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Total 478012 results found since Jan 2013.
Classification and identification of mosquitoes in China based on rDNA 28S D5 region
In conclusion, the rDNA 28S D5 region could effectively distinguish Culex, Aedes, Armigeres, and Anopheles species at the lower category level, demonstrating its potential as a mini-DNA barcode for mosquito identification.PMID:37730192 | DOI:10.1016/j.actatropica.2023.107028
Source: Acta Tropica - September 20, 2023 Category: Infectious Diseases Authors: Li Hu Guodian Xiong Yae Zhao Rong Chai Jiaxuan Xie Yuyao Xiao Yue Du Juan Teng Wanyu Zhang Chenglin Guan Source Type: research
Potential impact of HercepTest ™ mAb PharmDx (Dako Omnis) (ge001) in breast cancer diagnosis
Pol J Pathol. 2023;74(2):82-88. doi: 10.5114/pjp.2023.129352.ABSTRACTThe HER2 gene is a biomarker for breast cancer prognosis and treatment. Overexpression of HER2 protein determined by immunohistochemistry (IHC) or amplification of the HER2 gene determined by fluorescence in situ hybridization (FISH) is a condition for qualifying patients for anti-HER2 therapy. Due to the high toxicity of anti-HER2 treatment, proper patient selection is essential. In our study we compared 40 cases with IHC staining of HER2 antibody determined by Ventana PATHWAY anti-HER2/neu antibody (4B5) as HER2 2+ with the new antibody (HercepTest™ m...
Source: Polish Journal of Pathology - September 20, 2023 Category: Pathology Authors: Andrzej Marsza łek Agata Kubicka Inga Jagie łło Anna Malicka-Durczak Source Type: research
Generating the 1.5?kW mode-tunable fractional vortex beam by a coherent beam combining system
As an essential component of the vortex beam, the fractional vortex beam has significantly advanced various applications, such as optical ...
Source: Optics Letters - September 20, 2023 Category: Physics Authors: Jinhu Long Kaikai Jin Qi Chen Hongxiang Chang Qi Chang Yanxing Ma Jian Wu Rongtao Su Pengfei Ma Pu Zhou Source Type: research
Semi-embedded slot waveguide electro-optic modulator
Electro-optic modulators are essential devices on silicon photonic chips in modern optical communication networks. This paper presents a ...
Source: Applied Optics - September 20, 2023 Category: Physics Authors: Renjie Li Ming Chen Xinyu Shi Wenhao Han Xiangyang Wang Wanli Zhao Jinbiao Liu Chuanxin Teng Shijie Deng Yu Cheng Libo Yuan Source Type: research
Ligand ‐Directed Shape Reconfiguration in Inorganic Materials
Shape-changing nanoparticles are synthesized using an asymmetrical surface functionalization method. Contrary to the prevalent view of inorganic clays as inflexible, it is found that the halloysite particles can reversibly switch their shape state upon altering ligand-driven chemistry, resulting from the unbalanced structural hindrance on the particle surface. AbstractPolymer elastomers with reversible shape-changing capability have led to significant development of artificial muscles, functional devices, and soft robots. By contrast, reversible shape transformation of inorganic nanoparticles is notoriously challenging due...
Source: Small - September 20, 2023 Category: Nanotechnology Authors: Nishat Paul,
Lecheng Zhang,
Shijun Lei,
Dali Huang,
Ling Wang,
Zhengdong Cheng,
Minxiang Zeng Tags: Research Article Source Type: research
Establishing consensus on essential resources for musculoskeletal trauma care worldwide: a modified Delphi study - MacKechnie MC, Shearer DW, Verhofstad MHJ, Martin C, Graham SM, Pesantez R, Schuetz M, H üttl T, Kojima K, Bernstein BP, Miclau T.
BACKGROUND: Despite evidence that formalized trauma systems enhance patient functional outcomes and decrease mortality rates, there remains a lack of such systems globally. Critical to trauma systems are the equipment, materials, and supplies needed to sup...
Source: SafetyLit - September 20, 2023 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Gender-based violence narratives in internet-based conversations in Nigeria: social listening study - Silva M, Anaba U, Jani Tulsani N, Sripad P, Walker J, Aisiri A.
BACKGROUND: Overcoming gender inequities is a global priority recognized as essential for improved health and human development. Gender-based violence (GBV) is an extreme manifestation of gender inequities enacted in real-world and internet-based environme...
Source: SafetyLit - September 20, 2023 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Glenohumeral osteoarthritis: what the surgeon needs from the radiologist
This article reviews the above concepts and details what a surgeon needs from a radiologist and could benefit from accurate reporting of preoperative imaging studies.
Source: Skeletal Radiology - September 20, 2023 Category: Radiology Source Type: research
The ultrasound assessment of osteoarthritis: the current status
AbstractTraditionally, osteoarthritis (OA) is diagnosed with the clinical examination supplemented by the conventional radiography (CR). In the research literature, the role of ultrasound (US) imaging in the diagnostics of OA has risen steadily during the last two decades. US imaging is cheap and globally widely available often already in primary healthcare. Here, we reviewed the most essential US literature focusing on OA diagnostics and progression prediction using the various search engines. Starting from the year 2000, our search provided 1 445 journal articles. After reviewing the abstracts, 89 articles were finally i...
Source: Skeletal Radiology - September 20, 2023 Category: Radiology Source Type: research
REPercussions: how geminiviruses recruit host factors for replication
Circular single-stranded DNA viruses of the family Geminiviridae encode replication-associated protein (Rep), which is a multifunctional protein involved in virus DNA replication, transcription of virus genes, and suppression of host defense responses. Geminivirus genomes are replicated through the interaction between virus Rep and several host proteins. The Rep also interacts with itself and the virus replication enhancer protein (REn), which is another essential component of the geminivirus replicase complex that interacts with host DNA polymerases α and δ. Recent studies revealed the structural and functional complexi...
Source: Frontiers in Microbiology - September 20, 2023 Category: Microbiology Source Type: research
Rhodobacteraceae dominate the core microbiome of the sea star Odontaster validus (Koehler, 1906) in two opposite geographical sectors of the Antarctic Ocean
Microbiota plays essential roles in the health, physiology, and in adaptation of marine multi-cellular organisms to their environment. In Antarctica, marine organisms have a wide range of unique physiological functions and adaptive strategies, useful for coping with extremely cold conditions. However, the role of microbiota associated with Antarctic organisms in such adaptive strategies is underexplored. In the present study, we investigated the diversity and putative functions of the microbiome of the sea star Odontaster validus, one of the main keystone species of the Antarctic benthic ecosystems. We compared the whole-b...
Source: Frontiers in Microbiology - September 20, 2023 Category: Microbiology Source Type: research
Mechanism of Bazhen decoction in the treatment of colorectal cancer based on network pharmacology, molecular docking, and experimental validation
ConclusionBZD treats CRC through multiple components, targets, and metabolic pathways. BZD can reverse the abnormal expression of genes such as PI3K, AKT, MYC, EGFR, HIF-1A, VEGFR, JUN, STAT3, CASP3, and TP53, and suppresses the progression of colorectal cancer by regulating signaling pathways such as PI3K-AKT, P53, and VEGF. Furthermore, BZD can increase the number of T cells and promote T cell activation in tumor-bearing mice, enhancing the immune function against colorectal cancer. Among them, quercetin, kaempferol, licochalcone A, naringenin, and formaronetin are more highly predictive components related to the T cell ...
Source: Frontiers in Immunology - September 20, 2023 Category: Allergy & Immunology Source Type: research
Bacterial community assembly driven by temporal succession rather than spatial heterogeneity in Lake Bosten: a large lake suffering from eutrophication and salinization
This study aims to address this knowledge gap by examining samples collected from five areas of Lake Bosten over four seasons. Using the 16S rRNA gene sequencing method, we identified a total of 510 to 1,005 operational taxonomic units (OTUs) belonging to 37 phyla and 359 genera in Lake Bosten. The major bacterial phyla were Proteobacteria (46.5%), Actinobacteria (25.9%), Bacteroidetes (13.2%), and Cyanobacteria (5.7%), while the major genera were hgcI_clade (12.9%), Limnohabitans (6.2%), and Polynucleobacter (4.7%). Water temperature emerged as the primary driver of these community structure variations on global level. Ho...
Source: Frontiers in Microbiology - September 20, 2023 Category: Microbiology Source Type: research
Stage shift and relative survival for head and neck cancer during the 2020 COVID-19 pandemic: a population-based study of temporal trends
ConclusionThe COVID-19 pandemic led to underdiagnosis of HNC, resulting in shifts to more advanced stage at presentation in certain subgroups. A stage shift can be expected for the 9.5% of tumors not yet diagnosed at the end of 2020. HNC patients diagnosed in 2020 suffered higher than expected mortality.
Source: Frontiers in Oncology - September 20, 2023 Category: Cancer & Oncology Source Type: research
Case Report: Stereotactic body radiation treatment for immunotherapy escaped oligometastatic progression in cutaneous melanoma and merkel cell carcinoma
In this report, we describe two cases of one patient with metastatic melanoma and the other with metastatic Merkel cell carcinoma (MCC) who were treated with ICI and later developed localized resistance due to oligometastatic progression. We further highlight our experience using stereotactic body radiation therapy (SBRT) as a salvage approach to treat the oligometastatic progression. In addition, we describe the temporal and dynamic relationship of circulating-tumor DNA (ctDNA) prior to, during and after SBRT, which highly suggested the diagnosis without obtaining a histological specimen. Our cases highlight a potential r...
Source: Frontiers in Oncology - September 20, 2023 Category: Cancer & Oncology Source Type: research
