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Total 478012 results found since Jan 2013.
Britanin inhibits titanium wear particle ‑induced osteolysis and osteoclastogenesis
Mol Med Rep. 2023 Nov;28(5):205. doi: 10.3892/mmr.2023.13092. Epub 2023 Sep 21.ABSTRACTWear particle‑induced osteolysis is a serious complication that occurs in individuals with titanium (Ti)‑based implants following long‑term usage due to loosening of the implants. The control of excessive osteoclast differentiation and inflammation is essential for protecting against wear particle‑induced osteolysis. The present study evaluated the effect of britanin, a pseudoguaianolide sesquiterpene isolated from Inula japonica, on osteoclastogenesis in vitro and Ti particle‑induced osteolysis in vivo. The effect of britanin ...
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Ju Ang Kim Soomin Lim Hye Jung Ihn Jung-Eun Kim Kyungmoo Yea Jimin Moon Hyukjae Choi Eui Kyun Park Source Type: research
Early diagnosis of chronic kidney disease in patients with diabetes in France: multidisciplinary expert opinion, prevention value and practical recommendations
This article provides an overview of critical laboratory evidence of CKD and their limitations, such as estimated glomerular filtration rate (eGFR), urine albumin-to-creatinine ratio (UACR), Kidney Failure Risk Equation (KFRE), and serum potassium. eGFR is estimated using the CKD-EPI 2009 formula, more relevant in Europe, from the calibrated dosage of plasma creatinine. The estimation formula and the diagnostic thresholds have been the subject of recent controversies. Recent guidelines emphasized the combined equation using both creatinine and cystatin for improved estimation of GFR. UACR on a spot urine sample is a simple...
Source: Postgraduate Medicine - September 21, 2023 Category: Internal Medicine Authors: Thierry Hannedouche Patrick Rossignol Patrice Darmon Jean-Michel Halimi Patrick Vuattoux Albert Hagege Ludivine Videloup Francis Guinard Source Type: research
Crystal Structures of Human Serum Albumin in Complex with Lysophosphatidylcholine
In this study, we employed fluorescence quenching and optical interferometry assays to demonstrate direct binding between lysophosphatidylcholine (LPC) and HSA (KRDR= 25 μM). Furthermore, we determined crystal structures of HSA in complex with LPC, both in the absence and presence of the endogenous fatty acid myristate (14:0). The crystal structure of binary HSA:LPC revealed that six LPC molecules are bound to HSA at the primary fatty acid binding sites. Interestingly, the ternary HSA:Myr:LPC structure demonstrated the continued binding of three LPC molecules to HSA at binding sites 1, 3, and 5 in the presence of myristat...
Source: Biophysical Journal - September 21, 2023 Category: Physics Authors: Yu Wang Zhipu Luo Xavier Morelli Peng Xu Longguang Jiang Xiaoli Shi Mingdong Huang Source Type: research
Compositional and spectroscopic analysis of dissolved organic matter samples from Everglades periphyton and water
This study provided fundamental information on periphyton DOM that is essential for further investigating its role in carbon cycle and its biogeochemistry.PMID:37730981 | DOI:10.1007/s11356-023-29461-1
Source: Environmental Science and Pollution Research International - September 21, 2023 Category: Environmental Health Authors: Afia Anjuman Yuping Xiang Guangliang Liu Yong Cai Source Type: research
A novel bacterial sulfite dehydrogenase that requires three < em > c < /em > -type cytochromes for electron transfer
In this study, we identify SorCABD of S. oneidensis as a novel sulfite dehydrogenase (SDH), which catalyzes the oxidation of sulfite to sulfate. In addition to catalytic subunit SorA, this enzymatic complex includes three c-Cyt subunits, which all together carry out electron transfer. The electrons extracted from sulfite oxidation are ultimately delivered to oxygen, leading to oxygen reduction, a process relying on terminal oxidase cyt cbb3. Genomic analysis suggests that the homologs of this SDH are present in a small number of bacterial genera, Shewanella and Vibrio in particular. Because these bacteria are generally cap...
Source: Applied and Environmental Microbiology - September 21, 2023 Category: Microbiology Authors: Weining Sun Yuanyou Xu Yawen Liang Qingzi Yu Haichun Gao Source Type: research
Acetylation of K188 and K192 inhibits the DNA-binding ability of NarL to regulate < em > Salmonella < /em > virulence
In this study, we demonstrate that the DNA-binding sites K188 and 192 of NarL can be acetylated by bacterial metabolite acetyl phosphate and that the degree of acetylation has a considerable influence on the regulatory function of NarL. Specifically, acetylation of NarL negatively regulates the transcription of narG, narK, and napF, which affects the utilization of nitrate in Salmonella. Besides, both cell and mouse models show that acetylated K188 and K192 result in attenuated replication in RAW 264.7 cells, as well as impaired virulence in mouse model. Together, this research identifies a novel NarL acetylation mechanism...
Source: Applied and Environmental Microbiology - September 21, 2023 Category: Microbiology Authors: Liu-Qing Zhang Yi-Lin Shen Bang-Ce Ye Ying Zhou Source Type: research
Phenomenological interpretations of the mechanism for the concentration-dependent positive effect of antibiotic lincomycin on < em > Streptomyces coelicolor < /em > A3(2)
Appl Environ Microbiol. 2023 Sep 21:e0113323. doi: 10.1128/aem.01133-23. Online ahead of print.ABSTRACTThe antibiotic lincomycin binds to the 23S ribosomal RNA peptidyl transferase loop region to inhibit protein synthesis. However, lincomycin can also stimulate the growth and secondary metabolism of actinomycetes in a concentration-dependent manner. In Streptomyces coelicolor A3(2), lincomycin stimulates the production of the blue-pigmented antibiotic actinorhodin at concentrations below the minimum inhibitory concentration. To better understand the molecular mechanism underlying these concentration-dependent positive effe...
Source: Applied and Environmental Microbiology - September 21, 2023 Category: Microbiology Authors: Keiichiro Mukai Tomoko Shibayama Yu Imai Takeshi Hosaka Source Type: research
Identification of a novel transcriptional regulator, CorR, for copper stress response in < em > Edwardsiella piscicida < /em >
Appl Environ Microbiol. 2023 Sep 21:e0089923. doi: 10.1128/aem.00899-23. Online ahead of print.ABSTRACTCopper plays a vital role in the host-pathogen interface, potentially making components of the bacterial copper response suitable targets for the development of innovative antimicrobial strategies. The anti-copper arsenal of intracellular pathogens has expanded as an adaptation to survive copper toxicity in order to escape intracellular killing by the host immune system. Herein, we employed transposon insertion sequencing to investigate the genetic mechanisms underlying the survival of Edwardsiella piscicida under copper ...
Source: Applied and Environmental Microbiology - September 21, 2023 Category: Microbiology Authors: Feng Xia Pengfei Xu Boya Zhang Yibei Zhang Xiaohong Liu Yue Ma Yuanxing Zhang Qiyao Wang Shuai Shao Source Type: research
Endophytic Fungus Talaromyces sp. MR1 Promotes the Growth and Cadmium Uptake of Arabidopsis thaliana L. Under Cadmium Stress
Curr Microbiol. 2023 Sep 21;80(11):346. doi: 10.1007/s00284-023-03453-3.ABSTRACTEndophytes play essential roles in plant growth under metal(loid)s stress. An endophytic fungus strain MR1 was isolated from the roots of Miscanthus floridulus collected from a lead-zinc mining area (Huayuan, China), which could produce indole-3-acetic acid and have Cadmium (Cd) tolerance. Further 18S rRNA sequencing analysis showed that it was highly similar (99.83%) to Talaromyces pinophilus. In pot experiments, we explored the effects of strain MR1 on the growth and Cd uptake of a wide-type Arabidopsis thaliana under low (LC) and high (HC) C...
Source: Current Microbiology - September 21, 2023 Category: Microbiology Authors: Yunhua Xiao Rui Chen Liang Chen Bo Yang Lihong Jiang Jun Fang Source Type: research
Progress advances in the production of bio-sourced methionine and its hydroxyl analogues
Biotechnol Adv. 2023 Sep 19:108259. doi: 10.1016/j.biotechadv.2023.108259. Online ahead of print.ABSTRACTThe essential sulphur-containing amino acid, methionine, is becoming a mass-commodity product with an annual production that exceeded 1,500,000 tons in 2018. This amino acid is today almost exclusively produced by chemical process from fossil resources. The environmental problems caused by this industrial process, and the expected scarcity of oil resources in the coming years, have recently accelerated the development of bioprocesses for producing methionine from renewable carbon feedstock. After a brief description of ...
Source: Biotechnology Advances - September 21, 2023 Category: Biotechnology Authors: Jean Marie Fran çois Source Type: research
Nutrition-associated health levels in persons with cancer: item response modelling based on the International Classification of Functioning, Disability and Health
CONCLUSIONS: The study constructed an evidence-based ICF scale for nutrition conditions in patients with cancer with 32-item and 2PLM for evaluating nutrition-associated health level in persons with cancer, including high validity and reliability.CLINICAL REHABILITATION IMPACT: The IRT model based on ICF provided a promising assessment tool to discriminate nutrition-associated health level of persons with cancer, and offered an auxiliary method for selecting rehabilitation intervention targets. This has the potential to lead to improved outcomes in cancer treatment and increased quality of life for cancer survivors.PMID:37...
Source: Health Physics - September 21, 2023 Category: Physics Authors: Jin-Jin Chen Zi-Yan Zhu Jia-Jia Bian Feng Lin Source Type: research
The NEF-SPA Approach as a Framework for Developing a Neurobiologically Inspired Spiking Neural Network Model for Speech Production
CONCLUSIONS: The model presented here is a promising approach for describing speech processing in a bottom-up manner based on a set of micro-circuit neural network elements for generating a large-scale neural network. In addition, the model conforms to a top-down design, as it is available in a condensed form in box-and-arrow models based on functional imaging and electrophysiological data recruited from speech processing tasks.PMID:37735137 | DOI:10.31083/j.jin2205124
Source: Journal of Integrative Neuroscience - September 21, 2023 Category: Neuroscience Authors: Bernd J Kr öger Source Type: research
White Matter Microstructural Differences between Essential Tremor and Parkinson Disease, Evaluated Using Advanced Diffusion MRI Biomarkers
CONCLUSIONS: Advanced diffusion-based metrics may provide a better understanding of the white matter microstructural characteristics in disparate motor-associated diseases with different underlying phenotypes, such as ET and PD.PMID:37735131 | DOI:10.31083/j.jin2205114
Source: Journal of Integrative Neuroscience - September 21, 2023 Category: Neuroscience Authors: Maurizio Bergamino Sana Aslam Jacob J Knittel Lea Alhilali Ashley M Stokes Source Type: research
Demonstration of equivocal anti-glomerular basement membrane antibody positivity as a non-specific reaction through multiple immunologic assays in a case of pediatric asymptomatic hematuria
CONCLUSION: The commercial assays for anti-GBM antibody can lead to false-positive results. We recommend confirmation of anti-GBM antibody positivity through the use of multiple assays in patients demonstrating an atypical clinical course for anti-GBM disease.PMID:37734646 | DOI:10.1016/j.clinbiochem.2023.110650
Source: Clinical Biochemistry - September 21, 2023 Category: Biochemistry Authors: Masayuki Sato Yuka Nishibata Sakiko Masuda Tsunehisa Nagamori Emi Ishibazawa Yoichiro Yoshida Hironori Takahashi Akihiro Ishizu Satoru Takahashi Source Type: research
Insights from the COVID-19 pandemic: trends in development assistance committee countries' aid allocation, 2011-2021
CONCLUSIONS: Emerging from this analysis is a strong recommendation for DAC members to re-evaluate aid objectives and escalate their financial commitments to reinforce SDGs and sustainable development efforts. While the rise in health aid is essential, other sectors also require equal focus to offset the ramifications of the COVID-19 pandemic. Understanding the intricacies of aid allocation can improve aid efficacy, culminating in greater, transformative results for recipient countries.PMID:37733029 | DOI:10.1080/16549716.2023.2258707
Source: Global Health Action - September 21, 2023 Category: International Medicine & Public Health Authors: Shuhei Nomura Cyrus Ghaznavi Kazuki Shimizu Alton Cao Miho Sassa Manae Uchibori Rauniyar Santosh Kumar Lisa Yamasaki Hana Tomoi Haruka Sakamoto Source Type: research
