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Total 478012 results found since Jan 2013.
Inhibition of PAK1 generates an ameliorative effect on MPLW515L mouse model of myeloproliferative neoplasms by regulating the differentiation and survival of the megakaryocytes
Classical myeloproliferative neoplasms (MPNs) are clonal haematological disorders that result in the overproduction of cells derived from the myeloid lineage [1]. A new diagnostic approach classifies MPN into three types: polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). These three types of myelofibrosis can progress to post-PV or ET myelofibrosis (PPV-MF and PET-MF, respectively) [2,3]. MPNs are characterized by bone marrow reticulin/collagen fibrosis, aberrant inflammatory cytokine expression, hepatosplenomegaly, extramedullary leukemic progression, and shortened survival [4].
Source: Experimental Hematology - September 21, 2023 Category: Hematology Authors: Chunling Fu, Xueting Hu, Shujin Wang, Xiangru Yu, Qigang Zhang, Liwei Zhang, Kunming Qi, Zhenyu Li, Kailin Xu Source Type: research
Depression in the next generation is related with maternal behaviors: A cross-comparison by alternating rat ’s mother care
In conclusion, offspring exposed to a postnatal depressive maternal environment developed a depressive-like behavior. Contrarily, postpartum maternal behaviors play an essential role, which might determine the outcome of the next generation. Furthermore, the appropriate timing of postpartum maternal ca ring sequences, which might eliminate prenatal stressful influences, was recognized and might be a promising approach for reducing children’s predisposition to mental disorders in their life time.
Source: PLoS One - September 21, 2023 Category: Biomedical Science Authors: Ruixin Yong Source Type: research
Assessment of comorbid symptoms in pediatric autonomic dysfunction
ConclusionThis effort can facilitate collaboration among clinical settings to advance the science and clinical treatment of these youth. This effort is essential to improving management of these vulnerable patients as well as to comparing research findings from different centers.
Source: Clinical Autonomic Research - September 21, 2023 Category: Research Source Type: research
Regurgitation during the fully supported condition of the percutaneous left ventricular assist device
Objective. A percutaneous left ventricular assist device (PLVAD) can be used as a bridge to heart transplantation or as a temporary support for end-stage heart failure. Transvalvularly placed PLVADs may result in aortic regurgitation due to unstable pump position during fully supported operation, which may diminish the pumping effect of forward flow and predispose to complications. Therefore, accurate characterization of aortic regurgitation is essential for proper modeling of heart-pump interactions and validation of control strategies. Approach. In the present study, an improved aortic valve model was used to analyze the...
Source: Physiological Measurement - September 21, 2023 Category: Physiology Authors: Anyun Yin, Biyang Wen, Zijian Cao, Qilian Xie and Ming Dai Source Type: research
Synthesis and Immunological Evaluation of Escherichia coli O1-
Derived Oligosaccharide –Protein Conjugates toward Avian Pathogenic Escherichia coli O1 Vaccine Development
In this study, the first synthesis of the pentasaccharide repeating units of the O1B and O1C antigens was successfully achieved. The synthesis and immunological evaluation of their conjugates with bovine serum albumin (BSA) were conducted. Only the O1A-pentasaccharide structure is a glycotope candidate for APEC O1. Keyhole limpet hemocyanin (KLH)–O1A-pentasaccharide conjugate was also synthesized, and its immunogenicity was evaluated by the ELISA assay. The efficient production of antibodies capable of binding to both APEC O1 LPS and the O1A-pentasaccharide structure was observed, indicating that O1A-pentasaccharide is a...
Source: Synthesis - September 21, 2023 Category: Chemistry Authors: Seki, Katsunori Makikawa, Takumi Toshima, Kazunobu Takahashi, Daisuke Tags: special topic Source Type: research
A look at radiation detectors and their applications in medical imaging
AbstractThe effectiveness and precision of disease diagnosis and treatment have increased, thanks to developments in clinical imaging over the past few decades. Science is developing and progressing steadily in imaging modalities, and effective outcomes are starting to show up as a result of the shorter scanning periods needed as well as the higher-resolution images generated. The choice of one clinical device over another is influenced by technical disparities among the equipment, such as detection medium, shorter scan time, patient comfort, cost-effectiveness, accessibility, greater sensitivity and specificity, and spati...
Source: Japanese Journal of Radiology - September 21, 2023 Category: Radiology Source Type: research
Assessment of comorbid symptoms in pediatric autonomic dysfunction
ConclusionThis effort can facilitate collaboration among clinical settings to advance the science and clinical treatment of these youth. This effort is essential to improving management of these vulnerable patients as well as to comparing research findings from different centers.
Source: Clinical Autonomic Research - September 21, 2023 Category: Research Source Type: research
Comprehensive geriatric assessment to predict adverse events in elderly patients undergoing posterior lumbar fusion surgery
ConclusionsThese results indicate that preoperative screening preoperative delirium, cognitive, nutrition and CCI are essential to prevent postoperative major AEs of the surgical elderly.
Source: European Spine Journal - September 21, 2023 Category: Orthopaedics Source Type: research
Hyperglycemia increases SCO-spondin and Wnt5a secretion into the cerebrospinal fluid to regulate ependymal cell beating and glucose sensing
by Francisco Nualart, Manuel Cifuentes, Eder Ram írez, Fernando Martínez, María José Barahona, Luciano Ferrada, Natalia Saldivia, Ernesto R. Bongarzone, Bernard Thorens, Katterine Salazar
Hyperglycemia increases glucose concentrations in the cerebrospinal fluid (CSF), activating glucose-sensing mechanisms and feeding behavior in the hypothalamus. Here, we discuss how hyperglycemia temporarily modifies ependymal cell ciliary beating to increase hypothalamic glucose sensing. A high level of glucose in the rat CSF stimulates glucose transporter 2 (GLUT2)-positive subcommissural organ (SCO) cells to release SCO-spondin in...
Source: PLoS Biology: Archived Table of Contents - September 21, 2023 Category: Biology Authors: Francisco Nualart Source Type: research
Does it work and can we do it? Hybrid research that answers both questions.
Families, Systems, & Health, Vol 41(3), Sep 2023, 291-296; doi:10.1037/fsh0000837The perceived disconnect between research and clinic contexts may thus result in frontline clinicians and administrators questioning the approachability and applicability of science to their day-to-day work with patients and families in integrated care. Science grinds along so painstakingly slowly that even within the research community, some thought leaders have called for a moratorium on RCTs in favor of approaches that will yield more immediate public health impact (Kessler & Glasgow, 2011). The aim of this editorial is to describe a both/a...
Source: Families, Systems, and Health - September 21, 2023 Category: International Medicine & Public Health Source Type: research
Assessing the self-reported honesty threshold in adolescent epidemiological research: comparing supervised machine learning and inferential statistical techniques
Epidemiological surveys offer essential data on adolescent substance use. Nevertheless, the precision of these self-report-based surveys often faces mistrust from researchers and the public. We evaluate the ef...
Source: BMC Medical Research Methodology - September 21, 2023 Category: Research Authors: Janaka V. Kosgolla, Douglas C. Smith, Shahana Begum and Crystal A. Reinhart Tags: Research Source Type: research
Clinician’s commentary to accompany barriers to referral and evaluation and corresponding navigation services for toddlers screening positive for autism spectrum disorder.
This article described how a largely Latinx sample experienced unique barriers and how the (autism family navigators) AFNs were able to respond directly to the needs of families by remaining flexible. It appears that AFNs were engaging in cultural humility by considering each family’s culture and social factors, like when they advocated for adequate interpretation services for collaborative planning meetings. The current author would be interested to know more about the cultural training and skills used to facilitate engagement and build rapport. The case studies illustrate the necessity of having good working relationsh...
Source: Families, Systems, and Health - September 21, 2023 Category: International Medicine & Public Health Source Type: research
Identifying nature-positive futures in new cities: an application of the Urban Nature Futures Framework
This study, therefore, aims to understand how nature is incorporated into existing plans for new cities and iden tify pro-nature perspectives envisioned within these plans. We use the Urban Nature Futures Framework (UNFF) to conduct a content analysis on the masterplans of new city and town developments within the Jakarta Metropolitan Area (JMA). The UNFF promotes the creation of multiple positive visions of n ature in cities by considering three broad nature perspectives: Nature for Nature, Nature for Society, and Nature as Culture, as well as emphasizing equity in these visions. Our findings show that the Nature for Soci...
Source: Sustainability Science - September 21, 2023 Category: Science Source Type: research
Fluid restrictive resuscitation with high molecular weight hyaluronan infusion in early peritonitis sepsis
Sepsis is a condition with high morbidity and mortality. Prompt recognition and initiation of treatment is essential. Despite forming an integral part of sepsis management, fluid resuscitation may also lead to...
Source: Intensive Care Medicine Experimental - September 21, 2023 Category: Surgery Authors: Annelie Barrueta Tenhunen, Jaap van der Heijden, Paul Skorup, Marco Maccarana, Anders Larsson, Anders Larsson, Gaetano Perchiazzi and Jyrki Tenhunen Tags: Research Articles Source Type: research
Research recommends best time of day to exercise if you want to prevent type 2 diabetes
Exercise is essential for both controlling and preventing type 2 diabetes, and now new research has pinpointed the best time of day to do it.
Source: Daily Express - Health - September 20, 2023 Category: Consumer Health News Source Type: news
