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Total 478012 results found since Jan 2013.
Deuterium Magnetic Resonance Imaging Using Deuterated Water-Induced 2H-Tissue Labeling Allows Monitoring Cancer Treatment at Clinical Field Strength
CONCLUSIONS: Deuterium MRI at 1.5T proved feasibility to track 2H distribution throughout mouse tissues during D2O administration and revealed a higher 2H accumulation in the tumor xenografts. This research demonstrated a promising successful method for preliminary assessment of radiotherapy and chemotherapy of cancer.PMID:37732903 | DOI:10.1158/1078-0432.CCR-23-1635
Source: Clinical Cancer Research - September 21, 2023 Category: Cancer & Oncology Authors: Hirofumi Asano Abdelazim Elsayed Elhelaly Fuminori Hyodo Ryota Iwasaki Yoshifumi Noda Hiroki Kato Koki Ichihashi Hiroyuki Tomita Masaharu Murata Takashi Mori Masayuki Matsuo Source Type: research
Simultaneous Targeting of IL-1-Signaling and IL-6-Trans-Signaling Preserves Human Pulmonary Endothelial Barrier Function During a Cytokine Storm
CONCLUSIONS: These findings strongly suggest a major role for both IL-6 trans-signaling and IL-1β signaling in the pathological increase in permeability of the human lung microvasculature and reveal combinatorial strategies that enable the gradual control of pulmonary endothelial barrier function in response to a cytokine storm.PMID:37732482 | DOI:10.1161/ATVBAHA.123.319695
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 21, 2023 Category: Cardiology Authors: Natalia Col ás-Algora Pablo Mu ñoz-Pinillos Cristina Cacho-Navas Jos é Avendaño-Ortiz Gema de Rivas Susana Barroso Eduardo L ópez-Collazo Jaime Mill án Source Type: research
Britanin inhibits titanium wear particle ‑induced osteolysis and osteoclastogenesis
Mol Med Rep. 2023 Nov;28(5):205. doi: 10.3892/mmr.2023.13092. Epub 2023 Sep 21.ABSTRACTWear particle‑induced osteolysis is a serious complication that occurs in individuals with titanium (Ti)‑based implants following long‑term usage due to loosening of the implants. The control of excessive osteoclast differentiation and inflammation is essential for protecting against wear particle‑induced osteolysis. The present study evaluated the effect of britanin, a pseudoguaianolide sesquiterpene isolated from Inula japonica, on osteoclastogenesis in vitro and Ti particle‑induced osteolysis in vivo. The effect of britanin ...
Source: Molecular Medicine Reports - September 21, 2023 Category: Molecular Biology Authors: Ju Ang Kim Soomin Lim Hye Jung Ihn Jung-Eun Kim Kyungmoo Yea Jimin Moon Hyukjae Choi Eui Kyun Park Source Type: research
Polarized contact behavior in directionally migrating < em > Xenopus < /em > gastrula mesendoderm
Int J Dev Biol. 2023 Sep 18. doi: 10.1387/ijdb.230123rw. Online ahead of print.ABSTRACTThe control of cell-cell adhesion and detachment is essential for collective migration and cell rearrangement. Here, we have used the contact behavior of Xenopus gastrula mesoderm explants migrating directionally on ectoderm conditioned substratum to study the regulation of active cell-cell detachment. When colliding laterally, explants repelled each other, whereas they fused front-to-back when aligned in the direction of migration. For this mesoderm polarization by the substratum, we identified three control modules. First, PDGF-A signa...
Source: International Journal of Developmental Biology - September 21, 2023 Category: Biology Authors: Martina Nagel Rudolf Winklbauer Source Type: research
A comparative study of thoracoscopic left atrial appendage clipping versus stapled resection
CONCLUSIONS: The clipping group demonstrated a higher rate of complete LAA closure compared to the stapled resection group. Close monitoring of patients with residual LAA stumps is essential. Further research with larger cohorts is needed to elucidate impact of residual LAA stump on thromboembolic events.PMID:37734642 | DOI:10.1016/j.athoracsur.2023.09.010
Source: The Annals of Thoracic Surgery - September 21, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Suk Kyung Lim Chu Hyun Kim Ki Hong Choi Joong Hyun Ahn Young Keun On Sung Mok Kim Dong Seop Jeong Source Type: research
Health data ecosystem in Pakistan: a multisectoral qualitative assessment of needs and opportunities
CONCLUSIONS: Our study identified key areas of focus that can contribute to orient a national health data roadmap and ecosystem in Pakistan.PMID:37734897 | DOI:10.1136/bmjopen-2023-071616
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Sana Mahmood Ali Aahil Noorali Afshan Manji Noreen Afzal Saadia Abbas Javeria Bilal Qamar Sameen Siddiqi Zahra Hoodbhoy Salim S Virani Zulfiqar A Bhutta Zainab Samad Source Type: research
Deuterium Magnetic Resonance Imaging Using Deuterated Water-Induced 2H-Tissue Labeling Allows Monitoring Cancer Treatment at Clinical Field Strength
CONCLUSIONS: Deuterium MRI at 1.5T proved feasibility to track 2H distribution throughout mouse tissues during D2O administration and revealed a higher 2H accumulation in the tumor xenografts. This research demonstrated a promising successful method for preliminary assessment of radiotherapy and chemotherapy of cancer.PMID:37732903 | DOI:10.1158/1078-0432.CCR-23-1635
Source: Clinical Colorectal Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Hirofumi Asano Abdelazim Elsayed Elhelaly Fuminori Hyodo Ryota Iwasaki Yoshifumi Noda Hiroki Kato Koki Ichihashi Hiroyuki Tomita Masaharu Murata Takashi Mori Masayuki Matsuo Source Type: research
Role of three-dimensional transesophageal echocardiography in cardiac myxomas: an imaging challenge
Monaldi Arch Chest Dis. 2023 Sep 19. doi: 10.4081/monaldi.2023.2768. Online ahead of print.ABSTRACTNowadays, the diagnosis of cardiac myxomas (CM), particularly the histological types, remains a challenge. Two-dimensional (2D) transthoracic (TT) and transesophageal (TEE) echocardiography (ECHO) represent the first steps in the imaging pathway. 3D ECHO, implemented in imaging practice, appears to be an emerging diagnostic technique that overcomes some of the limitations of 2D ECHO while integrating the information provided by magnetic resonance (MRI). However, its role in the imaging arena is still debatable. Analyzing 17 m...
Source: Monaldi Archives for Chest Disease - September 21, 2023 Category: Respiratory Medicine Authors: Bandar Alamro Valeria Pergola Abdalla Eltayeb Amal Alshammari Naji Kholaif Ahmad Alhamshari Mohammed Al Admawi Shamayel Mohammed Feras Khaliel Domenico Galzerano Source Type: research
Nutrition-associated health levels in persons with cancer: item response modelling based on the International Classification of Functioning, Disability and Health
CONCLUSIONS: The study constructed an evidence-based ICF scale for nutrition conditions in patients with cancer with 32-item and 2PLM for evaluating nutrition-associated health level in persons with cancer, including high validity and reliability.CLINICAL REHABILITATION IMPACT: The IRT model based on ICF provided a promising assessment tool to discriminate nutrition-associated health level of persons with cancer, and offered an auxiliary method for selecting rehabilitation intervention targets. This has the potential to lead to improved outcomes in cancer treatment and increased quality of life for cancer survivors.PMID:37...
Source: Methods of Information in Medicine - September 21, 2023 Category: Information Technology Authors: Jin-Jin Chen Zi-Yan Zhu Jia-Jia Bian Feng Lin Source Type: research
RIPTACs: A groundbreaking approach to drug discovery
Drug Discov Today. 2023 Sep 19:103774. doi: 10.1016/j.drudis.2023.103774. Online ahead of print.ABSTRACTRegulated induced proximity targeting chimeras (RIPTACs), a new class of heterobifunctional molecules, show promise in specifically targeting and eliminating cancer cells while leaving healthy cells unharmed. As a groundbreaking drug discovery approach, RIPTACs work by forming a stable complex with two proteins, one specifically found in cancer cells (target protein, TP) and the other pan-essential for cell survival (effector protein, EP), selectively disrupting the function of the EP in cancer cells and causing cell dea...
Source: Drug Discovery Today - September 21, 2023 Category: Drugs & Pharmacology Authors: Zonghui Ma Andrew A Bolinger Jia Zhou Source Type: research
French validation of the Quality of life in Essential Tremor Questionnaire (QUEST) and the Essential Tremor Embarrassment Assessment (ETEA)
In conclusion, the French versions of QUEST and ETEA are comprehensive, valid and reliable instruments for assessing patients with head tremor.PMID:37735016 | DOI:10.1016/j.neurol.2023.03.030
Source: Revue Neurologique - September 21, 2023 Category: Neurology Authors: A Marques I Rieu B Pereira G Castelnovo F Fluch ère C Laurencin B Degos A Poujois A Kreisler S Sangla M Tir I Benatru G Blanchet-Fourcade D Guehl D Gayraud L Tatu C Tranchant M Simonetta-Moreau F Durif Source Type: research
The Role of Pyroptosis in Alzheimer's Disease
J Integr Neurosci. 2023 Aug 22;22(5):129. doi: 10.31083/j.jin2205129.ABSTRACTPyroptosis is a type of regulated cell death that relies on caspases, vesicles, and the cleavage of gasdermin proteins (which create pores in the cell membrane). The nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome, which is involved in this process, is the most widely studied inflammasome. Caspase-1 activates pro-inflammatory cytokines, such as IL-1β and IL-18. Gasdermin D (GSDMD) is the most important executive protein. GSDMD, a substrate rather than an upstream protease, determines the occurrence of pyropt...
Source: Journal of Integrative Neuroscience - September 21, 2023 Category: Neuroscience Authors: Yanxiu Ju Ling Zhao Songtao Li Qing Zhao Source Type: research
Inhibition of PRKAA/AMPK (Ser485/491) phosphorylation by crizotinib induces cardiotoxicity via perturbing autophagosome-lysosome fusion
Autophagy. 2023 Sep 21. doi: 10.1080/15548627.2023.2259216. Online ahead of print.ABSTRACTCrizotinib, a small-molecule tyrosine kinase inhibitor targeting ALK, MET and ROS1, is the first-line drug for ALK-positive metastatic non-small cell lung cancer and is associated with severe, sometimes fatal, cases of cardiac failure, which increases the risk of mortality. However, the underlying mechanism remains unclear, which causes the lack of therapeutic strategy. We established in vitro and in vivo models for crizotinib-induced cardiotoxicity and found that crizotinib caused left ventricular dysfunction, myocardial injury and p...
Source: Autophagy - September 21, 2023 Category: Cytology Authors: Zhifei Xu Zezheng Pan Ying Jin Zizheng Gao Feng Jiang Huangxi Fu Xueqin Chen Xiaochen Zhang Hao Yan Xiaochun Yang Bo Yang Qiaojun He Peihua Luo Source Type: research
5 essential design books to read this fall
From a history of digital design to a stunning book on Es Devlin’s stage design, these are the best design books to add to your stack. In many ways, I feel like the quantity and quality of design books has never been higher. The height of my “to-read” stacks is growing much, much faster than my…#esdevlin #readfullstory
Source: Reuters: Health - September 21, 2023 Category: Consumer Health News Source Type: news
Complex Psychiatric Histories and Transgender and Gender Diverse Youth
Transgender and gender diverse (TGD) individuals face higher rates of stressors driving disproportionate health risks. Although psychiatric conditions are important to consider in the context of greater health-promoting efforts for TGD youth, any mental health concerns may or may not be related to gender identity or associated dysphoria. Nevertheless, it is essential to consider the impact of complex mental health factors on decisional capacity and gender care discussions. Psychiatric care of TGD youth includes stratifying risk factors through a minority stress lens, balancing acute needs with patient and caregiver priorit...
Source: Child and Adolescent Psychiatric Clinics of North America - September 21, 2023 Category: Psychiatry Authors: Amy Curtis, Shanna Swaringen, Aron Janssen Source Type: research
