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Total 478012 results found since Jan 2013.
Potential impact of HercepTest ™ mAb PharmDx (Dako Omnis) (ge001) in breast cancer diagnosis
Pol J Pathol. 2023;74(2):82-88. doi: 10.5114/pjp.2023.129352.ABSTRACTThe HER2 gene is a biomarker for breast cancer prognosis and treatment. Overexpression of HER2 protein determined by immunohistochemistry (IHC) or amplification of the HER2 gene determined by fluorescence in situ hybridization (FISH) is a condition for qualifying patients for anti-HER2 therapy. Due to the high toxicity of anti-HER2 treatment, proper patient selection is essential. In our study we compared 40 cases with IHC staining of HER2 antibody determined by Ventana PATHWAY anti-HER2/neu antibody (4B5) as HER2 2+ with the new antibody (HercepTest™ m...
Source: Polish Journal of Pathology - September 20, 2023 Category: Pathology Authors: Andrzej Marsza łek Agata Kubicka Inga Jagie łło Anna Malicka-Durczak Source Type: research
Efficient trapping and destruction of SARS-CoV-2 using PECO-assisted Molekule air purifiers in the laboratory and real-world settings
Ecotoxicol Environ Saf. 2023 Sep 18;264:115487. doi: 10.1016/j.ecoenv.2023.115487. Online ahead of print.ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted human-to-human via aerosols and air-borne droplets. Therefore, capturing and destroying viruses from indoor premises are essential to reduce the probability of human exposure and virus transmission. While the heating, ventilation, and air conditioning (HVAC) systems help in reducing the indoor viral load, a targeted approach is required to effectively remove SARS-CoV-2 from indoor air to address human exposure concerns. The present study...
Source: Ecotoxicology and Environmental Safety - September 20, 2023 Category: Environmental Health Authors: Arpan Acharya Kerri Surbaugh Michellie Thurman Chatura Wickramaratne Philip Myers Rajat Mittal Kabita Pandey Elizabeth Klug Sarah J Stein Ashley R Ravnholdt Vicki L Herrera Danielle N Rivera Paul Williams Joshua L Santarpia Ajeet Kaushik Jaspreet S Dhau S Source Type: research
A New Strategy for Rejuvenating Primary Healthcare: The Government-Society Partnership Model
J Prim Care Community Health. 2023 Jan-Dec;14:21501319231200763. doi: 10.1177/21501319231200763.ABSTRACTPrimary healthcare systems worldwide are under stress as increased demands during pandemic surges have exposed deficiencies in the system. Primary healthcare centers have significant responsibilities but are often underfunded and understaffed. Recent events, including the COVID-19 pandemic, have highlighted the importance of a strong primary health center network to promote community health and save lives. Most governments have multiple competing financial needs for scarce resources, ultimately limiting the advancement o...
Source: Primary Care - September 20, 2023 Category: Primary Care Authors: Siddarth S Kasi Source Type: research
The interactome of the UapA transporter reveals putative new players in anterograde membrane cargo trafficking
Fungal Genet Biol. 2023 Sep 18:103840. doi: 10.1016/j.fgb.2023.103840. Online ahead of print.ABSTRACTNeosynthesized plasma membrane (PM) proteins co-translationally translocate to the ER, concentrate at regions called ER-exit sites (ERes) and pack into COPII secretory vesicles which are sorted to the early-Golgi through membrane fusion. Following Golgi maturation, membrane cargoes reach the late-Golgi, from where they exit in clathrin-coated vesicles destined to the PM, directly or through endosomes. Post-Golgi membrane cargo trafficking also involves the cytoskeleton and the exocyst. The Golgi-dependent secretory pathway ...
Source: Fungal Genetics and Biology - September 20, 2023 Category: Biology Authors: Xenia Georgiou Sofia Dimou George Diallinas Martina Samiotaki Source Type: research
Synthesis and antitumor activity of bagasse xylan derivatives modified by graft-esterification and cross-linking
Int J Biol Macromol. 2023 Sep 18:126867. doi: 10.1016/j.ijbiomac.2023.126867. Online ahead of print.ABSTRACTA crucial aspect in achieving sustainable development of biomass materials is the modification of renewable polysaccharides to create various high-value functional materials. In this paper, bagasse xylan (BX) was used as a raw material to introduce benzyl methacrylate (BMA) through graft copolymerization reaction to generate the intermediate product BX-g-BMA. Subsequently, the target product (CA-BX-g-BMA) was synthesized by catalytic esterification of BX-g-BMA with citric acid (CA) in AmimCl ionic liquid. Meanwhile, ...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Bin Zhao Heping Li Kexin Tian Yue Su Zhiming Zou Source Type: research
Lavandula stoechas extract incorporated polylactic acid nanofibrous mats as an antibacterial and cytocompatible wound dressing
In this study, Lavandula stoechas extract (LSE) (0.25 %, 0.5 %, and 1%wt) incorporated-polylactic acid (PLA) nanofibrous mats were successfully produced and characterized. Microstructural analysis by SEM revealed that the fiber diameter changed with the increase in the amount of LSE. Also, the nanofibrous mats were evaluated for their in vitro antibacterial, cytotoxicity, and wound healing properties for their use as a wound dressing material. According to the results of the disc diffusion test, PLA nanofibrous mats containing LSE %1 showed 9.65 ± 0.46 and 7.37 ± 0.03 inhibition zone (mm) against E. coli and S. aureus, r...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Bet ül Mutlu Fatih Çiftçi Cem B ülent Üstündağ Rabia Çakır-Koç Source Type: research
Conserved residues at the family and subfamily levels determine enzyme activity and substrate binding in glycoside hydrolase family 13
Int J Biol Macromol. 2023 Sep 18:126980. doi: 10.1016/j.ijbiomac.2023.126980. Online ahead of print.ABSTRACTSite-directed mutagenesis is a valuable strategy for modifying enzymes, but the lack of understanding of conserved residues regulating glycosidase function hinders enzyme design. We analyzed 1662 enzyme sequences to identify conserved amino acids in maltohexaose-forming amylase at both family and subfamily levels. Several conserved residues at the family level (G37, P45, R52, Y57, D101, V103, H106, G230, R232, D234, E264, H330, D331, and G360) were found, mutations of which resulted in reduced enzyme activity or inac...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Shixia Xi Xiaofeng Ban Haocun Kong Caiming Li Zhengbiao Gu Zhaofeng Li Source Type: research
Shuttle between arginine and lysine: influence on cancer immunonutrition
Amino Acids. 2023 Sep 20. doi: 10.1007/s00726-023-03327-9. Online ahead of print.ABSTRACTAmino acids which are essential nutrients for all cell types' survival are also recognised to serve as opportunistic/alternative fuels in cancers auxotrophic for specific amino acids. Accordingly, restriction of amino acids has been utilised as a therapeutic strategy in these cancers. Contrastingly, amino acid deficiencies in cancer are found to greatly impair immune functions, increasing mortality and morbidity rates. Dietary and supplemental amino acids in such conditions have revealed their importance as 'immunonutrients' by modulat...
Source: Amino Acids - September 20, 2023 Category: Biochemistry Authors: R Sindhu M Supreeth Shashanka K Prasad M Thanmaya Source Type: research
Exploring associations between built environment and crash risk of children in school commuting
Accid Anal Prev. 2023 Sep 18;193:107287. doi: 10.1016/j.aap.2023.107287. Online ahead of print.ABSTRACTUnderstanding how built environment are associated with crash risk (CR) in school commuting is essential to improving travel safety through land use and transportation policies. Scholars often assume that this relationship is consistent across space, but this may lead to inconsistent estimates. To address this issue, using data in Shenzhen, China, the data covers traffic accident data of children taken from police incident reports and supplemented with local land use, transportation network and specific school information...
Source: Accident; Analysis and Prevention. - September 20, 2023 Category: Accident Prevention Authors: Yaxin Wu Xiaowei Hu Xiaofeng Ji Ke Wu Source Type: research
Comprehensive profiling of the metabolome in corn silage inoculated with or without < em > Lactiplantibacillus plantarum < /em > using different untargeted metabolomics analyses
Arch Anim Nutr. 2023 Sep 19:1-19. doi: 10.1080/1745039X.2023.2247824. Online ahead of print.ABSTRACTSilage fermentation is a complicated biochemical process involving interactions between microbes and metabolites. However, the overall metabolome feature of ensiled forage and its response to lactic acid bacteria inoculation is poorly understood. Hence, in this study metabolome profiles of whole-plant corn silage inoculated with or without Lactiplantibacillus plantarum were characterised via solid-phase microextraction/gas chromatography/mass spectrometry (SPME-GC-MS), gas chromatography/time-of-flight mass spectrometry (GC-...
Source: Archives of Animal Nutrition - September 20, 2023 Category: Nutrition Authors: Rina Su Wencan Ke Jie Bai Musen Wang Samaila Usman Dongmei Xie Dongmei Xu Mengyan Chen Xusheng Guo Source Type: research
Impact of tidal volume strategy at birth on initiating lung injury in preterm lambs
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 20. doi: 10.1152/ajplung.00159.2023. Online ahead of print.ABSTRACTTidal ventilation is essential in supporting the transition to air-breathing at birth, but excessive tidal volume (VT) is an important factor in preterm lung injury. Few studies have assessed the impact of specific VT levels on injury development. Here we used a lamb model of preterm birth to investigate the role of different levels of VT during positive pressure ventilation (PPV) in promoting aeration and initiating early lung injury pathways. VT was delivered as; (i) 7ml/kg throughout (VTstatic), (ii) begun at ...
Source: Am J Physiol Lung Ce... - September 20, 2023 Category: Respiratory Medicine Authors: Prue M Pereira-Fantini Kelly R Kenna Monique Fatmous Arun Sett Ellen Douglas Sophia Dahm Magdy Sourial Haoyun Fang David W Greening David G Tingay Source Type: research
Cell surface plasticity in response to shape change in the whole organism
Curr Biol. 2023 Sep 13:S0960-9822(23)01148-X. doi: 10.1016/j.cub.2023.08.068. Online ahead of print.ABSTRACTPlasma membrane rupture can result in catastrophic cell death. The skeletal muscle fiber plasma membrane, the sarcolemma, provides an extreme example of a membrane subject to mechanical stress since these cells specifically evolved to generate contraction and movement. A quantitative model correlating ultrastructural remodeling of surface architecture with tissue changes in vivo is required to understand how membrane domains contribute to the shape changes associated with tissue deformation in whole animals. We and o...
Source: Current Biology - September 20, 2023 Category: Biology Authors: Thomas E Hall Nicholas Ariotti Harriet P Lo James Rae Charles Ferguson Nick Martel Ye-Wheen Lim Jean Giacomotto Robert G Parton Source Type: research
Classification and identification of mosquitoes in China based on rDNA 28S D5 region
In conclusion, the rDNA 28S D5 region could effectively distinguish Culex, Aedes, Armigeres, and Anopheles species at the lower category level, demonstrating its potential as a mini-DNA barcode for mosquito identification.PMID:37730192 | DOI:10.1016/j.actatropica.2023.107028
Source: Acta Tropica - September 20, 2023 Category: Infectious Diseases Authors: Li Hu Guodian Xiong Yae Zhao Rong Chai Jiaxuan Xie Yuyao Xiao Yue Du Juan Teng Wanyu Zhang Chenglin Guan Source Type: research
The Evolving Practice of Hospital at Home in the United States
Annu Rev Med. 2023 Sep 20. doi: 10.1146/annurev-med-051022-042210. Online ahead of print.ABSTRACTHospital at Home (HaH) provides hospital-level services in the home to eligible patients who would otherwise require facility-based hospitalization. In the last two decades, studies have shown that HaH can improve patient outcomes and satisfaction and reduce hospital readmissions. Improved technology and greater experience with the model have led to expansion in the scope of patients served and services provided by the model, but dissemination in the United States has been hampered by lack of insurance coverage until recently. ...
Source: Annual Review of Medicine - September 20, 2023 Category: General Medicine Authors: Tuyet-Trinh Truong Albert L Siu Source Type: research
Effects of management objectives and rules on marine conservation outcomes
This article is protected by copyright. All rights reserved.PMID:37728514 | DOI:10.1111/cobi.14156
Source: Conservation Biology - September 20, 2023 Category: Biology Authors: Natalie C Ban Emily S Darling Georgina G Gurney Whitney Friedman Stacy D Jupiter W Peni Lestari Irfan Yulianto Sinta Pardede Sukma A R Tarigan Puji Prihatiningsih Sangeeta Mangubhai Waisea Naisilisili Sirilo Dulunaqio Josheena Naggea Ravaka Ranaivoson Ver Source Type: research
