented scale, and its swift, adaptable response to humanitarian crises. This reinforces its vital role in WHO emergency response efforts across the WHO Eastern Mediterranean Region and beyond.
Report on WHO’s logistics hub in Dubai
“The supplies delivered by WHO’s logistics hub in Dubai have been a...
Source: WHO EMRO News - September 21, 2023 Category: Middle East Health Source Type: news
Addressing the Mental Health Crisis: Why Personalized Digital Solutions Are Essential To Meet Growing Demand
The following is a guest article by Byron Crowe, MD, Chief Medical Officer at Solera
Demand for mental services has never been higher, and an ongoing shortage of psychiatrists and psychologists is preventing millions of Americans from timely access to mental health services. And the timing couldn’t be worse — findings from Solera Health’s recent Mental Health Index, a nationally representative survey of over 3,000 U.S. adults, found that 42% of Americans continue to be bothered by symptoms of anxiety and depression, a staggering figure that remains substantially elevated from pre-pandemic numbers. Moreover, these sym...
Source: EMR and HIPAA - September 21, 2023 Category: Information Technology Authors: Guest Author Tags: Healthcare IT Telemedicine and Remote Monitoring CBT Cognitive Behavioral Therapy Digital CBT Digital Mental Health Tools Dr. Byron Crowe M.D. Healthcare Barriers Personalized Healthcare Solera Solera Network Teletherapy Therapist Source Type: blogs
Rapid and sensitive determination of folic acid by facile synthesized dsDNA-CuNCs fluorescent probe
New J. Chem., 2023, Advance Article DOI: 10.1039/D3NJ02363J, PaperLuyao Liu, Yuchen Luo, Xuebing Zhang, Bo Deng, Deshuai Zhen, Zhangye Zhou, Hongbin Xie, Hao Liang, Lili Chen Folic acid (FA) is one of the essential vitamins for the growth and reproduction of human cells, and it is of great significance to detect FA in real time. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - September 21, 2023 Category: Chemistry Authors: Luyao Liu Source Type: research
What Early Career Hospitalists View as Essential in HMFE What Early Career Hospitalists View as Essential in HMFE
This study surveyed early career hospitalists to get their views.Southern Medical Journal
Source: Medscape Today Headlines - September 21, 2023 Category: Consumer Health News Tags: Hospital Medicine Journal Article Source Type: news
China just stopped exporting two minerals the world ’s chipmakers need
Editor’s Note: Sign up for CNN’s Meanwhile in China newsletter which explores what you need to know about the country’s rise and how it impacts the world. China’s exports of two rare minerals essential for manufacturing semiconductors fell to zero in August, a month after Beijing imposed curbs on…#beijing #heyadong #eurasiagroup #shanghaimetalmarket #netherlands #micron #huawei #smic #jefferies
Source: Reuters: Health - September 21, 2023 Category: Consumer Health News Source Type: news
Simultaneous Targeting of IL-1-Signaling and IL-6-Trans-Signaling Preserves Human Pulmonary Endothelial Barrier Function During a Cytokine Storm
CONCLUSIONS: These findings strongly suggest a major role for both IL-6 trans-signaling and IL-1β signaling in the pathological increase in permeability of the human lung microvasculature and reveal combinatorial strategies that enable the gradual control of pulmonary endothelial barrier function in response to a cytokine storm.PMID:37732482 | DOI:10.1161/ATVBAHA.123.319695
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 21, 2023 Category: Cardiology Authors: Natalia Col ás-Algora Pablo Mu ñoz-Pinillos Cristina Cacho-Navas Jos é Avendaño-Ortiz Gema de Rivas Susana Barroso Eduardo L ópez-Collazo Jaime Mill án Source Type: research
Elevated profiles of peripheral Th22, Th17, Th2 cells, and decreased percentage of Th1 cells in breast cancer patients
CONCLUSION: Th22, Th17, Th1, and Th2 subsets may play an essential role in BC patients. Th22, Th17, Th1, and Th2 cells may have potential significance to be used as clinical markers in BC patients with different molecular classification. Th22 cells may have potential value in BC patients' outcomes prediction, providing clinical value.PMID:37732365 | DOI:10.1111/1759-7714.15119
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Zhiguo Peng Xinyue Dong Miao He Yajing Zhao Yujia Liu Mo Li Guosheng Li Xiuwen Wang Li Li Yu Hu Source Type: research
Tetrahydrobiopterin from cyanide-degrading bacterium Bacillus pumilus strain SVD06 induces apoptosis in human lung adenocarcinoma cell (A549)
Biotechnol Appl Biochem. 2023 Sep 20. doi: 10.1002/bab.2509. Online ahead of print.ABSTRACTTetrahydrobiopterin (BH4) is an essential biological cofactor and a derivative of pterin which is considered potent anticancer agents. In continuation of our previous study on the identification of BH4 from cyanide-degrading Bacillus pumilus, the present study focuses on evaluating the anticancer properties of BH4 on A549, a human lung adenocarcinoma. Anticancer activity analysis shows that BH4 inhibited A549 cell growth after 24 h of incubation with 0.02 mg/mL. In acridine orange/ethidium bromide staining, BH4-treated A549 cells sho...
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Ramasamy Mahendran Sanjay Prasad Selvaraj Anand Raj Dhanapal Sabna Bhaskaran Sarasa Beutline Malgija Mathias Bency Thankappan Daniel Raja Femil Selta Palanivel Naveen Rhenghachar Poorani Navaneethan Sundhar Mamatha M Pillai Rajendran Selvakumar Chih-Yang Source Type: research
Nutrition-associated health levels in persons with cancer: item response modelling based on the International Classification of Functioning, Disability and Health
CONCLUSIONS: The study constructed an evidence-based ICF scale for nutrition conditions in patients with cancer with 32-item and 2PLM for evaluating nutrition-associated health level in persons with cancer, including high validity and reliability.CLINICAL REHABILITATION IMPACT: The IRT model based on ICF provided a promising assessment tool to discriminate nutrition-associated health level of persons with cancer, and offered an auxiliary method for selecting rehabilitation intervention targets. This has the potential to lead to improved outcomes in cancer treatment and increased quality of life for cancer survivors.PMID:37...
Source: Methods of Information in Medicine - September 21, 2023 Category: Information Technology Authors: Jin-Jin Chen Zi-Yan Zhu Jia-Jia Bian Feng Lin Source Type: research
Role of three-dimensional transesophageal echocardiography in cardiac myxomas: an imaging challenge
Monaldi Arch Chest Dis. 2023 Sep 19. doi: 10.4081/monaldi.2023.2768. Online ahead of print.ABSTRACTNowadays, the diagnosis of cardiac myxomas (CM), particularly the histological types, remains a challenge. Two-dimensional (2D) transthoracic (TT) and transesophageal (TEE) echocardiography (ECHO) represent the first steps in the imaging pathway. 3D ECHO, implemented in imaging practice, appears to be an emerging diagnostic technique that overcomes some of the limitations of 2D ECHO while integrating the information provided by magnetic resonance (MRI). However, its role in the imaging arena is still debatable. Analyzing 17 m...
Source: Monaldi Archives for Chest Disease - September 21, 2023 Category: Respiratory Medicine Authors: Bandar Alamro Valeria Pergola Abdalla Eltayeb Amal Alshammari Naji Kholaif Ahmad Alhamshari Mohammed Al Admawi Shamayel Mohammed Feras Khaliel Domenico Galzerano Source Type: research
Deuterium Magnetic Resonance Imaging Using Deuterated Water-Induced 2H-Tissue Labeling Allows Monitoring Cancer Treatment at Clinical Field Strength
CONCLUSIONS: Deuterium MRI at 1.5T proved feasibility to track 2H distribution throughout mouse tissues during D2O administration and revealed a higher 2H accumulation in the tumor xenografts. This research demonstrated a promising successful method for preliminary assessment of radiotherapy and chemotherapy of cancer.PMID:37732903 | DOI:10.1158/1078-0432.CCR-23-1635
Source: Clinical Colorectal Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Hirofumi Asano Abdelazim Elsayed Elhelaly Fuminori Hyodo Ryota Iwasaki Yoshifumi Noda Hiroki Kato Koki Ichihashi Hiroyuki Tomita Masaharu Murata Takashi Mori Masayuki Matsuo Source Type: research
Emotional intelligence in preregistration nurse education
This article details a literature review that was undertaken to explore EI in preregistration nurse education and to identify effective methods for developing nursing students' EI skills. A total of 12 articles were included in the review, from which data were extracted, compared and categorised. Three main areas were identified regarding EI in preregistration nurse education: EI constructs, EI components and EI teaching methods. The review found that a range of EI constructs and components may be included in nurse education curricula, meaning that there is often inconsistency in the approaches used. Classroom teaching met...
Source: Nursing Standard - September 21, 2023 Category: Nursing Authors: Marwan Hamad Russell Gurbutt Source Type: research
Involving patients and the public in nursing PhD projects: practical guidance, potential benefits and points to consider
CONCLUSION: Patients and the public should be involved in nursing PhD projects. Not only does this improve the quality of the research and raise the profile of nursing research, but it provides the opportunity for students to learn skills that they can develop further throughout their academic careers.IMPLICATIONS FOR PRACTICE: Obtaining high-quality patient and public involvement is an important skill for nurse researchers. The first steps in acquiring this skill should be taken during research training.PMID:37731298 | DOI:10.7748/nr.2023.e1891
Source: Nurse Researcher - September 21, 2023 Category: Nursing Authors: Chris McParland Bridget Johnston Bahaa Alassoud Maria Drummond Annabel Farnood Chandra Isabella Hostanida Purba Muzeyyen Seckin Saengrawee Thanthong Source Type: research
Deuterium Magnetic Resonance Imaging Using Deuterated Water-Induced 2H-Tissue Labeling Allows Monitoring Cancer Treatment at Clinical Field Strength
CONCLUSIONS: Deuterium MRI at 1.5T proved feasibility to track 2H distribution throughout mouse tissues during D2O administration and revealed a higher 2H accumulation in the tumor xenografts. This research demonstrated a promising successful method for preliminary assessment of radiotherapy and chemotherapy of cancer.PMID:37732903 | DOI:10.1158/1078-0432.CCR-23-1635
Source: Clinical Cancer Research - September 21, 2023 Category: Cancer & Oncology Authors: Hirofumi Asano Abdelazim Elsayed Elhelaly Fuminori Hyodo Ryota Iwasaki Yoshifumi Noda Hiroki Kato Koki Ichihashi Hiroyuki Tomita Masaharu Murata Takashi Mori Masayuki Matsuo Source Type: research
