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Computed Tomography and Magnetic Resonance Imaging Findings of Bicuspid Aortic Valve and Related Abnormalities of the Heart and Thoracic Aorta
Korean J Radiol. 2023 Sep 14. doi: 10.3348/kjr.2023.0312. Online ahead of print.ABSTRACTThe bicuspid aortic valve (BAV) is the most common congenital cardiovascular malformation. Patients with BAV are at higher risk of other congenital cardiovascular malformations and valvular dysfunction, including aortic stenosis/regurgitation and infective endocarditis. BAV may also be related to aortic wall abnormalities such as aortic dilatation, aneurysm, and dissection. The morphology of the BAV varies with the presence and position of the raphe and is associated with the type of valvular dysfunction and aortopathy. Therefore, accur...
Source: Korean Journal of Radiology - September 19, 2023 Category: Radiology Authors: You Jin You Sung Min Ko Source Type: research
CSNK1A1/CK1 α suppresses autoimmunity by restraining the CGAS-STING1 signaling
Autophagy. 2023 Sep 18:1-18. doi: 10.1080/15548627.2023.2256135. Online ahead of print.ABSTRACTSTING1 (stimulator of interferon response cGAMP interactor 1) is the quintessential protein in the CGAS-STING1 signaling pathway, crucial for the induction of type I IFN (interferon) production and eliciting innate immunity. Nevertheless, the overactivation or sustained activation of STING1 has been closely associated with the onset of autoimmune disorders. Notably, the majority of these disorders manifest as an upregulated expression of type I interferons and IFN-stimulated genes (ISGs). Hence, strict regulation of STING1 activi...
Source: Autophagy - September 19, 2023 Category: Cytology Authors: Mingyu Pan Tongyu Hu Jiao Lyu Yue Yin Jing Sun Quanyi Wang Lingxiao Xu Haiyang Hu Chen Wang Source Type: research
Preoperative estimation of retinal hole location using ultra-wide-field imaging
CONCLUSION: It is feasible to locate retinal holes using UWF fundus photography before SB, which is helpful for quick localization, thereby reducing the learning curve of SB surgery.PMID:37725940 | DOI:10.1080/07853890.2023.2258790
Source: Annals of Medicine - September 19, 2023 Category: Internal Medicine Authors: Donghui Li Nalei Zhou Rui Gao Jialiang Duan Qingli Shang Source Type: research
Effect of interferon- α on COVID-19 in-hospital mortality: a large-scale propensity score-matched study
CONCLUSION: Our findings indicate that subcutaneous administration of IFN-α, with or without remdesivir, does not have any significant impact on COVID-19 mortality and ICU admission. Future clinical trials considering the time, subtype, and form of IFN-α administration are warranted to investigate the potential therapeutic effects of IFN-α on COVID-19.PMID:37724852 | DOI:10.1684/ecn.2023.0485
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Mohamad Amin Pourhoseingholi Amirreza Rafiei Javazm Naghmeh Asadimanesh Fatemeh Shojaeian Mehdi Azizmohammad Looha Seyed Amir Ahmad Safavi-Naini Benyamin Mohammadzadeh Parnian Jamshidi Fatemeh Gholampoor Omid Yazdani Nadia Zameni Zahra Azizan Amirhossein Source Type: research
Low dose of levetiracetam counteracts amyloid β-induced alterations of hippocampal gamma oscillations by restoring fast-spiking interneuron activity
Exp Neurol. 2023 Sep 17:114545. doi: 10.1016/j.expneurol.2023.114545. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is characterized at an early stage by memory alterations that worsen during the development of the disease. Several clinical trials in phase 3 have failed despite being able to counteract classical AD-related alterations, possibly because of the lack of recovery of the regular neuronal network activity essential for memory including low gamma oscillations (γ-Osc). Nowadays, Levetiracetam (LEV), an SV2A modulator approved for epilepsy, is being used in trials with AD patients without further support ...
Source: Experimental Neurology - September 19, 2023 Category: Neurology Authors: Arturo G Isla Hugo Balleza-Tapia Fengna Chu Gefei Chen Janne Johansson Per Nilsson Andr é Fisahn Source Type: research
Preclinical evaluation of a SARS-CoV-2 variant B.1.351-based candidate DNA vaccine
Vaccine. 2023 Sep 17:S0264-410X(23)01091-5. doi: 10.1016/j.vaccine.2023.09.021. Online ahead of print.ABSTRACTThe SARS-CoV-2 pandemic revealed the critical shortfalls of global vaccine availability for emergent pathogens and the need for exploring additional vaccine platforms with rapid update potential in response to new variants. Thus, it remains essential, for the present evolving SARS-CoV-2/Covid-19 and future pandemics, to continuously develop and characterize new and different vaccine platforms. Here, we describe an expression-optimized DNA vaccine candidate based on the SARS-CoV-2 spike protein of the Beta variant (...
Source: Vaccine - September 19, 2023 Category: Allergy & Immunology Authors: Ria Lassauni ère Charlotta Polacek Jeanette Linnea Tingstedt Anders Fomsgaard Source Type: research
Foxn1 is not essential for T cell development in teleosts
This article is protected by copyright. All rights reserved.PMID:37724048 | DOI:10.1002/eji.202350725
Source: European Journal of Immunology - September 19, 2023 Category: Allergy & Immunology Authors: Michael Schorpp Jeremy B Swann Isabell Hess Hsuan-Ching Ho Theodore W Pietsch Thomas Boehm Source Type: research
A Review on the Antibiotic Resistance of < em > Shigella < /em > Strains in Iran
Infect Disord Drug Targets. 2023 Aug 31. doi: 10.2174/1871526523666230811093114. Online ahead of print.ABSTRACTShigella infection is commonly related to diarrhea and has been a noteworthy source of morbidity and mortality worldwide. There is a wide range of symptoms associated with these contagious microorganisms, from watery diarrhea to fulminant dysentery manifesting with recurrent bloody stools, fever, and prostration. While the mortality rate from Shigellosis has decreased significantly during the past three decades, it remains a principal cause of death in the world. The use of antibiotics in Shigella treatment remark...
Source: Infectious Disorders Drug Targets - September 19, 2023 Category: Infectious Diseases Authors: Mahdi Shooraj Marziye Taheri Mohammadmahdi Karimi-Yazdi Source Type: research
Heparin-collagen I bilayers stimulate FAK/ERK ½ signaling via α2β1 integrin to support the growth and anti-inflammatory potency of mesenchymal stromal cells
J Biomed Mater Res A. 2023 Sep 18. doi: 10.1002/jbm.a.37614. Online ahead of print.ABSTRACTUnderstanding mesenchymal stromal cells (MSCs) growth mechanisms in response to surface chemistries is essential to optimize culture methods for high-quality and robust cell yields in cell manufacturing applications. Heparin (HEP) and collagen 1 (COL) substrates have been reported to enhance cell adhesion, growth, viability, and secretory potential in MSCs. However, the biomolecular mechanisms underlying the benefits of combined HEP/COL substrates are unknown. This work used HEP/COL bilayered surfaces to investigate the role of integ...
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Said J Cifuentes Maribella Domenech Source Type: research
The role of psychological factors in the development and treatment of infertility
Neuropsychopharmacol Hung. 2023 Sep;25(3):123-130.ABSTRACTInfertility can be caused by several factors, thus the effective treatment of infertility is a complex and multidisciplinary task. While psychological support is an essential part of infertility treatment, there is growing evidence that the role of psychological factors is much greater, as personality and psychological factors have a significant impact on the development, long-term course, and treatment success of several somatic diseases. Exploring the possible mechanisms through which these psychological factors directly or indirectly contribute to infertility and...
Source: Neuropsychopharmacologia Hungarica - September 19, 2023 Category: Psychiatry Authors: Georgina Szabo Judit F Szigeti Szabolcs Varbiro Xenia Gonda Source Type: research
Effect of interferon- α on COVID-19 in-hospital mortality: a large-scale propensity score-matched study
CONCLUSION: Our findings indicate that subcutaneous administration of IFN-α, with or without remdesivir, does not have any significant impact on COVID-19 mortality and ICU admission. Future clinical trials considering the time, subtype, and form of IFN-α administration are warranted to investigate the potential therapeutic effects of IFN-α on COVID-19.PMID:37724852 | DOI:10.1684/ecn.2023.0485
Source: European Cytokine Network - September 19, 2023 Category: Molecular Biology Authors: Mohamad Amin Pourhoseingholi Amirreza Rafiei Javazm Naghmeh Asadimanesh Fatemeh Shojaeian Mehdi Azizmohammad Looha Seyed Amir Ahmad Safavi-Naini Benyamin Mohammadzadeh Parnian Jamshidi Fatemeh Gholampoor Omid Yazdani Nadia Zameni Zahra Azizan Amirhossein Source Type: research
Amphipathic Helical Peptide L37-pA Protects Against Lung Vascular Endothelial Dysfunction Caused by Truncated Oxidized Phospholipids via Antagonism with CD36 Receptor
Am J Respir Cell Mol Biol. 2023 Sep 19. doi: 10.1165/rcmb.2023-0127OC. Online ahead of print.ABSTRACTGeneration of bioactive truncated oxidized phospholipids (Tr-OxPLs) from oxidation of cell membrane or circulating lipoproteins is a common feature of various pathological states. Scavenger receptor CD36 is involved in lipid transport and acts as a ligand for Tr-OxPLs. Interestingly, both Tr-OxPLs and CD36 are involved in endothelial dysfunction-derived acute lung injury but precise mechanistic connections remain unexplored. In the present study, we investigated the role of CD36 in mediating pulmonary endothelial cell (EC) ...
Source: American Journal of Respiratory Cell and Molecular Biology - September 19, 2023 Category: Molecular Biology Authors: Pratap Karki Yue Li Chen-Ou Zhang Yunbo Ke Kamoltip Promnares Anna A Birukova Thomas L Eggerman Alexander V Bocharov Konstantin G Birukov Source Type: research
YY1 is regulated by ALKBH5-mediated m6A modification and promotes autophagy and cancer progression through targeting ATG4B
This study aimed to assess the essential transcription factors (TFs) involved in autophagy regulation in GC. Western blot, RFP-GFP-LC3 double fluorescence and transmission electron microscopy (TEM) assays were used to probe autophagy activity in GC cells. Methylated RNA immunoprecipitation (MeRIP) was utilized to evaluate the ALKBH5-regulated m6A levels of YY1. Gain- and loss-of-function assays were employed in the scrutiny of the biological effects of the ALKBH5/YY1/ATG4B axis on cancer cell proliferation and invasion abilities in vitro. Per the findings, YY1 was identified as a crucial transcriptional activator of cancer...
Source: Aging - September 19, 2023 Category: Biomedical Science Authors: Shijiang Wang Jiangbo Nie Kaiying Xu Yangyang Liu Weilai Tong Anan Li Wei Zuo Zhili Liu Feng Yang Source Type: research
Heparin-collagen I bilayers stimulate FAK/ERK ½ signaling via α2β1 integrin to support the growth and anti-inflammatory potency of mesenchymal stromal cells
J Biomed Mater Res A. 2023 Sep 18. doi: 10.1002/jbm.a.37614. Online ahead of print.ABSTRACTUnderstanding mesenchymal stromal cells (MSCs) growth mechanisms in response to surface chemistries is essential to optimize culture methods for high-quality and robust cell yields in cell manufacturing applications. Heparin (HEP) and collagen 1 (COL) substrates have been reported to enhance cell adhesion, growth, viability, and secretory potential in MSCs. However, the biomolecular mechanisms underlying the benefits of combined HEP/COL substrates are unknown. This work used HEP/COL bilayered surfaces to investigate the role of integ...
Source: Biomed Res - September 19, 2023 Category: Research Authors: Said J Cifuentes Maribella Domenech Source Type: research
Computed Tomography and Magnetic Resonance Imaging Findings of Bicuspid Aortic Valve and Related Abnormalities of the Heart and Thoracic Aorta
Korean J Radiol. 2023 Sep 14. doi: 10.3348/kjr.2023.0312. Online ahead of print.ABSTRACTThe bicuspid aortic valve (BAV) is the most common congenital cardiovascular malformation. Patients with BAV are at higher risk of other congenital cardiovascular malformations and valvular dysfunction, including aortic stenosis/regurgitation and infective endocarditis. BAV may also be related to aortic wall abnormalities such as aortic dilatation, aneurysm, and dissection. The morphology of the BAV varies with the presence and position of the raphe and is associated with the type of valvular dysfunction and aortopathy. Therefore, accur...
Source: Korean J Radiol - September 19, 2023 Category: Radiology Authors: You Jin You Sung Min Ko Source Type: research
