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Total 478012 results found since Jan 2013.
GSE210497 SARS-CoV-2 pathogenesis mediated by E protein's PBM was prevented by modulators of CFTR function
Contributors : Jose M Honrubia ; Francisco J Guti érrez-Álvarez ; Alejandro Sanz ; Diego Muñoz ; Ezequiel González ; Carlos Castaño-Rodríguez ; Jorge Ripoll ; Ana Esteban ; Raúl Fernández-Delgado ; Juan C Oliveros ; Stanley Perlman ; Paul McCray ; Luis EnjuanesSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe three human deadly coronaviruses (CoVs) (SARS-CoV, MERS-CoV and SARS-CoV-2) have infected around eight thousand, two thousand six hundred and 262 million people so far (December 2021), causing the death of 10%, 37% and 2% of them, respectively, so their implication in h...
Source: GEO: Gene Expression Omnibus - September 22, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Epigenetic targeting to enhance acute myeloid leukemia-directed immunotherapy
AML is a malignant disease of hematopoietic progenitor cells with unsatisfactory treatment outcome, especially in patients that are ineligible for intensive chemotherapy. Immunotherapy, comprising checkpoint inhibition, T-cell engaging antibody constructs, and cellular therapies, has dramatically improved the outcome of patients with solid tumors and lymphatic neoplasms. In AML, these approaches have been far less successful. Discussed reasons are the relatively low mutational burden of AML blasts and the difficulty in defining AML-specific antigens not expressed on hematopoietic progenitor cells. On the other hand, epigen...
Source: Frontiers in Immunology - September 22, 2023 Category: Allergy & Immunology Source Type: research
Comprehensive bacterial-metabolite profiles of Hawaijar, Bekang, and Akhone: a comparative study on traditional fermented soybeans of north-east India
AbstractPreparation of traditionally fermented soybeans varies across ethnicities with distinct tastes, flavour, and nutritional values. The fermented soybean varietiesHawaijar,Bekang, andAkhone of north-east India are associated with diverse ethnic groups from Manipur, Mizoram, and Nagaland, respectively. These varieties differ in substrate and traditional practice that exerts differential bacterial-metabolite profile, which needs an in-depth analysis i. Culture-dependent and independent techniques investigated the bacterial diversity of the fermented soybean varieties. Gas chromatography and mass spectroscopy (GC-MS) stu...
Source: World Journal of Microbiology and Biotechnology - September 22, 2023 Category: Microbiology Source Type: research
Remote ultrasound diagnostics disrupting traditional military frontline healthcare delivery
This report discusses the first use of a consultant radiologist guiding a clinician, untrained in ultrasound, to perform an ultrasound scan via a live tele-guidance feed in the deployed environment using the Butterfly iQ+ tele-guidance system. Distance scanning provided a diagnostic quality report when compared with locally performed imaging to improve patient care and maintain operational output. This example demonstrates feasibility of remote point-of-care imaging systems in provision of location-agnostic high-quality diagnostic capability. Future opportunities to develop care pathways using bedside tele-diagnostics will...
Source: Journal of the Royal Army Medical Corps - September 22, 2023 Category: General Medicine Authors: Blenkinsop, G., Heller, R. A., Carter, N. J., Burkett, A., Ballard, M., Tai, N. Tags: Personal view Source Type: research
Molecules, Vol. 28, Pages 6769: Revealing the Control Mechanisms of pH on the Solution Properties of Chitin via Single-Molecule Studies
Zheng
Lu Qian
Chitin is one of the most common polysaccharides and is abundant in the cell walls of fungi and the shells of insects and aquatic organisms as a skeleton. The mechanism of how chitin responds to pH is essential to the precise control of brewing and the design of smart chitin materials. However, this molecular mechanism remains a mystery. Results from single-molecule studies, including single-molecule force spectroscopy (SMFS), AFM imaging, and molecular dynamic (MD) simulations, have shown that the mechanical and conformational behaviors of chitin molecules show surprising pH responsiveness. This can be...
Source: Molecules - September 22, 2023 Category: Chemistry Authors: Song Zhang Miao Yu Guoqiang Zhang Guanmei He Yunxu Ji Juan Dong Huayan Zheng Lu Qian Tags: Article Source Type: research
Molecules, Vol. 28, Pages 6767: Antioxidant Properties and Secondary Metabolites Profile of Hyptis colombiana at Various Phenological Stages
In this study, H. colombiana plants at different phenological stages (vegetative, flowering, and post-flowering) were harvested to obtain essential oils (EOs) and extracts (from fresh plant materials or post-distillation waste) whose chemical compositions and antioxidant activities were determined. H. colombiana EOs distilled by microwave-assisted hydrodistillation were analyzed by GC/MS/FID, and hydroalcoholic extracts obtained from fresh plant materials or post-distillation waste were analyzed by UHPLC-ESI+/−-Orbitrap-MS. The antioxidant activity was evaluated by the ABTS+• and ORAC assays. The...
Source: Molecules - September 22, 2023 Category: Chemistry Authors: Sheila B. Beltr án Lady J. Sierra Jos é L. Fernández-Alonso Angie K. Romero Jairo R. Mart ínez Elena E. Stashenko Tags: Article Source Type: research
Molecules, Vol. 28, Pages 6760: Compatibility of Nucleobases Containing Pt(II) Complexes with Red Blood Cells for Possible Drug Delivery Applications
In this study, we evaluated the feasibility of loading model nucleobase-containing Pt(II) complexes into human RBCs that were highly stabilized by four N-donors and susceptible to further modification for possible antitumor/antiviral applications. Specifically, platinum-based nucleoside derivatives [PtII(dien)(N7-Guo)]2+, [PtII(dien)(N7-dGuo)]2+, and [PtII(dien)(N7-dGTP)] (dien = diethylenetriamine; Guo = guanosine; dGuo = 2′-deoxy-guanosine; dGTP = 5′-(2′-deoxy)-guanosine-triphosphate) were investigated. These Pt(II) complexes were demonstrated to be stable species suitable for in...
Source: Molecules - September 22, 2023 Category: Chemistry Authors: Federica De Castro Erika Stef àno Francesco Paolo Fanizzi Riccardo Di Corato Pasant Abdalla Francesca Luchetti Maria Gemma Nasoni Rosaria Rinaldi Mauro Magnani Michele Benedetti Antonella Antonelli Tags: Article Source Type: research
Sensors, Vol. 23, Pages 8026: Mobile Manipulators in Industry 4.0: A Review of Developments for Industrial Applications
This article delves into MMs’ essential role in achieving Industry 4.0’s automation and adaptability by integrating mobility with manipulation capabilities. The study reviews MMs’ industrial applications and integration into manufacturing systems. The most observed applications are logistics (49%) and manufacturing (33%). As Industry 4.0 advances, the paper emphasizes updating and aligning MMs with the smart factory concept by networks of sensors and the real-time analysis of them, especially for an enhanced human–robot interaction. Another objective is categorizing c...
Source: Sensors - September 22, 2023 Category: Biotechnology Authors: Nooshin Ghodsian Khaled Benfriha Adel Olabi Varun Gopinath Aur élien Arnou Tags: Review Source Type: research
Sensors, Vol. 23, Pages 8022: Semi-Supervised Anomaly Detection of Dissolved Oxygen Sensor in Wastewater Treatment Plants
Barbu
As the world progresses toward a digitally connected and sustainable future, the integration of semi-supervised anomaly detection in wastewater treatment processes (WWTPs) promises to become an essential tool in preserving water resources and assuring the continuous effectiveness of plants. When these complex and dynamic systems are coupled with limited historical anomaly data or complex anomalies, it is crucial to have powerful tools capable of detecting subtle deviations from normal behavior to enable the early detection of equipment malfunctions. To address this challenge, in this study, we analyzed five semi-...
Source: Sensors - September 22, 2023 Category: Biotechnology Authors: Liliana Maria Ghinea Mihaela Miron Marian Barbu Tags: Article Source Type: research
Should we suspect primary aldosteronism in patients with hypokalaemic rhabdomyolysis? A systematic review
Severe hypokalaemia causing rhabdomyolysis (RML) in primary aldosteronism (PA) is a rare entity, and only a few cases have been reported over the last four decades. This systematic review and case report aims to gather all published data regarding a hypokalaemic RML as presentation of PA in order to contribute to the early diagnosis of this extremely rare presentation. With the use of PubMed Central, EMBASE, and Google Scholar, a thorough internet-based search of the literature was conducted to identify articles and cases with RML secondary to hypokalaemia due to PA between June 1976 and July 2023. The case study concerns ...
Source: Frontiers in Endocrinology - September 22, 2023 Category: Endocrinology Source Type: research
Impact of COVID-19 on the supply chain of essential health commodities: a mixed method study, in Dar es Salaam, Tanzania
ConclusionsCOVID-19 led to shortage, increased prices and delayed delivery of essential health commodities. This might happen in the future whenever unexpected crises causing disruption in the supply chain occur underscoring the need for the country preparedness measures.
Source: Journal of Pharmaceutical Policy and Practice - September 22, 2023 Category: Pharmaceuticals Source Type: research
Professional virtue of civility and the responsibilities of medical educators and academic leaders
Incivility among physicians, between physicians and learners, and between physicians and nurses or other healthcare professionals has become commonplace. If allowed to continue unchecked by academic leaders and medical educators, incivility can cause personal psychological injury and seriously damage organisational culture. As such, incivility is a potent threat to professionalism. This paper uniquely draws on the history of professional ethics in medicine to provide a historically based, philosophical account of the professional virtue of civility. We use a two-step method of ethical reasoning, namely ethical analysis inf...
Source: Journal of Medical Ethics - September 22, 2023 Category: Medical Ethics Authors: McCullough, L. B., Coverdale, J., Chervenak, F. A. Tags: Open access Feature article Source Type: research
Crystal structure of the lipopolysaccharide outer core galactosyltransferase WaaB involved in pathogenic bacterial invasion of host cells
Lipopolysaccharide (LPS) is essential for most gram-negative bacteria and plays an important role in serum resistance, pathogenesis, drug resistance, and protection from harsh environments. The outer core oligosaccharide of LPS is involved in bacterial recognition and invasion of host cells. The D-galactosyltransferase WaaB is responsible for the addition of D-galactose to the outer core oligosaccharide of LPS, which is essential for Salmonella typhimurium invasion. Here we report the first crystal structures of WaaB and WaaB in complex with UDP to resolutions of 1.8 and 1.9 Å, respectively. Mutagenesis and enzyme activit...
Source: Frontiers in Microbiology - September 22, 2023 Category: Microbiology Source Type: research
Proteome level analysis of drug-resistant Prevotella melaninogenica for the identification of novel therapeutic candidates
In conclusion, our study reported novel drug and vaccine targets and designed a multi-epitope vaccine against the P. melaninogenica infection. Further experimental validation will help open new avenues in the treatment of this multi-drug-resistant pathogen.
Source: Frontiers in Microbiology - September 22, 2023 Category: Microbiology Source Type: research
A novel oncolytic virus-based biomarker participates in prognosis and tumor immune infiltration of glioma
ConclusionOur research uncovered a critical role of PTBP1 in outcomes and immune cell infiltration of glioma patients, particularly in those with LGG.
Source: Frontiers in Microbiology - September 22, 2023 Category: Microbiology Source Type: research
