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How Could Digital Technology Make An Impact On Primary Care?
I truly hope that very soon I do not have to make an appointment at the GP when I suspect signs of a disease, but my GP will send me a message that she spotted something irregular in my latest test results and my digital health data, so I’d better visit. Let me show you in detail how primary care should be carried out in the future!
Digital health should become an organic part of primary care in the future
I live a fairly healthy life. I use data to improve my lifestyle and to make better decisions by optimising my sleep pattern, my physical, my cognitive or my emotional abilities; and I had several genetic tests....
Source: The Medical Futurist - September 21, 2023 Category: Information Technology Authors: berci.mesko Tags: Digital Health Research Healthcare Innovation technology wearables GP primary care general practitioner Source Type: blogs
Synthetic cannabinoids in hair —Prevalence of use in abstinence control programs for driver's license regranting in Germany
Synthetic cannabinoids (SCs) have steadily increased on the drug market but are rarely analyzed in abstinence control programs for driver's license regranting. Between March 2020 and March 2021, hair samples from this collective were retrospectively screened for SCs by liquid chromatography –tandem mass spectrometry (LC–MS/MS) analysis, and those testing positive were additionally screened by liquid chromatography-high resolution time of flight mass spectrometry (LC-qTOF/MS). AbstractAlthough the use, structural variety, and prevalence of synthetic cannabinoids (SCs) have steadily increased on the drug market, they are...
Source: Drug Testing and Analysis - September 21, 2023 Category: Drugs & Pharmacology Authors: Johannes Kutzler,
Aldo Eliano Polettini,
Sergej Bleicher,
Christoph Sauer,
Wolfgang Schultis,
Merja A. Neukamm,
Volker Auw ärter Tags: RESEARCH ARTICLE Source Type: research
Mitochondrial protein and organelle quality control —Lessons from budding yeast
AbstractMitochondria are essential for normal cellular function and have emerged as key aging determinants. Indeed, defects in mitochondrial function have been linked to cardiovascular, skeletal muscle and neurodegenerative diseases, premature aging, and age-linked diseases. Here, we describe mechanisms for mitochondrial protein and organelle quality control. These surveillance mechanisms mediate repair or degradation of damaged or mistargeted mitochondrial proteins, segregate mitochondria based on their functional state during asymmetric cell division, and modulate cellular fitness, the response to stress, and lifespan co...
Source: IUBMB Life - September 21, 2023 Category: Research Authors: Emily Jie ‐Ning Yang,
Pin‐Chao Liao,
Liza Pon Tags: SPECIAL ISSUE Source Type: research
Tetrahydrobiopterin from cyanide ‐degrading bacterium Bacillus pumilus strain SVD06 induces apoptosis in human lung adenocarcinoma cell (A549)
AbstractTetrahydrobiopterin (BH4) is an essential biological cofactor and a derivative of pterin which is considered potent anticancer agents. In continuation of our previous study on the identification of BH4 from cyanide-degradingBacillus pumilus, the present study focuses on evaluating the anticancer properties of BH4 on A549, a human lung adenocarcinoma. Anticancer activity analysis shows that BH4 inhibited A549 cell growth after 24 h of incubation with 0.02 mg/mL. In acridine orange/ethidium bromide staining, BH4-treated A549 cells showed apoptotic morphology. BH4 treatment caused cell cycle arrest at G0/G1 phase c...
Source: Biotechnology and Applied Biochemistry - September 21, 2023 Category: Biochemistry Authors: Ramasamy Mahendran,
Sanjay Prasad Selvaraj,
Anand Raj Dhanapal,
Sabna Bhaskaran sarasa,
Beutline Malgija Mathias,
Bency Thankappan,
Daniel Raja Femil Selta,
Palanivel Naveen,
Rhenghachar Poorani,
Navaneethan Sundhar,
Mamatha M. Pillai,
Rajendra Tags: ORIGINAL ARTICLE Source Type: research
3D salient object detection based on light field integral imaging
Potent usage of the multi-scale light field information for salient object detection (SOD) is the essential requirement of ...
Source: Optics Letters - September 21, 2023 Category: Physics Authors: Yu Kou Junfeng Guo Shouxin Liu Chongyang Zhang Chongji Zhao Ying Li Qiang Li Seok-Tae Kim Xiaowei Li Source Type: research
GSE243398 Inhibition of the Chromatin Remodeling Factor NURF Rescued Sterility by a Clinic Variant of NuRD RNA-seq
Contributor : Zijie ShenSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansThe nucleosome remodeling and deacetylase (NuRD) complex is essential for gene expression and cell fate determination, and missense mutations of NuRD caused neurodevelopmental diseases. However, the molecular pathogenesisof clinic NuRD variants is unknown. Here, we introduced a clinic CHD3(L915F) variant into C. elegans homolog LET-418, impairing germline and vulva development and ultimately causing animal sterility. Our ATAC-seq and RNA-seq analyses revealed that this variant generated an abnormal open ...
Source: GEO: Gene Expression Omnibus - September 21, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Caenorhabditis elegans Source Type: research
GSE243397 Inhibition of the Chromatin Remodeling Factor NURF Rescued Sterility by a Clinic Variant of NuRD ATAC-seq
Contributor : Zijie ShenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Caenorhabditis elegansThe nucleosome remodeling and deacetylase (NuRD) complex is essential for gene expression and cell fate determination, and missense mutations of NuRD caused neurodevelopmental diseases. However, the molecular pathogenesisof clinic NuRD variants is unknown. Here, we introduced a clinic CHD3(L915F) variant into C. elegans homolog LET-418, impairing germline and vulva development and ultimately causing animal sterility. Our ATAC-seq and RNA-seq analyses revealed that this variant generated an ...
Source: GEO: Gene Expression Omnibus - September 21, 2023 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Caenorhabditis elegans Source Type: research
Influence of motivational interviewing on postoperative mobilization in the ERAS ® pathway in elective bowel surgery - a randomized blinded pilot study
This study aims to test the hypothesis that MI can improve postoperative mobilization.
Source: Clinical Nutrition ESPEN - September 21, 2023 Category: Nutrition Authors: Rico Wiesenberger, Julian M üller, Mario Kaufmann, Christel Weiß, Sandra Weber, Christoph Reissfelder, Florian Herrle Source Type: research
Patient blood management, an essential step in enhanced recovery after surgery programs
Background: The aim of perioperative medicine is to provide comprehensive, patient-centred care through 2 multimodal, multidimensional programmes: enhanced recovery after surgery (ERAS) and patient blood management (PBM). The aim of ERAS programmes is to improve outcomes and optimize patient recovery by reducing the stress response to surgery. The aim of PBM programmes is to improve outcomes by boosting and conserving the patient's own blood. Both programmes require a multidisciplinary effort throughout the perioperative process, which often makes their actual implementation difficult.
Source: Clinical Nutrition ESPEN - September 21, 2023 Category: Nutrition Authors: Guillermo Puig, Esther Mendez, Marta Barquero, Ariadna Leon, Javier Bellafont, Maria Jos é Colomina Source Type: research
Preoperative education is associated with adherence to individual components of enhanced recovery
This study aimed to evaluate the association between adherence to preoperative education and adherence to downstream components of ERPs.
Source: Clinical Nutrition ESPEN - September 21, 2023 Category: Nutrition Authors: Bayley A. Jones, Lauren Wood, Burkely P. Smith, Robert H. Hollis, Michael Rubyan, Daniel I. Chu Source Type: research
A cross-sectional survey of gastroenterology trainees in the United Kingdom: experiences, confidence and satisfaction in Nutrition Training
Nutrition is an essential part of Gastroenterology Higher Specialist Training although there is limited evidence regarding trainee experiences in this area. The introduction of the new curriculum for training in Gastroenterology in the United Kingdom will reduce training duration overall which may lead to reduced exposure to this subspeciality. We aimed to explore current experiences, confidence, and satisfaction in Nutrition training to inform future improvements in the curriculum and the content of additional training courses offered.
Source: Clinical Nutrition ESPEN - September 21, 2023 Category: Nutrition Authors: S. Sartain, C. Wong, E. Murray, L. Dyall, F. Kokwaro, S.A. Raju, BAPEN trainees committee, E. Clarke Source Type: research
Maintained ERAS compliance and outcomes after major colorectal cancer surgery in a designated cold site hospital during the SARS-CoV-2 pandemic
Background: The SARS-CoV-2 pandemic overwhelmed health systems during spring 2020. The concept of cold site hospitals emerged: infection-free centres providing essential non-COVID-19 health care. In March 2020, Ersta Hospital implemented a cold site infrastructure to provide safe and scaled up imperative colorectal surgery for the Stockholm Health Care Region. Few data have been published on the feasibility and efficacy of the cold site concept and effects on ERAS compliance and related postoperative outcomes.
Source: Clinical Nutrition ESPEN - September 21, 2023 Category: Nutrition Authors: Jonas Nygren, Claes Gedda, Linda Hoffstr öm, Anna Garpenbeck, Mattias Soop Source Type: research
Comparative genomic analysis reveals differential genomic characteristics and featured genes between rapid- and slow-growing non-tuberculous mycobacteria
In this study, we screened 335 high-quality, non-redundant NTM genome sequences covering 187 species from 3,478 online NTM genomes, and then performed a comprehensive comparative genomic analysis to identify differential genomic characteristics and featured genes/protein domains between RGM and SGM.ResultsOur findings reveal that RGM has a larger genome size, more genes, lower GC content, and more featured genes/protein domains in metabolism of some main substances (e.g. carbohydrates, amino acids, nucleotides, ions, and coenzymes), energy metabolism, signal transduction, replication, transcription, and translation process...
Source: Frontiers in Microbiology - September 21, 2023 Category: Microbiology Source Type: research
Exploration of probiotic attributes in lactic acid bacteria isolated from fermented Theobroma cacao L. fruit using in vitro techniques
This study provides valuable insights into the in vitro characterization of LAB isolated from Indian Theobroma cacao L., highlighting their potential as probiotic candidates with advantageous traits, including survival in hostile conditions, beneficial enzymatic activities, bioactivity, and other essential attributes.
Source: Frontiers in Microbiology - September 21, 2023 Category: Microbiology Source Type: research
The role of APOBEC3C in modulating the tumor microenvironment and stemness properties of glioma: evidence from pancancer analysis
ConclusionThe A3 family exhibits heterogeneous expression across various cancer types, with its expression profile serving as a predictive marker for overall survival in glioma patients. A3C emerges as a regulator of glioma progression, exerting its influence through modulation of the tumor microenvironment and regulation of stemness.
Source: Frontiers in Immunology - September 21, 2023 Category: Allergy & Immunology Source Type: research
